References of "Leclercq, Philippe"
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See detailepiploic appendagitis
Leclercq, Philippe ULiege; Dorthu, Laurent

in Canadian Medical Association Journal = Journal de l'Association Médicale Canadienne (2010), 182(9), 939

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See detailCotrimoxazole induced mixed type II cryoglobulinemia.
Leclercq, Philippe ULiege; Frippiat, Frédéric ULiege; Lambermont, Bernard ULiege

in European Journal of Internal Medicine (2008), 19(4),

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See detailEmphysematous cystitis.
Leclercq, Philippe ULiege; Hanssen, Michel ULiege; Borgoens, Philippe ULiege et al

in Canadian Medical Association Journal = Journal de l'Association Médicale Canadienne (2008), 178(7),

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See detailL'oesophagite à éosinophiles chez l'adulte : à propos d'un cas
Marting, Audrey ULiege; Leclercq, Philippe ULiege; Gast, Pierrette ULiege et al

in Revue Médicale de Liège (2008), 63

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See detaileosinophilic esophagitis
Leclercq, Philippe ULiege; Marting, Audrey; Gast, Pierrette ULiege

in New England Journal of Medicine [=NEJM] (2007), 357(14),

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See detailAutoimmune pancreatitis
Leclercq, Philippe ULiege; Meurisse, Nicolas ULiege; Honore, Pierre ULiege

in New England Journal of Medicine [=NEJM] (2007), 356(15),

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See detailWhen the book is wrong
Leclercq, Philippe ULiege; Betz, Romain ULiege; Lambermont, Bernard ULiege et al

in Lancet (2007), 369

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See detailF-18-FDG PET imaging of rheumatoid knee synovitis correlates with dynamic magnetic resonance and sonographic assessments as well as with the serum level of metalloproteinase-3
Beckers, Catherine ULiege; Jeukens, Xavier; Ribbens, Clio ULiege et al

in European Journal of Nuclear Medicine and Molecular Imaging (2006), 33(3), 275-280

Purpose: The aim of this study was to assess rheumatoid arthritis (RA) synovitis with positron emission tomography (PET) and F-18-fluorodeoxyglucose (F-18-FDG) in comparison with dynamic magnetic ... [more ▼]

Purpose: The aim of this study was to assess rheumatoid arthritis (RA) synovitis with positron emission tomography (PET) and F-18-fluorodeoxyglucose (F-18-FDG) in comparison with dynamic magnetic resonance imaging (MRI) and ultrasonography (US). Methods: Sixteen knees in 16 patients with active RA were assessed with PET, MRI and US at baseline and 4 weeks after initiation of anti-TNF-alpha treatment. All studies were performed within 4 days. Visual and semi-quantitative (standardised uptake value, SUV) analyses of the synovial uptake of FDG were performed. The dynamic enhancement rate and the static enhancement were measured after i.v. gadolinium injection and the synovial thickness was measured in the medial, lateral patellar and suprapatellar recesses by US. Serum levels of C-reactive protein (CRP) and metalloproteinase-3 (MMP-3) were also measured. Results: PET was positive in 69% of knees while MRI and US were positive in 69% and 75%. Positivity on one imaging technique was strongly associated with positivity on the other two. PET-positive knees exhibited significantly higher SUVs, higher MRI parameters and greater synovial thickness compared with PET-negative knees, whereas serum CRP and MMP-3 levels were not significantly different. SUVs were significantly correlated with all MRI parameters, with synovial thickness and with serum CRP and MMP-3 levels at baseline. Changes in SUVs after 4 weeks were also correlated with changes in MRI parameters and in serum CRP and MMP-3 levels, but not with changes in synovial thickness. Conclusion: F-18-FDG PET is a unique imaging technique for assessing the metabolic activity of synovitis. The PET findings are correlated with MRI and US assessments of the pannus in RA, as well as with the classical serum parameter of inflammation, CRP, and the synovium-derived parameter, serum MMP-3. Further studies are warranted to establish the place of metabolic imaging of synovitis in RA. [less ▲]

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