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See detailUsing platelet-rich plasma to treat jumper's knees: Exploring the effect of a second closely-timed infiltration
Kaux, Jean-François ULg; Croisier, Jean-Louis ULg; Forthomme, Bénédicte ULg et al

in Journal of Science and Medicine in Sport (in press)

Some clinical series have evaluated the effect of platelet-rich plasma (PRP) in the treatment of proximal patellar tendinopathy. Although it is possible that a single infiltrative administration may prove ... [more ▼]

Some clinical series have evaluated the effect of platelet-rich plasma (PRP) in the treatment of proximal patellar tendinopathy. Although it is possible that a single infiltrative administration may prove to be an effective treatment for this indication, most of the existing studies evaluated the effects of two or three successive infiltrations. The aim of this study was to evaluate whether two infiltrations of PRP proves more effective than a single treatment. DESIGN: Prospective, randomized and comparative study of level 2. METHODS: Twenty patients suffering from chronic proximal patellar tendinopathy were enrolled into the study and split into two randomized groups (one or two infiltrations of PRP, respectively). The 3-month follow-up evaluation consisted of VAS, IKDC and VISA-P scores, along with algometer, isokinetic and ultrasounds evaluations. After 1 year, subjects were contacted to define their functional evolution. RESULTS: The concentration of the PRP used for each infiltration was similar in both groups, and contained no red or white cells. Results revealed no difference in treatment efficacy between the groups. CONCLUSIONS: The comparison between one or two infiltrations of PRP did not reveal any difference between the two groups at short to mid term. A second closely-timed infiltration of PRP to treat proximal patellar tendinopathies is not necessary to improve the efficacy of this treatment in the short term. [less ▲]

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See detailMeasurement of circulating 25-hydroxyvitamin D: A historical review
Delvin, Edgar; LE GOFF, Caroline ULg; CAVALIER, Etienne ULg et al

in Practical Laboratory Medicine (in press)

The constantly increasing requests for the measurement of serum 25-hydroxyvitamin D over the last years has led reagent manufacturers to market different automated and semi-automated methods, that being ... [more ▼]

The constantly increasing requests for the measurement of serum 25-hydroxyvitamin D over the last years has led reagent manufacturers to market different automated and semi-automated methods, that being unfortunately not fully harmonized, yield different results. Liquid chromatography coupled to tandem mass spectrometry (LC/MS2) has more recently been introduced. This approach allows the distinction between the two forms of 25-hydroxyvitamin D and to measure other metabolites. This approach also requires harmonization to curtail the differences between the different analytical methods. To meet this requirement, the American National Institutes of Health (NIH), the CDC (Centre for Disease Control and Prevention) in Atlanta, the NIST (National Institute of Standards and Technology) and the vitamin D Reference laboratory of Ghent University have pooled their expertise to develop a standardization program. This article reviews the main elements and the difficulties of the automated and semi-automated methods for 25-hydroxyvitamin D, from sample preparation to the analytical phase, as well as those related to mass spectrometry. It also addresses the issues related to the clinical decision thresholds and the possibility of measurements in different biological liquids. [less ▲]

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See detailVitamin D status after a high dose of cholecalciferol in healthy and burn subjects
ROUSSEAU, Anne-Françoise ULg; DAMAS, Pierre ULg; LEDOUX, Didier ULg et al

in Burns : Journal of the International Society for Burn Injuries (in press)

Background: Burn patients are at risk of vitamin D (VD) deficiency and may benefit from its pleiotropic effects as soon as acute phase. Aim of this observational study was to assess effects of a ... [more ▼]

