References of "Marini Djang'Eing'A, Roland"
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See detailDevelopment, validation and comparison of NIR and Raman methods for the identification and assay of poor-quality oral quinine drops.
Mbinze Kidenge, Jérémie; Sacre, Pierre-Yves ULg; Yemoa, Achille et al

in Journal of Pharmaceutical & Biomedical Analysis (2015), 111

Poor quality antimalarial drugs are one of the public’s major health problems in Africa. The depth of this problem may be explained in part by the lack of effective enforcement and the lack of efficient ... [more ▼]

Poor quality antimalarial drugs are one of the public’s major health problems in Africa. The depth of this problem may be explained in part by the lack of effective enforcement and the lack of efficient local drug analysis laboratories. To tackle part of this issue, two spectroscopic methods with the ability to detect and to quantify quinine dihydrochloride in children’s oral drops formulations were developed and validated. Raman and Near Infrared (NIR) spectroscopy were selected for the drug analysis due to their low cost, non-destructive and rapid characteristics. Both of the methods developed were successfully validated using the total error approach in the range of 50-150% of the target concentration (20% W/V) within the 10% acceptance limits. Samples collected on the Congolese pharmaceutical market were analyzed by both techniques to detect potentially substandard drugs. After a comparison of the analytical performance of both methods, it has been decided to implement the method based on NIR spectroscopy to perform the routine analysis of quinine oral drop samples in the Quality Control Laboratory of Drugs at the University of Kinshasa (DRC). [less ▲]

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See detailRADIOPHARMACY GMP QC HPLC VALIDATION
Aerts, Joël ULg; Giacomelli, Fabrice ULg; Hubert, Philippe ULg et al

Conference (2015, May 09)

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See detailMédicaments: Faux et usage de faux
Sacre, Pierre-Yves ULg; Marini Djang'Eing'A, Roland ULg; Ziemons, Eric ULg et al

Article for general public (2015)

La contrefaçon des médicaments est en constante progression, voire en pleine explosion. Chaque année, elle tue des centaines de milliers de personnes, principalement en Afrique. Véritable fléau, elle est ... [more ▼]

La contrefaçon des médicaments est en constante progression, voire en pleine explosion. Chaque année, elle tue des centaines de milliers de personnes, principalement en Afrique. Véritable fléau, elle est de plus en plus souvent aux mains de réseaux transnationaux d'une profonde opacité. [less ▲]

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See detailFalsification des médicaments: Est-il possible d'améliorer la puissance des outils de détection ?
Ziemons, Eric ULg; Sacre, Pierre-Yves ULg; Marini Djang'Eing'A, Roland ULg et al

Conference given outside the academic context (2015)

La mise sur le marché de médicaments falsifiés est une réalité dont on imagine rarement l’importance et la nuisance : on estime pourtant que ce marché rapporte plus que le trafic de drogue et il arrive ... [more ▼]

La mise sur le marché de médicaments falsifiés est une réalité dont on imagine rarement l’importance et la nuisance : on estime pourtant que ce marché rapporte plus que le trafic de drogue et il arrive que localement, des produits falsifiés soient plus nombreux que les produits originaux (cas des anti-malariques au Congo). La lutte contre la falsification s’est d’abord focalisée sur les emballages et les identificateurs tels que les codes-barres, qui aujourd’hui ne garantissent plus le contenu du médicament vu les progrès réalisés par les organisations criminelles en matière de reproduction d’emballage. La solution sûre consiste donc à analyser, sur place, la composition du produit à travers l’emballage et à comparer le résultat à la «carte d’identité» du médicament établie par le producteur. Les besoins portent donc sur des instruments d’analyse portables et capables de dialoguer à distance avec des banques de données de «cartes d’identité». Ceux-ci requièrent une approche pluridisciplinaire impliquant notamment des micro-électroniciens et des informaticiens. [less ▲]

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See detailIntroduction à l’incertitude de mesure - Partim 2
Marini Djang'Eing'A, Roland ULg; Vermaercke, Peter; Hubert, Philippe ULg

Learning material (2015)

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See detailIntroduction à l’incertitude de mesure - Partim 1
Marini Djang'Eing'A, Roland ULg; Vermaercke, Peter; Hubert, Philippe ULg

Learning material (2015)

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See detailAPPUI ANALYTIQUE A LA LUTTE CONTRE LES MEDICAMENTS DE QUALITE INFERIEURE
Mbinze Kindenge, Jérémie; Hubert, Philippe ULg; Marini Djang'Eing'A, Roland ULg

Conference (2015, January 27)

