References of "Leonet, J"
     in
Bookmark and Share    
Full Text
Peer Reviewed
See detailEvolution of Native Kidney Function After Pancreas Transplantation Alone
LE DINH, Hieu; DE ROOVER, Arnaud ULg; COIMBRA MARQUES, Carla ULg et al

in Transplantation Proceedings (2012), 44

Introduction. This study investigated changes in kidney function over time among a cohort of patients undergoing pancreas transplantation alone (PTA) from January 2002 to December 2011. Patients and ... [more ▼]

Introduction. This study investigated changes in kidney function over time among a cohort of patients undergoing pancreas transplantation alone (PTA) from January 2002 to December 2011. Patients and Methods. Ten of eighteen PTA patients bearing functioning grafts for at least 1 year were recruited for the analysis. Primary endpoints were changes in mean serum creatinine (SCr, mg/L) and mean estimated glomerular filtration rate (eGFR) using the 4-variable Levey-MDRD equation (mL/min/1.73 m2) comparing baseline (pretransplantation) to 6-month, 1-year, 3-year, and 5-year posttransplantation values. Mean follow-up time was 75.7 20.5 months (range, 46–106.5). Results. Baseline eGFR was 89.3 27.9 (range, 58–145). eGFR decreased to 75.7 26.2, 71 20.6, 66.5 14.8, and 62.1 11.2 at 6 months, 1, 3, and 5 years representing 15.2%, 20.5%, 15.8%, and 22.6% percentage decreases respectively (P .05 for all pairwise comparisons). The Baseline SCr was 8.6 2.3 mg/L (range, 5–13). SCr progressively increased to 10.1 3, 10.5 3.1, 10.9 3.1, and 11.3 1.7 at 6 months, 1, 3, and 5 years a 17.1%, 22%, 16.6%, and 19.9% increase respectively (P .05 for all pairwise comparisons). One of ten, 2/8, and 3/7 patients displayed an eGFR 60 at transplantation versus 3 and 5 years thereafter, respectively. No patient developed a SCr 25 mg/L or eGFR 30 or needed dialysis or kidney transplantation. Five of ten patients had micro-albuminuria or proteinuria before transplantation. Tacrolimus levels were within recommended therapeutic ranges over time. Conclusion. Kidney function deteriorated significantly after PTA. Understanding of risk factors for the development of renal impairment is important to preserve kidney function and to select appropriate candidates for PTA. [less ▲]

Detailed reference viewed: 23 (6 ULg)
Full Text
Peer Reviewed
See detailRefractory insulin allergy : pancreas transplantation or immunosuppressive therapy alone?
Leonet, J.; Squifflet, Jean-Paul ULg; Malaise, J.

in Transplant International (2010)

Detailed reference viewed: 22 (6 ULg)
Full Text
Peer Reviewed
See detailAllergie systémique à l’insuline: traitement médical ou chirurgical (greffe de pancréas vascularisé).
Leonet, J; RADERMECKER, Régis ULg; Malaise, J et al

in Diabète & Métabolisme (2005), 31

Detailed reference viewed: 10 (1 ULg)
Full Text
Peer Reviewed
See detailAllergie systémique à l'insuline: traitement médical ou chirurgical (greffe de pancréas vascularisé)?
Leonet, J.; RADERMECKER, Régis ULg; Malaise, J. et al

in Diabète & Métabolisme (2005), 31

Detailed reference viewed: 18 (1 ULg)