Background: Burn patients are at risk of vitamin D (VD) deficiency and may benefit from its pleiotropic effects as soon as acute phase. Aim of this observational study was to assess effects of a cholecalciferol (VD3) bolus on VD status in adult burn patients (Group B, GB) after admission, compared to healthy subjects (Group H, GH). Methods: Both groups received an oral dose of 100,000 IU VD3. Blood samples were collected before (D0) and 7 days (D7) after bolus to measure 250H-D, 1,25(OH)2-D, parathyroid hormone (PTH) and fibroblast growth factor 23 (FGF23). Albumin (ALB) and VD binding protein (DBP) were measured and used to calculate free 25OH-D level. Data were expressed as median (min–max) or proportions. Results: A total of 49 subjects were included: 29 in GH and 20 in GB. At D0, prevalence of VD deficiency was higher in GB: 25OH-D was 21.5 (10.1–46.3) ng/ml in GH vs 11 (1.8–31.4) ng/ml in GB. DBP and ALB were lower in GB. At D7, DBP was stable in both groups while ALB decreased in GB. 25OH-D increased by 66.6 (13.5–260.3)% in GH. In GB, changes in 25OH-D extended from 36.7% to 333.3% with a median increase of 33.1%. Similar changes were observed in each group for free 25OH-D. High FGF23 levels were observed in GB. Conclusions: This study highlighted the differences in VD status and in response to a high dose VD3 in burn patients when compared to healthy patients. Pitfalls in VD status assessment are numerous during acute burn care: 25OH-D measurement needs cautious interpretation and interest of free 25OH-D is still questionable. They should not prevent burn patients to receive VD supplements during acute care. Higher doses than general recommendations should probably be considered. [less ▲]

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See detailIdentification of cardiac repercussions after intense and prolonged concentric isokinetic exercise in young sedentary people
LE GOFF, Caroline ULg; Kaux, Jean-François ULg; Couffignal, Vincent et al

in Clinical physiology and functional imaging (2015), 35(5), 368-375

INTRODUCTION: Cardiopathies are the world's leading cause of mortality and morbidity. Although rare, cardiovascular accidents can occur during intense and infrequent sporting activity, particularly among ... [more ▼]

INTRODUCTION: Cardiopathies are the world's leading cause of mortality and morbidity. Although rare, cardiovascular accidents can occur during intense and infrequent sporting activity, particularly among those who are unaware of their heart condition. The development of cardiospecific biochemical markers has led to a reconsideration of the role of biology in the diagnosis of cardiovascular illnesses. The aim of this study therefore was, through the use of cardiac biomarker assays, to highlight the impact of sustained physical effort in the form of intense and prolonged concentric isokinetic exercise and to research potential cardiovascular risks. MATERIALS AND METHODS: Eighteen subjects participated in a maximal concentric isokinetic exercise involving 30 knee flexion-extensions for each leg. Five blood tests were taken to study the kinetics of the cardiac biomarkers. Haemodynamic parameters were measured continuously using a Portapres, and respiratory parameters were measured using a Sensormedics Vmax 29C. RESULTS: The results showed significant increases in the creatine kinase, myoglobin, homocysteine and haemoglobin cardiac markers. Evolutionary trends were also observed for the following biomarkers: NT-proBNP, myeloperoxydase and C-reactive protein. All the physiological parameters measured presented statistically significant changes. CONCLUSION: Isokinetic effort leads to the release of cardiac markers in the blood, but these do not exceed the reference values in healthy subjects. Maximal concentric isokinetic exercise does not, therefore, lead to an increased risk of cardiovascular pathologies. [less ▲]

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See detailOne-year follow-up of platelet-rich plasma infiltration to treat chronic proximal patellar tendinopathies
Kaux, Jean-François ULg; Bruyère, Olivier ULg; Croisier, Jean-Louis ULg et al

in Acta Orthopaedica Belgica (2015), 81(2), 251-256

Infiltration of Platelet-Rich Plasma (PRP) may be considered as a recent therapeutic option for chronic tendinopathies. The aim of this study is to evaluate the clinical status and the return to sports ... [more ▼]

