References of "MARTIN, Didier"
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See detailAdipsic diabetes insipidus revealing a bifocal intracranial germinoma
KREUTZ, Julie ULg; Potorac, Iulia ULg; LUTTERI, Laurence ULg et al

in Annales d'Endocrinologie (2017)

Abstract Adipsic diabetes insipidus is a rare complication of intracranial tumors in which impaired antidiuretic hormone secretion is associated with the loss of thirst sensation. Here, we present the ... [more ▼]

Abstract Adipsic diabetes insipidus is a rare complication of intracranial tumors in which impaired antidiuretic hormone secretion is associated with the loss of thirst sensation. Here, we present the case of a patient with bifocal intracranial germinoma, diagnosed due to symptoms mainly caused by adipsic diabetes insipidus. This is, to our knowledge, the first case of adipsic diabetes insipidus revealing an intracranial germinoma reported in the literature. We describe the diagnostic procedures and the three-year follow-up of this patient. Management of intracranial germ-cell tumors is made complex by the wide range of histological features. Although germinomas have a generally better prognosis than most nongerminomatous tumors, they can have severe or even life-threatening presentations. Adipsic diabetes insipidus is one such severe presentation and its rarity can make it difficult to recognize and manage. Awareness of this potential entity is therefore important for clinical practice. Le diabète insipide adipsique est une des rares complications des tumeurs intracrâniennes. Il associe une baisse de la sécrétion d’hormone antidiurétique à une perte de la sensation de soif et ilsignale souvent la présence d’une lésion qui atteint ou envahit l’hypothalamus. Nous présentons le cas d’une patiente avec un germinome intracrânien bifocal diagnostiqué devant un tableau de diabète insipide adipsique. À notre connaissance, il s’agit du premier cas de la littérature d’un diabète insipide révélant un germinome intracrânien. La prise en charge des tumeurs germinales intracrâniennes est complexe du fait des phénotypes histologiques divers. Bien que les germinomes ont généralement un meilleur pronostic que les tumeurs non-germinomateuses, ils peuvent avoir des présentations sévères. Le diabète insipide adipsique est une de ces présentations sévères et sa rareté peut rendre son diagnostic et sa prise en charge difficiles. La reconnaissance de cette entité potentielle est, dès lors, importante pour la pratique clinique [less ▲]

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See detailCXCL12 mediates glioblastoma resistance to radiotherapy in the subventricular zone.
Goffart, Nicolas ULg; Lombard, Arnaud; Lallemand, François ULg et al

in Neuro-Oncology (2017), 19(1), 66-77

BACKGROUND: Patients with glioblastoma (GBM) have an overall median survival of 15 months despite multimodal therapy. These catastrophic survival rates are to be correlated to systematic relapses that ... [more ▼]

BACKGROUND: Patients with glioblastoma (GBM) have an overall median survival of 15 months despite multimodal therapy. These catastrophic survival rates are to be correlated to systematic relapses that might arise from remaining glioblastoma stem cells (GSCs) left behind after surgery. In this line, it has recently been demonstrated that GSCs are able to escape the tumor mass and preferentially colonize the adult subventricular zone (SVZ). At a distance from the initial tumor site, these GSCs might therefore represent a high-quality model of clinical resilience to therapy and cancer relapses as they specifically retain tumor-initiating abilities. METHOD: While relying on recent findings that have validated the existence of GSCs in the human SVZ, we questioned the role of the SVZ niche as a potential GSC reservoir involved in therapeutic failure. RESULTS: Our results demonstrate that (i) GSCs located in the SVZ are specifically resistant to radiation in vivo, (ii) these cells display enhanced mesenchymal roots that are known to be associated with cancer radioresistance, (iii) these mesenchymal traits are specifically upregulated by CXCL12 (stromal cell-derived factor-1) both in vitro and in the SVZ environment, (iv) the amount of SVZ-released CXCL12 mediates GBM resistance to radiation in vitro, and (v) interferes with the CXCL12/CXCR4 signalling system, allowing weakening of the tumor mesenchymal roots and radiosensitizing SVZ-nested GBM cells. CONCLUSION: Together, these data provide evidence on how the adult SVZ environment, through the release of CXCL12, supports GBM therapeutic failure and potential tumor relapse. [less ▲]

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See detailIntracanalar lumbar neurinoma
Manto, Florence; HOUET, Elise ULg; LACREMANS, Pierre ULg et al

in Abstract Book of Annual Congress of Physical & Rehabilitation Medicine 2016 (2016, December 09)

Neurinoma are slow growing encapsulated tumors, coming from Schwann cells. They are a rare cause of low back pain, possibly with a radiating pain in the inferior limb. This case report describes the ... [more ▼]

Neurinoma are slow growing encapsulated tumors, coming from Schwann cells. They are a rare cause of low back pain, possibly with a radiating pain in the inferior limb. This case report describes the managing of a patient with right cruralgia without strength lost. The CT- scan had failed to highlight a lesion corresponding to the symptoms of the patient. A MRI was therefore realized, and was able to show a lumbar intradural tumor. The MRI signal of neurinoma is usually typical. However, in this case, the histo-pathological analysis has been necessary to confirm the diagnosis. The patient underwent laminectomy and tumor resection with nearly complete resolution of symptoms, excepting a right perineal hemihypoesthesia, probably corresponding to the location of the concerned nervous root. The MRI is the best method to explore cruralgia or a sciatica not responding to treatment, and without precipitating factor such as disc herniation explaining the symptoms. [less ▲]

