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See detailPharmacological effects of tiludronate in horses after long-term immobilization
Delguste, Catherine ULg; Amory, Hélène ULg; Doucet, Michèle et al

in BONE (2007), 41(3), 414-421

Introduction: Tiludronate, a bisphosphonate, has recently been introduced in veterinary medicine to treat orthopedic conditions in the horse. This study was designed to evaluate its effects on biochemical ... [more ▼]

Introduction: Tiludronate, a bisphosphonate, has recently been introduced in veterinary medicine to treat orthopedic conditions in the horse. This study was designed to evaluate its effects on biochemical biomarkers of bone metabolism and on bone density and structure in an experimental model of disuse osteoporosis induced by cast application in horses. Methods: Two groups of eight horses were immobilized during 8 weeks. The first group (P-group) received a placebo, and the second group (T-group) received tiludronate 1 mg/kg by slow IV infusion. Both treatments were administered twice, 28 days apart. Immobilization consisted of stall rest with the left forelimb packed in a fiberglass cast. It was followed by a 4-week remobilization period and an 8-week standardized training protocol. One biomarker of bone resorption, the C-telopeptides of type 1 collagen cross-links (CTX-1) and one biomarker of bone formation, the bone isoenzyme of alkaline phosphatase (bone ALP), were assessed. Metacarpus III (MCIII) bone mineral density (BMD) and speed of sound (SOS) were evaluated respectively by dual energy X-ray absorptiometry (DEXA) and quantitative ultrasonography (QUS). Lameness was regularly assessed during the remobilization and training periods. Group- and time-related effects were tested by analysis of variance on repeated measurements. Results: A rapid, transient and significant decrease in CTX-1 concentration was seen after each treatment in the T-group only. No significant differences between groups were seen in the evolution of bone ALP activity. At the end of the experiment, the loss of MCIII BMD measured by DEXA in the immobilized limb was significantly less in the T-group than in the P-group. The MCIII SOS measured by QUS did not significantly vary within or between groups throughout the study. Discussion and conclusions: Tiludronate was found to significantly reduce bone resorption during immobilization, as well as to prevent long-term osteopenia in the immobilized limb. Disuse osteopenia did not affect the lateral superficial cortex of MCIII. (C) 2007 Elsevier Inc. All rights reserved. [less ▲]

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See detailSerum osteocalcin and CTX-MMP concentration in young exercising thoroughbred racehorses
Carstanjen, B.; Amory, Hélène ULg; Sulon, Joseph ULg et al

in Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine (2005), 52(3), 114-120

Bone responds to exercise with changes in bone (re-)modelling, which might be monitored non-invasively with biochemical bone markers. The aim of this study was to evaluate the influence of exercise on ... [more ▼]

Bone responds to exercise with changes in bone (re-)modelling, which might be monitored non-invasively with biochemical bone markers. The aim of this study was to evaluate the influence of exercise on serum osteocalcin and serum carboxy-terminal cross-linked telopeptide of type I collagen generated by matrix metalloproteinases (CTX-MMP) concentration in young racehorses. Seventy-one 2 to 4-year-old Thoroughbreds were included in this prospective infield study. Blood sampling was performed six times (i.e. six sampling cycles) during a 9-month period. Serum samples were analysed with commercial osteocalcin and CTX-MMP radioimmunoassays. Two-year-old racehorses had higher serum osteocalcin and CTX-MMP values than 3-year-old horses. Gender and training amplitude did not significantly influence serum osteocalcin and CTX-MMP values. Two-year-old horses showed an increase in osteocalcin values between cycles 2 and 3 and an increase in serum CTX-MMP values between cycles 1 and 2. Serum osteocalcin and CTX-MMP concentrations decreased between cycles 4 and 5, and 5 and 6. Three-year-old horses showed an increase in serum osteocalcin levels between cycles 3 and 4 and an increase in serum CTX-MMP concentrations between cycles 1 and 2, and 3 and 4. Serum osteocalcin levels decreased between cycles 5 and 6, whereas serum CTX-MMP levels decreased between cycles 4 and 5, and 5 and 6. Two- and three-year-old horses showed a decreased osteocalcin/CTX-MMP ratio between cycles 1 and 2. Moreover, 2-year-old horses showed an increase in the osteocalcin/CTX-MMP ratio between cycles 2 and 3. Sore shin formation did not significantly influence serum osteocalcin and CTX-MMP values. Serum osteocalcin and CTX-MMP are promising bone markers for monitoring exercise induced changes in equine bone metabolism. [less ▲]

