References of "Lecomte, Philippe"
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See detailAdvances in the synthesis of degradable polymers for biomedical applications
Lecomte, Philippe ULg

Conference (2014, October 20)

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See detailRecent development in the ring-opening polymerization of cyclic phosphates
Lecomte, Philippe ULg

Scientific conference (2014, September 09)

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See detailMicellization of PEO-b-polyphosphate for drug delivery applications
Vanslambrouck, Stéphanie ULg; Clément, Benoit; Riva, Raphaël ULg et al

Conference (2014, July 11)

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See detailReversibly cross-linked polymer micelle as smart drug dellivery device
Lecomte, Philippe ULg; Riva, Raphaël ULg; Cajot, Sébastien et al

Conference (2013, November 20)

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See detailOrganocatalyzed ring-opening polymerization of cyclic phosphate monomers
Clement, Benoît ULg; Vanslambrouck, Stéphanie ULg; Koole, Leo H. et al

Conference (2013, November 19)

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See detailDrug delivery systems based on amphiphilic polyphosphate-copolymers
Vanslambrouck, Stéphanie ULg; Clement, Benoît ULg; Riva, Raphaël ULg et al

Poster (2013, September 18)

Thanks to their biocompatibility, biodegradability and their structure similar to natural biomacromoleculesn such as nucleic acids, polyphosphates (PPhos) are of prime interest as biomaterials. In ... [more ▼]

Thanks to their biocompatibility, biodegradability and their structure similar to natural biomacromoleculesn such as nucleic acids, polyphosphates (PPhos) are of prime interest as biomaterials. In contrast to poly--caprolactone and polylactides, PPhos properties and functionality are easily tuned via the nature of the pendant group of the starting cyclic monomer. For example, by varying the length of the alkyl chain the hydrophobicity of the PPhos can be adjusted. In this work, an efficient organo-catalytic system was developed to synthesize a series of amphiphilic diblock copolymers, i.e. poly(ethylene oxide)-b-polyphosphate (PEO-b-PPhos) by ring-opening polymerization of cyclic phosphates. This novel approach prevents metallic residues to polute the final product, and which is highly desirable when biomedical applications are foreseen. For drug delivery application, the micellization of these novel diblock copolymers in aqueous media was investigated, as well as, encapsulation of an hydrophobic drug. Data on, the influence of the polyphosphate nature of the polymer on drug loading will be presented. [less ▲]

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See detailA novel strategy towards cyclic aliphatic (co)polyesters
Gao, Ch; Li, Y; Chi, J et al

in eXPRESS Polymer Letters (2013), 7(8), 690-702

This feature article focuses on a novel strategy towards macrocyclic (co)polyesters that combines controlled ring-opening polymerization of lactones initiated by a cyclic tin(IV) dialkoxide and ... [more ▼]

This feature article focuses on a novel strategy towards macrocyclic (co)polyesters that combines controlled ring-opening polymerization of lactones initiated by a cyclic tin(IV) dialkoxide and intramolecular cyclization by photocross- linking of pendant unsaturations next to the propagating sites. No linear species is ever involved in the polymerization and permanent cyclization steps, which allows higher molecular weight macrocycles to be prepared with high efficiency and no need for further purification. Moreover, this synthetic route is very flexible to the point where macrocyclic polyesters with more complex although well-defined architectures, such as tadpole-shaped and sun-shaped copolyesters, can be tailored. Synthesis of well-defined eight-shaped polyesters and twin tadpole-shaped copolymers has also been explored by using a spirocyclic tin(IV) alkoxides as an initiator. When functional lactones were introduced, the ‘click’ copper-mediated cycloaddition [3+2] reaction was utilized to make the eight-shaped and twin tadpole-shaped copolyesters amphiphilic. [less ▲]

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See detailBiomimetic polymers
Clement, Benoît ULg; Vanslambrouck, Stéphanie ULg; Koole, Leo H. et al

Poster (2013, July 08)

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See detailDesign and development of new polyamides by ring-opening polymerization for high performance composite materials
Tunc, Deniz; Carlotti, Stéphane; Lecomte, Philippe ULg et al

Poster (2013, May 16)

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See detailPolyphosphate-based copolymers for drug delivery applications
Lecomte, Philippe ULg

Conference (2013, April 09)

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See detailSynthesis and fabrication of polyesters as biomaterials
Lecomte, Philippe ULg; Jérôme, Christine ULg

in Popa, Valentin; Dumitriu, Daniela (Eds.) Polymeric biomaterials: structure and function, volume 1 (2013)

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See detailNovel functional degradable block copolymers for the building of reactive micelles
Cajot, Sébastien; Lecomte, Philippe ULg; Jérôme, Christine ULg et al

in Polymer Chemistry (2013), 4(4), 1025-1037

Amphiphilic biocompatible copolymers are promising materials for the elaboration of nanosystems for drug delivery applications. This paper aims at reporting on the synthesis of new functional amphiphilic ... [more ▼]

Amphiphilic biocompatible copolymers are promising materials for the elaboration of nanosystems for drug delivery applications. This paper aims at reporting on the synthesis of new functional amphiphilic copolymers based on biocompatible and bioeliminable blocks. Poly(ethylene oxide) was selected as the hydrophilic block, whereas an aliphatic polyester, i.e. poly(epsilon-caprolactone), or a polycarbonate, i.e. poly(trimethylene carbonate), were chosen as the degradable hydrophobic block. In order to allow a post-functionalization of the micelles core, azide groups were introduced on the hydrophobic segment to provide reactivity towards functional alkyne derivatives by the copper azide-alkyne cycloaddition (CuAAC). For this purpose, a functional lactone, i.e. alpha-chloro-epsilon-caprolactone was introduced during the polymerization of the hydrophobic block before being converted into azide on the preformed copolymer. Such reactivity of the block copolymers and their self-assemblies is of prime interest for drugs or fluorescent dyes grafting, so as for micelles cross-linking. The influence of the azides distribution along the degradable block on the micelles post-functionalization ability has been studied by using alkyne bearing fluorescent dyes as model for drugs. The hydrophilicity of the dye on the micelles post-functionalization efficiency has also been investigated. [less ▲]

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