References of "Leclercq, Joëlle"
     in
Bookmark and Share    
Full Text
Peer Reviewed
See detailAntimalarial Activities of Alkyl Cyclohexenone Derivatives Isolated from the Leaves of Poupartia borbonica
Ledoux, Allison ULiege; St-Gelais, Alexis; Cieckiewicz, Ewa ULiege et al

in Journal of Natural Products (2017), 80(6), 1750-1757

Bioactivity-guided fractionation of the ethyl acetate extract of the leaves of Poupartia borbonica led to the isolation of three new alkyl cyclohexenone derivatives 1−3, and named Poupartone A−C. The ... [more ▼]

Bioactivity-guided fractionation of the ethyl acetate extract of the leaves of Poupartia borbonica led to the isolation of three new alkyl cyclohexenone derivatives 1−3, and named Poupartone A−C. The structures of the new compounds were elucidated by 1D and 2D NMR spectroscopic data analysis and MS, whereas calculated and experimental ECD spectra were used to define the absolute configurations. These compounds were active against 3D7 and W2 Plasmodium falciparum strains with IC50 values between 0.55 and 1.81 μM. In vitro cytotoxicity against WI38 human fibroblasts and the human cervical cancer cell line HeLa (WST-1 assay) showed that these compounds were also cytotoxic, but no hemolytic activity was observed for the extract and pure compounds. An in vivo antimalarial assay was performed on the major cyclohexenone using P. berghei-infected mice at a dose of 15 mg/kg/day ip. The assay revealed growth inhibition of 59.1 and 69.5% at days 5 and 7 postinfection, respectively, although some toxicity was observed. Zebrafish larvae were used as a model to determine the type of toxicity, and the results showed cardiac toxicity. The methanol extract was also studied, and it displayed moderate antiplasmodial properties in vitro. This extract contained the known flavonoids, quercetin, 3′-O-hydroxysulfonylquercetin, quercitrin, and isoquercitrin as well as ellagic acid, which showed high to low activity against the 3D7 P. falciparum strain. [less ▲]

Detailed reference viewed: 25 (9 ULiège)
Full Text
Peer Reviewed
See detailThe structure of isostrychnopentamine, a bisindole monoterpene alkaloid from Strychnos usambarensis
Tavernier, Dirk; Zhang, Weiguo; Angenot, Luc ULiege et al

in Phytochemistry (1987), 26(2), 557-560

The alkaloid isostrychnopentamine has been shown to be epimeric with strychnopentamine at the asymmetric carbon atom of the N-methylpyrrolidin-2-yl group. Its IUPAC name is also given.

Detailed reference viewed: 31 (3 ULiège)
Full Text
Peer Reviewed
See detailScreening of cytotoxic activities of Strychnos alkaloids ( methods and results)
Leclercq, Joëlle; De Pauw-Gillet, Marie-Claire ULiege; Bassleer, Roger et al

in Journal of Ethnopharmacology (1986), 15

The potential cytotoxic activities of 46 alkaloids isolated from different Strychnos species were tested on different cancer or normal cells cultured in vitro. The authors use a relatively simple ... [more ▼]

The potential cytotoxic activities of 46 alkaloids isolated from different Strychnos species were tested on different cancer or normal cells cultured in vitro. The authors use a relatively simple microtest which gives good reproducibility. Most of the active compounds belong to the usambarane skeleton but other structure-activity relationships are being discussed. [less ▲]

Detailed reference viewed: 39 (17 ULiège)
Full Text
Peer Reviewed
See detailDescription, identification et utilisation du Yumel ( Ecorce de Guatteria gaumeri GREENMAN)
Leclercq, Joëlle; Dehaussy, Hélène; Goblet, Marie-Claire et al

in Journal de Pharmacie de Belgique (1985), 40(4), 251-256

The authors give a survey of the known data and biological studies about the bark and the tincture of Guatteria gaumeri (Yumel). They describe not only methods of micrographic and chromatographic ... [more ▼]

The authors give a survey of the known data and biological studies about the bark and the tincture of Guatteria gaumeri (Yumel). They describe not only methods of micrographic and chromatographic identification of the drug, but also a quantitative determination of the two main constituents: alpha-asarone ( propenylbenzene derivative) and guattegaumerine ( bisbenzylisoquinoleine alkaloid). [less ▲]

Detailed reference viewed: 451 (4 ULiège)
Full Text
Peer Reviewed
See detailDolichantoside, Main Alkaloid from Stem Bark of Strychnos Tricalysioides
Leclercq, Joëlle; Angenot, Luc ULiege

in Planta Medica (1984), 50(5), 457-8

The bark of Strychnos tricalysioides from Cameroon has been studied. The main alkaloid (present in a minute amount) was identified to dolichantoside (TLC, UV, IR and CD) and compared to a reference ... [more ▼]

The bark of Strychnos tricalysioides from Cameroon has been studied. The main alkaloid (present in a minute amount) was identified to dolichantoside (TLC, UV, IR and CD) and compared to a reference compound previously isolated in our laboratory from Strychnos gossweileri root bark. [less ▲]

Detailed reference viewed: 37 (3 ULiège)
Full Text
Peer Reviewed
See detailAbout Drosera peltata and the standardization of the sundew's tincture ( Tinctura Droserae)
Leclercq, Joëlle; Angenot, Luc ULiege

Poster (1984, July)

Detailed reference viewed: 39 (1 ULiège)
Full Text
Peer Reviewed
See detailA propos du Drosera peltata et de la standardisation de la teinture de Drosera
Leclercq, Joëlle; Angenot, Luc ULiege

in Journal de Pharmacie de Belgique (1984), 39(5), 269-274

The authors describe Drosera peltata , an Asiatic species newly appeared on the European marke, and give a method of identification and quantitative determination of plumbagin to standardize the drug and ... [more ▼]

The authors describe Drosera peltata , an Asiatic species newly appeared on the European marke, and give a method of identification and quantitative determination of plumbagin to standardize the drug and mainly the tincture that is used in pharmaceutical preparations against cough. [less ▲]

Detailed reference viewed: 79 (3 ULiège)