References of "LAYIOS, Nathalie"
     in
Bookmark and Share    
Full Text
See detailEvaluation of Temocillin for treatment of nosocomial infections
LAYIOS, Nathalie ULg; CIUTEA, Mirela ULg; LONGUEVILLE, Manon et al

Poster (2014, September)

Detailed reference viewed: 8 (1 ULg)
Full Text
See detailEpidemiology of VAP and VAC
LAYIOS, Nathalie ULg; DAMAS, Pierre ULg

Poster (2014, May)

Detailed reference viewed: 6 (0 ULg)
Full Text
Peer Reviewed
See detailModelled target attainment after meropenem infusion in patients with severe nosocomial pneumonia: the PROMESSE study.
Frippiat, Frederic; Musuamba, Flora Tshinanu; Seidel, Laurence ULg et al

in The Journal of antimicrobial chemotherapy (2014)

OBJECTIVES: The objective of this study was to propose an optimal treatment regimen of meropenem in critically ill patients with severe nosocomial pneumonia. PATIENTS AND METHODS: Among 55 patients in ... [more ▼]

OBJECTIVES: The objective of this study was to propose an optimal treatment regimen of meropenem in critically ill patients with severe nosocomial pneumonia. PATIENTS AND METHODS: Among 55 patients in intensive care treated with 1 g of meropenem every 8 h for severe nosocomial pneumonia, 30 were assigned to intermittent infusion (II; over 0.5 h) and 25 to extended infusion (EI; over 3 h) groups. Based on plasma and epithelial lining fluid (ELF) concentrations determined at steady-state, pharmacokinetic modelling and Monte Carlo simulations were undertaken to assess the probability of attaining drug concentrations above the MIC for 40%-100% of the time between doses (%T > 1-fold and 4-fold MIC), for 1 or 2 g administered by either method. RESULTS: Penetration ratio, measured by the ELF/plasma ratio of AUCs, was statistically higher in the EI group than in the II group (mean +/- SEM: 0.29 +/- 0.030 versus 0.20 +/- 0.033, P = 0.047). Considering a maximum susceptibility breakpoint of 2 mg/L, all dosages and modes of infusions achieved 40%-100% T > 1-fold MIC in plasma, but none did so in ELF, and only the 2 g dose over EI achieved 40%-100% T > 4-fold MIC in plasma. CONCLUSIONS: The optimum regimen to treat severe nosocomial pneumonia was 2 g of meropenem infused over 3 h every 8 h. This regimen achieved the highest pharmacodynamic targets both in plasma and in ELF. [less ▲]

Detailed reference viewed: 4 (0 ULg)
Full Text
Peer Reviewed
See detailMortierella wolfii-Associated Invasive Disease.
LAYIOS, Nathalie ULg; Canivet, Jean-Luc; Baron, Frédéric ULg et al

in Emerging infectious diseases (2014), 20(9), 1591-2

Detailed reference viewed: 14 (5 ULg)
Full Text
See detailFirst report of Mortierella wolfii causing human disease
LAYIOS, Nathalie ULg; HAYETTE, Marie-Pierre ULg; HUWART, Aline ULg et al

Conference (2013, September)

Detailed reference viewed: 9 (6 ULg)
Full Text
Peer Reviewed
See detailProcalcitonin for antibiotic treatment in intensive care unit patients.
LAYIOS, Nathalie ULg; Lambermont, Bernard

in Current infectious disease reports (2013), 15(5), 394-9

Procalcitonin (PCT), a 116-aminoacids prohormone, has been substantially studied over the last 2 decades in the field of sepsis. Disappointingly low sensitivity values led to the abandonment of the ... [more ▼]

