References of "Klein, M"
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See detailSomatic mosaicism is implicated in the etiology of XLAG syndrome
Rostomyan, Liliya ULiege; Daly, Adrian ULiege; Yuan, Bo et al

in Abstract book : Symposium "Perspectives in Endocrinology" (2017, January)

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See detailHistologically Proven Bronchial Neuroendocrine Tumors in MEN1: A GTE 51-Case Cohort Study.
Lecomte, Pierre ULiege; Binquet, C.; Le Bras, M. et al

in World Journal of Surgery (2017)

OBJECTIVE: To evaluate the natural history of MEN1-related bronchial endocrine tumors (br-NETs) and to determine their histological characteristics, survival and causes of death. br-NETs frequency ranges ... [more ▼]

OBJECTIVE: To evaluate the natural history of MEN1-related bronchial endocrine tumors (br-NETs) and to determine their histological characteristics, survival and causes of death. br-NETs frequency ranges from 3 to 13% and may reach 32% depending on the number of patients evaluated and on the criteria required for diagnosis. METHODS: The 1023-patient series of symptomatic MEN1 patients followed up in a median of 48.7 [35.5-59.6] years by the Groupe d'etude des Tumeurs Endocrines was analyzed using time-to-event techniques. RESULTS: br-NETs were found in 51 patients (4.8%, [95% CI 3.6-6.2%]) and were discovered by imaging in 86% of cases (CT scan, Octreoscan, Chest X-ray, MRI). Median age at diagnosis was 45 years [28-66]. Histological examination showed 27 (53%) typical carcinoids (TC), 16 (31%) atypical carcinoids (AC), 2 (4%) large cell neuroendocrine carcinomas (LCNEC), 3(6%) small cell neuroendocrine carcinomas (SCLC), 3(6%) TC associated with AC. Overall survival was not different from the rest of the cohort (HR 0.29, [95% CI 0.02-5.14]). AC tended to have a worse prognosis than TC (p = 0.08). Seven deaths were directly related to br-NETs (three AC, three SCLC and one LCNEC). Patients who underwent surgery survived longer (p = 10-4) and were metastasis free, while 8 of 14 non-operated patients were metastatic. There were no operative deaths. CONCLUSIONS: Around 5% of MEN1 patients develop br-NETs. br-NETs do not decrease overall survival in MEN1 patients, but poorly differentiated and aggressive br-NETs can cause death. br-NETs must be screened carefully. A biopsy is essential to operate on patients in time. [less ▲]

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See detailSomatic mosaicism is implicated in the etiology of XLAG syndrome
Rostomyan, Liliya ULiege; Daly, Adrian ULiege; Yuan, Bo et al

in 26nd meeting of the Belgian Endocrine Society - Abstract book (2016, October)

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See detailOperation of a quantum dot in the finite-state machine mode: Single-electron dynamic memory
Klymenko, Mykhailo ULiege; Klein, M.; Levine, R. D. et al

in Journal of Applied Physics (2016), 120(2), 024503

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See detailX-Linked acro-gigantism (X-LAG) syndrome : two new cases with long-term follow-up
Daly, Adrian ULiege; Cuny, T; Rabl, w et al

in Abstract book - 4th ENEA Workshop topic : acromegaly (2015)

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See detailBalanced ternary addition using a gated silicon nanowire
Mol, J. A.; Van der Heijden, J.; Verduijn, J. et al

in Applied Physics Letters (2011), 99(26), 263109

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See detailLogic implementations using a single nanoparticle-protein hybrid
Medalsy, I.; Klein, M.; Heyman, A. et al

in Nature Nanotechnology (2010), 5

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See detailTernary logic implemented on a single dopant atom field effect silicon transistor
Klein, M.; Mol, J. A.; Verduijn, J. et al

in Applied Physics Letters (2010), 96

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See detailReconfigurable Logic Devices on a Single Dopant Atom-Operation up to a Full Adder by Using Electrical Spectroscopy
Klein, M.; Lansbergen, G. P.; Mol, J. A. et al

in Chemphyschem : A European Journal of Chemical Physics and Physical Chemistry (2009), 10(1), 162-173

A silicon field-effect transistor is operated as a logic circuit by electrically addressing the ground and excited electronic states of an embedded single dopant atom. Experimental results-complemented by ... [more ▼]

A silicon field-effect transistor is operated as a logic circuit by electrically addressing the ground and excited electronic states of an embedded single dopant atom. Experimental results-complemented by analytical and computational calculations-are presented. First, we show how a complete set of binary logic gates can be realized on the same hardware. Then, we show that these gates can be operated in parallel on the very some dopant up to the logic level of a full adder. To use the device not as a switch but as a full logic circuit, we make essential use of the excited electronic states of the dopant and of the ability to shift their energy by gating. The experimental ability to use two channels to measure the current flowing through the device and the conductance (dI/dV) allows for a robust reading of the output of the logic operations. [less ▲]

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See detailPrinciples of design of a set-reset finite state logic nanomachine
Klein, M.; Levine, R. D.; Remacle, Françoise ULiege

in Journal of Applied Physics (2008), 104(4),

Pulsed electrical set and reset inputs are used to simulate the temporal action of a finite state machine in a three terminal configuration for a variety of arrangements. The gate electrode is necessary ... [more ▼]

Pulsed electrical set and reset inputs are used to simulate the temporal action of a finite state machine in a three terminal configuration for a variety of arrangements. The gate electrode is necessary only if it is of interest to tune the tunneling rate and to compensate for background charges. When the output is the current, a source and drain electrodes are required. If the output is determined by measuring charge occupancy, then a single junction suffices. The electron transfer rates are computed from the free energy change for a single electron transfer to or from a quantum dot of size such that only charge quantization matters. For a small enough dot the device could operate at room temperature. An asymmetric configuration of the source and drain favors a longer term time preservation of the memory of the device. An alternative design that operates with the same energetics and kinetic parameters is to pulse the resistance rather than the voltage. (C) 2008 American Institute of Physics. [less ▲]

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See detailTranscending binary logic by gating three coupled quantum dots
Klein, M.; Rogge, S.; Remacle, Françoise ULiege et al

in Nano Letters (2007), 7

Physical considerations supported by numerical solution of the quantum dynamics including electron repulsion show that three weakly coupled quantum dots can robustly execute a complete set of logic gates ... [more ▼]

Physical considerations supported by numerical solution of the quantum dynamics including electron repulsion show that three weakly coupled quantum dots can robustly execute a complete set of logic gates for computing using three valued inputs and outputs. Input is coded as gating (up, unchanged, or down) of the terminal dots. A nanosecond time scale switching of the gate voltage requires careful numerical propagation of the dynamics. Readout is the charge (0, 1, or 2 electrons) on the central dot. [less ▲]

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