The interaction between Bovine Leukemia Virus and its target cell.

in AIDS Research and Human Retroviruses (1992), 8

Previous results indicate that the external glycoprotein gp51 of bovine leukemia virus plays an important role in the process of cell fusion induced by bovine leukemia virus (Bruck, C., Mathot, S ... [more ▼]

Previous results indicate that the external glycoprotein gp51 of bovine leukemia virus plays an important role in the process of cell fusion induced by bovine leukemia virus (Bruck, C., Mathot, S., Portetelle, D., Berte, C., Franssen, J. D., Herion, P., and Burny, A. (1982) Virology 122, 342-352; Voneche, V., Portetelle., D., Kettmann, R., Willems, L., Limbach, K., Paoletti, E., Ruysschaert, J. M., Burny, A., and Brasseur, R. (1992) Proc. Natl. Acad. Sci. U. S. A. 89, 3810-3814) and suggest that a region encompassing residues 23 and 25 of gp51 is involved in this process (Portetelle, D., Couez, D., Bruck, C., Kettmann, R., Mammerickx, M., Van der Maaten, M., Brasseur, R., and Burny, A. (1989) Virology 169, 27-33; Mamoun, R., Morisson, M., Rebeyrotte, N., Busetta, B., Couez, D., Kettmann, R., Hospital, M., and Guillemain, B. (1990) J. Virol. 64, 4180-4188). X-ray diffraction studies performed on envelope glycoproteins of influenza virus indicate that the NH2-terminal part of the external glycoprotein lies very close to the fusion peptide. The same overall structure seems to exist in human immunodeficiency virus as suggested by site-directed mutagenesis followed by syncytia induction assays. Our theoretical studies indicate that a segment expanding between residues 19 and 27 of gp51 probably adopts an amphipathic beta-strand structure. We hypothesize that the amphipathic 19-27 structure of gp51 plays an important role in the process of membrane fusion by interacting with the fusion peptide or with another region of gp30. Mutational analysis disrupting the amphipathy of the 19-27 region strongly altered the fusogenic capacity of the gp51-gp30 complex. [less ▲]

Development of a specific serological test and an efficient subunit vaccine to control bovine leukemia virus infection.

in Developments in Biological Standardization (1990), 72

Even transcriptionally competent proviruses are silent in bovine leukemia virus-induced sheep tumor cells.

in Modern trends in human leukemia VIII (R. Neth., ed.), Springer Verlag, Berlin (1989)

The diagnosis of enzootic bovine leukosis.

in Comparative Immunology, Microbiology and Infectious Diseases (1985), 8

Application of an enzyme-linked immunosorbent assay (ELISA) involving monoclonal antibody for detection of BLV antibodies in individual or pooled bovine milk samples

in Zentralblatt für Veterinarmedizin. Reihe B = Journal of Veterinary Medicine. Series B (1985), 32

Use of an ELISA involving monoclonal antibody for the detection of antibodies against BLV in a herd with high incidence of enzootic bovine leucosis.

in Zentralblatt für Veterinarmedizin. Reihe B = Journal of Veterinary Medicine. Series B (1984), 31

Bovine Leukosis. Recents developments with use of monoclonal antibodies and ELISA tests

in Mc Nutly; Mc Ferran (Eds.) Recent Advances in Viral Diagnosis-Current Topics in Veterinary-Medecine and Animal Science (1984)

Epitopes of BLV glycoprotein gp51 recognized by sera infected cattle and sheep

in Leukemia Research (1984), 8

Use of monoclonal antibodies in the study of BLV glycoprotein gp51.

in Straub, O. C. (Ed.) Proceedings of the Fifth International Symposium on bovine leukosis (1984)

Use of monoclonal antibody in an ELISA test for the detection of antibodies to Bovine Leukemia Virus.

in Journal of Virological Methods (1983), 6