Procalcitonin (PCT), a 116-aminoacids prohormone, has been substantially studied over the last 2 decades in the field of sepsis. Disappointingly low sensitivity values led to the abandonment of the concept of it as a diagnostic tool and then to its being considered more as a prognostic marker with a good correlation with severe infection. Later on, growing concerns about multidrug-resistant bacteria in the ICU environment and about the cost and side effects of antibiotics suggested that PCT might prove to be a valuable asset in stewardship programs. Numerous but hardly comparable randomized controlled trials assessing either initiation or deescalation in ICU patients have been published. Stewardship encompassing PCT should focus on the latter, because of the high negative predictive value of this biomarker. However, there still would be safety concerns if a systematic implementation of PCT were to be considered in daily stewardship programs in the ICU, especially in extra-thoracic sepsis. [less ▲]

Detailed reference viewed: 4 (0 ULg)
Full Text
Peer Reviewed
See detailThe authors reply
DAMAS, Pierre ULg; LAYIOS, Nathalie ULg

in Critical Care Medicine (2013), 41(2), 19

Detailed reference viewed: 7 (1 ULg)
Full Text
Peer Reviewed
See detailThe authors reply
LAYIOS, Nathalie ULg; DAMAS, Pierre ULg

in Critical Care Medicine (2013), 41(3), 28

Detailed reference viewed: 5 (1 ULg)
Full Text
See detailThe severity of ICU-acquired pneumonia
MARECHAL, Hugues; LAYIOS, Nathalie ULg; DAMAS, Pierre ULg

in Current Infectious Disease Reports (2013), 15(5), 380-384

Detailed reference viewed: 13 (5 ULg)
Full Text
See detailAntibiotic therapy and outcome in ICU
ANCION, Arnaud ULg; LAYIOS, Nathalie ULg; NYS, Monique ULg et al

Conference (2012)

Detailed reference viewed: 21 (8 ULg)
Full Text
Peer Reviewed
See detailProcalcitonin usefulness for the initiation of antibiotic treatment in intensive care unit patients.
LAYIOS, Nathalie ULg; LAMBERMONT, Bernard ULg; CANIVET, Jean-Luc ULg et al

in Critical Care Medicine (2012), 40(8), 2304-9

OBJECTIVES: : To test the usefulness of procalcitonin serum level for the reduction of antibiotic consumption in intensive care unit patients. DESIGN: : Single-center, prospective, randomized controlled ... [more ▼]

OBJECTIVES: : To test the usefulness of procalcitonin serum level for the reduction of antibiotic consumption in intensive care unit patients. DESIGN: : Single-center, prospective, randomized controlled study. SETTING: : Five intensive care units from a tertiary teaching hospital. PATIENTS: : All consecutive adult patients hospitalized for > 48 hrs in the intensive care unit during a 9-month period. INTERVENTIONS: : Procalcitonin serum level was obtained for all consecutive patients suspected of developing infection either on admission or during intensive care unit stay. The use of antibiotics was more or less strongly discouraged or recommended according to the Muller classification. Patients were randomized into two groups: one using the procalcitonin results (procalcitonin group) and one being blinded to the procalcitonin results (control group). The primary end point was the reduction of antibiotic use expressed as a proportion of treatment days and of daily defined dose per 100 intensive care unit days using a procalcitonin-guided approach. Secondary end points included: a posteriori assessment of the accuracy of the infectious diagnosis when using procalcitonin in the intensive care unit and of the diagnostic concordance between the intensive care unit physician and the infectious-disease specialist. MEASUREMENTS AND MAIN RESULTS: : There were 258 patients in the procalcitonin group and 251 patients in the control group. A significantly higher amount of withheld treatment was observed in the procalcitonin group of patients classified by the intensive care unit clinicians as having possible infection. This, however, did not result in a reduction of antibiotic consumption. The treatment days represented 62.6 +/- 34.4% and 57.7 +/- 34.4% of the intensive care unit stays in the procalcitonin and control groups, respectively (p = .11). According to the infectious-disease specialist, 33.8% of the cases in which no infection was confirmed, had a procalcitonin value >1microg/L and 14.9% of the cases with confirmed infection had procalcitonin levels <0.25 microg/L. The ability of procalcitonin to differentiate between certain or probable infection and possible or no infection, upon initiation of antibiotic treatment was low, as confirmed by the receiving operating curve analysis (area under the curve = 0.69). Finally, procalcitonin did not help improve concordance between the diagnostic confidence of the infectious-disease specialist and the ICU physician. CONCLUSIONS: : Procalcitonin measuring for the initiation of antimicrobials did not appear to be helpful in a strategy aiming at decreasing the antibiotic consumption in intensive care unit patients. [less ▲]

