References of "Mariat, Christophe"
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See detailDetection of decreased glomerular filtration rate in intensive care units: serum cystatin C versus serum creatinine
DELANAYE, Pierre ULg; CAVALIER, Etienne ULg; Morel, Jérôme et al

in BMC Nephrology (2014), 15(9), 1471-2369

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See detailThe applicability of eGFR equations to different populations
DELANAYE, Pierre ULg; Mariat, Christophe

in Nature Reviews Nephrology (2013), 9

The Cockcroft–Gault equation for estimating glomerular filtration rate has been learnt by every generation of medical students over the decades. Since the publication of the Modification of Diet in Renal ... [more ▼]

The Cockcroft–Gault equation for estimating glomerular filtration rate has been learnt by every generation of medical students over the decades. Since the publication of the Modification of Diet in Renal Disease (MDRD) study equation in 1999, however, the supremacy of the Cockcroft–Gault equation has been relentlessly disputed. More recently, the Chronic Kidney Disease Epidemiology (CKD-EPI) consortium has proposed a group of novel equations for estimating glomerular filtration rate (GFR). The MDRD and CKD-EPI equations were developed following a rigorous process, are expressed in a way in which they can be used with standardized biomarkers of GFR (serum creatinine and/or serum cystatin C) and have been evaluated in different populations of patients. Today, the MDRD Study equation and the CKD-EPI equation based on serum creatinine level have supplanted the Cockcroft–Gault equation. In many regards, these equations are superior to the Cockcroft–Gault equation and are now specifically recommended by international guidelines. With their generalized use, however, it has become apparent that those equations are not infallible and that they fail to provide an accurate estimate of GFR in certain situations frequently encountered in clinical practice. After describing the processes that led to the development of the new GFR-estimating equations, this Review discusses the clinical situations in which the applicability of these equations is questioned. [less ▲]

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See detailMDRD Versus CKD_EPI equation to estimate glomerular filtration rate in kidney transplant recipients
masson, Ingrid; Flamant, Martin; Maillard, Nicolas et al

in Transplantation (2013), 95(10),

Background. The new Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) creatinine-based equation was developed to address the systematic underestimation of the glomerular filtration rate (GFR) by ... [more ▼]

Background. The new Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) creatinine-based equation was developed to address the systematic underestimation of the glomerular filtration rate (GFR) by the Modification of Diet in Renal Disease (MDRD) Study equation in patients with a relatively well-preserved kidney function. The performance of the new equation for kidney transplant recipients is discussed. Methods. We analyzed the performances of the CKD-EPI equation in comparison with the MDRD Study equation in 825 stable kidney transplant recipients. Bias, precision, and accuracy within 30% of true GFR were determined. GFR was measured by urinary clearance of inulin (n=488) and plasma clearance of 51Cr-EDTA (n=337). Results. Mean measured GFR (mGFR) was 50T19 mL/min/1.73 m2. On the whole cohort, bias was significantly lower for MDRD Study equation compared with CKD-EPI creatinine. This superiority translates into a better accuracy (80% and 74% for the MDRD and CKD-EPI creatinine, respectively). The best performance of the MDRD Study equation is confirmed both in the subgroups of patients with mGFR G60 mL/min/1.73 m2 and between 60 and 90 mL/min/1.73 m2. For mGFR 990 mL/min/1.73 m2, there were no significant differences between the two equations in terms of performance. Conclusions. The CKD-EPI creatinine equation does not offer a better GFR prediction in renal transplant patients compared with the MDRD Study equation, even in the earlier CKD stages. [less ▲]

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See detailMDRD versus CKD-EPI equation to estimate glomerular filtration rate in kidney transplant recipients
Masson, Ingrid; Flamant, Martin; Maillard, Nicolas et al

in Transplantation (2013), 95(10), 1211-1217

Background. The new Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) creatinine-based equation was developed to address the systematic underestimation of the glomerular filtration rate (GFR) by ... [more ▼]

Background. The new Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) creatinine-based equation was developed to address the systematic underestimation of the glomerular filtration rate (GFR) by the Modification of Diet in Renal Disease (MDRD) Study equation in patients with a relatively well-preserved kidney function. The performance of the new equation for kidney transplant recipients is discussed. Methods. We analyzed the performances of the CKD-EPI equation in comparison with the MDRD Study equation in 825 stable kidney transplant recipients. Bias, precision, and accuracy within 30% of true GFR were determined. GFR was measured by urinary clearance of inulin (n=488) and plasma clearance of 51Cr-EDTA (n=337). Results. Mean measured GFR (mGFR) was 50T19 mL/min/1.73 m2. On the whole cohort, bias was significantly lower for MDRD Study equation compared with CKD-EPI creatinine. This superiority translates into a better accuracy (80% and 74% for the MDRD and CKD-EPI creatinine, respectively). The best performance of the MDRD Study equation is confirmed both in the subgroups of patients with mGFR G60 mL/min/1.73 m2 and between 60 and 90 mL/min/1.73 m2. For mGFR 990 mL/min/1.73 m2, there were no significant differences between the two equations in terms of performance. Conclusions. The CKD-EPI creatinine equation does not offer a better GFR prediction in renal transplant patients compared with the MDRD Study equation, even in the earlier CKD stages. [less ▲]