Infiltration of Platelet-Rich Plasma (PRP) may be considered as a recent therapeutic option for chronic tendinopathies. The aim of this study is to evaluate the clinical status and the return to sports activities in patients with chronic proximal patellar tendinopathies. Twenty subjects with chronic proximal patellar tendinopathy benefited from 1 infiltration of PRP coupled with a standardized eccentric rehabilitation. The follow-up (up to 1 year) was assessed by means of a Visual Anologue Scale (VAS), the International Knee Documentation Committee (IKDC) form and the Victorian Institute of Sport Assessment (VISA-P) score. Moreover, subjects had to answer an information questionnaire concerning their life and sports activities. Seventy percents of the patients reported a favourable evolution with decrease of pain, and returned to sports activities. With time, VAS dropped significantly and both IKDC and VISA-P scores improved also significantly. This study confirms that a local injection of PRP coupled with a program of eccentric rehabilitation for treating a chronic jumper’s knee, improves pain symptoms and the functionaliti [less ▲]

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See detailGalectin-3 and suppression of tumorignenicity 2 measurment in participat at the "Tor des Géants"
LE GOFF, Caroline ULg

in Final programme European College of sport Science (2015)

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See detailGalectin-3 and Suppression of Tumorigenicity 2 measurement in participants at the “Tor des Géants”
LE GOFF, Caroline ULg; Kaux, Jean-François ULg; Gergelé, Laurent et al

in Radmann, A; Hedenborg, S; Tsolakidis, E (Eds.) 20th annual Congress of the EUROPEAN COLLEGE OF SPORT SCIENCE - BOOK OF ABSTRACTS0th annual Congress of the EUROPEAN COLLEGE OF SPORT SCIENCE - BOOK OF ABSTRACTS (2015, June)

Introduction: Gal-3 is a carbohydrate binding lectin produced by macrophages, upregulated in hypertrophied heart, emerging as a mediator for fibrosis development and cardiac remodeling. ST2 is a family ... [more ▼]

Introduction: Gal-3 is a carbohydrate binding lectin produced by macrophages, upregulated in hypertrophied heart, emerging as a mediator for fibrosis development and cardiac remodeling. ST2 is a family member of IL-1 receptors initially known for its role in immunological processes. It has a potential role in the cardiac pathogenesis. These receptors are led in cardiomyocytes and fibroblasts due to a mechanical stress. We aimed to examine the evolution of Gal-3 and ST2 in trailers who ran one of the most challenging ultra-marathon in the world: the Tor des Géants (330 km, altitude range: 24000m). Methods: Levels of plasma Gal-3 and ST2 were determined at 4 times: before the start, after 158km, at the end and 3 days after the end of the race in 33 trailers. Samples were directly centrifuged and frozen at -80°C. Gal-3 measurement was performed on the VIDAS (Biomerieux) and ST2 was analyzed with the Presage ST2 Assay (Critical Diagnostic). The reference values are <17.8ng/mL for Gal-3 and <35ng/mL for ST2. Statistica was used for the statistical analysis (ANOVA). We calculated the difference between the different time and expressed in delta: Δ1=(T2-T1)/T1*100, Δ2=(T3-T2)/T2*100, Δ3=(T4-T3)/T3*100, Δ4=(T3-T1)/T1*100, Δ5=(T4-T1)/T1*100. After that, we tried to correlate the delta between them (results= R(p-value)). Results were considered as significant with p<0.05. Results: Plasmatic levels of Gal-3 did never exceed the cut-off of 17.8ng/mL, except for 1 trailer in T2. A slight increase of levels of Gal-3 was observed at T2 (min-max:7.5-17.6ng/mL). These ones did not vary a lot at T3 (min-max:7.0- 18.8ng/mL) but return to normality at T4 (min-max:6.0-12.8ng/mL). For ST2, at T1, 12 subjects had plasmatic levels above the reference value of 35ng/ml. At T2, only 2 trailers blood samples were still in the reference interval. Indeed, a great increase of ST2 plasmatic levels observed (min-max:18.8-158.8ng/mL). A slight decrease of ST2 levels was observed at T3, but only one subject had a value below 30ng/ml (min-max:20.1-182.7ng/mL). However, a subject had still plasmatic levels above T2 values. A return to normality was observed at T4 with 16 trailers blood levels in the reference interval (min-max:12.0-56.4ng/mL). We observed an increase for Gal-3 and ST2, above the reference values only for ST2. We noted for both a decrease up to the normal values 3 days after the trail. For the correlation between deltas, we observed that Gal-3 and ST2 are correlated for each delta. Discussion: A logical correlation is observed between Gal-3 andST2 as they are involved in cardiac fibrosis and inflammation. But we do not known why it is not in the same proportion. We know that some trailers take NSAIDs and painkillers during the race. The results of this study demonstrate that this exercise was associated with biochemical abnormalities that may reflect adverse consequences on cardiac structure as fibrosis. However, ST2 values were higher, perhaps due to a mechanical stress more than a cardiac stress. Gal-3 is perhaps then more cardiospecific than ST2. [less ▲]

