References of "Laville, E"
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See detailPolymorphic miRNA-target interactions : A Novel Source of Phenotypic Variation
Georges, Michel ULg; Clop, Alex; Marcq, Fabienne ULg et al

in Cold Spring Harbor Symposia on Quantitative Biology (2006, June), 71

Studying the muscular hypertrophy of Texel sheep by forward genetics, we have identified an A-to-G transition in the 3'UTRof the GDF8 gene that reveals an illegitimate target site for microRNAs miR-1 and ... [more ▼]

Studying the muscular hypertrophy of Texel sheep by forward genetics, we have identified an A-to-G transition in the 3'UTRof the GDF8 gene that reveals an illegitimate target site for microRNAs miR-1 and miR-206 that are highly expressed in skeletal muscle. This causes the down-regulation of this muscle-specific chalone and hence contributes to the muscular hypertrophyof Texel sheep. We demonstrate that polymorphisms which alter the content of putative miRNA target sites are commonin human and mice, and provide evidence that both conserved and nonconserved target sites are selectively constrained. Wespeculate that these polymorphisms might be important mediators of phenotypic variation including disease. To facilitatestudies along those lines, we have constructed a database (www.patrocles.org) listing putative polymorphic microRNA–targetinteractions. [less ▲]

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See detailProteomic analysis of ovine muscle hypertrophy.
Hamelin, M.; Sayd, T.; Chambon, C. et al

in Journal of Animal Science (2006), 84(12), 3266-76

Two-dimensional electrophoresis was used to investigate the effects of a QTL for muscle hypertrophy on sarcoplasmic protein expression in ovine muscles. In the Belgian Texel breed, the QTL for muscle ... [more ▼]

Two-dimensional electrophoresis was used to investigate the effects of a QTL for muscle hypertrophy on sarcoplasmic protein expression in ovine muscles. In the Belgian Texel breed, the QTL for muscle hypertrophy is localized in the myostatin-encoding gene. Based on microsatellite markers flanking the myostatin gene, we compared the hypertrophied genotype with the normal genotype. The average age of the sheep was 3 mo. Among the 4 muscles studied, in the hypertrophied genotype only the vastus medialis was normal, whereas the semimembranosus, tensor fasciae latae, and LM were hypertrophied. In the hypertrophied genotype, these muscles showed upregulation of enzymes involved in glycolytic metabolism together with oxidative metabolism in LM. Certain chaperone proteins, including glutathione S-transferase-Pi, heat shock protein-27, and heat shock cognate-70, were also more highly expressed, probably due to increased use of energetic pathways. Expression of the iron transport protein transferrin was increased. Alpha-1-antitrypsin was the only protein showing a similar pattern of expression (i.e., less expressed) in all 4 muscles of the hypertrophied genotype. It is suggested that transferrin and alpha-1-antitrypsin may interact to reinforce myogenic proliferative signaling. [less ▲]

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See detailEffects of a quantitative trait locus for muscle hypertrophy from Belgian Texel sheep on carcass conformation and muscularity
Laville, E.; Bouix, J.; Sayd, T. et al

in Journal of Animal Science (2004), 82(11), 3128-3137

A QTL for muscle hypertrophy has been identified in the Belgian Texel breed. A population of F-2 and backcross lambs created from crosses of Belgian Texel rams with Romanov ewes was studied. Effects on ... [more ▼]

A QTL for muscle hypertrophy has been identified in the Belgian Texel breed. A population of F-2 and backcross lambs created from crosses of Belgian Texel rams with Romanov ewes was studied. Effects on carcass traits and muscle development of the Belgian Texel breed polygenes and Belgian Texel single QTL were compared. In both cases, carcass conformation and muscularity were improved. The Texel polygenic environment improved conformation mainly through changes in skeletal frame shape. Segments were shorter and bone weight lower. Muscles were more compact, shorter, and thicker. The single QTL affected muscle development. Thickness and weight of muscles were increased. Composition in myosin changed toward an increase of fast contractile type. The relative contribution of hind limb joint to carcass weight was increased. Differences in skeletal frame morphology among the three genotypes of the single QTL were small. Conformation scoring was mainly influenced by leg muscularity. Back and shoulder muscle development, which largely contributed to variability of muscularity, were less involved in the conformation scoring. Lastly, the QTL explains a small part of differences between these Belgian Texel and Romanov breeds for conformation or muscle development. A large part of genetic variability remains to be explored. [less ▲]

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See detailLa conformation bouchère des agneaux. Etude d'après la variabilité génétique entre races
Laville, E.; Bouix, J.; Sayd, T. et al

in INRA Productions Animales (2002), 15(1), 53-66

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See detailMapping QTL influencing muscularity in a Texel x Romanov intercross
Marcq, Fabienne ULg; Elsen, J.-M.; Marot, V. et al

(2000)

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See detailMapping quantitative trait loci causing the muscular hypertrophy of Belgian Texel sheep
Marcq, Fabienne ULg; Elsen, J.-M.; Marot, V. et al

(1999)

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