References of "Mathy, Marianne"
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See detailNew alginate-chitosan hydrogel beads with anti-inflammatory and anabolic effects on human chondrocytes
Oprenyeszk, Frédéric ULg; Mathy, Marianne ULg; Sanchez, Christelle ULg et al

in Osteoarthritis and Cartilage (2011), 19(Suppl 1), 222

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See detailThe mechanosensitivity of cells in joint tissues: Role in the pathogenesis of joint diseases
Sanchez, Christelle ULg; Mathy, Marianne ULg; Henrotin, Yves ULg

in Kamkin, André; Kiseleva, Irina (Eds.) Mechanosensitivity and Mechanotransduction (2011)

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See detailSynovium angiogenesis in osteoarthritis: a new therapy target for chondroitin sulfate
Mathy, Marianne ULg; Lambert, Cécile ULg; Dubuc, Jean Emile et al

in Osteoarthritis and Cartilage (2010, October), 18

Purpose: Osteoarthritis (OA) is an important cause of pain and disability in the ageing population. Angiogenesis and inflammation are closely integrated process in OA and may contribute to its ... [more ▼]

Purpose: Osteoarthritis (OA) is an important cause of pain and disability in the ageing population. Angiogenesis and inflammation are closely integrated process in OA and may contribute to its pathogenesis, as well as, affect disease progression and pain. Chondroitin sulfate (CS) is a symptomatic slow acting drug for OA and there is strong evidence suggesting that CS may also be a structure disease modifying osteoarthritis drug. The mechanisms underlying these effects remain poorly understood. This work aimed to demonstrate the relation between inflammation and angiogenesis of synovium and to study the effect of CS on synovium angiogenesis. [less ▲]

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See detailSynovium angiogenesis in osteoarthritis: a new therapy target for chondroitin sulfate
Mathy, Marianne ULg; Lambert, Cécile ULg; Dubuc, Jean Emile et al

Poster (2010, September)

Osteoarthritis (OA) is an important cause of pain and disability in the ageing population. Angiogenesis and inflammation are closely integrated process in OA and may contribute to its pathogenesis, as ... [more ▼]

Osteoarthritis (OA) is an important cause of pain and disability in the ageing population. Angiogenesis and inflammation are closely integrated process in OA and may contribute to its pathogenesis, as well as, affect disease progression and pain. Chondroitin sulfate (CS) is a symptomatic slow acting drug for OA and there is strong evidence suggesting that CS may also be a structure disease modifying osteoarthritis drug. The mechanisms underlying these effects remain poorly understood. This work aimed to demonstrate the relation between inflammation and angiogenesis of synovium and to study the effect of CS on synovium angiogenesis. [less ▲]

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See detailLa chondroitine sulfate stimule la production des facteurs anti angiogéniques TSP-1 et VEGI par les synoviocytes arthrosiques : un nouveau mécanisme d’action pour cette molécule.
Mathy, Marianne ULg; Lambert, Cécile ULg; Dubuc, Jean Emile et al

Poster (2010, September)

: La chondroïtine sulfate (CS), la glucosamine sulfate (GS), la glucosamine HCl (GH) et l’acide hyaluronique (AH) sont des anti-arthrosiques symptomatiques d’action lente (AASAL) dont l’utilisation est ... [more ▼]

: La chondroïtine sulfate (CS), la glucosamine sulfate (GS), la glucosamine HCl (GH) et l’acide hyaluronique (AH) sont des anti-arthrosiques symptomatiques d’action lente (AASAL) dont l’utilisation est recommandée dans le traitement de l’arthrose. Les mécanismes d’action de ces molécules demeurent mal compris. Notre étude a comme objectif d’étudier les effets de ces molécules sur la production de médiateurs impliqués dans l’angiogenèse de la membrane synoviale (MS) arthrosique. [less ▲]

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See detailChondroitin sulfate in the treatment of osteoarthritis: from in vitro studies to clinical recommendations
Henrotin, Yves ULg; Mathy, Marianne ULg; Sanchez, Christelle ULg et al

in Therapeutic Advances in Musculoskeletal Disease (2010), 2(6), 335-348

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See detailLa chondroitine sulfate stimule la production des facteurs anti angiogéniques TSP-1 et VEGI par les synoviocytes arthrosiques : un nouveau mécanisme d’action pour cette molécule.
Mathy, Marianne ULg; Lambert, Cécile ULg; Dubuc, Jean Emile et al

in Revue du Rhumatisme (2010), 77

La chondroïtine sulfate (CS), la glucosamine sulfate (GS), la glucosamine HCl (GH) et l’acide hyaluronique (AH) sont des anti-arthrosiques symptomatiques d’action lente (AASAL) dont l’utilisation est ... [more ▼]

