References of "LAMBERT, France"
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See detailGestion implantaire de l'édentement unitaire dans le secteur esthétique : une approche visant à optimiser les tissus. Partie I : aspect chirurgical
LAMBERT, France ULg

in Réalites Cliniques : Revue Européenne d'Odontologie (2015), 26(n°1),

Nous sommes tous bien conscients de la problématique liée au remodelage osseux après extraction dentaire, en particulier dans la zone esthétique. Les conséquences cliniques sont telles que le recours à ... [more ▼]

Nous sommes tous bien conscients de la problématique liée au remodelage osseux après extraction dentaire, en particulier dans la zone esthétique. Les conséquences cliniques sont telles que le recours à des techniques de régénération tissulaire est souvent nécéssaire pour la pose de l'implant et pour assurer des résultats esthétiques. Cet article vise à démontrer l'efficacité d'un protocole d'optimisation tissulaire basé sur la préservation du capital osseux et sur l'optimisation des tissus gingivaux lors d'une extraction dentaire dans la zone esthétique. L'objectif de cet article est de suggérer un processus décisionnel en matière de technique chirurgicale, reposant d'une part sur l'examen clinique initial et, d'autre part, sur une excellente compréhension du concept biologique. [less ▲]

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See detailDramatic osteonecrosis of the jaw associated with oral bisphosphonates, periodontitis and dental implant removal
Ayora, A F; HERION, Francine ULg; ROMPEN, Eric ULg et al

in Journal of Clinical Periodontology (2015), 42

Osteoporosis affects millions of elderly patients, and anti-resorptive drugs (ARD) such as bisphosphonates (BP) represent the first-line therapy. Despite the benefits related to the use of these ... [more ▼]

Osteoporosis affects millions of elderly patients, and anti-resorptive drugs (ARD) such as bisphosphonates (BP) represent the first-line therapy. Despite the benefits related to the use of these medications, osteonecrosis of the jaw is a significant complication in a subset of patients receiving these drugs. CASE PRESENTATION: This report documents a case of dramatic bisphosphonate-related osteonecrosis associated with periodontitis and dental implant removal in an osteoporotic patient treated with per os bisphosphonates for an uninterrupted period of 15 years. CONCLUSION: The aim of this report was to discuss the administration period of BP in the treatment of osteoporosis, the decision-making and clinical management of severe MRONJ and the indications for dental implant placement in these specific patients. [less ▲]

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See detailLess invasive surgical procedures using narrow diameter implants: a prospective study in 20 consecutive patients.
LAMBERT, France ULg; LECLOUX, Geoffrey ULg; GRENADE, Charlotte ULg et al

in Journal of Oral Implantology (The) (2014)

Narrow diameter implants (NDIs) are increasingly produced and used in implant dentistry especially since the introduction of new and more resistant materials. The objective of the present study was to ... [more ▼]

Narrow diameter implants (NDIs) are increasingly produced and used in implant dentistry especially since the introduction of new and more resistant materials. The objective of the present study was to evaluate the clinical performance of NDIs (3.3 mm) placed in thin alveolar crests. Methods: Twenty consecutive patients needing implant-supported fixed partial dentures and presenting an alveolar thickness ≤ 6 mm were treated with one or several NDIs. The surgical protocol was chosen according to the clinical situation: °1 flapless; °2 mini-cervical flap; 3° wide flap; 4° wide flap + guided bone regeneration (GBR). Implants were immediately loaded if the primary stability was higher than 20 Ncm. Implant survival and success, prosthodontic success rates and patient-centered outcomes were evaluated after a follow-up period of 1 year. Results: A total of 39 implants were placed in 20 patients, 12 and 27 implants in the anterior regions and in the posterior mandible, respectively. All implants but one reached an insertion torque higher than 20 Ncm and were loaded within 48 hours. The implant survival and success rates both reached 94.7 %. The need for GBR was avoided in 60 % of the implant sites. The mean peri-implant bone remodeling after a follow-up period of 1 year was -0.35 mm at the implant level. Peri-implant bone remodeling was higher in the posterior region, when the alveolar crest was thinner than 4 mm and GBR was required in addition.Conclusion: The use of NDIs to restore partial edentation in sites with limited horizontal bone thickness seems to be an effective treatment option that prevented GBR in the majority of the present cases. Immediate provisionalization of NDIs does not seem to impair the results. [less ▲]

