References of "Lipoldová, Marie"
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See detailGenetic regulation of immunoglobulin E level in different pathological states: integration of mouse and human genetics
Gusareva, Elena ULg; Kurey, Irina; Grekov, Igor et al

in Biological Reviews of the Cambridge Philosophical Society (2014), 89(2), 375-405

Immunoglobulin E (IgE) first evolved in mammals. It plays an important role in defence against helminths and parasitic infection and in pathological states including allergic reactions, anti-tumour ... [more ▼]

Immunoglobulin E (IgE) first evolved in mammals. It plays an important role in defence against helminths and parasitic infection and in pathological states including allergic reactions, anti-tumour defence and autoimmune diseases. Elucidation of genetic control of IgE level could help us to understand regulation of the humoral immune response in health and disease, the etiology and pathogenesis of many human diseases, and to facilitate discovery of more effective methods for their prevention and cure. Herein we summarise progress in the genetics of regulation of IgE level in human diseases and show that integration of different approaches and use of animal models have synergistic effects in gaining new knowledge about both protective and pathological roles of this important antibody. [less ▲]

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See detailAtopy controlling loci in Czech and Russian populations
Gusareva, Elena ULg; Badalová, Jana; Havelková, Helena et al

Poster (2010, April)

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See detailChromosome 12q24.3 controls sensitization to cat allergen in patients with asthma from Siberia, Russia
Gusareva, Elena ULg; Bragina, Elena; Buinova, Svetlana et al

in Immunol Letters (2009), 125(1), 1-6

In Russian population of Siberia asthma is usually concomitant with high sensitization to indoor allergens (cat, dog and house dust mites), overproduction of total immunoglobulin E (IgE) and airway ... [more ▼]

In Russian population of Siberia asthma is usually concomitant with high sensitization to indoor allergens (cat, dog and house dust mites), overproduction of total immunoglobulin E (IgE) and airway hyperreactivity. Definition of genes that predispose to development of various sub-components of the asthma phenotype is important for understanding of etiology of this disease. To map genes predisposing to asthma,we tested 21 microsatellite markers from candidate chromosomal regions in 136 Russian nuclear families with asthma from Siberia.We performed non-parametric analysis for linkage with asthma, total IgE, specific IgE to cat, dog, and dust mites, and spirometric indices (FEV1 (%) – percentage of predicted forced expiratory volume in 1 s, FVC (%) – percentage of predicted forced vital capacity, and FEV1/FVC (%) – Tiffenau index). The most significant linkagewas to the candidate region on chromosome 12. Locus controlling cat-specific IgE, which is the most abundant in asthma patients fromSiberian population, mapped within the interval between 136 and 140 cM on chromosome 12q24.3, with the suggestive linkage at the marker D12S1611 (LOD= 2.23, P = 0.0007). Total IgE was also linked to this region (D12S1611 – LOD= 1.12, P = 0.012). FEV1 (%) exceeded LOD> 1 threshold for significance with the same locus 12q24.3, but with the peak at a more proximal region at 111.87cM (D12S338 – LOD= 1.21, P = 0.009). Some evidence of linkage (LOD> 1.0) was also detected for asthma at 6p21.31 (D6S291) and total IgE at 13q14.2 (D13S165). These data indicate that the locus 12q24.3 is the most promising candidate for identification of asthma genes in Russian population of Siberia. [less ▲]

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See detailRelationship between total and specific IgE in patients with asthma from Siberia
Gusareva, Elena ULg; Ogorodova, Lyudmila; Chernyak, Boris et al

in Journal of Allergy and Clinical Immunology (The) (2008), 121(3), 781

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See detailDifferent environmental influences on etiology of atopic diseases in European populations as a basis for study of geneenvironment interactions.
Gusareva, Elena ULg; Belozorov, Aleksey; Havelková, Helena et al

in Torres, S. L.; Marin, M. S. (Eds.) Genetic Predisposition to Disease (2008)

Atopy is a predisposition to hyperproduction of immunoglobulin E (IgE) against common environmental allergens. Sensitization to various airborne and food allergens contributes to different types of atopic ... [more ▼]

Atopy is a predisposition to hyperproduction of immunoglobulin E (IgE) against common environmental allergens. Sensitization to various airborne and food allergens contributes to different types of atopic diseases, including asthma, eczema, and allergic rhinitis. The development of these diseases is influenced by both genetic and environmental factors. Several loci and genes that control IgE level have been described in different chromosomal regions. Some of them have been detected in several populations, others only in one or a few populations. These differences might be caused by variations of genetic composition between populations, different lifestyles and/or by environmental variations in major allergens triggering development of atopic diseases. Thus, the environmental conditions may likely determine, which from the potential atopy-controlling genes will operate in a certain population. As the first step in study of such gene-environment interactions we analyzed the specificity and intensity of sensitization to 40 different allergens in atopic patients from the Czech Republic and Ukraine, representing two genetically not very distant populations, which live in different environmental conditions. The atopic patients from both countries displayed a higher reactivity to inhalant than to food allergens. We found highly significant differences in sensitization to airborne allergens between patients from the two countries. The most pronounced allergens for the atopic patients from Ukraine were allergens from dust mites Dermatophagoides pteronyssinus (38.5%), Dermatophagoides farinae (48.1%) and cat (44.2%). In the atopic patients from the Czech Republic the level of sensitization to these allergens was similar, but the level of sensitization to outdoor allergens, grasses and trees was dramatically higher. More than 68% of the patients from the Czech Republic in comparison with less than 25% of the patients from Ukraine have been sensitized to cocksfoot, sweet vernal grass, timothy grass and cultivated rye (Bonferroni-corrected P values ranged from 0.0007 to 0.000000003). More than 50% and 60% of the patients from the Czech Republic but only 2% and 19.2% of the patients from Ukraine reacted to alder (corrected P < 0.00009) and birch (corrected P < 0.002), respectively. The higher sensitization to plant allergens of the patients from the Czech Republic was present in those with asthma and rhinitis, but not with dermatitis. The higher sensitization levels to outdoor allergens in the Czech Republic suggest an influence of westernization on development of allergic reactivity. Genetic analysis of atopic patients from these two countries will establish which geneloci control development of atopy under different environmental conditions. [less ▲]

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See detailCat is a major allergen in patients with asthma from west Siberia, Russia
Gusareva, Elena ULg; Bragina, Elena; Deeva, Evgenia et al

in Allergy (2006), 61(4), 509-510

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See detailIgE controlling loci in Czech atopic patients.
Gusareva, Elena ULg; Havelková, Helena; Blažková, Hanna et al

Poster (2006, September 07)

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See detailThe major allergens in Russian atopic asthmatic patients.
Gusareva, Elena ULg; Bragina, Elena; Deeva, Evgenia et al

Poster (2005, July)

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