Spinal paraganglioma: case report and review of the literature.

Poster (2013, March 30)

Third ventricle colloid cysts

Conference (2012, March 10)

Métastase septique dorsale secondaire d’un abcès rétropharyngé responsable d’une tétraparésie

in Revue Neurologique (2011), 167(8-9), 638-640

Introduction: Peri-tonsillar abscess remains one of the most frequent serous complications of oropharyngeal or dental infections. It can evolve to parapharyngeal and/or retropharyngeal spaces. It can be ... [more ▼]

Introduction: Peri-tonsillar abscess remains one of the most frequent serous complications of oropharyngeal or dental infections. It can evolve to parapharyngeal and/or retropharyngeal spaces. It can be life-threatning and, more rarely, neurological complications are described. Observations: We report the case of a 56 year old woman who developed within few days a progressive tetraparesia due to cervical medullary compression. This compression was consecutive to an epidurite which was a complication of a retropharyngeal abscess. The only surgical act was a cervicotomy to drain the abscess and identify the pathological germ. A targeted antibiotherapy was quickly begun. The recovery was obtained rather quickly and the neurological evolution was good. After one year, the cervical spine presents a post-infectious deformation without sign of root or spinal-cord compression. Conclusion: A cervical tetraparesia induced by spondylodiscitis and epiduritis following a retropharyngeal abscess with Staphylococcus aureus is a rare complication. Adequate diagnosis, as fast as possible, is mandatory in order to carry out an adapted antibiotherapy in the hopes of a complete recovery. The place of surgery on the spine remains to be specified. [less ▲]

Surgical resection of a sphenoid wing meningioma in a patient with Glanzmann thrombasthenia.

in Acta anaesthesiologica Belgica (2011), 62(2), 83-6

Glanzmann thrombasthenia (GT) is a rare autosomal recessive disorder characterized by a deficiency or functional defect of platelet glycoprotein (GP) IIb/IIIa. Physiologically, this platelet receptor ... [more ▼]

Glanzmann thrombasthenia (GT) is a rare autosomal recessive disorder characterized by a deficiency or functional defect of platelet glycoprotein (GP) IIb/IIIa. Physiologically, this platelet receptor mediates aggregation of activated platelets by binding the adhesive proteins, fibrinogen, von Willebrand factor (VWF) and fibronectin. This facilitates attachment and aggregation of platelets at sites of vascular injury. We reported the management of a pterional meningioma resection in a patient with Glanzmann thrombasthenia, with recombinant factor VIIa (rFVIIa - NovoSeven) as haemostatic agent. A 48-year-old woman suffering from Glanzmann thrombasthenia was scheduled for spheno-orbital meningioma en plaque surgery. Because of repeated platelet transfusions, this patient developed isoantibodies against missing GPIIbIIIa and alloantibodies against Human Leukocyte Antigen (HLA) leading to refractoriness to platelet transfusions. We observed that Novoseven offered sufficient haemostasis conditions. Therefore, we noticed a deep vein thrombosis. This imposed us to use low weight molecular heparin despite recent surgery. [less ▲]

Propianibactrium acnes in neurosurgery : weak in cultures, stronger under scalp.

Conference (2010, March 20)

Does radiation treatment delay affect survival in glioblastoma ?

Conference (2009, March 21)

Preliminary observations after discectomy plus fusion with the use of bioresorbable cages

Poster (2008, March 08)

Extensive epidural and paraspinal follicular Non-Hodgkin lymphoma

Conference (2006, March)

Two stages total vertebrectomy : about a series of 16 patients.

Conference (2005, March)

Primary central nervous system lymphoma - Report of 32 cases and review of the literature

in Clinical Neurology & Neurosurgery (2004), 107(1), 55-63

We retrospectively analyzed 32 cases of primary central nervous system lymphoma (PCNSL). Five cases were diagnosed in the period 1987-1994, for 27 cases in the period 1995-2002. There were 17 men and 15 ... [more ▼]

We retrospectively analyzed 32 cases of primary central nervous system lymphoma (PCNSL). Five cases were diagnosed in the period 1987-1994, for 27 cases in the period 1995-2002. There were 17 men and 15 women whose median age was 69 years. Three patients were immunodeficient. The commonest symptoms were focal deficit (16 patients) and cognitive/behaviour disturbances (14 patients). Radiologically, a total of 47 contrast-enhancing lesions were observed in 32 patients; 18 patients had deep-seated lesions. All but two patients underwent histological diagnosis following craniotomy (11 patients) and/or stereotaxic biopsy (22 patients); diagnosis was obtained on CSF cytology in one patient with a third ventricle tumour. In the last patient, the diagnosis was based on the finding of marked tumour shrinkage under corticotherapy, despite two negative histological examinations. Treatment included surgical resection (10 patients), chemotherapy (25 patients) and/or radiotherapy (12 patients). According to the therapeutic recommendations of the GELA (Groupe d'Etude des Lymphomes de l'Adulte), 19 patients received at least two courses of high-dose methotrexate; intrathecal chemotherapy was used in 20 patients with methotrexate and/or cytosine arabinoside. Radiation therapy consisted of whole brain irradiation followed by a boost on tumour site. Nine patients received a combined treatment of chemotherapy and radiotherapy. Twelve patients showed rapid progression to death. At the time of last contact, 28/32 patients (88%) had died, all from PCNSL disease or from complications due to its treatment. The median Survival time was 13.9 months. We conclude that PCNSL is an increasingly frequent tumour. The diagnosis is obtained by stereotactic biopsy in the majority of cases. The prognosis appears dismal despite an intensive multidisciplinary therapeutic approach. (C) 2004 Elsevier B.V. All rights reserved. [less ▲]