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See detailCoronally advanced flap versus the pouch technique combined with a connective tissuegraft to treat Miller's class I gingival recession: a randomized controlled trial
SALHI, Leila ULg; LECLOUX, Geoffrey ULg; Seidel, Laurence ULg et al

in Journal of Clinical Periodontology (2013)

AIM: The objective of this study was to compare two different periodontal plastic surgery procedures to treat Miller's class I recession: a coronally advanced flap (control group) versus the pouch ... [more ▼]

AIM: The objective of this study was to compare two different periodontal plastic surgery procedures to treat Miller's class I recession: a coronally advanced flap (control group) versus the pouch technique (test group), both of which were associated with connective tissue graft. METHODS: Forty consecutive patients were included, with 20 patients being allocated for each group. The level of recession coverage, the keratinized tissue (KT) quantity, gingival aesthetics (PES) and post-operative outcomes were assessed for a follow-up period of 6 months. RESULTS: After 6 months, both techniques allowed for the excellent mean root coverage of 96.3 ± 12.1% in the control group and of 91.3 ± 17.6% in the test group. Complete root coverage was achieved in 89.5% (17/19) and 79% (15/19) of the recession cases in the control and the test groups respectively. A significant increase in KT height (p = 0.0011) was observed in the test group. A significant improvement in the pink aesthetic score was found in the two groups, but gingival texture displayed significantly better results in the test group (p < 0.0001). No significant difference between the two groups was found in terms of the morbidity outcomes. Pain killer consumption was similar in the two groups and significantly decreased over time. CONCLUSIONS: Both surgical techniques are relevant in treating Miller's class I recession. The pouch technique seems to increase the height of KT better and provides good gingival-related aesthetic outcomes. [less ▲]

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See detailChirurgie plastique parodontale: Traitement des récessions multiples de grandes étendues
LAMBERT, France ULg

in Alpha Omega France (2013), 160

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See detailDRAMATIC OSTEONECROSIS OF THE JAW ASSOCIATED WITH ORAL BIPHOSPHONATES TREATMENT AFTER IMPLANT REMOVAL: A CASE REPORT
FERNANDEZ AYORA, Alberto ULg; HERION, Francine ULg; LAMBERT, France ULg et al

Poster (2013, October)

BACKGROUND Osteoporosis affects millions of elderly patients. Bisphosphonates represent first-line therapy. Osteonecrosis of the jaws in patients treated with bisphosphonates is mostly associated with ... [more ▼]

BACKGROUND Osteoporosis affects millions of elderly patients. Bisphosphonates represent first-line therapy. Osteonecrosis of the jaws in patients treated with bisphosphonates is mostly associated with intravenous bisphosphonates while the incidence associated with oral bisphosphonates is not significant. AIM This report documents a case of bisphosphonate-related osteonecrosis of the jaw (BRONJ) after dental implant removal in an osteoporotic patient treated with alendronate and risedronate for 15 years. MATERIAL AND METHODS An 83-years-old patient with no significant systemic disease underwent implant removal in the first molar left hemimandible position in 2010 due to a peri-implantitis. The surgical procedure was uneventful thought preventive measures were no taken. In June 2011, the patient was referred to our department with a wide bone sequestration of the left mandibular body. A panoramic radiograph showed an increased bone marrow density with bone sequestration. Since then, the patient underwent several courses of antibiotics and conservative therapy, without relief of symptoms. RESULTS Since 2011, the patient has lost 13 teeth in the mandible and the osteonecrosis has disseminated to the entire jaw and the left mandible condyle. The patient has even lost the left hearing. Resective surgery under general anesthesia is not indicated due to the risk because of the age of the patient. CONCLUSION AND CLINICAL IMPLICATIONS Despite the low risk of BRONJ occurrence after implant surgery in oral N-BP users, the fate of dental implants in these patients remains uncertain. Therefore patients at risk must be given a full explanation of the potential risks of implant failure and BRONJ development. Osteonecrosis of the jaws in association with bisphosphonate therapy is a very serious condition with which all dentists should be familiar. Since the treatment of BRONJ is difficult, prevention is the main goal. When the osteonecrosis begins, it can be very painful to the patient, difficult to treat, and can lead to very deleterious sequelae. [less ▲]

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See detailEffect of Leukocyte- and Platelet-Rich Fibrin (L-PRF) on Bone Regeneration: A Study in Rabbits.
Knapen, Michel; Gheldof, Damien; Drion, Pierre ULg et al

in Clinical Implant Dentistry & Related Research (2013)

