References of "Lenaerts, M"
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See detailEffectiveness of High-Dose Riboflavin in Migraine Prophylaxis. A Randomized Controlled Trial
Schoenen, Jean ULg; Jacquy, J.; Lenaerts, M.

in Neurology (1998), 50(2), 466-70

A deficit of mitochondrial energy metabolism may play a role in migraine pathogenesis. We found in a previous open study that high-dose riboflavin was effective in migraine prophylaxis. We now compared ... [more ▼]

A deficit of mitochondrial energy metabolism may play a role in migraine pathogenesis. We found in a previous open study that high-dose riboflavin was effective in migraine prophylaxis. We now compared riboflavin (400 mg) and placebo in 55 patients with migraine in a randomized trial of 3 months duration. Using an intention-to-treat analysis, riboflavin was superior to placebo in reducing attack frequency (p = 0.005) and headache days (p = 0.012). Regarding the latter, the proportion of patients who improved by at least 50%, i.e. "responders," was 15% for placebo and 59% for riboflavin (p = 0.002) and the number-needed-to-treat for effectiveness was 2.3. Three minor adverse events occurred, two in the riboflavin group (diarrhea and polyuria) and one in the placebo group (abdominal cramps). None was serious. Because of its high efficacy, excellent tolerability, and low cost, riboflavin is an interesting option for migraine prophylaxis and a candidate for a comparative trial with an established prophylactic drug. [less ▲]

Detailed reference viewed: 58 (3 ULg)
See detailSodium Valproate in Severe Migraine and Tension-Type Headache: An Open Study of Long-Term Efficacy and Correlation with Blood Levels
Lenaerts, M.; Bastings, E.; Sianard, J. et al

in Acta Neurologica Belgica (1996), 96(2), 126-9

We performed an open prospective study of the prophylactic efficacy of sodium valproate in 56 patients among which 35 migraineurs, 7 chronic tension-type headache patients and 14 patients with combined ... [more ▼]

We performed an open prospective study of the prophylactic efficacy of sodium valproate in 56 patients among which 35 migraineurs, 7 chronic tension-type headache patients and 14 patients with combined headaches. We compared the mean number of headache days per month during a one-month-baseline period without prophylactic treatment and during the last month of a 6-month-treatment course. Among secondary parameters, we assessed headache intensity, adverse experiences and we measured valproate blood levels after one and after six months of treatment. Sixty percent of migraineurs had a 75% or more improvement in the number of headache days under sodium valproate, most of the remaining attacks being less severe. There was no significant improvement in chronic tension-type headache patients and only a mild effect in patients with combined headaches, almost exclusively on the migraine component. Thirty percent of patients reported adverse effects of which none was serious: there were 3 drop-outs. We found a moderate, but statistically significant, correlation between efficacy and blood levels of sodium valproate. [less ▲]

Detailed reference viewed: 20 (1 ULg)
See detailHigh-Dose Riboflavin as a Prophylactic Treatment of Migraine: Results of an Open Pilot Study
Schoenen, Jean ULg; Lenaerts, M.; Bastings, E.

in Cephalalgia : An International Journal of Headache (1994), 14(5), 328-9

If the brain of migraineurs is characterized between attacks by a reduction of mitochondrial phosphorylation potential, riboflavin, which has the potential of increasing mitochondrial energy efficiency ... [more ▼]

If the brain of migraineurs is characterized between attacks by a reduction of mitochondrial phosphorylation potential, riboflavin, which has the potential of increasing mitochondrial energy efficiency, might have prophylactic effects in migraine. In this preliminary open pilot study, 49 patients suffering from migraine (45 without aura, 4 with aura) were treated with 400 mg of riboflavin as a single oral dose for at least 3 months. Twenty-three patients received in addition 75 mg of aspirin. Mean global improvement after therapy was 68.2% and there was no difference between the two groups of patients. With the exception of one patient in the riboflavin plus aspirin group who withdrew because of gastric intolerance, no drug-related side effects were reported. High-dose riboflavin could thus be an effective, low-cost prophylactic treatment of migraine devoid of short-term side effects. A placebo-controlled trial of its efficacy seems worthwhile. [less ▲]

Detailed reference viewed: 24 (0 ULg)
See detailNo significant effect of an "atraumatic" needle on incidence of post-lumbar puncture headache or traumatic tap.
Lenaerts, M.; Pepin, J. L.; Tombu, S. et al

in Cephalalgia : An International Journal of Headache (1993), 13(4), 296-7

We compared the incidence of post-lumbar puncture headache and of red blood cells in the first CSF sample (traumatic tap) in 35 inpatients punctured with a standard 20 G Yale needle and in 26 patients ... [more ▼]

We compared the incidence of post-lumbar puncture headache and of red blood cells in the first CSF sample (traumatic tap) in 35 inpatients punctured with a standard 20 G Yale needle and in 26 patients punctured with Sprotte's "atraumatic" needle. No significant difference was found between the two groups in incidence of headache or in frequency of traumatic taps. [less ▲]

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See detailSuppressions of temporalis muscle activity and their modulations by transcranial magnetic stimulations may reflect direct excitation of the trigeminal nerve or ganglion, and not cortical activation
MAERTENS DE NOORDHOUT, Alain ULg; Lenaerts, M.; Gérard, P. et al

in Olesen, J.; Schoenen, Jean (Eds.) Tension-Type Headache: classification, mechanisms and treatment (Frontiers in Headache Research) (1993)

Detailed reference viewed: 2 (1 ULg)
See detailInhibition of temporal second exteroceptive suppression produced by single or long-lasting electrical stimuli and noxious thermal stimuli in peripheral limbs: effects of Naloxone
Schoenen, Jean ULg; Lenaerts, M.; Gérard, P.

in Olesen, J.; Schoenen, Jean (Eds.) Tension-Type Headache: classification, mechanisms, treatment (Frontiers in Headache Research) (1993)

Detailed reference viewed: 6 (0 ULg)
See detailBlood Magnesium Levels in Migraine
Schoenen, Jean ULg; Sianard-Gainko, J.; Lenaerts, M.

in Cephalalgia : An International Journal of Headache (1991), 11(2), 97-9

Serum and erythrocyte magnesium levels were screened between attacks in patients with migraine without aura (n = 38) and with aura (n = 6), and for comparison in a group of patients suffering from chronic ... [more ▼]

Serum and erythrocyte magnesium levels were screened between attacks in patients with migraine without aura (n = 38) and with aura (n = 6), and for comparison in a group of patients suffering from chronic tension-type headache (n = 25) as well as a group of neurological, non-headache patients (n = 19). Serum magnesium levels were not significantly different between the four groups of patients. In contrast, magnesium in erythrocytes was on average significantly reduced in patients with migraine without aura compared to the other groups. It is hypothesized that this reduction might be due to an abnormal regulation of intracellular magnesium possibly reflecting at the periphery changes observed in the brain of migraineurs. [less ▲]

Detailed reference viewed: 21 (1 ULg)