References of "Kharfi, M"
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See detailHealing effect of ketanserin on chronic leg ulcers in patients with diabetes.
Quatresooz, Pascale ULg; Kharfi, M.; Paquet, Philippe ULg et al

in Journal of the European Academy of Dermatology & Venereology (2006), 20(3), 277-81

BACKGROUND: The treatment of chronic leg ulcers remains a stubborn problem in many patients. Topical 2% ketanserin ointment, a 5HT2-serotoninergic blocking agent, has been reported to improve healing of ... [more ▼]

BACKGROUND: The treatment of chronic leg ulcers remains a stubborn problem in many patients. Topical 2% ketanserin ointment, a 5HT2-serotoninergic blocking agent, has been reported to improve healing of decubitus, venous, diabetic and ischaemic ulcers. METHOD: The present double-blind intra-individual comparative study was performed in 12 women with diabetes presenting with at least two similar leg ulcers. In each subject, the two lesions were randomly assigned to be treated for 8 weeks by 2% ketanserin ointment or its unmedicated vehicle. OBJECTIVE: assessments of the dynamics of wound healing were performed using computerized morphometry. Evaluations were performed at 2-week intervals for 8 weeks. RESULTS: A significant decrease in relative wound area was observed on the ketanserin-treated ulcers compared with the placebo group. CONCLUSION: Topical ketanserin is a valuable therapy for difficult-to-treat leg ulcers. [less ▲]

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See detailItracoanzole in human aspergillosis revisited.
Pierard, Gérald ULg; Kharfi, M.; Salomon-Neira, M. D. et al

in Journal de Mycologie Médicale (2004), 14

Itraconazole is a broad spectrum antifungal agent of the bis-triazole class. The drug is an important option in the management of many human mycoses including various clinical presentations of ... [more ▼]

Itraconazole is a broad spectrum antifungal agent of the bis-triazole class. The drug is an important option in the management of many human mycoses including various clinical presentations of aspergillosis. Indeed, the compound exhibits potent in vitro antifungal activity against Aspergillus spp. and shows variable fungicidal effect against the different species and strains. After amphotericin B, itraconazole has been the very first agent, and the first azole antifungal to have demonstrated clinical efficacy in aspergillosis. In vivo, the antifungal efficacy of itraconazole has been demonstrated in several types of aspergillosis both in immunocompetent and immunocompromised animal models. The drug administered in its oral or intravenous formulations displays non-linear plasma pharmacokinetics. Despite best current therapies, the outcome of invasive aspergillosis may remain dismal. Fungal cells can induce enormous damage on a background of immunosuppression. Medical help comes often too slow or is too weak. It will be a long time before the ideal strategy is found for an effective prophylaxis or for the optimal therapy of disseminated and invasive aspergillosis. In spite of this limitation, itraconazole has a definite chemotherapeutic effect in experimental aspergillosis. Non-comparative clinical data of itraconazole in the treatment of suspected or proven invasive aspergillosis indicate response rates at least similar and possibly superior to those of amphotericin B. Itraconazole has clearly improved the clinical outcome in some of the less immunosuppressed patients with invasive aspergillosis. The experience with itraconazole for induction therapy of invasive aspergillosis is more limited in profoundly neutropenic patients. Itraconazole has an important role for consolidation and maintenance therapy of patients with invasive aspegillosis. Itraconazole oral cyclodextrin solution is particularly suitable in these indications. Novel combination and sequential therapies involving itraconazole with other antifungals are promising. Itraconazole is usually well tolerated, but a potential for drug interactions exists, mediated through the cytochrome P450 3A4 system. This possibility should be considered when itraconazole is used as part of a multi-drug regimen. [less ▲]

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See detailL'allergie au latex--quand l'incertitude reste la seule certitude
Goffin, Véronique ULg; Kharfi, M.; Pierard-Franchimont, Claudine ULg et al

in Revue Médicale de Liège (2001), 56(3), 165-9

Latex devices release allergenic proteins which are responsible for immune IgE mediated reactions. Casual surgical gloves are most often responsible for contact urticaria. Other allergic manifestations ... [more ▼]

