References of "Mesnil, Claire"
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See detailRelease and Innate detection of host cell DNA mediates the adjuvant effects of aluminum salts on adaptive responses
Marichal, Thomas ULg; Ohata, Keichii; Bedoret, Denis et al

in Proceedings of the 1St Winter School Immunology (2012, January)

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See detailResident CD11b(+)Ly6C(-) Lung Dendritic Cells Are Responsible for Allergic Airway Sensitization to House Dust Mite in Mice.
Mesnil, Claire ULg; Sabatel, Catherine ULg; Marichal, Thomas ULg et al

in PLoS ONE (2012), 7(12), 53242

Conventional dendritic cells (DCs) are considered to be the prime initiators of airway allergy. Yet, it remains unclear whether specific DC subsets are preferentially involved in allergic airway ... [more ▼]

Conventional dendritic cells (DCs) are considered to be the prime initiators of airway allergy. Yet, it remains unclear whether specific DC subsets are preferentially involved in allergic airway sensitization. Here, we systematically assessed the respective pro-allergic potential of individually sorted lung DC subsets isolated from house dust mite antigen (HDM)-treated donor mice, following transfer to naive recipients. Transfer of lung CD11c(+)CD11b(+) DCs, but not CD11c(+)CD11b(-)CD103(+) DCs, was sufficient to prime airway allergy. The CD11c(+)CD11b(+) DC subpopulation was composed of CD11c(+)CD11b(+)Ly6C(+) inflammatory monocyte-derived cells, whose numbers increase in the lungs following HDM exposure, and of CD11c(+)CD11b(+)Ly6C(-) DCs, which remain stable. Counterintuitively, only CD11c(+)CD11b(+)Ly6C(-) DCs, and not CD11c(+)CD11b(+)Ly6C(+) DCs, were able to convey antigen to the lymph nodes and induce adaptive T cell responses and subsequent airway allergy. Our results thus support that lung resident non-inflammatory CD11c(+)CD11b(+)Ly6C(-) DCs are the essential inducers of allergic airway sensitization to the common aeroallergen HDM in mice. [less ▲]

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See detailDNA released from dying host cells mediates aluminum adjuvant activity
Marichal, Thomas ULg; Ohata, Keiichi; Bedoret, Denis et al

in Nature Medicine (2011), 17

Aluminum-based adjuvants (alum) are widely used in human vaccination, although little is understood of their mechanisms of action. Here, we report that, in mice, alum causes the release of host cell DNA ... [more ▼]

Aluminum-based adjuvants (alum) are widely used in human vaccination, although little is understood of their mechanisms of action. Here, we report that, in mice, alum causes the release of host cell DNA, which acts as a potent endogenous immunostimulatory signal mediating alum adjuvant activity. Furthermore, we propose that host DNA signaling differentially regulates IgE and IgG1 production upon alum immunization. Indeed, we support that host DNA induces primary B cell responses, including IgG1 production, through Interferon Response Factor (Irf) 3-independent mechanisms, and 'canonical' type 2 T cell responses associated with IgE isotype switching and peripheral effector responses through Irf3-dependent mechanisms. The finding that host cell DNA is a damage-associated molecular pattern relaying alum adjuvant activity may thus help in the comprehension of the mechanisms of action of current vaccines and in the design of novel adjuvants. [less ▲]

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See detailIRF3 is essential for house dust mite-induced airway allergy in mice
Marichal, Thomas ULg; Bedoret, Denis; Mesnil, Claire ULg et al

in Proceedings GIGA-Day 2011 (2011, May)

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See detailRelease and innate immune detection of host cell DNA mediate the adjuvant activity of aluminum salts
Marichal, Thomas ULg; Ohata, K; Bedoret, D et al

Poster (2011)

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See detailRelease and innate immune detection of host cell DNA mediate the adjuvant activity of aluminum salts
Marichal, Thomas ULg; Ohata, K; Bedoret, Denis et al

Conference (2011)

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See detailSelf-DNA release mediates the adjuvant effects of aluminum salts
Marichal, Thomas ULg; Ohata, K; Bedoret, Denis et al

