References of "Malaise, Olivier"
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See detailUne forme compliquée d'hypercalcémie hypocalciurique familiale
Potorac, Iulia ULg; BETEA, Daniela ULg; MALAISE, Olivier ULg et al

in Abstract book - Symposium "Perspectives in Endocrinology" (2016, January)

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See detailUne forme compliquée d'hypercalcémie hypocalciurique familiale
Potorac, Iulia ULg; BETEA, Daniela ULg; MALAISE, Olivier ULg et al

in Abstract book - Annales d'Endocrinologie - 32ème Congrès de la Société Française d'Endocrinologie (2015, October)

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See detailUse of Tomosynthesis for Detection of Bone Erosions of the Foot in Patients With Established Rheumatoid Arthritis: Comparison With Radiography and CT.
SIMONI, Paolo ULg; Gerard, Lionel ULg; KAISER, Marie-Joëlle ULg et al

in American Journal of Roentgenology (2015), (205), 364-370

The purpose of this study was to compare tomosynthesis with radiography for the detection of bone erosions of the foot in patients with established rheumatoid arthritis (RA) using MDCT as a reference ... [more ▼]

The purpose of this study was to compare tomosynthesis with radiography for the detection of bone erosions of the foot in patients with established rheumatoid arthritis (RA) using MDCT as a reference standard. [less ▲]

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See detailPancreatitis in familial hypocalciuric hypercalcaemia
Potorac, Iulia ULg; MALAISE, Olivier ULg; Daly, Adrian ULg et al

in Endocrine Abstracts (2015, May)

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See detailLa dépression est une complication fréquente du lupus érythémateux disséminé : considérations épidémiologiques, pathogéniques et thérapeutiques
Lemaire, Benoît ULg; Geron, Donatienne ULg; MALAISE, Olivier ULg et al

in Revue Médicale de Liège (2015), 70(4), 215-218

Le lupus érythémateux disséminé (LED) est une maladie de système aux conséquences aussi multiples qu’invalidantes. La prévalence des épisodes dépressifs majeurs y est significativement supérieure à celle ... [more ▼]

Le lupus érythémateux disséminé (LED) est une maladie de système aux conséquences aussi multiples qu’invalidantes. La prévalence des épisodes dépressifs majeurs y est significativement supérieure à celle des sujets sains ou atteints d’autres pathologies inflammatoires. S’il est évident que le statut de maladie chronique au dénouement souvent péjoratif et le nombre de traitements qu’elle impose constituent des facteurs favorisants, il est probable que les mécanismes pathogéniques du LED occasionnent une atteinte cérébrale précipitant une symptomatologie dépressive. Cet article approfondit les liens entre LED et dépression à travers des notions épidémiologiques, étiopathogéniques et thérapeutiques. [less ▲]

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See detailSelective glucocorticoid receptor modulator compound A, in contrast to prednisolone, does not induce leptin or the leptin receptor in human osteoarthritis synovial fibroblasts.
MALAISE, Olivier ULg; Relic, Biserka; QUESADA CALVO, Florence ULg et al

in Rheumatology (Oxford, England) (2015)

OBJECTIVE: Glucocorticoids are powerful anti-inflammatory compounds that also induce the expression of leptin and leptin receptor (Ob-R) in synovial fibroblasts through TGF-betasignalling and Smad1/5 ... [more ▼]