Latex devices release allergenic proteins which are responsible for immune IgE mediated reactions. Casual surgical gloves are most often responsible for contact urticaria. Other allergic manifestations include conjunctivitis, rhinitis, asthmatiform dyspnoea and diverse gastro-intestinal troubles. Cardiovascular collapse and anaphylactic shock are possible. Physicians and the paramedical staff are particularly affected by the allergy to latex proteins. Multi-operated patients and those under prolonged health care using latex-made medical probes also present a high-risk group for this type of allergy. [less ▲]

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See detailReactions indesirables au contact d'organismes marins
Letot, Bernard ULg; Kharfi, M.; Mandojana, R. et al

in Revue Médicale de Liège (2000), 55(6), 531-7

The contact of some marine organisms with the skin may prove to be traumatic and sometimes very dangerous. Some coelenterates, fishes, urchins, sea snakes, cephalopods, molluscs and other sea organisms ... [more ▼]

The contact of some marine organisms with the skin may prove to be traumatic and sometimes very dangerous. Some coelenterates, fishes, urchins, sea snakes, cephalopods, molluscs and other sea organisms are responsible for dermatological lesions, associated or not with toxic or allergic reactions exhibiting systemic effects. [less ▲]

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See detailLe vieillissement de l'épiderme
Pierard, Gérald ULg; Nikkels, Arjen ULg; Fazaa, B. et al

in Médecine et Hygiène (1992), 50(1924), 664-666

Skin aging is defined by the progressive loss in homeostatic capacity of the epidermis and dermis to respond to various stimuli. Photoaging is a peculiar type of aging which occurs on sun exposed areas ... [more ▼]

Skin aging is defined by the progressive loss in homeostatic capacity of the epidermis and dermis to respond to various stimuli. Photoaging is a peculiar type of aging which occurs on sun exposed areas. We review the structural and functional alterations of the epidermis in relation to the origin of aging. [less ▲]

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See detailVulvar basal cell carcinoma
Kharfi, M.; Mokhtar, I.; Fazaa, B. et al

in European Journal of Dermatology (1992), 2

Vulva is an uncommon localization for basal cell carcinomas. We report three cases and review the literature. There is often a long delay before patients seek medical attention for these lesions. Moreover ... [more ▼]

Vulva is an uncommon localization for basal cell carcinomas. We report three cases and review the literature. There is often a long delay before patients seek medical attention for these lesions. Moreover the clinical aspect is often indistinctive and misleading. The gross polymorphism of vulvar neoplasms therefore calls for biopsy of any suspicious areas. Surgical excision or Moh's chemotherapy are the treatments of choice for vulvar basal cell carcinomas. The recurrence rate remains quite high even when the lesion looks completely resected. [less ▲]

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See detailCongenital sebaceous trichofolliculoma
Kharfi, M.; Fazaa, B.; Mokhtar, I. et al

in Giornale Internazionale Dermatologia Pediatrica (1992), 4(1), 33-35

We report the clinical and histological presentation of a sebaceous trichofolliculoma present on the dorsum of the nose of a 1-year-old boy. This lesion was present since birth and appears to be the forst ... [more ▼]

We report the clinical and histological presentation of a sebaceous trichofolliculoma present on the dorsum of the nose of a 1-year-old boy. This lesion was present since birth and appears to be the forst reported cas of a congenital sebaceous trichofolliculoma. [less ▲]

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See detailGranulomatous rosacea and demodicidosis
Kharfi, M.; Zarrouk, H.; Nikkels, Arjen ULg et al

in African journal of Dermatology (1991), 4(2), 39-43

Granulomatous rosacea is a rare disease sometimes mistaken for sarcoidosis or tuberculosis. We briefly review the historical evolution of the concept of this disease. We document this study with twelve ... [more ▼]

Granulomatous rosacea is a rare disease sometimes mistaken for sarcoidosis or tuberculosis. We briefly review the historical evolution of the concept of this disease. We document this study with twelve clinico-pathological confrontations, and we emphasize the resemblance with granulomatous demodicidosis. [less ▲]

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