BACKGROUND: The positive effect of leukocyte- and platelet-rich fibrin (L-PRF) on osteogenesis has been widely described in vitro. However, clinical and preclinical studies are very little and ... [more ▼]

BACKGROUND: The positive effect of leukocyte- and platelet-rich fibrin (L-PRF) on osteogenesis has been widely described in vitro. However, clinical and preclinical studies are very little and controversial in demonstrating a significant beneficial effect of L-PRF in bone regeneration. PURPOSE: The goal of the present study was to compare the potential effect of L-PRF in a standardized model. MATERIALS AND METHODS: A total of 72 hemispheres were implanted on the calvaria of 18 rabbits and filled with three different space fillers: L-PRF, bovine hydroxyapatite (BHA), BHA + L-PRF, and an empty hemisphere was used as control. Six rabbits were sacrificed at three distinct time points: 1 week, 5 weeks, and 12 weeks. Histological and histomorphometrical analyses were carried out. RESULTS: At the early phase of bone regeneration (1 week), from a descriptive analysis, a higher proportion of connective tissue colonized the regeneration chamber in the two groups containing BHA particles. Nevertheless, no statistical differences were found within the four groups in terms of bone quantity and quality at each timepoint (p = .3623). CONCLUSIONS: According to the present study, L-PRF does not seem to provide any additional effect on the kinetics, quality, and quantity of bone in the present model of guided bone regeneration. [less ▲]

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See detailLe maxillaire édenté complet
ROMPEN, Eric ULg; LAMBERT, France ULg; LAMY, Marc ULg

in Missika, Patrick (Ed.) 25 cas d'école en implantologie (2013)

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See detailHard and soft tissue regeneration in anterior cases: Materials and Procedures.
LAMBERT, France ULg

Conference (2013, June 21)

Hard and soft tissues around implants are not similar to those around natural teeth. Peri-implant tissues required being thicker and self-supportive in order to allow optimal and long-term aesthetic ... [more ▼]

Hard and soft tissues around implants are not similar to those around natural teeth. Peri-implant tissues required being thicker and self-supportive in order to allow optimal and long-term aesthetic results. The objective of this presentation is to emphasize the importance of hard and soft tissues surgical management for long-lasting tissues volumes and therefore aesthetic outcomes. [less ▲]

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See detailHard and soft tissue management in the esthetic zone
LAMBERT, France ULg

Conference (2013, May 17)

Esthetic results in dentistry are determined by the harmony between the dental prostheses and the soft tissues. To reach an optimal result, each single step of the treatment has a great importance, from ... [more ▼]

Esthetic results in dentistry are determined by the harmony between the dental prostheses and the soft tissues. To reach an optimal result, each single step of the treatment has a great importance, from the smile analyses to the final restoration delivery. The goal of this lecture is to describe how to elaborate a treatment planning for single tooth replacement in the aesthetic zone. A decision tree for the surgical protocols will be proposed according to our clinical experience at the university of Liège and, the current scientific evidences. The overall objective is, from an initial clinical situation, to determine the appropriate treatment approach and timing. [less ▲]

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See detailUn approche moderne de la régénération osseuse
LAMBERT, France ULg; LECLOUX, Geoffrey ULg; ROMPEN, Eric ULg

Scientific conference (2013, March)

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See detailA methodological approach to assessing alveolar ridge preservation procedures in humans: soft tissue profile.
VANHOUTTE, Vanessa ULg; ROMPEN, Eric ULg; LECLOUX, Geoffrey ULg et al

in Clinical Oral Implants Research (2013)

Introduction: The aesthetic results of implant restoration in the anterior maxilla are particularly related to the soft tissue profile. Although socket preservation techniques appear to reduce bone ... [more ▼]