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See detailUn neurinome intra-canalaire lombaire
Manto, Florence; HOUET, Elise ULg; LACREMANS, Pierre ULg et al

in Revue Médicale de Liège (2016), 71(6), 269-271

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See detailClinical and molecular classification of glioblastoma patients
Lambert, Jérémy ULg; Kaoma, Tony; Van Dyck, Eric et al

Poster (2016, March 19)

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See detailClinical and molecular classification of glioblastoma patients
Lambert, Jérémy ULg; Gorlia, Thierry; Van Dyck, Eric et al

Scientific conference (2015, December 03)

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See detailUne lésion sellaire d'évolution hautement fluctuante
BETEA, Daniela ULg; Potorac, Iulia ULg; BONNEVILLE, Jean-François ULg et al

in Abstract book - Annales d'Endocrinologie - 32ème Congrès de la Société Française d'Endocrinologie (2015, October)

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See detailAge and WHO Performance Score are major clinical prognostic factors in glioblastoma
Lambert, Jérémy ULg; Scholtes, Félix ULg; MARTIN, Didier ULg

Conference (2015, March 21)

In glioblastoma patients with similar prognostic factors—like age, performance status and extent of surgical resection—clinical evolution is still variable. In addition, the benefit of resection of ... [more ▼]

In glioblastoma patients with similar prognostic factors—like age, performance status and extent of surgical resection—clinical evolution is still variable. In addition, the benefit of resection of recurrent tumours is uncertain. In this study, prognostic subgroups are established on a clinical basis and the benefit of surgery for recurrence is compared between them. Recursive partitioning analysis on EORTC sample 26981 (n=239) identified clinical factors influencing Progression-Free Survival (PFS), in order to create prognostic subgroups, whose PFS and survival after recurrence were compared using Kaplan-Meier curves and log-rank tests. Results were validated on a sample from Liège University Hospital (n=92). WHO Performance Status (WHO-PS) and age at first intervention (“age”) defined 4 subgroups. PFS was shorter in WHO-PS 2–3 than WHO PS 0–1 patients. In both groups, age was the second classifying factor (cut-off: 47.5y for WHO-PS 0–1, 60.5y for WHO-PS 2–3). The 4 subgroups had significantly different median PFS (77.5, 144, 234.5 and 346.5 days) and median overall survival (126, 330, 476 and 675 days). Survival after recurrence was correlated with PFS, and recurrence resection was associated with longer survival, regardless of the prognostic subgroup. Clinical prognostic glioblastoma subgroups with distinct PFS exist and can be defined by WHO-PS and age. This classification can be used as a clinical basis to identify molecular patterns associated with prognosis. In addition, in all subgroups, this retrospective analysis suggests a benefit of surgical resection when feasible. [less ▲]

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See detailIdentification de sous-groupes de glioblastome sur base de critères cliniques
Lambert, Jérémy ULg; Scholtes, Félix ULg; MARTIN, Didier ULg

Poster (2014, December)

Glioblastoma has terrible outcomes, but the disease evolution varies a lot between patients. We used a sample of 239 patients (EORTC 26981) and a validation sample of 93 patients (CHU Liège) to class ... [more ▼]

Glioblastoma has terrible outcomes, but the disease evolution varies a lot between patients. We used a sample of 239 patients (EORTC 26981) and a validation sample of 93 patients (CHU Liège) to class patients in groups with the same risk of recurrence. 4 distinct subgroups were created using recursive partitioning analysis. In the future, genetic profile will be compared between these groups to find markers of aggressiveness. Moreover, survival after recurrence is closely related to subgroups, and a surgical resection of the recurrence shows positive effect in each subgroup. [less ▲]

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See detailFacteurs de mauvais pronostic d’une lomboradiculalgie opérée par (micro) discectomie
Demoulin, Christophe ULg; Bavi, F.; DEFAWEUX, Michel ULg et al

in Revue du Rhumatisme (2014, December), 81S

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See detailOriginalités de la vascularisation cérébrale
RABISCHONG, Pierre; Martin, Didier ULg

Conference (2014, October 22)

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See detailLa plainte du patient et sa gestion par voie de médiation.
DOPPAGNE, Caroline ULg; Martin, Didier ULg

Scientific conference (2014, June 11)

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See detailReceptor expression in craniopharyngiomas causing tumor growth in pregnancy: case report and review of the literature
VROONEN, Laurent ULg; TOME, Monica; THIRY, Albert ULg et al

in Abstract book : 57èmes Journées Internationales d'Endocrinologie Clinique - Henri-Pierre Klotz (2014, June)

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See detailGlioma metastatis : a case series and review
REUTER, Gilles ULg; LOMBARD, Arnaud ULg; SCHOLTES, Félix ULg et al

Poster (2014, March 29)

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See detailNotre cerveau reptilien
Scholtes, Félix ULg; Martin, Didier ULg

Scientific conference (2014, March 12)

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See detailReceptor expression in craniopharyngiomas causing tumor growth in pregnancy : case report and review of the literature
VROONEN, Laurent ULg; Tome Garcia, M; THIRY, Albert ULg et al

in Abstract book - Symposium "Perspectives in Endocrinology" Congresses Highlights 2013:ECE Copenhagen, ENDO SF, SFE Paris (2014, February)

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See detailNeurochirurgie et grossesse
EMONTS, Patrick ULg; HENROTEAUX, Adrienne ULg; Martin, Didier ULg

Scientific conference (2014, January 15)

Detailed reference viewed: 70 (9 ULg)