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See detailPerformance of creatinine and cystatin C-based glomerular filtration rate estimating equations in a European HIV-positive cohort.
Gagneux-Brunon, Amandine; DELANAYE, Pierre ULg; Maillard, Nicolas et al

in AIDS (2013)

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See detailGFR Estimation Using Standardized Cystatin C in Kidney Transplant Recipients
Masson, Ingrid; Maillard, Nicolas; Tack, Ivan et al

in American Journal of Kidney Diseases (2013), 61(2), 279-284

Background: The utility of serum cystatin C (SCysC) as a filtration marker in kidney transplantation is uncertain. We took advantage of the recent validation of a reference calibrator for SCysC and of ... [more ▼]

Background: The utility of serum cystatin C (SCysC) as a filtration marker in kidney transplantation is uncertain. We took advantage of the recent validation of a reference calibrator for SCysC and of newly developed CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration) equations (2012) expressed for use with standardized SCysC level to reassess the performance of SCysC as a filtration marker in kidney transplant recipients. Study Design: Study of diagnostic test accuracy. Setting & Participants: 670 kidney transplant recipients from 3 centers undergoing glomerular filtration rate (GFR) measurements from December 2006 to November 2012. Index Test: Estimated GFR (eGFR) using the 2012 SCysC-based and serum creatinine (SCr)/SCysCbased CKD-EPI equations (eGFRcys and eGFRcr-cys, respectively) and the 2009 SCr-based CKD-EPI equation (eGFRcr), with SCysC and SCr measured at a single laboratory between April 2011 and June 2011. Reference Test: Measured GFR (mGFR) using urinary clearance of inulin. Results: Bias (the difference between mGFR and eGFR) was significantly smaller for eGFRcys and eGFRcr-cys versus eGFRcr ( 2.82 and 0.54 vs 4.4 mL/min/1.73 m2, respectively; P 0.001). Precision (standard deviation of the mean bias) also was better for eGFRcys and eGFRcr-cys versus eGFRcr (12 and 11 vs 13 mL/min/1.73 m2 [P 0.001 for both comparisons]). Accuracy (percentage of GFR estimates within 30% of mGFR) was greater for eGFRcys and eGFRcr-cys versus eGFRcr (81% and 86% vs 75%, respectively [P 0.004 and P 0.001]). Net reclassification index with respect to mGFR of 30 mL/min/1.73 m2 for eGFRcr-cys and eGFRcys versus eGFRcr was 18.8% [95% CI, 8.6%-28.9%] and 22.5% [95% CI, 10.2%-34.9%]. Limitations: Patients were exclusively of European descent; association with transplant outcome was not evaluated. Conclusions: Our data validate the use of both the newly developed SCysC-based and SCr/SCysC-based CKD-EPI equations (2012) in kidney transplant recipients. Both equations perform better than the SCr-based CKD-EPI equation (2009). [less ▲]

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See detailNGAL biomarqueur de lésion rénale
Gagneux-Brunon, Amandine; DELANAYE, Pierre ULg; LEGRAND, Delphine ULg et al

in Néphrologie & Thérapeutique (2012), 8(7), 508-515

Le diagnostic precoce de l’insufissance renale aigue (IRA) est necessaire et devrait se faire au stade de lesion renale avant meme la degradation du debit de filtration glomerulaire. Plusieurs ... [more ▼]

Le diagnostic precoce de l’insufissance renale aigue (IRA) est necessaire et devrait se faire au stade de lesion renale avant meme la degradation du debit de filtration glomerulaire. Plusieurs biomarqueurs d’atteinte renale aigue sont actuellement a l’etude. Parmi ceux-ci, le Neutrophil Gelatinase Associated Lipocalin (NGAL) semble l’un des plus prometteurs et fait l’objet de nombreuses publications. La performance diagnostique de NGAL, dose dans le plasma ou les urines, pour le depistage de l’IRA depend de nombreux facteurs. Bien que les donnees experimentales recentes soient en faveur de l’utilisation preferentielle du dosage urinaire de NGAL, les donnees cliniques issues de nombreuses etudes ne permettent pas de trancher formellement sur la superiorite du dosage urinaire par rapport au dosage plasmatique pour le depistage des atteintes renales aigues. Il n’en reste pas moins que sur le plan analytique, les techniques de dosage du NGAL urinaire sont actuellement plus fiables que celles du dosage plasmatique. La performance diagnostique de NGAL dans un contexte d’IRA est maximale en chirurgie cardiaque pediatrique. Les resultats, chez l’adulte en postoperatoire de chirurgie cardiaque et dans d’autres situations (reanimation, urgences, transplantation), sont moins convaincants. Par ailleurs, il n’est actuellement pas possible d’extrapoler des etudes cliniques une valeur seuil discriminante unique de NGAL, aussi bien dans les urines que dans le plasma. D’autres etudes sont necessaires pour valider definitivement NGAL comme biomarqueur de l’atteinte renale aigue et en preciser les conditions d’utilisation en pratique clinique. [less ▲]

