  Toxic epidermal necrolysis and antifolate drugs in cancer chemotherapy.Franchimont, Claudine  ; ; et alin Current Drug Safety (2012), 7(5), 357-60 Folates are one-carbon donors essential for synthesizing purines, pyrimidines, serine, and methionine. They correspond to anionic hydrophilic molecules essential for DNA synthesis in mammalian cells. The ... [more ▼] Folates are one-carbon donors essential for synthesizing purines, pyrimidines, serine, and methionine. They correspond to anionic hydrophilic molecules essential for DNA synthesis in mammalian cells. The latter cells lack the capacity to synthesize folates. In some patients, high dosages of antifolate drugs (eg: methotrexate, pemetrexed) used in cancer chemotherapy alter the keratinocytes, endothelial cells and Factor XIIIa+ dermal dendrocytes in a range of various severities. Such conditions clinically designed under the heading antifolate cytotoxic skin reaction (ACSR) occasionally resemble the toxic epidermal necrolysis (TEN) / Stevens-Johnson syndrome (SJS) spectrum. Whether or not the TEN/SJS presentation of ACSR is a regular condition similar to that induced by other drugs or a variant condition supported by a unique pathomechanism is unsettled. [less ▲] Detailed reference viewed: 17 (0 ULg)Impact climatique sur les ulcères veineux de jambe.FRANCHIMONT, Claudine ; Hermanns-Le, Trinh ; et alin Revue Médicale de Liège (2012), 67 Detailed reference viewed: 12 (2 ULg)Challenging regional psoriasis and ustekinumab biotherapy: impact of the patterns of disease.Hermanns-Le, Trinh ; ; PIERARD, Gérald et alin Journal of Biomedicine & Biotechnology (2012), 2012 In some patients, psoriasis appears refractory to many treatments, particularly when the disease is confined to some specific body regions. In this respect, palmoplantar psoriasis and palmoplantar ... [more ▼] In some patients, psoriasis appears refractory to many treatments, particularly when the disease is confined to some specific body regions. In this respect, palmoplantar psoriasis and palmoplantar pustulosis are possibly related conditions in their immunopathomechanisms involving Il-12, IL-23, and Th17. Nail psoriasis and scalp psoriasis are two other particular psoriasis manifestations. Accordingly, ustekinumab was tested in a few of these patients. The present paper is limited to peer-reviewed case reports. Data were not supported by bioinstrumental assessments and controlled trials. Overall, they are indicative of potential efficacy. The cost-effectiveness and the risk-benefit assessments merit further investigations. [less ▲] Detailed reference viewed: 2 (1 ULg)La peau infectée par des bactéries au cours des hémopathies malignes.FRANCHIMONT, Claudine ; SZEPETIUK, Grégory ; et alin Dermatologie Actualité (2012), 133 Detailed reference viewed: 7 (2 ULg)La drosophile, les récepteurs Toll-like et nous.PIERARD, Gérald ; FRANCHIMONT, Claudine ; SZEPETIUK, Grégory et alin Dermatologie Actualité (2012), 132 Detailed reference viewed: 2 (1 ULg)Autoimmunity-related granulomatous dermatitis in association with hepatitis.; ; PIERARD, Gérald et alin Case Reports in Dermatology (2012), 4(1), 80-4 AIM: Both interstitial granulomatous dermatitis (IGD) and palisaded neutrophilic granulomatous dermatitis (PNGD) are rare disorders typically associated with systemic autoimmune conditions. They probably ... [more ▼] AIM: Both interstitial granulomatous dermatitis (IGD) and palisaded neutrophilic granulomatous dermatitis (PNGD) are rare disorders typically associated with systemic autoimmune conditions. They probably represent different aspects of a disease spectrum encompassing the concept of autoimmunity-related granulomatous dermatitis (ARGD). CASE REPORT: A 61-year-old woman presented with ARGD and autoimmune hepatitis. The clinical presentation suggested PNGD, while histopathology was consistent with IGD. DISCUSSION: The association of ARGD with autoimmune hepatitis is apparently a rare event. The present case shows that the clinicopathological correlation in ARGD does not always clearly fit with the classical presentations of IGD or PNGD. [less ▲] Detailed reference viewed: 15 (2 ULg)L'iatrogénie cytostatique simulatrice. Apparence d'un pityriasis lichénoïde aigu induit par le pemetrexed.SABATIELLO, Murielle ; ; et alin Dermatologie Actualité (2011), 125 Detailed reference viewed: 14 (0 ULg)Nodules violacés sporotrichoïdes chez une patiente immunodéprimée.Devillers, Céline ; Franchimont, Claudine ; Quatresooz, Pascale et alin Dermatologie Actualité (2009), 115 Detailed reference viewed: 36 (2 ULg)Granulome de Majocchi sur tinea incognito chez une Africaine.Devillers, Céline ; ; et alin Dermatologie Actualité (2009), 116 Detailed reference viewed: 42 (3 ULg) |
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