La chondroïtine sulfate (CS), la glucosamine sulfate (GS), la glucosamine HCl (GH) et l’acide hyaluronique (AH) sont des anti-arthrosiques symptomatiques d’action lente (AASAL) dont l’utilisation est recommandée dans le traitement de l’arthrose. Les mécanismes d’action de ces molécules demeurent mal compris. Notre étude a comme objectif d’étudier les effets de ces molécules sur la production de médiateurs impliqués dans l’angiogenèse de la membrane synoviale (MS) arthrosique [less ▲]

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See detailEtude du phenotype des synoviocytes fibroblast-like isolés à partir de tissu synovial arthrosique
Lambert, Cécile ULg; Mathy, Marianne ULg; Dubuc, Jean Emile et al

in Revue du Rhumatisme (2010), 77

L’inflammation et l’angiogenèse sont deux processus étroitement associés à la progression de l’arthrose. Dans cette étude, nous avons comparé la production de médiateurs pro-inflammatoires et ... [more ▼]

L’inflammation et l’angiogenèse sont deux processus étroitement associés à la progression de l’arthrose. Dans cette étude, nous avons comparé la production de médiateurs pro-inflammatoires et angiogéniques par les synoviocytes de type fibroblastique isolés des zones enflammées (ZE) et non-enflammées (ZNE) de la membrane synoviale de genoux arthrosiques. [less ▲]

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See detailBiological actions of curcumin on articular chondrocytes.
Henrotin, Yves ULg; Clutterbuck, A. L.; Allaway, D. et al

in Osteoarthritis and Cartilage (2010), 18(2), 141-9

OBJECTIVES: Curcumin (diferuloylmethane) is the principal biochemical component of the spice turmeric and has been shown to possess potent anti-catabolic, anti-inflammatory and antioxidant, properties ... [more ▼]

OBJECTIVES: Curcumin (diferuloylmethane) is the principal biochemical component of the spice turmeric and has been shown to possess potent anti-catabolic, anti-inflammatory and antioxidant, properties. This article aims to provide a summary of the actions of curcumin on articular chondrocytes from the available literature with the use of a text-mining tool. We highlight both the potential benefits and drawbacks of using this chemopreventive agent for treating osteoarthritis (OA). We also explore the recent literature on the molecular mechanisms of curcumin mediated alterations in gene expression mediated via activator protein 1 (AP-1)/nuclear factor-kappa B (NF-kappaB) signalling in chondrocytes, osteoblasts and synovial fibroblasts. METHODS: A computer-aided search of the PubMed/Medline database aided by a text-mining tool to interrogate the ResNet Mammalian database 6.0. RESULTS: Recent work has shown that curcumin protects human chondrocytes from the catabolic actions of interleukin-1 beta (IL-1beta) including matrix metalloproteinase (MMP)-3 up-regulation, inhibition of collagen type II and down-regulation of beta1-integrin expression. Curcumin blocks IL-1beta-induced proteoglycan degradation, AP-1/NF-kappaB signalling, chondrocyte apoptosis and activation of caspase-3. CONCLUSIONS: The available data from published in vitro and in vivo studies suggest that curcumin may be a beneficial complementary treatment for OA in humans and companion animals. Nevertheless, before initiating extensive clinical trials, more basic research is required to improve its solubility, absorption and bioavailability and gain additional information about its safety and efficacy in different species. Once these obstacles have been overcome, curcumin and structurally related biochemicals may become safer and more suitable nutraceutical alternatives to the non-steroidal anti-inflammatory drugs that are currently used for the treatment of OA. [less ▲]

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See detailCurcumin inhibits pro-inflammatory mediators and metalloproteinase-3 production by chondrocytes
Mathy, Marianne ULg; Jacquemond-Collet, Ingrid; Priem, Fabian et al

in Inflammation research (2009), 58

Objective and Design. This study aims to investigate the effects of curcumin (Cur) on the production of inflammatory mediators and on the extracellular matrix proteins metabolism by articular chondrocytes ... [more ▼]

Objective and Design. This study aims to investigate the effects of curcumin (Cur) on the production of inflammatory mediators and on the extracellular matrix proteins metabolism by articular chondrocytes. Methods. Human chondrocytes in alginate beads and human cartilage explants were cultured in the absence or in the presence of interleukin (IL)-1beta(10-11 M) and with or without Cur (5 to 20 µM). Nitric oxide (NO) synthesis was measured by Griess spectrophotometric method, prostaglandin (PG) E2 by a specific radioimmunoassay and IL-6, IL-8, aggrecan (Agg), matrix metalloproteinase (MMP)-3 and tissue inhibitor of metalloproteinase (TIMP)-1 by specific enzyme-amplified immunoassays. Proteoglycans degradation was evaluated by the release of 35S-glycosaminoglycans (GAG) from human cartilage explants. Results. In alginate beads and cartilage explants models, Cur inhibited in a concentration dependent manner the basal and the IL-1beta stimulated NO, PGE2, IL-6, IL-8 and MMP-3 production by human chondrocytes. The TIMP-1 and the Agg productions were not modified. In basal condition, 35S-GAG release from cartilage explants was decreased by Cur. Conclusions. Cur was a potent inhibitor of the production of inflammatory and catabolic mediators by chondrocytes, suggesting that this natural compound could be efficient in the treatment of osteoarthritis. [less ▲]

