References of "Kaux, Jean-François"
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See detailImpact de l’hygiène bucco-dentaire sur le sport. Revue de la littérature
Kipgen, Laurence; Kaux, Jean-François ULg; Rompen, Eric ULg et al

in Journal de Traumatologie du Sport (in press)

Teeth are the object of multiple attentions and care but unfortunately, it is not the same case of the periodonte, their point of anchoring and essential support. What could be more commonplace than a ... [more ▼]

Teeth are the object of multiple attentions and care but unfortunately, it is not the same case of the periodonte, their point of anchoring and essential support. What could be more commonplace than a bleeding arising during the daily brushing? Being not painful, it activates very often no concern and no request of consultation. It is nevertheless about one of the most obvious clinical signs of the periodontal diseases which affect, to varying degrees, practically 90 % of the population in France in all groups of ages and is responsible of the loss from 30 to 40 % of the teeth. For several decades, the scientific world admits a relation between the periodontal disease and certain systematic diseases, as the endocarditis, the atherosclerosis, the diabetes… And what about tendinopathies? Their appearance is often spontaneous without specific medical origin and their cure turns out long and painful. This review has for objective to highlight the relations between the oral hygiene and sportsmen. [less ▲]

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See detailIdentification of cardiac repercussions after intense and prolonged concentric isokinetic exercise in young sedentary people.
LE GOFF, Caroline ULg; Kaux, Jean-François ULg; Couffignal, Vincent et al

in Clinical physiology and functional imaging (in press)

INTRODUCTION: Cardiopathies are the world's leading cause of mortality and morbidity. Although rare, cardiovascular accidents can occur during intense and infrequent sporting activity, particularly among ... [more ▼]

INTRODUCTION: Cardiopathies are the world's leading cause of mortality and morbidity. Although rare, cardiovascular accidents can occur during intense and infrequent sporting activity, particularly among those who are unaware of their heart condition. The development of cardiospecific biochemical markers has led to a reconsideration of the role of biology in the diagnosis of cardiovascular illnesses. The aim of this study therefore was, through the use of cardiac biomarker assays, to highlight the impact of sustained physical effort in the form of intense and prolonged concentric isokinetic exercise and to research potential cardiovascular risks. MATERIALS AND METHODS: Eighteen subjects participated in a maximal concentric isokinetic exercise involving 30 knee flexion-extensions for each leg. Five blood tests were taken to study the kinetics of the cardiac biomarkers. Haemodynamic parameters were measured continuously using a Portapres, and respiratory parameters were measured using a Sensormedics Vmax 29C. RESULTS: The results showed significant increases in the creatine kinase, myoglobin, homocysteine and haemoglobin cardiac markers. Evolutionary trends were also observed for the following biomarkers: NT-proBNP, myeloperoxydase and C-reactive protein. All the physiological parameters measured presented statistically significant changes. CONCLUSION: Isokinetic effort leads to the release of cardiac markers in the blood, but these do not exceed the reference values in healthy subjects. Maximal concentric isokinetic exercise does not, therefore, lead to an increased risk of cardiovascular pathologies. [less ▲]

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See detailOne injection of platelet-rich plasma associated to a submaximal eccentric protocol to treat chronic jumper's knee
Kaux, Jean-François ULg; Croisier, Jean-Louis ULg; Bruyère, Olivier ULg et al

in The Journal of sports medicine and physical fitness (in press)

INTRODUCTION: Jumper's knee is a frequent chronic overuse syndrome of the upper part of the patellar tendon. Platelets contain lots of growth factors which could enhance the healing process of tendons ... [more ▼]

INTRODUCTION: Jumper's knee is a frequent chronic overuse syndrome of the upper part of the patellar tendon. Platelets contain lots of growth factors which could enhance the healing process of tendons. METHODS: Twenty patients with chronic upper patellar tendinopathy were enrolled. Assessments were made before infiltration of PRP, and 6 weeks and 3 months after the infiltration, using a 10--point Visual Analogic Scale, clinical examinations with a pressure algometer, algofunctional scores (IKDC and VISA--P), functional assessments (isokinetic and optojump evaluations) and imagery (ultrasounds and MRI). The PRP was obtained with an apheresis system (COM.TEC, Fresenius). Six millilitres of PRP were injected without local anaesthetic. One week after infiltration, patients started a standardised sub--maximal eccentric reeducation. RESULTS: Pain during daily activities significantly decreased with time. During functional evaluation, it decreased as well, but without significant functional improvement. No improvements in the imagery measurements were observed. Younger patients seemed to be more susceptible to have an improvement of pain by the PRP infiltration. CONCLUSION: This study demonstrates that a local infiltration of PRP associated with a submaximal eccentric protocol can improve symptoms of chronic jumper's knee in patients non--responsive to classical conservative treatments. [less ▲]

