  Sustainable and bio-inspired chemistry for robust antibacterial activity of stainless steelFaure, Emilie  ; Lecomte, Philippe ; et alin Journal of Materials Chemistry (2011), 21(22), 7901-7904 We report on the original synthesis of a poly(methacrylamide) bearing (oxidized) 3,4-dihydroxyphenylalanine specially designed to (i) insure film growth by covalent coupling, (ii) covalently bind an ... [more ▼] We report on the original synthesis of a poly(methacrylamide) bearing (oxidized) 3,4-dihydroxyphenylalanine specially designed to (i) insure film growth by covalent coupling, (ii) covalently bind an antibacterial peptide and (iii) contribute to the film cross-linking that is essential for the durability of the properties. [less ▲] Detailed reference viewed: 66 (25 ULg)Biomimetic coatings with robust antibacterial propertiesJérôme, Christine ; ; Faure, Emilie et alConference (2010, July 01) Detailed reference viewed: 16 (4 ULg) A green and refillable antibacterial coating for stainless steelFaure, Emilie ; ; et alPoster (2010, June 29) Because of its resistance to corrosion and chemicals, relevant mechanical and esthetical properties, stainless steel (SS) is widely used in the daily life (food industry, household appliances, surgery … ... [more ▼] Because of its resistance to corrosion and chemicals, relevant mechanical and esthetical properties, stainless steel (SS) is widely used in the daily life (food industry, household appliances, surgery …). However, SS is unable to prevent bacteria from adhering, proliferating and forming a resistant biofilm when ageing. Therefore, surface modification is needed for providing durable antibacterial properties. We report here on an all-in-one approach to prepare refillable antimicrobial films using the layer-by-layer deposition of polyelectrolytes. Specifically designed biocidal multilayered polyelectrolyte films that bear 3,4-dihydroxyphenylalanine (DOPA), known as a promoter of adhesion to inorganic surfaces, were deposited onto SS. DOPA was incorporated in the polycationic chains by radical copolymerisation of N-methacrylated DOPA with the quaternary ammonium salt of 2-(dimethylamino)ethyl methacrylate (DMAEMA+). In order to boost the antibacterial activity of the polycationic layer, AgNO3 was added to the aqueous solution of P(DOPA)-co-P(DMAEMA+), which resulted in the in-situ formation of silver based nanoparticles, sources of biocial Ag+. The layer-by-layer deposition of aqueous P(DOPA)-co-P(DMAEMA+)/AgCl/Ag0 suspension and aqueous solution of poly(styrene sulfonate) provides high antibacterial activity against Gram-negative E. Coli bacteria. Moreover, after silver depletion, films retain some antimicrobial activity, thanks to ammonium groups of the copolymer. We also show that the antibacterial activity of the films can then be easily re-boosted. [less ▲] Detailed reference viewed: 98 (15 ULg)A robust antibacterial coating for stainless steelFaure, Emilie ; ; et alConference (2010, March 23) Because of corrosion, chemical resistance, relevant mechanical and esthetical properties, stainless steel is widely used in the daily life, not only in the building industry but also in the food industry ... [more ▼] Because of corrosion, chemical resistance, relevant mechanical and esthetical properties, stainless steel is widely used in the daily life, not only in the building industry but also in the food industry, the appliances or in the medical field, including implants in orthopedic surgery. However, stainless steel is unable to prevent bacteria from adhering, proliferating and forming a resistant biofilm. Therefore, surface modification is needed for providing the metal surface with antibacterial properties. The scientific literature is very rich in describing various methods for imparting antibacterial properties to different inorganic supports. However, the activity of the coating is generally time limited by the diffusion of the biocide in the environment. Novel robust and stable antibacterial coatings on stainless steel are thus highly desirable for the durability of the functionality. In this communication, we report on an all-in-one approach to prepare robust antimicrobial films on stainless steel using the layer-by-layer deposition of polyelectrolytes. Novel biocidal multilayered polyelectrolyte films in which the polycationic layer is silver loaded and bears 3,4-dihydroxyphenylalanine (DOPA), known as a promoter of adhesion to inorganic surfaces, were deposited onto stainless steel. DOPA was incorporated in the polycationic chains by radical copolymerisation of N-methacrylated DOPA with the commercially available quaternary ammonium salt of 2-(dimethylamino)ethyl methacrylate (DMAEMA+). Polystyrene sulfonate (PSS) was the polyanionic constituent of the films. In order to boost