OBJECTIVE: Glucocorticoids are powerful anti-inflammatory compounds that also induce the expression of leptin and leptin receptor (Ob-R) in synovial fibroblasts through TGF-betasignalling and Smad1/5 phosphorylation. Compound A (CpdA), a selective glucocorticoid receptor agonist, reduces inflammation in murine arthritis models and does not induce diabetes or osteoporosis, thus offering an improved risk:benefit ratio in comparison with glucocorticoids. Due to the detrimental role of leptin in OA pathogenesis, we sought to determine whether CpdA also induced leptin and Ob-R protein expression as observed with prednisolone. METHODS: Human synovial fibroblasts and chondrocytes were isolated from the synovium and cartilage of OA patients after joint surgery. The cells were treated with prednisolone, TGF-beta1, TNF-alpha and/or CpdA. Levels of leptin, IL-6, IL-8, MMP-1 and MMP-3 were measured by ELISA and expression levels of Ob-R phospho-Smad1/5, phospho-Smad2, alpha-tubulin and glyceraldehyde 3-phosphate dehydrogenase were analysed by western blotting. RESULTS: CpdA, unlike prednisolone, did not induce leptin secretion or Ob-R protein expression in OA synovial fibroblasts. Moreover, CpdA decreased endogenous Ob-R expression and down-regulated prednisolone-induced leptin secretion and Ob-R expression. Mechanistically, CpdA, unlike prednisolone, did not induce Smad1/5 phosphorylation. CpdA, similarly to prednisolone, down-regulated endogenous and TNF-alpha-induced IL-6, IL-8, MMP-1 and MMP-3 protein secretion. The dissociative effect of CpdA was confirmed using chondrocytes with no induction of leptin secretion, but with a significant decrease in IL-6, IL-8, MMP-1 and MMP-3 protein secretion. CONCLUSION: CpdA, unlike prednisolone, did not induce leptin or Ob-R in human OA synovial fibroblasts, thereby demonstrating an improved risk:benefit ratio. [less ▲]

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See detailRestriction of spontaneous and prednisolone-induced leptin production to dedifferentiated state in human hip OA chondrocytes: role of Smad1 and b-catenin activation
CHARLIER, Edith ULg; MALAISE, Olivier ULg; Zeddou, Mustapha et al

in Osteoarthritis and Cartilage (2015)

Objective: The aetiology of OA is not fully understood although several adipokines such as leptin are known mediators of disease progression. Since leptin levels were increased in synovial fluid compared ... [more ▼]

Objective: The aetiology of OA is not fully understood although several adipokines such as leptin are known mediators of disease progression. Since leptin levels were increased in synovial fluid compared to serum in OA patients, it was suggested that joint cells themselves could produce leptin. However, exact mechanisms underlying leptin production by chondrocytes are poorly understood. Nevertheless, prednisolone, although displaying powerful anti-inflammatory properties has been recently reported to be potent stimulator of leptin and its receptor in OA synovial fibroblasts. Therefore, we investigated, in vitro, spontaneous and prednisolone-induced leptin production in OA chondrocytes, focusing on transforming growth factor-b (TGFb) and Wnt/b-catenin pathways. Design: We used an in vitro dedifferentiation model, comparing human freshly isolated hip OA chondrocytes cultivated in monolayer during 1 day (type II, COL2A1 þ; type X, COL10A1 þ and type I collagen, COL1A1 ") or 14 days (COL2A1 "; COL10A1 " and COL1A1þ). Results: Leptin expression was not detected in day1 OA chondrocytes whereas day14 OA chondrocytes produced leptin, significantly increased with prednisolone. Activin receptor-like kinase 1 (ALK1)/ALK5 ratio was shifted during dedifferentiation, from high ALK5 and phospho (p)-Smad2 expression at day1 to high ALK1, endoglin and p-Smad1/5 expression at day14. Moreover, inactive glycogen synthase kinase 3 (GSK3) and active b-catenin were only found in dedifferentiated OA chondrocytes. Smad1 and b-catenin but not endoglin stable lentiviral silencing led to a significant decrease in leptin production by dedifferentiated OA chondrocytes. Conclusions: Only dedifferentiated OA chondrocytes produced leptin. Prednisolone markedly enhanced leptin production, which involved Smad1 and b-catenin activation [less ▲]

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See detail(18)F-FPRGD2 PET/CT imaging of musculoskeletal disorders.
WITHOFS, Nadia ULg; CHARLIER, Edith ULg; Simoni, Paolo et al

in Annals of nuclear medicine (2015), 29(10), 839-47

OBJECTIVE: This work reports on musculoskeletal uptake of (18)F-FPRGD2, targeting the integrin alphavbeta3, in patients who had undergone (18)F-FPRGD2 positron emission tomography combined with computed ... [more ▼]