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See detailCommotion cérébrale
Kaux, Jean-François ULg

Conference (2015, January 19)

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See detailEvidence based medicine - Tendon and platelet-rich plasma (PRP)
Kaux, Jean-François ULg

in Annual Congress RSBPRM (2014, December 06)

Platelets have known roles in coagulation, inflammatory processes, and immunity modulation; they also have ‘‘restorative’’ properties. Indeed, during degranulation, platelets release different cytokines ... [more ▼]

Platelets have known roles in coagulation, inflammatory processes, and immunity modulation; they also have ‘‘restorative’’ properties. Indeed, during degranulation, platelets release different cytokines and growth factors (VEGF, PDGF, TGF-B, IGF-I, and HGF) that promote angiogenesis, tissue remodeling (bone, skin, muscle, tendon, etc.), and wound healing. PRP is obtained by centrifuging autologous blood to obtain a concentration of platelets, usually between 3 and 10 times that of whole blood, depending on the isolation method. For this reason, different PRP preparation techniques cannot provide a consistently identical final product, but there is currently no international consensus on this issue. Overall, PRP could be an attractive therapeutic option for treating chronic musculoskeletal conditions, such as tendinopathy or plantar fasciitis. Tendons do not have a high metabolic index. Growth factors released by platelets promote tenocyte proliferation, stimulate angiogenesis and have analgesic properties. Thus it could stimulate and accelerate tissue regeneration in animal models. In addition to PRP, optimal tissue quality requires the application of mechanical loads. PRP should be considered for chronic tendinopathies. Indeed, the goal is to initiate an acute inflammatory reaction that quickly moves on to the proliferative phase that involves collagen synthesis. The latter is necessary for appropriate tendon healing. PRP should therefore not be used for acute tendinitis or tenosynovitis. Even if most of the preclinical studies showed that PRP stimulates the tendon healing process, clinical series remain more controversial. Based on literature and our clinical experience, we suggest some ideas for improving this treatment. Optimization of the technique for collecting the PRP is paramount. Different risk factors must be corrected before infiltration, and chronic tendinopathies must be carefully selected. Finally, post-infiltration rehabilitation remains absolutely necessary. Standardisation of the use of PRP remains necessary in order to optimise the results. [less ▲]

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See detailPlasma riche en plaquettes et tendinopathies
KAUX, Jean-François ULg; Crielaard, Jean-Michel ULg

in Ortho-Rhumato (2014), 12(6), 35-39

Certaines tendinopathies présentent une évolution désespérément chronique malgré l’instauration d’un traitement conservateur bien conduit. Diverses études soulignent les propriétés réparatrices des ... [more ▼]

Certaines tendinopathies présentent une évolution désespérément chronique malgré l’instauration d’un traitement conservateur bien conduit. Diverses études soulignent les propriétés réparatrices des plaquettes qui pourraient accélérer la cicatrisation de différents tissus. Le plasma riche en plaquettes (platelet-rich plasma ou PRP) représenterait une thérapeutique d’avenir. Les plaquettes libéraient, lors de leur dégranulation, divers facteurs de croissance. Ceux-ci favoriseraient la cicatrisation tendineuse. Actuellement, les effets du PRP restent toujours discutés voire controversés : les résultats cliniques sont parfois contradictoires même si son efficacité in vitro et sur animal apparait plus franche. Cette variabilité pourrait s’expliquer par l’absence de consensus relatif au mode de préparation du PRP, à la concentration plaquettaire, à la présence ou non de leucocytes, à la technique d’infiltration et au protocole post-infiltration. [less ▲]

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See detailCalcifications des tissus mous des jambes
COLLIN, Romain ULg; ANDRE, Béatrice ULg; Crielaard, Jean-Michel ULg et al

in Revue Médicale de Liège (2014), 69(12), 641-643

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See detailEvaluation de la fatigue musculaire des membres supérieurs
Forthomme, Bénédicte ULg; Kaux, Jean-François ULg; Crielaard, Jean-Michel ULg et al

in Abstract Book des XVIèmes Rencontres isocinétiques de Médimex (2014, November 28)

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See detailIsocinétisme et tendinopathies
Croisier, Jean-Louis ULg; Kaux, Jean-François ULg; Crielaard, Jean-Michel ULg et al

in Abstract Book des XVIèmes Rencontres isocinétiques de Médimex (2014, November 28)

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See detailTraitements conservateurs de la gonarthrose
Kaux, Jean-François ULg

Conference (2014, November 20)

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See detailPlasma riche en plaquettes et lésions tendineuses
KAUX, Jean-François ULg; Drion, Pierre ULg; Croisier, Jean-Louis ULg et al

in Revue Médicale de Liège (2014), 69(Synthèse 2014), 72-77

Platelets contain growth factors released during their degranulation following activation. These growth factors promote tissue remodeling, wound healing and angiogenesis. Currently, the clinical effect of ... [more ▼]

