  MATHEMATICAL MODELING OF ENDOCHONDRAL OSSIFICATION THROUGH MUTUAL INHIBITION AND BISTABILITYGermain, Morgan  ; Kerkhofs, Johan ; Geris, Liesbet Conference (2013) Detailed reference viewed: 16 (3 ULg)Relating the Chondrocyte Gene Network to Growth Plate Morphology: From Genes to PhenotypeKerkhofs, Johan ; ; et alin PLoS ONE (2012) During endochondral ossification, chondrocyte growth and differentiation is controlled by many local signalling pathways. Due to crosstalks and feedback mechanisms, these interwoven pathways display a ... [more ▼] During endochondral ossification, chondrocyte growth and differentiation is controlled by many local signalling pathways. Due to crosstalks and feedback mechanisms, these interwoven pathways display a network like structure. In this study, a large-scale literature based logical model of the growth plate network was developed. The network is able to capture the different states (resting, proliferating and hypertrophic) that chondrocytes go through as they progress within the growth plate. In a first corroboration step, the effect of mutations in various signalling pathways of the growth plate network was investigated. [less ▲] Detailed reference viewed: 19 (6 ULg)A Boolean network approach to developmental engineeringKerkhofs, Johan ; ; et alConference (2011, June 13) Detailed reference viewed: 8 (0 ULg)A Boolean network model of the growth plateKerkhofs, Johan ; ; et alPoster (2010, November 26) Detailed reference viewed: 7 (0 ULg)A Boolean network model of the growth plateKerkhofs, Johan ; ; et alPoster (2010, October 10) Detailed reference viewed: 5 (0 ULg)BMP signalling in growth plate chondrocytes: a Boolean modelling approachKerkhofs, Johan ; ; et alPoster (2010, September 15) Detailed reference viewed: 5 (0 ULg) |
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