the antibacterial activity of the polycationic layer, AgNO3 was added to the aqueous solution of P(DOPA)-co-P(DMAEMA+), which resulted in the in-situ formation of silver based nanoparticles (Ag° and AgCl) that are sources of biocial Ag+. The layer-by-layer deposition of aqueous P(DOPA)-co-P(DMAEMA+)/AgCl/Ag0 suspension and aqueous solution of PSS provides stainless steel with high antibacterial activity against Gram-negative E. Coli bacteria. Moreover, after silver depletion, films retain some antimicrobial activity, thanks to the ammonium groups of the copolymer. We will also show how the antibacterial activity of the films can then be easily re-boosted. The multi-functionality of the P(DOPA)-co-P(DMAEMA+) is a key issue in this process (i) the DOPA co-units are anchored to stainless steel, (ii) these co-units reduce partly AgNO3 into Ag0 nanoparticles and stabilize them by chelation, (iii) the chloride counter-anions react with AgNO3 by ionic exchange, leading to the in situ formation of AgCl particles, and (iv) the ammonium groups are responsible for permanent antibacterial activity. Besides the advantage of the all-in-one process, another major advantage of the approach proposed here is the implementation of the whole process of film formation, including the synthesis of P(DOPA)-co-P(DMAEMA+), in aqueous media under very mild conditions. It makes the strategy very attractive for industrial scaling-up and sustainability applications. [less ▲] Detailed reference viewed: 136 (22 ULg)All-in-one strategy for the fabrication of antimicrobial biomimetic films on stainless steel; ; et al in Journal of Materials Chemistry (2009), 19 Here we report on an all-in-one approach to prepare robust antimicrobial films on stainless steel. The strategy is based on the layer-by-layer deposition of polyelectrolytes. A polycationic copolymer ... [more ▼] Here we report on an all-in-one approach to prepare robust antimicrobial films on stainless steel. The strategy is based on the layer-by-layer deposition of polyelectrolytes. A polycationic copolymer bearing 3,4-dihydroxyphenylalanine units (DOPA, a major component of natural adhesives) was synthesized and co-deposited with precursors of silver nanoparticles as the first layer. The presence of DOPA units ensures a strong anchoring on the stainless steel substrate, and the silver nanoparticles are sources of biocidal Ag+, providing stainless steel with antimicrobial activity. We show that multilayered films, obtained by alternating this nanoparticle-loaded polycationic copolymer with polystyrene sulfonate, a commercial polyanion, results in stainless steel with high antibacterial activity against Gram-negative E. coli bacteria. The polycationic layers are a reservoir of Ag+ that can be reactivated after depletion. The whole process of film formation, including the synthesis of the copolymer, is conducted in aqueous media under very mild conditions, which makes it very attractive for industrial scale-up and sustainable applications. [less ▲] Detailed reference viewed: 55 (26 ULg)Nanocoatings of inorganic surfaces by the layer by layer (LbL) technologyFaure, Emilie ; Zocchi, Germaine ; et alPoster (2009, April 02) Detailed reference viewed: 42 (17 ULg)Polyolefin matrixes with permanent antibacterial activity: preparation, antibacterial activity, and action mode of the active species; ; Galleni, Moreno et alPoster (2008, May 22) Detailed reference viewed: 26 (12 ULg)Structure and morphology of thin films of fulorinated copolymers; ; Jérôme, Christine et alPoster (2006, May 18) Detailed reference viewed: 20 (0 ULg)ATRP of aminated methacrylates: a route to effective antimicrobial surfactants, coatings and additives; ; Detrembleur, Christophe et alConference (2005, June 01) Detailed reference viewed: 10 (3 ULg)ATRP of aminated methacrylates: a route to effective antimicrobial surfactants, coatings and additives; ; Galleni, Moreno et alConference (2005, May 19) Detailed reference viewed: 11 (2 ULg) Contribution of atom transfer radical processes to the functionalization and grafting of poly-ε-caprolactoneRiva, Raphaël ; ; Lecomte, Philippe et alPoster (2004, May 27) Detailed reference viewed: 13 (2 ULg)Novel biocompatible coatings strongly adhering onto stainless steel and carbon fibers, endowed with antibacterial properties; ; et al Poster (2003, May 16) Detailed reference viewed: 9 (1 ULg)Polymer blending: a convenient technique for the preparation of new antimicrobial polymeric mateirals; ; et al Poster (2003, May 16) Detailed reference viewed: 6 (2 ULg)Poly(α-chloro-ε-caprolactone), a new precursor for functionalized and graft polyestersRiva, Raphaël ; ; Lecomte, Philippe et alPoster (2003, May 16) Detailed reference viewed: 14 (2 ULg) |
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