Introduction: The aesthetic results of implant restoration in the anterior maxilla are particularly related to the soft tissue profile. Although socket preservation techniques appear to reduce bone remodelling after tooth extraction, there is still few investigations assessing the external soft tissue profile after such procedures. The goal of the present study was to describe an accurate technique to evaluate soft tissue contour changes after performing socket preservation procedures. The secondary objective was to apply the newly develop measuring method to a specific socket preservation using a “saddled” connective tissue graft combined with the insertion of slowly resorbable biomaterials into the socket. Materials and Methods: A total of 14 patients needing tooth replacement in the aesthetic region were included to receive a socket preservation procedure using a connective tissue graft. Impressions were taken before the tooth extraction (baseline) and at 2, 4, and 12 weeks after the procedure. The corresponding plaster casts were scanned, and the evolution of the soft tissue profile in relation to the baseline situation was assessed using imaging software. Results: The measuring technique allowed assessing the soft tissue profiles accurately at different level of the alveolar process. The insertion of a saddled connective tissue appeared to compensate significantly for the horizontal and vertical bone remodelling after a socket preservation procedure in most regions of the alveolar crest. After 12 weeks, the only significant change was located in the more cervical and central region of the alveolar process and reached a mean of 0.76 mm. Conclusion: Within the limitations of this study, we found that a saddled connective tissue graft combined with a socket preservation procedure could almost completely counteract the bone remodelling in terms of the external soft tissue profile. The minor changes found in the cervical region might disappear with the emergence profile of the prosthodontic components. The described technique might therefore enhance the aesthetic outcomes when a tooth has to be replaced in the aesthetic zone. The described protocol can be used to further compare the effectiveness of different extraction socket preservation protocols in randomised controlled trials. [less ▲]

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See detailThe effect of collagenated space filling materials in sinus bone augmentation: a study in rabbits
LAMBERT, France ULg; Léonard, Angélique ULg; Drion, Pierre ULg et al

in Clinical Oral Implants Research (2013), 24(5),

Aim: The inclusion of biomaterial particles used for alveolar bone regeneration in a carrier or in binding agents such as collagen gel or fibers is of interest as a means to help with surgical handling ... [more ▼]

Aim: The inclusion of biomaterial particles used for alveolar bone regeneration in a carrier or in binding agents such as collagen gel or fibers is of interest as a means to help with surgical handling. However, the possible influence of collagen on bone tissue response to biomaterials is poorly studied. The objective of the present study was to investigate, in a sub-sinus bone augmentation model in rabbits, the effect of collagen at different stages of the osteogenesis process. Histologic, histomorphometric and volumetric analyses were performed. Materials and methods: Rabbits underwent a double sinus lift procedure using bovine hydroxyapatite (BHA), collagenated bovine hydroxyapatite (BHAColl), and prehydrated and collagenated porcine hydroxyapatite (PHAColl). Animals were sacrificed at 1 week, 5 weeks or 6 months. Samples were subjected to X-ray micro-tomography and histology. Qualitative analysis was performed on the non-decalcified sections and quantitative histomorphometric analyses were conducted using scanning electron microscopy (SEM). Volume variations of bone augmentations were calculated at different time points. Results: The three biomaterials allowed an optimal bone formation and were able to equally withstand sinusal reexpansion. A comparable percentage of new bone, as well as 3D volume stability, was found between the groups at each time point. However, the PHAColl resorption rate was significantly higher than the rates in other groups (P = 0.0003), with only 3.6% of the particles remaining at 6 months. At 1 week, both collagenated groups displayed the presence of inflammatory cells although BHA did not show any sign of inflammation. At 5 weeks and 6 months, the inflammatory process had disappeared completely in the BHAColl groups, whereas some inflammatory-like cells could still be observed around the remaining particles of PHAColl. Conclusions and clinical implications: Within the limitations of this study in rabbits, the findings showed the presence of inflammatory-like cells at the early stage of bone regeneration when collagenated xenogenic biomaterials were used compared to xenogenic granules alone. Nevertheless, similar bone formation occurred and comparable 3D volumes were found at 6 months in the different groups. [less ▲]

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See detailBone Regeneration Using Porous Titanium Particles versus Bovine Hydroxyapatite: A Sinus Lift Study in Rabbits.
LAMBERT, France ULg; LECLOUX, Geoffrey ULg; Léonard, Angélique ULg et al

in Clinical Implant Dentistry & Related Research (2013), 15(3),

Aim: The first objective of this study was to qualitatively and quantitatively assess the bone formation process, particularly the long-term behavior and three-dimensional volume stability of subsinusal ... [more ▼]

