A comparison of three calcium phosphate based space fillers in sinus elevation: a study in rabbits

in International Journal of Oral & Maxillofacial Implants (2013)

Aim: Sub-sinusal bone regeneration procedures are reliable procedures that are known to be efficient with the use of biomaterials alone. Nevertheless, many types of biomaterials are available, and their ... [more ▼]

Aim: Sub-sinusal bone regeneration procedures are reliable procedures that are known to be efficient with the use of biomaterials alone. Nevertheless, many types of biomaterials are available, and their efficacy in terms of bone formation and resorption rate have rarely been compared. This study aimed to compare the bone formation, resorption rate, osteoconductivity and 3D volume changes of three biomaterials often used for alveolar ridge augmentation. Materials and Methods: Rabbits underwent a double sinus lift procedure using three different types of space fillers: bovine hydroxyapatite (BHA), beta calcium phosphate (ß-TCP) and biphasic calcium phosphate (BCP). Animals were sacrificed at 1 week, 5 weeks and 6 months. Samples were subjected to X-ray microtomography and histology. Qualitative analysis was performed on non-decalcified sections, and quantitative histomorphometric analysis was conducted using SEM. Volume variations of bone augmentations were calculated at different time points. Results: All three particulated biomaterials proved to be effective in promoting osteogenesis. At 6 months, biomaterial resorption rates were significantly different across the 3 groups (p<0.0001). The highest resorption rate was found with β-TCP, in which only 6.7% of the baseline particle surface remained. At 6 months, bone was in close contact with the BHA particles, constituting a composite network; in contrast, BCP particles were often surrounded by soft tissues. In each group, no significant difference in volume variations were found at the different time point. Conclusions and clinical implications: Despite the limitations of the study, the three particulated space-filling biomaterials proved to be efficient to promote osteogenesis. High resorption rates and complete replacement of the biomaterials by bone seemed to withstand intrasinusal pressure. Further investigations in humans should consider longer follow-up periods. [less ▲]

Patient morbidity after socket preservation using a connective tissue graft versus a bilayer collagen matrix: Preliminary results of a comparative Randomized Control Trial.

Poster (2012, June)

INTRODUCTION AND AIM: The present randomized controlled trial compared socket preservation procedures using bovine hydroxyapatite (Bio-Oss®, Geistlich, Switzerland) covered with a connective tissue graft ... [more ▼]

INTRODUCTION AND AIM: The present randomized controlled trial compared socket preservation procedures using bovine hydroxyapatite (Bio-Oss®, Geistlich, Switzerland) covered with a connective tissue graft (CT) versus a bilayer collagen membrane (CM) (Mucograft®, Geistlich, Switzerland), placed from buccal to palatal in split-thickness pouches in order to seal the extraction site and to potentially thicken the buccal mucosa. The aim of this present abstract was to evaluate post-operative complications and patient-centered outcomes of the two independent surgical protocols. METHODS: This randomized controlled trial included 26 patients (16 female, 10 male) aged from 20 to 69 years (mean: 42.6, SD: 12). 26 teeth were extracted atraumatically and the 2 distinct surgical protocols were applied randomly. Patients filled out a VAS form 1 week after the surgery to evaluate their level of discomfort and post-operative pain. Drug intakes as well as complications were also recorded. RESULTS: No statistical significant differences were found between the 2 groups in terms of post-operative complications (bleeding) and post-operative pain. The consumption of painkillers after the surgery decreased over time but was similar in the two groups. CONCLUSION: According to the preliminary results of the present RCT, none of both protocols seemed to induce significant post-operative pain and discomfort. There was no difference between the two procedures regarding post-operative complications and patient centered outcomes. [less ▲]

Early Implant placement in socket preservations: 12-month results of a prospective case series.

Poster (2012, June)

Objectives: The aim of this study was to evaluate the clinical and histological outcomes of implant placed after socket preservation procedures in the esthetic zone. Implant survival rate and biological ... [more ▼]

Objectives: The aim of this study was to evaluate the clinical and histological outcomes of implant placed after socket preservation procedures in the esthetic zone. Implant survival rate and biological complications were recorded during a follow-up period of 1 year. Materials and methods: A series of 12 patients needing the replacement of a single tooth in the esthetic zone were included in the present study. The hopeless teeth were extracted atraumatically, the sockets were filled with bovine hydroxyapatite (0.25-1mm particles) and the sites were covered with a saddled connective tissue graft. After a healing period of 3 months, biopsies were retrieved in the socket preservation sites and implants were placed. The patients were followed for a period of 1 year. Results: The etiologies of tooth loss were : endodontic (9), caries (1), periodontal (1), and traumatic (1). A total of 12 implants (10 incisors, 2 premolars) were placed on 12 patients (6 men / 6 women) aged from 24 to 61 (42,3 – 11,91). All implant reached an adequate primary stability (> 20N/cm2). 7 out of 12 implants were immediately restored with a temporary crown, and the définitive restorations were successfully placed in all cases. After a follow-up period of 1 year, all implants fulfilled strict success criteria for dental implants with regard to osteointegration, including the absence of peri-implant radiolucency, implant mobility, suppuration, and pain and no further complications occurred. Out of 12 sites only 7 biopsies were retrieved for histological analyses. New bone was found in the apical third of the socket in every specimen, in the mid-third in only 3 specimen and no bone was found in any of the spécimen in the more cervical third of the socket. Conclusion: The results from this prospective case series suggest that early implant placement in extraction socket site seems to display good clinical outcomes despite the incomplete bone regeneration in the socket at 3 months. [less ▲]