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See detailNo interest for a second closely-timed infiltration of platelet-rich plasma (PRP) to treat jumper’s knees
Kaux, Jean-François ULg; CROISIER, Jean-Louis ULg; Forthomme, Bénédicte ULg et al

in Radmann, A; Hedenborg, S; Tsolakidis, E (Eds.) 20th annual Congress of the EUROPEAN COLLEGE OF SPORT SCIENCE - BOOK OF ABSTRACTS (2015, June)

Introduction: Some clinical series have evaluated the effect of platelet-rich plasma (PRP) in the treatment of jumper’s knee. Although it is possible that a single infiltrative administration may prove to ... [more ▼]

Introduction: Some clinical series have evaluated the effect of platelet-rich plasma (PRP) in the treatment of jumper’s knee. Although it is possible that a single infiltrative administration may prove to be an effective treatment for this indication, most of the existing studies evaluated the effects of 2 or 3 successive infiltrations. The aim of this study was to evaluate whether 2 infiltrations of PRP proves moreeffective than a single treatment. Methods: Twenty patients suffering from chronic jumper’s knee were enrolled into our prospective, randomized and comparative study of level 2, and split into two randomized groups (1 or 2 infiltrations of PRP, respectively). The 3-month follow-up evaluation consisted of VAS, IKDC and VISA-P scores, along with algometer, isokinetic and ultrasounds evaluations. After 1 year, subjects were contacted to define their functional evolution. Results: The concentration of the PRP used for each infiltration was similar in both groups, and contained no red or white cells. Results revealed no difference in treatment efficacy between the groups.Discussion: The comparison between 1 or 2 infiltrations of PRP did not reveal any difference between the 2 groups at short to mid term. A second closely-timed infiltration of PRP to treat jumper’s knees is not necessary to improve the efficacy of this treatment in the short term. References: Kaux JF, Croisier JL, Bruyere O, Rodriguez de la Cruz C, Forthomme B, Brabant G et al. One injection of platelet-rich plasma associated to a submaximal eccentric protocol to treat chronic jumper’s knee. J Sports Med Phys Fitness. 2014 Jun 19. [Epub ahead of print]. Kaux JF, Croisier JL, Forthomme B, Le Goff C, Buhler F, Savanier C et al. Using platelet-rich plasma to treat jumper’s knees: exploring the effect of a second closely-timed infiltration. J Sci Med Sport. Submitted. Kaux JF, Bruyère O, Croisier JL, Forthomme N, Le Goff C, Rohr N et al. One-year follow-up of platelet-rich plasma infiltration to treat chronic upper patellar tendinopathies. Acta Orthop Belg. In press. [less ▲]

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See detailCardiac Biomarkers and Cycling Race
LE GOFF, Caroline ULg; Kaux, Jean-François ULg; Goffaux, Sébastien et al

in Journal of Sports Science & Medicine (2015), 14(2 (eCollection 2015 Jun)), 475-476

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See detailLes peptides natriurétiques: le point de vue du biologiste
LE GOFF, Caroline ULg

Conference (2015, February 26)

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See detailLes peptides natriurétiques: le point de vue du biologiste
LE GOFF, Caroline ULg

Conference (2015, February 26)

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See detailLe dosage de la vitamine D: considérations pré-analytiques et analytiques
LE GOFF, Caroline ULg; Souberbielle, Jean-Claude; Delvin, Edgard et al

in Annales de Biologie Clinique (2015), 73(1), 79-92

The constantly increasing requests for the measurement of serum 25-hydroxyvitamin D over the last years has led reagent manufacturers to market different automated and semi-automated methods, that being ... [more ▼]