Poster (2011)

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See detailInterferon Response Factor 3 is required for airway allergy to house dust mite in mice
Marichal, Thomas ULg; Bedoret Denis; Mesnil, Claire ULg et al

in Short Book of the Annual Congress of the Euopean Respiratory Society (ERS), Barcelone (2010, September)

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See detailRelease and innate detection of hot cell DNA mediates the adjuvant effects of aluminium salts on adaptive responses.
Marichal, Thomas ULg; Ohata, Keichii; Bedoret, Denis et al

Conference (2010, February)

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See detailViral induction of Zac1b through TLR3- and IRF3-dependent pathways
Warzée, Barbara ULg; Mesnil, Claire ULg; Hober, D. et al

in Molecular Immunology (2010), 48(1-3), 119-127

Zinc finger protein regulator of apoptosis and cell cycle arrest (Zac1) is a transcription factor able to induce apoptosis or cell cycle arrest through independent pathways. In spite of the important ... [more ▼]

Zinc finger protein regulator of apoptosis and cell cycle arrest (Zac1) is a transcription factor able to induce apoptosis or cell cycle arrest through independent pathways. In spite of the important potential functions attributed to Zac1, little is known of its physiological regulation and biological function. We discovered that variant Zac1b was expressed in murine embryonic fibroblasts (MEFs) treated with polyriboinosinic polyribocytidylic acid [poly(I:C)], a synthetic double-stranded RNA. This regulation occurred mainly through Toll-Like Receptor 3 (TLR3)- and Interferon Regulatory Factor 3 (IRF3)-dependent pathways. As TLR3 and IRF3 are central activators of antiviral immunity, we hypothesized that Zac1 may be implicated in antiviral responses. In line with this notion, we observed that Zac1b was expressed in MEFs infected with Encephalomyocarditis virus (EMCV). We also observed that Zac1-deficient MEFs were less sensitive to EMCV-induced cell death than wild-type MEFs. However, Zac1 gene inactivation had no effect on the survival of mice infected with EMCV. In conclusion, this study describes for the first time a transcriptional regulation of Zac1b, induced by synthetic dsRNA and RNA viruses, the functional significance of which remains to be further investigated. [less ▲]

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See detailInterferon Response Factor 3 is essential for house dust mite-induced airway allergy
Marichal, Thomas ULg; Bedoret, Denis; Mesnil, Claire ULg et al

in Journal of Allergy and Clinical Immunology (The) (2010), 126(4), 836-844

IRF3, mainly known as a central orchestrator of antiviral responses, is required for proallergic functions of dendritic cells in response to aeroallergens. Thus, this study demonstratively identifies a ... [more ▼]

IRF3, mainly known as a central orchestrator of antiviral responses, is required for proallergic functions of dendritic cells in response to aeroallergens. Thus, this study demonstratively identifies a new pathway potentially implicated in the etiology of airway allergy [less ▲]

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See detailTableau clinique et mécanismes physiopathologiques des principales maladies inflammatoires chroniques des voies respiratoires du cheval
Mesnil, Claire ULg; Bureau, Fabrice ULg; Lekeux, Pierre ULg

in Annales de Médecine Vétérinaire (2006), 150(4), 227-240

The respiratory tract of the horse can be the seat of several chronic inflammatory diseases whose principal ones are the recurrent airway obstruction, the inflammatory airway disease, the summer pasture ... [more ▼]

The respiratory tract of the horse can be the seat of several chronic inflammatory diseases whose principal ones are the recurrent airway obstruction, the inflammatory airway disease, the summer pasture-associated obstructive pulmonary disease and the follicular pharyngitis. These diseases can have an important impact on horses’ health and on their sports performances. A good knowledge of their aetiologies and their physiopathological mechanisms would allow a better control of these affections. However, even if many studies were made on this subject, there are currently very few certainties as for the inflammatory mechanisms governing these diseases. This article aims to make an inventory of knowledge and deficiencies concerning these four chronic inflammatory diseases [less ▲]

Detailed reference viewed: 139 (14 ULg)