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See detailFighting Poor Quality Medicines: Develop-ment, Transfer and Validation of Generic HPLC Methods for Analyzing two WHO Recommended Antimalarial Tablets
Mbinze Kindenge, Jérémie; Yemoa, Achille; Lebrun, Pierre ULg et al

in American Journal of Analytical Chemistry (2015), 6

As serious but neglected public health problems, poor quality medicines, i.e. for antimalarial medicines, urged to be fought. One of the approaches is to consider the analytical chemistry and separative ... [more ▼]

As serious but neglected public health problems, poor quality medicines, i.e. for antimalarial medicines, urged to be fought. One of the approaches is to consider the analytical chemistry and separative techniques. In this study, a generic liquid chromatographic method was firstly devel-oped for the purpose of screening 8 antimalarial active ingredients, namely amodiaquine (AQ), piperaquine (PPQ), sulfalene (SL), pyrimethamine (PM), lumefantrine (LF), artesunate (AS), artemether (AM) and dihydroartemisinine (DHA) by applying DoE/DS optimization strategy. Since the method was not totally satisfying in terms of peak separation, further experiments were undergone applying the same development strategy while splitting the 8 ingredients into five groups. Excellent prediction was observed prior to correlation between retention times of predicted and observed separation conditions. Then, a successful geometric transfer was realized to reduce the analysis time focusing on the simultaneous quantification of two WHO's recommended ACTs in anti-malarial fixed-dose combination (AM-LF and AS-AQ) in tablets. The optimal separation was achieved using an isocratic elution of methanol-ammonium formate buffer (pH 2.8; 10mM) (82.5: 17.5, v/v) at 0.6ml/min through a C18 column (100mm×3.5mm, 3.5 μm) thermostated at 25°C. After a successful validation stage based on the total error approach, the method was applied to determine the content of AM/LF or AS/AQ in seven brands of antimalarial tablets currently marketed in West, Central and East Africa. Satisfying results were obtained compared to the claimed contents. [less ▲]

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See detailApplication of Total Error Strategy in Validation of Affordable and Accessible UV-Visible Spectrophotometric Methods for Quality Control of Poor Medicines
Mbinze, Kingenge; Nsangu Mpasi, Jean; Maghe, Elza et al

in American Journal of Analytical Chemistry (2015), 6

In the framework of fighting against the poor quality medicines sold in developing countries using classical analytical methods easily accessible in those countries, four UV-Visible spectrophotometric ... [more ▼]

In the framework of fighting against the poor quality medicines sold in developing countries using classical analytical methods easily accessible in those countries, four UV-Visible spectrophotometric methods for one antimalarial (quinine) and two antibiotics (amoxicillin and metronidazole) have been developed and validated according to the total error strategy using the accuracy profiles as a decision tool. The dosing range was 2-10µg/mL (for quinine sulfate in tablet), 4-12µg/mL (for quinine bichlorhydrate in oral drop - metronidazole benzaote in oral suspension) and 15-35µg/mL (for amoxicillin trihydrate in capsule). The validated methods were then applied in determining the content of some analogous medicines sold in the Democratic Republic of Congo. Thus, the proposed UV-Visible spectrophotometric methods are simple and suitable to quantify quinine, amoxicillin and metronidazole in different pharmaceutical forms. [less ▲]

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See detailFalsification des médicaments en Afrique : état de la question
Marini Djang'Eing'A, Roland ULg; Hubert, Philippe ULg

Scientific conference (2014, November 12)

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See detailA preliminary analysis of the quality of pediatric medicines supplied by private wholesalers in Kinshasa, DRC
Schiavetti, Benedetta; Ngeleka Mutolo, Daniel; Marini Djang'Eing'A, Roland ULg et al

in Abstract Book, Supplement to the American Journal of Tropical Medicine and Hygiene (2014, November)

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See detailIntroduction aux BPF/GMP : Chapitre 2 Personnel
Marini Djang'Eing'A, Roland ULg

Learning material (2014)

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See detailEvaluation of the quantitative performances of Supercritical Fluid Chromatography : from method development to validation
Dispas, Amandine ULg; Lebrun, Pierre ULg; Ziemons, Eric ULg et al

in Journal of Chromatography. A (2014), 1353(Method Validation), 78-88

Recently, the number of papers about SFC increased drastically but scientists did not truly focus their work on quantitative performances of this technique. In order to prove the potential of UHPSFC, the ... [more ▼]