The constantly increasing requests for the measurement of serum 25-hydroxyvitamin D over the last years has led reagent manufacturers to market different automated and semi-automated methods, that being unfortunately not fully harmonized, yield different results. Liquid chromatography coupled to tandem mass spectrometry has more recently been introduced. This approach allows the distinction between the two forms of 25-hydroxyvitamin D and to measure other metabolites. This approach also requires harmonization to curtail the differences between the different analytical methods. To meet this requirement, the American national institutes of health (NIH), the CDC (Center for disease control and prevention) in Atlanta, the NIST (National institute of standards and technology) and the vitamin D Reference laboratory of Ghent University have pooled their expertise to develop a standardization program. This article reviews the main elements and the difficulties of the automated and semi-automated methods for 25-hydroxyvitamin D, from sample preparation to the analytical phase, as well as those related to mass spectrometry. It also addresses the issues related to the clinical decision thresholds and the possibility of measurements in different biological liquids. [less ▲]

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See detailEpidemiological Review of Injuries in Rugby Union
Kaux, Jean-François ULg; Julia, Marc; Delvaux, François ULg et al

in Sports (2015), 3(1), 21-29

Rugby is a sport that is growing in popularity. A contact sport par excellence, it causes a significant number of injuries. In Rugby Union, there are 30 to 91 injuries per 1000 match hours. This ... [more ▼]

Rugby is a sport that is growing in popularity. A contact sport par excellence, it causes a significant number of injuries. In Rugby Union, there are 30 to 91 injuries per 1000 match hours. This epidemiological review of injuries incurred by rugby players mentions the position and type of injuries, the causes, time during the match and season in which they occur and the players’ positions as well as the length of players’ absences following the injury. [less ▲]

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See detailHTA d’origine endocrinienne : l’aide du laboratoire
LE GOFF, Caroline ULg

Conference (2014, October 01)

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See detailIntérêt d’une seconde infiltration de plasma riche en plaquettes dans le traitement des tendinopathies patellaires ?
Kaux, Jean-François ULg; Croisier, Jean-Louis ULg; Buhler, Frédéric et al

in 7ème Congrès National SFMES & SFTS 2014 (2014, September)

Introduction : Des études cliniques ont évalué l’effet du plasma riche en plaquettes (PRP) dans le traitement de la tendinopathie patellaire. Même si une seule infiltration peut améliorer les symptômes du ... [more ▼]

Introduction : Des études cliniques ont évalué l’effet du plasma riche en plaquettes (PRP) dans le traitement de la tendinopathie patellaire. Même si une seule infiltration peut améliorer les symptômes du sportif dans cette indication, la majorité des études évaluent les effets de 3 infiltrations successives. Le but de notre étude était donc de comparer l’efficacité d’une et de 2 infiltrations (rapprochées) de PRP dans le cade de tendinopathies patellaires chroniques, rebelles aux traitements conservateurs. Matériel et méthode : Vingt sportifs souffrant de tendinopathie patellaire depuis plus de 3 mois ont été inclus et randomisés en 2 groupes, respectivement 1 ou 2 infiltrations de PRP (15 jours d’intervalle). Le PRP a été obtenu à l’aide d’une machine d’aphérèse permettant d’obtenir une concentration plaquettaire identique pour tous les sujets. Ils ont bénéficié ensuite d’une rééducation excentrique sous-maximale standardisée. Le suivi a été réalisé à l’aide d’une échelle visuelle analogique de la douleur, de scores algo-fonctionnels (IKDC et VISA-P), ainsi qu’un questionnaire « mode de vie » avant l’infiltration, 3 et 12 mois post-infiltration. Résultats: La concentration de PRP employée était la même au sein des 2 groupes (9x106/µL), et ne contenait pas d’érythrocyte ni de leucocyte. Au terme du suivi (1 an), les résultats montrent une amélioration des scores EVA dans les deux groupes et significative pour le groupe 1 (p=0,005). Les scores VISA-P et IKDC ont tous deux augmentés, significativement dans les deux groupes. Un sujet par groupe n’a pas repris d’activité physique tandis 67% ont repris le sport au niveau antérieur dans le groupe 1 et 78% dans le groupe 2. Conclusion: La comparaison entre 1 et 2 infiltrations rapprochées de PRP n’a pas permis de mettre en évidence de différence entre les 2 groupes sur un suivi d’un an. Une seconde infiltration rapprochée ne semble donc pas indiquée pour améliorer l’efficacité de ce traitement. Cependant, un suivi à plus long terme serait nécessaire. De même l’évaluation d’une seconde infiltration plus à distance (3 mois) de la première mériterait d’être explorée. [less ▲]