Aim: The first objective of this study was to qualitatively and quantitatively assess the bone formation process, particularly the long-term behavior and three-dimensional volume stability of subsinusal bone regeneration, using titanium (Ti) or bovine hydroxyapatite (BHA) granules, in a rabbit model. The second objective was to evaluate the effect of the hydration of the BHA particles with a therapeutic concentration of doxycycline solution on the osteogenesis and biomaterial resorption. Materials and Methods: Rabbits underwent a double sinus lift procedure using one of three materials: grade 1 porous Ti particles, BHA, or BHA hydrated with doxycycline solution (0.1 mg/ml) (BHATTC). Animals were sacrificed after 1 week, 5 weeks, or 6 months. Samples were analyzed using µCT and nondecalcified histology. Results: The materials used in each of the three groups allowed an optimal bone formation; bone quantities and densities were not statistically different between the three groups. At 6 months, more stable three-dimensional volume stability was found with Ti and BHATTC (p = .0033). At 5 weeks and 6 months, bone to material contact corroborating osteoconduction was significantly higher with BHA and BHATTC than with Ti (p < .0001). Conclusions and Clinical Implications: Even though the studied biomaterials displayed different architectures, they are relevant candidates for sinus lift bone augmentation prior to dental implants because they allow adequate three-dimensional stability and osteogenesis. However, to recommend the clinical use of Ti, both an observation on the drilling effects of Ti particles and clinical trials are needed. [less ▲]

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See detailA comparison of three calcium phosphate based space fillers in sinus elevation: a study in rabbits
LAMBERT, France ULg; Léonard, Angélique ULg; LECLOUX, Geoffrey ULg et al

in The international Journal of Oral and Maxillofacial Implants (2013), 28(2), 393-402

Aim: Sub-sinusal bone regeneration procedures are reliable procedures that are known to be efficient with the use of biomaterials alone. Nevertheless, many types of biomaterials are available, and their ... [more ▼]

Aim: Sub-sinusal bone regeneration procedures are reliable procedures that are known to be efficient with the use of biomaterials alone. Nevertheless, many types of biomaterials are available, and their efficacy in terms of bone formation and resorption rate have rarely been compared. This study aimed to compare the bone formation, resorption rate, osteoconductivity and 3D volume changes of three biomaterials often used for alveolar ridge augmentation. Materials and Methods: Rabbits underwent a double sinus lift procedure using three different types of space fillers: bovine hydroxyapatite (BHA), beta calcium phosphate (ß-TCP) and biphasic calcium phosphate (BCP). Animals were sacrificed at 1 week, 5 weeks and 6 months. Samples were subjected to X-ray microtomography and histology. Qualitative analysis was performed on non-decalcified sections, and quantitative histomorphometric analysis was conducted using SEM. Volume variations of bone augmentations were calculated at different time points. Results: All three particulated biomaterials proved to be effective in promoting osteogenesis. At 6 months, biomaterial resorption rates were significantly different across the 3 groups (p<0.0001). The highest resorption rate was found with β-TCP, in which only 6.7% of the baseline particle surface remained. At 6 months, bone was in close contact with the BHA particles, constituting a composite network; in contrast, BCP particles were often surrounded by soft tissues. In each group, no significant difference in volume variations were found at the different time point. Conclusions and clinical implications: Despite the limitations of the study, the three particulated space-filling biomaterials proved to be efficient to promote osteogenesis. High resorption rates and complete replacement of the biomaterials by bone seemed to withstand intrasinusal pressure. Further investigations in humans should consider longer follow-up periods. [less ▲]

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See detailDecision making for teeth replacement in the esthetic area
LAMBERT, France ULg

Scientific conference (2013)

Esthetic results in dentistry are determined by the harmony between the dental prostheses and the soft tissues. To reach an optimal result, each single step of the treatment has a great importance, from ... [more ▼]

Esthetic results in dentistry are determined by the harmony between the dental prostheses and the soft tissues. To reach an optimal result, each single step of the treatment has a great importance, from the smile analyses to the final restoration delivery. The goal of this lecture is to describe how to elaborate a treatment planning for single and multiple tooth replacement in the aesthetic zone. A decision tree for the surgical protocols will be proposed according to our clinical experience at the university of Liège and, the current scientific evidences. The overall objective is, from an initial clinical situation, to determine the appropriate treatment approach and timing. The following scientific aspects will be developed: - The biological concept of extraction socket preservation. The use of biomaterials for alveolar bone augmentation or socket preservation. The goal is to clarify properties of the mostly used biomaterial in dentistry, as well as determine their clinical indications and limitations. Soft tissue management around teeth and implant [less ▲]

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