References of "Mc Entee, Kathleen"
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See detailAssociation between vertebral heart score measurement and overweight condition in dogs
François, Marion; Merveille, Anne-Christine ULg; Mc Entee, Kathleen ULg et al

in Veterinary Radiology & Ultrasound (2016)

Introduction Vertebral heart score (VHS) is used to assess heart size on thoracic radiographs. Association between VHS and overweight condition in dogs of different breeds is still unknown. The aim of ... [more ▼]

Introduction Vertebral heart score (VHS) is used to assess heart size on thoracic radiographs. Association between VHS and overweight condition in dogs of different breeds is still unknown. The aim of this study is to determine if VHS is influenced by overweight condition in dogs. The hypothesis is that VHS is influenced by BCS and T4 ratio. Methods Recruitment criteria for this retrospective study were the presence of a minimum of 2 thoracic radiographic views and a diagnosis of “normal echocardiographic examination” in medical records from 2013 to 2016. Body weight, BCS and breed were extracted. VHS and overweight condition were calculated. Dogs from breeds with a normal maximal VHS < 11 (group 1) and from breeds with a normal maximal VHS > 11 (group 2) were separated. Statistical analyses were performed using XLStat® software. Results Fifty-one dogs were included in the study. Body weight ranged from 3.7 to 44.8 kg and was not recorded in 2 dogs. These dogs were not excluded because of the BCS was recorded for these dogs. BCS ranged from 3 to 9. Thirteen dogs had a VHS value superior to the normal range and all of them had BCS ≥ 4. A weak positive correlation was found between BCS and T4 ratio (P ≤ 0.001, R2=0.4). There was a positive relationship between BCS and VHS (ANCOVA, P ≤ 0.003) for each group and between T4 ratio and VHS for each group (ANCOVA, P ≤ 0.001). Discussion/Conclusions This study confirms that the T4 ratio is correlated to BCS evaluated clinically. This ratio could be used to assess overweight condition on thoracic radiographs. VHS is influenced by BCS and the T4 ratio; therefore, VHS should be use with caution in overweighed dogs. [less ▲]

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See detailPulmonary Vein-to-Pulmonary Artery Ratio is an Echocardiographic Index of Congestive Heart Failure in Dogs with Degenerative Mitral Valve Disease
Merveille, Anne-Christine ULg; Bolen, Géraldine ULg; Krafft, Emilie et al

in Journal of Veterinary Internal Medicine (2015), 29

Background Early recognition of left-sided congestive heart failure (CHF) in dogs with degenerative mitral valve disease (DMVD) is important because it influences medical therapy, timing of follow-up, and ... [more ▼]

Background Early recognition of left-sided congestive heart failure (CHF) in dogs with degenerative mitral valve disease (DMVD) is important because it influences medical therapy, timing of follow-up, and outcome.HypothesisPulmonary vein diameter-to-pulmonary artery diameter ratio (PV/PA) measured by echocardiography can predict CHF.AnimalsNinety-eight client-owned dogs, 37 controls, and 61 dogs with DMVD.Methods Prospective clinical cohort study. History, physical examination and Doppler-echocardiography were performed. Dogs were classified as International Small Animal Cardiac Health Council class I, II or III. Congestive heart failure was identified in a subset of 56 dogs based on radiographic findings. The PV/PA was measured in bidimensional (2D) and M-mode by 2 investigators blinded to the radiologists’ conclusions.ResultsInterobserver coefficients of variation for PV/PA acquisition and measurement were <10%. The PV/PA in control dogs was approximately 1 and increased with class of heart failure. The presence of CHF could be best predicted by measuring PV/PA in 2D echocardiography (cut-off, 1.7; area under the curve, 0.98; CI, 0.97–0.98; P < .001) with a sensitivity of 96% and a specificity of 91%.Conclusion and clinical importanceThe PV/PA is a simple and reproducible echocardiographic variable that increases with class of heart failure and may help discriminate dogs in CHF from asymptomatic dogs with DMVD. Additional studies are required to determine whether PV/PA might provide additional information in the integrated interpretation of Doppler-echocardiographic indices of left ventricular filling pressures and could be used for rapid assessment of CHF in dogs in a critical care setting. [less ▲]

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See detailCorrelation between thoracic ct-scan angiography findings and echocardiographic right pulmonary vein to pulmonary artery ratio in west highland white terriers with idiopathic pulmonary fibrosis.
Roels, Elodie ULg; Merveille, Anne-Christine ULg; Couvreur, T. et al

in Proceedings of the 24th Ecvim Meeting, Mainz, Germany - 4-6 September 2014 (2014, September)