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See detailBiochemical biomarkers of oxidative collagen damage.
Henrotin, Yves ULg; Deberg, Michelle ULg; Mathy, Marianne ULg et al

in Advances in Clinical Chemistry (2009), 49

Collagens are major constituents of connective tissues in the animal kingdom. During aging and inflammatory-related diseases, the collagen network undergoes oxidation that leads to structural and ... [more ▼]

Collagens are major constituents of connective tissues in the animal kingdom. During aging and inflammatory-related diseases, the collagen network undergoes oxidation that leads to structural and biochemical alterations within the collagen molecule. Collagen oxidation appears to be a key determinant of aging and a critical physiopathologic mechanism of numerous diseases. Further, the detection of oxidized-collagen peptides seems to be a promising approach for the diagnosis and the prognosis of inflammatory diseases. This chapter reviews the structural and biochemical changes to collagen induced by reactive oxygen and nitrogen species and discusses recent data on the use of collagen-derived biomarkers for measuring oxidative damage. [less ▲]

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See detailInterleukin-1beta and Interleukin-6 Disturb the Antioxidant Enzyme System in Bovine Chondrocytes: A Possible Explanation for Oxidative Stress Generation
Mathy, Marianne ULg; Hogge, Laurence ULg; Sanchez, Christelle ULg et al

in Osteoarthritis and Cartilage (2008), 16

OBJECTIVE: Beside matrix metalloproteinases, reactive oxygen species (ROS) are the main biochemical factors of cartilage degradation. To prevent ROS toxicity, chondrocytes possess a well-coordinated ... [more ▼]

OBJECTIVE: Beside matrix metalloproteinases, reactive oxygen species (ROS) are the main biochemical factors of cartilage degradation. To prevent ROS toxicity, chondrocytes possess a well-coordinated enzymatic antioxidant system formed principally by superoxide dismutases (SODs), catalase (CAT) and glutathione peroxidase (GPX). This work was designed to assess the effects of interleukin (IL)-1beta and IL-6 on the enzymatic activity and gene expression of SODs, CAT and GPX in bovine chondrocytes. METHODS: Bovine chondrocytes were cultured in monolayer for 4-96h in the absence or in the presence of IL-1beta (0.018-1.8ng/ml) or IL-6 (10-100ng/ml). To study signal transduction pathway, inhibitors of mitogen-activated protein kinases (MAPK) (PD98059, SB203580 and SP600125) (5-20muM) and nuclear factor (NF)-kappaB inhibitors [BAY11-7082 (1-10muM) and MG132 (0.1-10muM)] were used. SODs, CAT and GPX enzymatic activities were evaluated in cellular extract by using colorimetric enzymatic assays. Mn SODs, Cu/Zn SOD, extracellular SOD (EC SOD), CAT and GPX gene expressions were quantified by real-time and quantitative polymerase chain reaction (PCR). RESULTS: Mn SOD and GPX activities were dose and time-dependently increased by IL-1beta. In parallel, IL-1beta markedly enhanced Mn SOD and GPX gene expressions, but decreased Cu/Zn SOD, EC SOD and CAT gene expressions. Induction of SOD enzymatic activity and Mn SOD mRNA expression were inhibited by NF-kappaB inhibitors but not by MAPK inhibitors. IL-6 effects were similar but weaker than those of IL-1beta. CONCLUSIONS: In conclusion, IL-1beta, and to a lesser extend IL-6, dysregulates enzymatic antioxidant defenses in chondrocyte. These changes could lead to a transient accumulation of H(2)O(2) in mitochondria, and consequently to mitochondria damage. These changes contribute to explain the mitochondrial dysfunction observed in osteoarthritis chondrocytes. [less ▲]

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See detailEtude des effets de la compression sur le métabolisme des ostéoblastes sous-chondraux humains
Sanchez, Christelle ULg; Mathy, Marianne ULg; Gabay, Odile et al

in Revue du Rhumatisme (2008), 75(10-11), 1021

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See detailCurcumin inhibits interleukin-6, -8, nitric oxide and prostaglandin E2 synthesis by bovine chondrocytes
Mathy, Marianne ULg; Sanchez, Christelle ULg; Priem, F. et al

in Osteoarthritis and Cartilage (2007), 15(Suppl C), 115

Detailed reference viewed: 48 (13 ULg)