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See detailThe effect of race training on biochemical bone markers in young thoroughbreds
Carstanjen, B; Lepage, OM; Sulon, J et al

in Proceedings of the 13th annual scientific meeting of the ECVS (2003)

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See detailSpeed of Sound Measurements of the Third Metacarpal Bone in Young Exercising Thoroughbred Racehorses
Carstanjen, B.; Lepage, O. M.; Hars, O. et al

in BONE (2003), 33

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See detailIsolation ad Characterization of osteocalcin in horses
Carstanjen, B; Wattiez, R; Amory, Hélène ULg et al

in Proceedings of the ECVS meeting 2002 (Resident Forum) (2002)

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See detailThe assessment of third metacarpal bone speed of sound measurements in young exercising thorougbreds
Carstanjen, B; Langlois, P; Detilleux, Johann ULg et al

in Proceedings of the European Society of the Veterinary Society (ESVOT) (2002)

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See detailIsolation and Radioimmunoassay Formation of Equine Osteocalcin- Preliminary Results
Carstanjen, B; Sulon, J; Banga-Mboko, H et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2002), 6(1), 8-9

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See detailEinsatz der quantitativen Ultrasonometrie in der Knochendiagnostik beim Pferd
Carstanjen, B; Lepage, OM; Detilleux, Johann ULg et al

Poster (2002)

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See detailMulti-site quantitative ultrasound measurements of the third metacarpal bone in young thoroughbred horses
Carstanjen, B; Lepage, OM; Langlois, P et al

in Proceedings of the CESMAS congress 2002 (2002)

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See detailEquine Third Metacarpal Bone Assessment by Quantitative Ultrasound and Dual-Energy-X-Ray absorptiometry
Carstanjen, B; Duboeuf, F; Amory, Hélène ULg et al

in Proceedings of the 11th annual scientific meeting of the ECVS (2001)

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See detailQuantitative ultrasound and dual-X-ray absorptiometry-measurements of the third metacarpal bone in horses
Carstanjen, B; Duboeuf, F; Detilleux, Johann ULg et al

in Journal of Bone and Mineral Research (2000), 15

The purpose of the study was to examine the relationship between in vivo and ex vivo quantitative ultrasound (QUS) measurements with and without soft tissue and ex vivo dual X-ray absorptiometry (DXA) at ... [more ▼]

The purpose of the study was to examine the relationship between in vivo and ex vivo quantitative ultrasound (QUS) measurements with and without soft tissue and ex vivo dual X-ray absorptiometry (DXA) at different aspects and levels of the third metacarpal bone (MC III) in horses. Both MC III of 8 clinically normal horses were divided in 9 sites (lateral, medial, dorsal aspect; proximal, mid, distal level). Speed of sound (SOS) measurements were performed with a QUS multisite device (Sunlight Ltd., Rehovot, Israel) and a DXA device (Hologic Inc., Bedford, USA) was used to evaluate cortical bone mineral density (BMD) at each site. Ex vivo data on MC III were analysed with a mixed model to test the hypothesis of no difference between aspect and level in QUS and DXA while adjusting for fixed member and for random horse effects. Pearson correlation coefficients between SOS and BMD obtained on MC III with soft tissue were calculated for each member and site. A mixed model was used to determine whether there is a difference between in vivo and ex vivo SOS data while adjusting for fixed aspect, level, and member and random horse effects. Highly significant (p<0.001) differences were obtained between aspects for ex vivo SOS and DXA measurements. Differences (p<0.001) were obtained between measurement levels for DXA data. The table shows least squares means (LSM) and standard errors (Std Err) for QUS and DXA measurements performed at different aspects. The correlation coefficient between SOS and DXA over all 9 sites and both MC III was negative (r=-0.28; p<0.001). In vivo and ex vivo SOS data were different (p<0.01) BUT NOT EX VIVO DATA WITH AND WITHOUT SOFT TISSUE (P>0.05). The study suggests that, in horses, SOS results can not be explained only by BMD, but could reflect additional properties of bone, such as elasticity, architecture or bone strength. Our results indicate that soft tissue does not influence ex vivo SOS measurement results. [less ▲]

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