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See detailLe débit de filtration glomérulaire est-il un déterminant de la concentration plasmatique du NGAL aux soins intensifs ?
DELANAYE, Pierre ULg; Claisse, Guillaume; Mehdi, Manoli et al

Poster (2012)

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See detailCystatin C in HIV-infected patients: promising but not yet ready for prime time.
Gagneux-Brunon, Amandine; Mariat, Christophe; DELANAYE, Pierre ULg

in Nephrology Dialysis Transplantation (2012), 27(4), 1305-1313

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See detailL'estimation du débit de filtration glomérulaire en 2012: quelle valeur ajoutée pour la nouvelle équation CKD-EPI
DELANAYE, Pierre ULg; Mariat, Christophe; Moranne, Olivier et al

in Néphrologie & Thérapeutique (2012), 8

Mesurer ou estimer le debit de filtration glomerulaire (DFG) reste l’un des meilleurs moyens d’apprehender la fonction glomerulaire du rein. En 2009, l’equation Chronic Kidney Disease Epidemiology (CKD ... [more ▼]

Mesurer ou estimer le debit de filtration glomerulaire (DFG) reste l’un des meilleurs moyens d’apprehender la fonction glomerulaire du rein. En 2009, l’equation Chronic Kidney Disease Epidemiology (CKD-EPI) a ete proposee en lieu et place de l’equation Modification of Diet in Renal Disease (MDRD) pour estimer le DFG. Cette nouvelle equation fait partie desormais des toutes dernieres recommandations de la Haute Autorite de sante (HAS). Par rapport a MDRD, la formule CKD-EPI est sensee moins sous-estimer le DFG mesure, principalement dans les valeurs les plus hautes de DFG. Dans cette revue critique de la litterature, nous presenterons et discuterons les performances de cette nouvelle equation. Sur base des articles publies entre 2009 et 2012, nous en soulignerons les avantages, notamment en terme d’estimation de la prevalence de la maladie renale chronique (MRC), mais aussi les faiblesses, principalement dans certaines populations specifiques. En effet, toutes ces equations reposant sur la mesure de la creatinine serique restent des estimations et le nephrologue doit donc garder son sens critique dans l’interpretation de ces resultats. [less ▲]

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See detailEstimating glomerular filtration rate in Asian subjects: where do we stand?
DELANAYE, Pierre ULg; CAVALIER, Etienne ULg; Mariat, Christophe et al

in Kidney International (2011), 80(5), 439-440

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See detailTrimethoprim, creatinine and creatinine-based equations
DELANAYE, Pierre ULg; CAVALIER, Etienne ULg; Mariat, Christophe et al

in Kidney International (2011), 80(5), 439-40

Co-trimoxazole is a frequently prescribed antibiotic worldwide. It is composed of both trimethoprim and sulfamethoxazol (Sfx) and is used in the treatment and prophylaxis of urinary tract and Pneumocystis ... [more ▼]

Co-trimoxazole is a frequently prescribed antibiotic worldwide. It is composed of both trimethoprim and sulfamethoxazol (Sfx) and is used in the treatment and prophylaxis of urinary tract and Pneumocystis jirovecii infections. The Sfx component appears to be nephrotoxic at high doses or doses inappropriately adjusted for glomerular filtration rate (GFR). The trimethoprim component, even at recommended doses, inhibits tubular creatinine secretion, leading to a rapid but ultimately reversible increase in serum creatinine independent of any changes in GFR. This translates into a falsely low estimated GFR when creatinine-based equations are used. This review focuses on evidence of the differential effects of trimethoprim and Sfx on serum creatinine concentrations and GFR and their relevance to clinical practice, with particular attention to kidney transplantation. [less ▲]

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See detailAre the creatinine-based equations accurate to estimate glomerular filtration rate in african american populations ?
DELANAYE, Pierre ULg; MARIAT, Christophe; MAILLARD, Nicolas et al

in Clinical Journal of the American Society of Nephrology (2011), 6

Regarding the high prevalence of African American patients with ESRD, it is important to estimate the prevalence of early stages of chronic kidney disease in this specific population. Because serum ... [more ▼]