Recently, the number of papers about SFC increased drastically but scientists did not truly focus their work on quantitative performances of this technique. In order to prove the potential of UHPSFC, the present work discussed about the different steps of the analytical life cycle of a method: from development to validation and application. Moreover, the UHPSFC quantitative performances were evaluated in comparison with UHPLC, which is the main technique used for quality control in the pharmaceutical industry and then could be considered as a reference. The methods were developed using Design Space strategy, leading to the optimization of robust method. In this context, when the Design Space optimization shows guarantee of quality, no more robustness study is required prior to the validation. Then, the methods were geometrically transferred in order to reduce the analysis time. The UHPSFC and UHPLC methods were validated based on the total error approach using accuracy profile. Even if UHPLC showed better precision and sensitivity, UHPSFC method is able to give accurate results in a dosing range larger than the 80–120% range required by the European Medicines Agency. Consequently, UHPSFC results are valid and could be used for the control of active substance in a finished pharmaceutical product. Finally, UHPSFC validated method was used to analyse real samples and gave similar results than the reference method (UHPLC). [less ▲]

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See detailINVESTIGATION OF TWO IMPROVED TRADITIONAL MEDICINES: DEVELOPMENT AND VALIDATION OF A LC-UV METHOD FOR THE DOSAGE OF A TRACER COMPOUND
Tshisekedi Tshibangu, Pascal; Kalenda Dibungi, Pascal; Rozet, Eric ULg et al

Poster (2014, June)

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See detailDéveloppement de méthodes séparatives pour détecter la contrefaçon de molécules biosynthétiques comme l'insuline et les GHRP
Lamalle, Caroline ULg; Baptiste, Emeline; Marini Djang'Eing'A, Roland ULg et al

in Spectra Analyse (2014), 43

Counterfeiting is a widespread problem in the world. The medicines, like insulin or GHRP, need a strict quality control. Capillary electrophoresis and liquid chromatography methods were developed to ... [more ▼]

Counterfeiting is a widespread problem in the world. The medicines, like insulin or GHRP, need a strict quality control. Capillary electrophoresis and liquid chromatography methods were developed to analyze these peptides. The human insulin and its different analogues (lispro, aspart, glulisin, glargin and detemir) were separated by MEKC within 15 minutes. The GHRP-2 and -6 were separated by HPLC also in 15 minutes. Several samples of GHRP-6 were analyzed and non-compliances were reported. These analytical approaches seem to be promising to fight against the counterfeiting of such medicines. [less ▲]

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See detailLa spectroscopie proche infrarouge, une technique non destructive dans la lutte contre la contrefaçon des médicaments
Mbinze Kindenge, Jérémie ULg; Kalenda Tshilombo, Nicodème; Chavez, Pierre-François ULg et al

in Spectra Analyse (2014), 43

Near infrared spectroscopy is a very promising and expanding analytical technique. It has to be noted that this technique is becoming more used in the pharmaceutical field for the quality control of ... [more ▼]

Near infrared spectroscopy is a very promising and expanding analytical technique. It has to be noted that this technique is becoming more used in the pharmaceutical field for the quality control of products. Indeed near infrared spectroscopy allows to perform fast, non-destructive, versatile analysis of the sample and minimization of the sample preparation. Based on those advantages, this spectroscopic method is one of the first reliable analytical techniques for fighting against counterfeit medicines. [less ▲]

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See detailStratégies analytiques pour la détection de contrefaçons de médicaments pour la dysfonction érectile
Sacre, Pierre-Yves ULg; Deconinck, Eric; Marini Djang'Eing'A, Roland ULg et al

in Spectra Analyse (2014), 43

Erectile dysfunction drugs are among the most counterfeit drug classes in industrialized countries. To fight against this plague, several analytical approaches are available for control laboratories. The ... [more ▼]

Erectile dysfunction drugs are among the most counterfeit drug classes in industrialized countries. To fight against this plague, several analytical approaches are available for control laboratories. The present article reviews the main used techniques and concludes presenting a general strategy for the detection and handling of drug counterfeits. [less ▲]

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See detailMéthodes chromatographiques génériques de criblage pour lutter contre les médicaments de qualité inférieure
Habyalimana, Védaste; Kalenda Tshilombo, Nicodème; Dispas, Amandine ULg et al

in Spectra Analyse (2014), 43

Poor quality medicines are a danger and a threat to public health. In this context, several generic analytical methods have been developed to screen molecules of interest grouped by pharmacological class ... [more ▼]

Poor quality medicines are a danger and a threat to public health. In this context, several generic analytical methods have been developed to screen molecules of interest grouped by pharmacological class using an innovative strategy based on design of experiments followed in some cases by independent component analysis and calculation of design space. Once validated via the classical total error measurement approach, these methods were applied to quantify antimalarial, non-steroidal anti-inflammatory and antibiotic medicines. Alarming results regarding the dosage of these drugs widely used by people confirm the need to fight against this scourge. [less ▲]

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