Detailed reference viewed: 52 (6 ULg)
Full Text
Peer Reviewed
See detailLes prélèvements microbiologiques ont-ils encore une place dans le diagnostic de pneumopathie acquise sous ventilation mécanique ?
LAYIOS, Nathalie ULg; DAMAS, Pierre ULg

in Réanimation (2012), 21

Diagnosis of ventilator-associated pneumonia (VAP) is based on non-specific clinical signs. Several indicators have been tested in order to improve the accuracy of VAP diagnosis. The quantification of ... [more ▼]

Diagnosis of ventilator-associated pneumonia (VAP) is based on non-specific clinical signs. Several indicators have been tested in order to improve the accuracy of VAP diagnosis. The quantification of clinical parameters by using the clinical pulmonary infection score (CPIS), however, failed to improve the specificity of the diagnosis. This was the same for all the biomarkers tested either in the serum (procalcitonin, C-reactive protein) or in the bronchoalveolar lavage (BAL) fluid [soluble triggering receptor expressed on myeloid cells 1 (sTREM 1), elastin fibers, endotoxin, pro-inflammatory cytokines, Clara cell protein 10]. The microscopic examination of endotracheal samples alone, especially of the BAL fluid, may provide useful information for the detection of infected cells. Thus, microbiology is still needed. [less ▲]

Detailed reference viewed: 25 (9 ULg)
Full Text
Peer Reviewed
See detailSeverity of ICU-acquired pneumonia according to infectious microorganisms
DAMAS, Pierre ULg; LAYIOS, Nathalie ULg; SEIDEL, Laurence ULg et al

in Intensive Care Medicine (2011), 37(7), 1128-35

Detailed reference viewed: 30 (6 ULg)
Full Text
See detailRenal failure and ICU-acquired infection
MICHIELS, Grégoire; WIESEN, Patricia ULg; LAYIOS, Nathalie ULg et al

Conference (2008, June 20)

Detailed reference viewed: 4 (0 ULg)
Full Text
See detailPseudomonas aeruginosa and severity of ventilator associated pneumonia
BROUSSE, Murielle; LAYIOS, Nathalie ULg; LEDOUX, Didier ULg et al

Conference (2008)

Detailed reference viewed: 4 (0 ULg)
Full Text
Peer Reviewed
See detailPseudomonas aeruginosa and severity of ventilator associated pneumonia
LAYIOS, Nathalie ULg; LEDOUX, Didier ULg; NYS, Monique ULg et al

in Intensive Care Medicine (2008), 34(Suppl 1), 38

Detailed reference viewed: 4 (0 ULg)
Full Text
Peer Reviewed
See detailRenal failure and ICU-acquired infection
WIESEN, Patricia ULg; LAYIOS, Nathalie ULg; NYS, Monique ULg et al

in Intensive Care Medicine (2008), 34(Suppl 1), 2650864

Detailed reference viewed: 10 (2 ULg)
Full Text
Peer Reviewed
See detailToxoplasma encephalitis after autologous stem cell transplantation.
Grosu, Irina; Ghekiere, Olivier; LAYIOS, Nathalie ULg et al

in Leukemia & Lymphoma (2007), 48(1), 201-3

Detailed reference viewed: 9 (0 ULg)
Full Text
Peer Reviewed
See detailRelapsing T-cell lymphoma mimicking adult respiratory distress syndrome and sepsis.
Boland, Claire; LAYIOS, Nathalie ULg; Ferrant, Augustin et al

in Leukemia & Lymphoma (2006), 47(9), 1989-90

Detailed reference viewed: 6 (0 ULg)