References of "Mhawej, Marie-José"
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See detailMathematical modeling of HIV dynamics after antiretroviral therapy initiation: A clinical research study
Moog, Claude; Rivadeneira, Pablo; Stan, Guy-Bart et al

in AIDS Research and Human Retroviruses (2014), 30(9), 831-834

Immunological failure is identified from the estimation of certain parameters of a mathematical model of the HIV infection dynamics. This identification is supported by clinical research results from an ... [more ▼]

Immunological failure is identified from the estimation of certain parameters of a mathematical model of the HIV infection dynamics. This identification is supported by clinical research results from an original clinical trial. Standard clinical data were collected from infected patients starting Highly Active Anti-Retroviral Therapy (HAART), just after one month following therapy initiation and were used to carry out the model identification. The early diagnosis is shown to be consistent with the patients monitoring after six months. [less ▲]

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See detailApoptosis characterizes immunological failure of HIV infected patients
Mhawej, Marie-José; Brunet-Francois, Cécile; Fonteneau, Raphaël ULg et al

in Control Engineering Practice (2009), 17(7), 798-804

This paper studies the influence of apoptosis in the dynamics of the HIV infection. A new modeling of the healthy CD4+ T-cells activation-induced apoptosis is used. The parameters of this model are ... [more ▼]

This paper studies the influence of apoptosis in the dynamics of the HIV infection. A new modeling of the healthy CD4+ T-cells activation-induced apoptosis is used. The parameters of this model are identified by using clinical data generated by monitoring patients starting Highly Active Anti-Retroviral Therapy (HAART). The sampling of blood tests is performed to satisfy the constraints of dynamical system parameter identification. The apoptosis parameter, which is inferred from clinical data, is then shown to play a key role in the early diagnosis of immunological failure. [less ▲]

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