A common reference population from four European Holstein populations increases reliability of genomic predictions.
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in Genetics, Selection, Evolution [=GSE] (2011), 43(1), 43
ABSTRACT: BACKGROUND: Size of the reference population and reliability of phenotypes are crucial factors influencing the reliability of genomic predictions. It is therefore useful to combine closely ... [more ▼]
ABSTRACT: BACKGROUND: Size of the reference population and reliability of phenotypes are crucial factors influencing the reliability of genomic predictions. It is therefore useful to combine closely related populations. Increased accuracies of genomic predictions depend on the number of individuals added to the reference population, the reliability of their phenotypes, and the relatedness of the populations that are combined. METHODS: This paper assesses the increase in reliability achieved when combining four Holstein reference populations of 4000 bulls each, from European breeding organizations, i.e. UNCEIA (France), VikingGenetics (Denmark, Sweden, Finland), DHV-VIT (Germany) and CRV (The Netherlands, Flanders). Each partner validated its own bulls using their national reference data and the combined data, respectively. RESULTS: Combining the data significantly increased the reliability of genomic predictions for bulls in all four populations. Reliabilities increased by 10%, compared to reliabilities obtained with national reference populations alone, when they were averaged over countries and the traits evaluated. For different traits and countries, the increase in reliability ranged from 2% to 19%. CONCLUSIONS: Genomic selection programs benefit greatly from combining data from several closely related populations into a single large reference population. [less ▲]Detailed reference viewed: 7 (3 ULg)
IMPROVING GENOMIC PREDICTION BY EUROGENOMICS COLLABORATION
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in Proceedings of the 9th World Congress on Genetics Applied to Livestock Production (2010)Detailed reference viewed: 52 (0 ULg)
Small-scale spatial associations between Artemisia frigida and Potentilla acaulis at zero, light, medium and heavy grazing intensities with sheep.
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in Applied Vegetation Science (2007), 10(1), 139-148Detailed reference viewed: 1 (0 ULg)
SHIP2 controls PtdIns(3,4,5)P3 and PKB activity in response to oxidative stress
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in Cellular Signalling (2007), 19
Reactive oxygen species (ROS) are known to be involved in redox signalling pathways that may contribute to normal cell function as well as disease progression. The tumour suppressor PTEN and the inositol ... [more ▼]
Reactive oxygen species (ROS) are known to be involved in redox signalling pathways that may contribute to normal cell function as well as disease progression. The tumour suppressor PTEN and the inositol 5-phosphatase SHIP2 are critical enzymes in the control of PtdIns(3,4,5)P(3) level. It has been reported that oxidants, including those produced in cells such as macrophages, can activate downstream signalling via the inactivation of PTEN. The present study evaluates the potential impact of SHIP2 on phosphoinositides in cells exposed to sodium peroxide. We used a model of SHIP2 deficient mouse embryonic fibroblasts (MEFs) stimulated by H(2)O(2): at 15 min, PtdIns(3,4,5)P(3) was markedly increased in SHIP2 -/- cells as compared to +/+ cells. In contrast, no significant increase in PtdIns(3,4)P(2) could be detected at 15 or 120 min incubation of the cells with H(2)O(2) (0.6 mM). PKB activity was also upregulated in SHIP2 -/- cells as compared to +/+ cells in response to H(2)O(2). SHIP2 add back experiments in SHIP2 -/- cells confirm its critical role as a lipid phosphatase in the control of PtdIns(3,4,5)P(3) level in response to H(2)O(2). We conclude that SHIP2 lipid phosphatase activity plays an important role in the metabolism PtdIns(3,4,5)P(3) which is demonstrated in oxygen stressed cells [less ▲]Detailed reference viewed: 14 (1 ULg)
Fine-scale spatial pattern of Cleistogenes squarrosa population under different grazing intensities.
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in Acta Prataculturae Sinica = Caoye xuebao (2005), 14(1), 11-17Detailed reference viewed: 4 (0 ULg)
Modelling chemo-hydro-mechanical behaviour of unsaturated clays: a feasibility study
; ; Li, Xikui et al
in International Journal for Numerical and Analytical Methods in Geomechanics (2005), 29(9), 919-940
Effective capabilities of combined chemo-elasto-plastic and unsaturated soil models to simulate chemohydro-mechanical (CHM) behaviour of clays are examined in numerical simulations through selected ... [more ▼]
Effective capabilities of combined chemo-elasto-plastic and unsaturated soil models to simulate chemohydro-mechanical (CHM) behaviour of clays are examined in numerical simulations through selected boundary value problems. The objective is to investigate the feasibility of approaching such complex material behaviour numerically by combining two existing models. The chemo-mechanical effects are described using the concept of chemical softening consisting of reduction of the pre-consolidation pressure proposed originally by Hueckel (Can. Geotech. J. 1992; 29:1071-1086; Int. J. Numer. Anal. Methods Geomech. 1997; 21:43-72). An additional chemical softening mechanism is considered, consisting in a decrease of cohesion with an increase in contaminant concentration. The influence of partial saturation on the constitutive behaviour is modelled following Barcelona basic model (BBM) formulation (Geotech. 1990; 40(3):405-430; Can. Geotech. J. 1992; 29:1013-1032). The equilibrium equations combined with the CHM constitutive relations, and the governing equations for flow of fluids and contaminant transport, are solved numerically using finite element. The emphasis is laid on understanding the role that the individual chemical effects such as chemo-elastic swelling, or chemo-plastic consolidation, or finally, chemical loss of cohesion have in the overall response of the soil mass. The numerical problems analysed concern the chemical effects in response to wetting of a clay specimen with an organic liquid in rigid wall consolidometer, during biaxial loading up to failure, and in response to fresh water influx during tunnel excavation in swelling clay. Copyright (c) 2005 John Wiley [less ▲]Detailed reference viewed: 64 (7 ULg)