Bone Regeneration Using Porous Titanium Particles versus Bovine Hydroxyapatite: A Sinus Lift Study in Rabbits.

in Clinical Implant Dentistry & Related Research (2011)

Aim: The first objective of this study was to qualitatively and quantitatively assess the bone formation process, particularly the long-term behavior and three-dimensional volume stability of subsinusal ... [more ▼]

Aim: The first objective of this study was to qualitatively and quantitatively assess the bone formation process, particularly the long-term behavior and three-dimensional volume stability of subsinusal bone regeneration, using titanium (Ti) or bovine hydroxyapatite (BHA) granules, in a rabbit model. The second objective was to evaluate the effect of the hydration of the BHA particles with a therapeutic concentration of doxycycline solution on the osteogenesis and biomaterial resorption. Materials and Methods: Rabbits underwent a double sinus lift procedure using one of three materials: grade 1 porous Ti particles, BHA, or BHA hydrated with doxycycline solution (0.1 mg/ml) (BHATTC). Animals were sacrificed after 1 week, 5 weeks, or 6 months. Samples were analyzed using µCT and nondecalcified histology. Results: The materials used in each of the three groups allowed an optimal bone formation; bone quantities and densities were not statistically different between the three groups. At 6 months, more stable three-dimensional volume stability was found with Ti and BHATTC (p = .0033). At 5 weeks and 6 months, bone to material contact corroborating osteoconduction was significantly higher with BHA and BHATTC than with Ti (p < .0001). Conclusions and Clinical Implications: Even though the studied biomaterials displayed different architectures, they are relevant candidates for sinus lift bone augmentation prior to dental implants because they allow adequate three-dimensional stability and osteogenesis. However, to recommend the clinical use of Ti, both an observation on the drilling effects of Ti particles and clinical trials are needed. [less ▲]

Marginal bone resorption and marginal bone level around implants in the posterior mandible: A 4-year retrospective study.

Poster (2009, June)

Long-term bone remodelling of implant placed in the posterior mandibule: a radiological study. France Lambert, Kim Vincent, Caroline Geron, Geoffrey Lecloux, Eric Rompen. Purpose: The aim of this study ... [more ▼]

Long-term bone remodelling of implant placed in the posterior mandibule: a radiological study. France Lambert, Kim Vincent, Caroline Geron, Geoffrey Lecloux, Eric Rompen. Purpose: The aim of this study was to analyse direct and long-term (4 years) marginal bone remodelling of various implant systems placed in the posterior mandibule with a single stage approach. Materials and methods: 50 partially edentulous patients received a total of 114 implants in the posterior mandibule (TE implant, Straumann®, Switzerland; Replace® Select Straight, Nobel Biocare, Sweden; Branemark System® MKIV, Nobel Biocare, Sweden). All implants were non-submerged, and loaded 8 to 12 weeks post surgery. X-rays were taken at baseline, 6 weeks, after loading and at long-term. Using a image processing program (Image J), bone losses were measured at each time point. Bone levels were also recorded using the first thread as reference point. Results: The mean bone loss reached 0.506±0.498 mm at 6 weeks, 0.798±0.599 after loading and 1.037±0.799 after 4 years. Bone losses were significatively higher on smokers and on patients displaying signs of bruxism. No statistical difference was found between the different implant types. Conclusion: 50% of the bone loss had already occurred within the 6 weeks post surgery with all implant types. Higher bone losses were often associated to risk factors such as tabacco addiction and bruxism. [less ▲]

Augmentation osseuse sous-sinusienne : actualisation du concept du sinus lift.

in Revue d'Odonto-Stomatologie (2008), 37(1), 3-17

L’élévation du plancher sinusal est une technique permettant de placer des implants d’une longueur suffisante au niveau du maxillaire postérieur. Depuis qu’elle a été initialement décrite dans les années ... [more ▼]

L’élévation du plancher sinusal est une technique permettant de placer des implants d’une longueur suffisante au niveau du maxillaire postérieur. Depuis qu’elle a été initialement décrite dans les années 80, cette technique a beaucoup évolué. A l’heure actuelle, on peut considérer cette approche comme prédictible, simple et réalisable au fauteuil sous anesthésie locale. Cet article vise d’abord à expliciter clairement le phénomène biologique du « sinus-lift », ensuite, de décrire le protocole chirurgical que nous appliquons à l’Université de Liège (Belgique) et de le confronter avec la littérature scientifique existante. [less ▲]

Sinus elevation and simultaneous implant placement: the influence of the remaining bone height.

Poster (2007, October)

Placement of non-submerged implants simultaneously with sinus augmentation with bovine HA

in Clinical Oral Implants Research (2005, September)

The best solution for you patient. A Biological Approach for Aesthetic Implant Dentistry.

Poster (2005, May)

Maxillary reconstruction by cortical bone grafts before implant placement.

Poster (1999)