OBJECTIVE: This work reports on musculoskeletal uptake of (18)F-FPRGD2, targeting the integrin alphavbeta3, in patients who had undergone (18)F-FPRGD2 positron emission tomography combined with computed tomography (PET/CT) for oncologic purposes. METHODS: Whole-body (18)F-FPRGD2 PET/CT images of 62 cancer patients were retrospectively reviewed to detect foci of musculoskeletal (18)F-FPRGD2 uptake. For 37 patients, a FDG PET/CT performed in clinical settings was available. In each joint with an abnormal uptake, the maximum standardized uptake value (SUVmax) was estimated. RESULTS: A total of 260 musculoskeletal foci of (18)F-FPRGD2 uptake were detected. Most common sites of uptake were joints and discs (n = 160; 61.5 %), entheses (osteotendinous and osteoligamentous junctions; n = 55; 21.2 %) and recent fractures (n = 18; 6.9 %). In addition, 27 (10.4 %) miscellaneous foci were detected. Out of the 146 lesions for which a FDG PET was available, 63 % showed both (18)F-FPRGD2 and FDG uptake, 33.6 % did not show FDG avidity and 3.4 % showed only FDG uptake. The uptake intensity of the 92 lesions positive with (18)F-FPRGD2 and FDG was similar with both radiopharmaceuticals, but the target-to-background (blood pool or muscle) ratios were significantly higher with (18)F-FPRGD2 than with FDG (p < 0.0001). CONCLUSION: The (18)F-FPRGD2 uptake in joints, spine degenerative diseases and tendons was highly prevalent in our population. Up to one-third of (18)F-FPRGD2 foci showed no FDG uptake suggesting that (18)F-FPRGD2 signal may not be related to inflammatory angiogenesis only. [less ▲]

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See detailFamilial hypocalciuric hypercalcemia : a rare cause of recurrent pancreatitis
Daniel, Sara ULg; Potorac, Iulia ULg; MALAISE, Olivier ULg et al

in Abstract book - 24th Meeting of the Belgian Endocrine Society (2014, October 18)

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See detailTwo spondylodiscitis due to a contamination by Brucella melitensis in a mother and daughter back from holidays
MALAISE, Olivier ULg; LIBON, Florence ULg; BRICMAAN J et al

in Revue Médicale de la Suisse Romande (2014), 10(404), 197-200

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See detailThe management of systemic lupus erythematosus with biological therapies
MALAISE, Olivier ULg; VON FRENCKELL, Christian ULg; ANDRE, Béatrice ULg et al

in Revue Médicale Suisse (2013), 9(395), 1507-11

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See detailp27(Kip1) as a master regulator of cortical neuron migration.
Godin, Juliette ULg; Thomas, Noémie; Laguesse, Sophie ULg et al

Conference (2013, June)

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See detailp27(Kip1) as a master regulator of cortical neuron migration.
Godin, Juliette ULg; Thomas, Noémie; Laguesse, Sophie ULg et al

Poster (2013)

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See detailUnusual presentation of osteopoikilosis.
Simoni, P.; Denut, J.; Ben Mustapha, S. et al

in JBR-BTR : organe de la Societe royale belge de radiologie (SRBR) = orgaan van de Koninklijke Belgische Vereniging voor Radiologie (KBVR) (2013), 96(6), 386-7

We present a case of osteopoikilosis in a 74-year-old woman with hip pain, presenting multiple osteoblastic lesions of the axial skeleton including an osteoblastic large lesion of her left femur. The ... [more ▼]

We present a case of osteopoikilosis in a 74-year-old woman with hip pain, presenting multiple osteoblastic lesions of the axial skeleton including an osteoblastic large lesion of her left femur. The imaging findings on X-rays and computed tomography are provided along with the discussion of the differential diagnosis on the basis of the recent literature. [less ▲]

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See detailRhupus: when rheumatoid arthritis meets lupus
MALAISE, Olivier ULg; HALLEUX, Sandrine ULg; VON FRENCKELL, Christian ULg et al

in Revue Médicale de Liège (2012), 67(9), 475-84

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See detailGenetic and environmental interactions on the development of rheumatoid arthritis
MALAISE, Olivier ULg; VON FRENCKELL, Christian ULg; Malaise, Michel ULg

in Revue Médicale de Liège (2012), 67(5-6), 305-13

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