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See detailAssessment of pulmonary hypertension in dogs with chronic pulmonary diseases by thoracic ct-angiography.
Couvreur, T.; Roels, Elodie ULg; Merveille, Anne-Christine ULg et al

in Proceedings of the ECVDI Meeting, Utrecht - Netherlands - 27-30 August 2014 (2014, August)

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See detailTransforming Growth Factor Beta 1 Activation, Storage, and Signaling Pathways in Idiopathic Pulmonary Fibrosis in Dogs.
Krafft, Emilie; Lybaert, P.; Roels, Elodie ULg et al

in Journal of Veterinary Internal Medicine (2014), 28

BACKGROUND: The pathogenesis of idiopathic pulmonary fibrosis (IPF) in dogs is poorly understood. In human, transforming growth factor beta1 (TGF-beta1) is considered central in the pathogenesis ... [more ▼]

BACKGROUND: The pathogenesis of idiopathic pulmonary fibrosis (IPF) in dogs is poorly understood. In human, transforming growth factor beta1 (TGF-beta1) is considered central in the pathogenesis. OBJECTIVES: To investigate TGF-beta1 pathway in IPF. ANIMALS: Lung tissues from 12 affected and 11 control dogs. Serum from 16 affected West Highland white Terriers (WHWTs) and healthy dogs from predisposed (13 WHWTs, 12 Scottish Terriers and 13 Bichons Frise) and nonpredisposed breeds (10 Whippets, 10 Belgian shepherds, 8 Labradors). METHODS: In this prospective study, immunohistochemistry was used to evaluate expression and localization of TGF-beta1 protein and proteins involved in TGF-beta1 signaling (TGF-beta receptor type I and phospho-Smad2/3). Pulmonary expression of TGF-beta1 and molecules involved in its storage (latent TGF-beta binding proteins [LTBP] 1, 2, and 4), activation (alphanubeta6 and alphanubeta8 integrins, thrombospondin-1) and signal inhibition (Smad 7) was analyzed by quantitative reverse transcriptase PCR. Circulating TGF-beta1 concentration was measured by ELISA. RESULTS: In IPF, high level of TGF-beta1 protein was found in areas of fibrosis, epithelial cells had strong expression of TGF-beta receptor type 1 and phospho-Smad2/3, gene expression was decreased for LTBP 4 (P = .009) and beta8 integrin (P < .001) and increased for thrombospondin-1 (P = .016); no difference was seen for Smad7, LTBP1 and 2. Serum TGF-beta1 concentration was higher in predisposed compared with nonpredisposed breeds (P < .0001). CONCLUSIONS AND CLINICAL IMPORTANCE: This study identified an enhanced TGF-beta1 signaling activity in IPF. TGF-beta1 storage and activation proteins with altered expression represent potential therapeutic targets. Higher circulating TGF-beta1 concentration in predisposed breeds might partly explain their susceptibility for IPF [less ▲]

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See detailIMMUNOHISTOCHEMICAL ANALYSIS OF TRANSFORMING GROWTH FACTOR BETA 1 AND ITS SIGNALLING PATHWAYS IN CANINE IDIOPATHIC PULMONARY FIBROSIS
Krafft, Emilie ULg; Laurila, HP; Rajamäki, MM et al

in Proceedings of the 23th ECVIM Meeting (2013, September)

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See detailPersistent right aortic arch associated with an aberrant left subclavian artery arising from a patent ductus arteriosus in a puppy
Rizza, Maïlis ULg; Claeys, Stéphanie ULg; Billen, Frédéric ULg et al

Poster (2013, August 31)

PERSISTENT RIGHT AORTIC ARCH ASSOCIATED WITH AN ABERRANT LEFT SUBCLAVIAN ARTERY ARISING FROM A PATENT DUCTUS ARTERIOSUS IN A PUPPY Rizza M.*, Claeys S.**, Billen F.***, Mc Entee K. ***, Bolen G ... [more ▼]