Regarding the high prevalence of African American patients with ESRD, it is important to estimate the prevalence of early stages of chronic kidney disease in this specific population. Because serum creatinine concentration is dependent on muscular mass, an ethnic factor has to be applied to creatinine-based equations. Such ethnic factors have been proposed in the Modification of Diet in Renal Disease (MDRD) study equation and in the more recent Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations. This review analyzes how these correction factors have been developed and how they have, or have not, been validated in external populations. It will be demonstrated that the African American factor in the MDRD study equation is accurate in African American chronic kidney disease (CKD) patients. However, it will be shown that this factor is probably too high for subjects with a GFR of >60 ml/min per 1.73 m2, leading to an underestimation of the prevalence of CKD in the global African American population. It will also be confirmed that this ethnic factor is not accurate in African (non-American) subjects. Lastly, the lack of true external validation of the new CKD-EPI equations will be discussed. Additional trials seem necessary in American African and African populations to better estimate GFR and apprehend the true prevalence of CKD in this population with a high renal risk. [less ▲]

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See detailParicalcitol for reduction of albuminuria in diabetes
DELANAYE, Pierre ULg; MARIAT, Christophe; KRZESINSKI, Jean-Marie ULg et al

in Journal-Lancet (The) (2011), 377

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See detailLe dosage de l'inuline: mise au point
DELANAYE, Pierre ULg; Souvignet, Marie; Dubourg, Laurence et al

in Annales de Biologie Clinique (2011), 69(3), 273-84

L’inuline, polymère de fructose, reste le marqueur de référence du débit de filtration glomérulaire (DFG). Popularisé par les études de Smith et Shannon, son dosage n’en demeure pas moins complexe et ... [more ▼]

L’inuline, polymère de fructose, reste le marqueur de référence du débit de filtration glomérulaire (DFG). Popularisé par les études de Smith et Shannon, son dosage n’en demeure pas moins complexe et sujet à des interférences dont celle du glucose est la plus importante. Il existe deux grands types de dosages de l’inuline : les méthodes de dosage « acide » et enzymatiques. Le dosage « acide » consiste en un dosage colorimétrique du fructose obtenu après hydrolyse de l’inuline en milieu très acide. Le dosage du fructose englobe différentes méthodes de dosage dont la plus utilisée est la réaction à l’anthrone. Toutes ces méthodes présentent des interférences au glucose. Différentes méthodes « enzymatiques » ont été décrites au cours du temps. Celles-ci apparaissent plus précises et sans doute moins sujettes aux interférences même si peu d’études comparatives sont disponibles. Plusieurs auteurs ont également développé des dosages de type CLHP. Cette méthode spécifique et précise demeure cependant moins adaptée à la routine. Ainsi, si l’utilisation de l’inuline comme marqueur de référence n’est pas remise en cause, son dosage reste délicat, sujet aux interférences et à une certaine interprétation. Des études supplémentaires restent nécessaires pour valider analytiquement et comparativement les techniques de dosage de l’inuline. [less ▲]

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See detailCystatin C as a GFR Marker in Renal Transplantation: Promises and Challenges.
Masson, Ingrid; Mariat, Christophe; DELANAYE, Pierre ULg

in Cohen, J. B.; Ryseck, L. P. (Eds.) Cystatins: Protease Inhibitors, Biomarkers and Immunomodulators (2011)

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See detailCystatin C in HIV Patients: More than just a GFR marker ?
Gagneux-Brunon, Amandine; Mariat, Christophe; DELANAYE, Pierre ULg

in Cohen, J. B.; Ryseck, L. P. (Eds.) Cystatins: Protease Inhibitors, Biomarkers and Immunomodulators (2011)

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See detailExploration de la fonction glomérulaire rénale (I). Méthodes de référence et créatinine sérique.
DELANAYE, Pierre ULg; Maillard, Nicolas; Thibaudin, Lyse et al

Book published by EMC, Elsevier Masson SAS (2011)

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See detailLa creatinine : d'hier a aujourd'hui.
Delanaye, Pierre ULg; Cavalier, Etienne ULg; Maillard, Nicolas et al

in Annales de Biologie Clinique (2010), 68(5), 531-43

Serum creatinine is certainly one of the most prescribed biological parameters. In this review article, we remind some historical data regarding creatinine. Different methodologies to measure creatinine ... [more ▼]

Serum creatinine is certainly one of the most prescribed biological parameters. In this review article, we remind some historical data regarding creatinine. Different methodologies to measure creatinine in blood and urine are deeply described. We also discuss the physiological reason for its use as a glomerular filtration rate marker. However, analytical and physiological limitations are described and discussed. Creatinine clearance usefulness is finally largely discussed. [less ▲]

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