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See detailMethof for the elution of 18F fluoride trapped on an anion-exchange phase in a form suitable for efficient radiolabelling without any evaporation step
Aerts, Joël ULg; Lemaire, Christian ULg; Lignon, Steve et al

Patent (2008)

The invention relates to a method to ext. out of an aq. soln., conc. and​/or reformulate [18F] fluorides without any evapn. step, characterized in that the eluting soln. is a low water content, preferably ... [more ▼]

The invention relates to a method to ext. out of an aq. soln., conc. and​/or reformulate [18F] fluorides without any evapn. step, characterized in that the eluting soln. is a low water content, preferably <3​% water, org. soln. contg. at least: a first compd. (A) which is a tertiary alc.-​function bearing mol., a second compd. (B) which is a phase transfer agent suitable for radiolabeling and which is necessary to the anion exchange process. Said org. solvent is selected from acetonitrile (ACN)​, DMSO)​, dimethylacetamide, DMF, THF, di-​Et ether, dioxane, Et acetate, acetone, isobutyronitrile, benzonitrile, pyridine, di-​Et carbonate, sulfolane, hexamethylphosphotriamide (HMPA​/HMPT)​, and any mix of these solvents. Said nonpolar org. solvent is selected from pentane, hexane, heptane, octane, nonane, decane, and cyclohexane. [less ▲]

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