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See detailComparaison du VeinoPlus Sport et du TENS sur la récupération de jeunes footballeurs
God, Maxime; LE GOFF, Caroline ULg; Evrard, Frédéric et al

in 7ème Congrès National SFMES & SFTS 2014 (2014, September)

Introduction : Toute activité physique fatigue l’organisme ; les muscles produisent des métabolites et de d’acide lactique, limitant leur fonctionnement. Il est donc nécessaire de pouvoir récupérer de ... [more ▼]

Introduction : Toute activité physique fatigue l’organisme ; les muscles produisent des métabolites et de d’acide lactique, limitant leur fonctionnement. Il est donc nécessaire de pouvoir récupérer de manière efficace au plus vite. En effet, une mauvaise récupération porte préjudice à la performance et à l’état physique du sportif. Aux côtés de la récupération active et de la balnéothérapie de nouvelles techniques comme de la cryothérapie et électrostimulation ont fait leur apparition pour une meilleure récupération. Le but de cette étude était de comparer l’impact de 2 types de stimulateurs : « VeinoPlus Sport » (VPS) et « TENS » sur la récupération des footballeurs amateurs après un effort de type Yo-Yo. Matériel et méthode : Dans un contexte identique, chaque sportif (20 footballeurs; âge moyen = 17,1 ans ± 0,79) a bénéficié du VPS ou du TENS lors de 2 séances différentes après 2 efforts de type Yo-Yo, séparés d’une période de récupération. Quatre prélèvements sanguins (lactate, gaz sanguins, ions, marqueurs cardiaques…) ainsi qu’un évaluation de l’explosivité par Myotest ont été réalisés respectivement avant l’épreuve, juste après, après la récupération et après la seconde épreuve. Un questionnaire relatif à l’état de fatigue a également été rempli par les sujets. Pour l’analyse statistique, nous avons utilisé le logiciel « StatPlus » et réalisé une Anova à mesures répétées ainsi qu’un test de Scheffé. Résultats : Les sportifs ont tous parcouru une plus grande distance lors des 2èmes efforts, surtout au sein du groupe VPS, mais sans différence significative. L’épreuve a déclenché une variation significative de lactatémie, du HCO3- ainsi que de la myoglobine. L’étude des autres paramètres sanguins ainsi que des paramètres de l’explosivité n’a révélé aucune évolution significative tout au long de l’étude. Par contre en ce qui concerne les critères subjectifs (« ressenti »), les footballeurs du groupe VPS ont noté, à 12h et 24h, une moindre douleur aux jambes, une moindre sensation de fatigue, une moindre diminution de la force, une plus grande légèreté ainsi qu’un meilleur état de forme par rapport au groupe TENS. Enfin, en général, et sans noter de préférence particulière pour l’un ou l’autre des appareils, les athlètes ont préféré l’utilisation de l’électrostimulation à leur récupération habituelle. Conclusion : Cette étude ne montre que des différences mineures, non significatives, entre les deux appareils. Les 2 groupes ont parcouru une distance plus grande lors du 2ème effort. Ceci suggère que le test n’était pas épuisant, malgré les signes biologiques de « fatigue ». Cependant, sur des critères subjectifs de récupération et de bien–être, une tendance était en faveur du VPS. Ces résultats seront à prendre en compte pour de nouvelles études avec cette fois des tests plus fatigants. [less ▲]

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