PERSISTENT RIGHT AORTIC ARCH ASSOCIATED WITH AN ABERRANT LEFT SUBCLAVIAN ARTERY ARISING FROM A PATENT DUCTUS ARTERIOSUS IN A PUPPY Rizza M.*, Claeys S.**, Billen F.***, Mc Entee K. ***, Bolen G.* *Diagnostic Imaging Section, **Small Animal Surgery Section, ***Small Animal Internal Medicine Section, Department of Clinical Sciences (Companion Animal and Equides), Faculty of Veterinary Medicine, University of Liege, Belgium. Introduction Vascular anomalies develop during foetal development and single or multiple aberrant vessels can be present. Persistent right aorta arch (PRAA) represents over 90% of described vascular ring anomalies and can be accompanied by a left ligamentum arteriosum or a patent left ductus arteriosus (approximately 10% of patients) that causes oesophageal entrapment and secondary sub-obstruction. Radiography is an effective means of detecting vascular ring anomalies when oesophageal dilation and left-sided tracheal displacement are visible. Computed tomography angiography (CTA) is necessary to confirm the nature and the patency of the vascular anomalies present and to identify which of the identified anomalies is causing the clinical signs. Materials and methods A 3.5-month-old, male French Bulldog was presented for regurgitation and vomiting since weaning. Besides a low body score, physical exam was unremarkable. Hypoglycemia was observed on routine blood analysis. Thoracic radiographs and CTA of the thorax were performed. Results The radiographs revealed severe oesophageal dilation cranial to the base of the heart and a ventral and left-sided tracheal displacement. A congenital oesophageal diverticulum secondary to a vascular anomaly was suspected. CTA showed multiple vascular anomalies. A PRAA was observed. An aberrant right subclavian artery (ARSA) was identified originating from the PRAA next to the brachiocephalic trunk. A patent left-to-right patent ductus arteriosus (PDA) was detected between the aorta and the pulmonary trunk and an aberrant left subclavian artery (ALSA) originated from the PDA. The oesophagus was compressed between the PDA and the trachea and was dilated cranially to this narrowing. Endoscopy revealed severely esophageal distension cranially to an extraluminal stenosis. Surgery was performed to ligate and cut the PDA. Discussion Seven types of vascular ring anomaly are described: types I - III have a PRAA, type IV has a double aortic arch, and types V -VII have a left aortic arch with combinations of persistent right ligamentum arteriosum and right subclavian arteries. In the patient described here, the vascular ring anomalies are a novel variant of the defined types. To the authors’ knowledge, an ALSA originating from a PDA has not been described previously. The severe compression of the oesophagus with severe dilation cranial to the heart was caused by the PDA and was resolved by surgical intervention. In conclusion, CTA is necessary to determine which vascular anomalies are present and to identify which of these anomalies is responsible for the clinical signs. This technique enables accurate pre-operative planning. Pownder S. Scrivani PV. Non-selective computed tomography angiography of a vascular ring anomaly in a dog. J Vet Cardiol. 2008 Dec;10(2):125-8 Henjes CR, Nolte I, Wefstaedt P. Multidetector-row computed tomography of thoracic aortic anomalies in dogs and cats: patent ductus arteriosus and vascular rings. BMC Vet Res. 2011 Sep 23;7:57 [less ▲]

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See detailTransforming growth factor beta 1 and its activation, storage and signalling pathways in canine idiopathic pulmonary fibrosis.
Krafft, Emilie ULg; Heikkilä, H.P.; Rajamäki, M.M. et al

Scientific conference (2013, July)

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See detailCardiac ultrasound in canine emergencies with a systemic inflammatory response syndrome
Gommeren, Kris ULg; Desmas, Isabelle; Garcia, Alexandra et al

Poster (2012, October 19)

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See detailEvolution of serum adiponectin and inflammatory markers in naturally-obese and obese-induced dogs submitted to a weight loss program
Ricci, Rebecca; Manens, Jefferson; Damoiseaux, Cécile et al

in ESVCN (Ed.) Proceedings of the 16th Annual Congress of the ESVCN (2012, September)

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See detailTransforming growth factor-beta 1 and its activating pathways in canine idiopathic pulmonary fibrosis
Krafft, Emilie ULg; Heikkila, H. P.; Day, M.J. et al

in Proceedings of the 22nd ECVIM-CA Congress (2012, September)

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See detailCardiac ultrasound in canine emergencies with a systemic inflammatory response syndrome
Gommeren, Kris ULg; Desmas, Isabelle; Garcia, Alexandra et al

in Proceedings of the 22nd ECVIM-CA Congress (2012, September)

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See detailEffect of heart failure on dipeptidyl peptidase IV activity in plasma of dogs.
Gomez, N.; Matheeussen, V.; Damoiseaux, Cécile ULg et al

in Journal of Veterinary Internal Medicine (2012)

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See detailCardiac troponin and natriuretic peptide in canine emergencies with a systemic inflammatory response syndrome
Gommeren, Kris ULg; Desmas, I.; Garcia, Alexandra ULg et al

in Proceedings of 21st ECVIM Meeting (2011, September 06)

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See detailHigh serum transforming growth factor-beta 1 concentration in West Highland white terriers : a key to the breed predisposition in canine idiopathic pulmonary fibrosis
Krafft, Emilie ULg; Heikkilä, H.P.; Jespers, P et al

in Proceedings of the 21st ECVIM-CA Congress (2011, September)

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