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See detailEffects of obesity on lung function and airway reactivity in healthy dogs
Manens, Jefferson ULg; Bolognin, M; Bernaerts, Frederique ULg et al

in Veterinary Journal (2012), 193(1), 217-221

The present study investigated the effects of bodyweight (BW) gain on respiratory function and airway responsiveness in healthy Beagles using barometric whole body plethysmography (BWBP). Six adult dogs ... [more ▼]

The present study investigated the effects of bodyweight (BW) gain on respiratory function and airway responsiveness in healthy Beagles using barometric whole body plethysmography (BWBP). Six adult dogs were examined before and after a fattening diet. The high-energy diet induced a mean increase in BW of 41 ± 6%. BWBP basal parameters were recorded prior to airway reactivity testing (using increasing concentrations of histamine nebulisations). An airway responsiveness index (H-Penh300) was calculated as the histamine concentration necessary to reach 300% of basal enhanced pause (Penh, bronchoconstriction index). The same dogs underwent a doxapram hydrochloride (Dxp) stimulation testing 2 weeks later. Basal measurements showed that obese dogs had tidal volume per kg (TV/BW) that was significantly decreased whilst respiratory rate (RR) increased significantly. H-Penh300 decreased significantly in obese Beagles, indicating increased bronchoreactivity. Dxp administration induced a significant increase in TV/BW, minute volume per kg (MV/BW), peak inspiratory and expiratory flows per kg (PIF/BW and PEF/BW) in both normal and obese dogs although the TV/BW increase was significantly less marked in the obese group. In conclusion, obesity induced changes in basal respiratory parameters, increased bronchoreactivity and a blunted response to Dxp-induced respiratory stimulation. This combination of basal respiratory parameters, bronchoreactivity testing and pharmacological stimulation testing using non-invasive BWBP can help characterize pulmonary function and airway responsiveness in obese dogs. [less ▲]

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See detailIdiopathic central diabetes insipidus and severe hypernatremia in a cat
Desmas, Isabelle ULg; Manens, Jefferson ULg; Rizza, Maïlis et al

Poster (2011, January 22)

Detailed reference viewed: 35 (9 ULg)
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See detailRespiratory functional assessment using barometric whole-body plethysmography in healthy growing and aging beagle dogs
Manens, Jefferson ULg; Bolognin, M.; Kirschvink, N. et al

in ACVIM Meeting - Anaheim, Californie - 9-12 juin 2010 (2010, June 09)

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See detailActivity of metalloproteinases MMP2 and MMP9 in matched serum and bronchoalveolar lavage fluid samples in a dog model of airway inflammation
Manens, Jefferson ULg; Bolognin, M.; Leemans, J. et al

in 19h ECVIM Meeting - Porto, Portugal - 8-10 septembre 2009 (2009, September 08)

Detailed reference viewed: 8 (2 ULg)
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See detailTherapeutic response in dogs with lymphoplasmacytic rhinitis: a retrospective study in 12 dogs
Manens, Jefferson ULg; Bolognin, M.; Mercier, Elise ULg et al

in 25th Symposium of the Veterinary Comarative Respiratory Society - Purdue, USA 10-13 octobre 2007 (2007, October 10)

Detailed reference viewed: 15 (1 ULg)