Platelets contain growth factors released during their degranulation following activation. These growth factors promote tissue remodeling, wound healing and angiogenesis. Currently, the clinical effect of Platelet-Rich Plasma (PRP) is still discussed or even controversial. Our researches have evaluated the effectiveness of PRP on the healing of animal tendons and human suffering from chronic jumper's knee. [less ▲]

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See detailTendon et tendinopathie
Kaux, Jean-François ULg; Crielaard, Jean-Michel ULg

in Journal de Traumatologie du Sport (2014), 31(4), 235-240

The tendon, connective fibrous tissue, mechanically responsible for the transmission of strength of muscles to bones, is a dynamic entity which, according to the constraints, restructures permanently and ... [more ▼]

The tendon, connective fibrous tissue, mechanically responsible for the transmission of strength of muscles to bones, is a dynamic entity which, according to the constraints, restructures permanently and, thanks to various metabolic and mechanical changes. This review describes the histology, vascularization and innervation of the healthy tendon. In addition, the biomechanics and tendinous physiological responses, as well as the pathophysiology of tendinopathy are exposed. © 2014 Elsevier Masson SAS. [less ▲]

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See detailInjections de PRP et tendinopathies
Kaux, Jean-François ULg

Conference (2014, October 30)

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See detailContribution à l’étude du Plasma Riche en Plaquettes (PRP) dans le traitement des lésions tendineuses
Kaux, Jean-François ULg

Doctoral thesis (2014)

Platelet-rich plasma (PRP) may represent a new therapeutic option for chronic tendinopathies. Platelets release various cytokines and growth factors which promote angiogenesis, tissue remodeling, and ... [more ▼]

Platelet-rich plasma (PRP) may represent a new therapeutic option for chronic tendinopathies. Platelets release various cytokines and growth factors which promote angiogenesis, tissue remodeling, and wound healing. We made an extended literature review of the use of PRP in chronic tendinopathies. Despite the proven efficacy of PRP on tissue regeneration in experimental studies, there is currently scanty tangible clinical evidence with respect to its efficacy in chronic tendon disorders. The few studies that have been performed appear unlikely to be comparable. Randomized controlled studies with appropriate placebo groups are needed to determine the real effectiveness of PRP for treating chronic musculoskeletal injuries. After, we made a study to compare the platelet concentrations using 5 techniques of preparation of PRP and observed that each provides a very different PRP, with variations in the platelet concentrations and of the amount (if any) of erythrocytes and leucocytes. White blood cells could adversely affect wound healing through the release of proinflammatory factors responsible for extracellular matrix degradation. In addition, erythrocyte lysis releases free radicals that harm tissue structures. We thus think that ideal PRP should not contain any erythrocytes or leucocytes, and that the quality of the PRP could perhaps partially explain the variable results observed in the literature. The aim of our next study was to determine if an injection of PRP could improve the healing of sectioned Achilles tendons of rats. After surgery, rats received an injection of PRP (n = 60) or a physiological solution (n = 60) in situ. After 5, 15, and 30 days, 20 rats of both groups were euthanized and 15 collected tendons were submitted to a biomechanical test using cryo-jaws before performing transcriptomic analyses. Histological and biochemical analyses were performed on the five remaining tendons in each group. Tendons in the PRP group were more resistant to rupture at 15 and 30 days. The mechanical stress was significantly increased in tendons of the PRP group at day 30. Histological analysis showed a precocious deposition of fibrillar collagen at day 5 confirmed by a biochemical measurement. The expression of tenomodulin was significantly higher at day 5. The messenger RNA levels of type III collagen, matrix metalloproteinases 2, 3, and 9, were similar in the two groups at all time points, whereas type I collagen was significantly increased at day 30 in the PRP group. We concluded that an injection of PRP in sectioned rat Achilles tendon influences the early phase of tendon healing and results in an ultimately stronger mechanical resistance. Vascular endothelial growth factor (VEGF) is a platelet growth factor known to regulate angiogenesis. VEGF-111, a biologically active and proteolysis-resistant splice variant of this family, was recently identified. We made a study with the aim of evaluating whether VEGF-111 could have a therapeutic interest in tendon pathologies with the same rat protocol as our previous study. The force necessary to induce tendon rupture was greater for tendons of the VEGF-111 group (but less than the results obtained with the PRP in our previous study), while the section areas of the tendons were similar. The mechanical stress was similar at 5 and 15 days in both groups but was improved for the VEGF-111 group at day 30. No differences were observed in the mRNA expression of collagen III, tenomodulin and MMP-9. Finally, we made a study, the aim of which was to evaluate the clinical status and the return to sports activities in patients with chronic upper patellar tendinopathies, up to one year after a single infiltration of PRP. Twenty patients with chronic upper patellar tendinopathy were enrolled. Assessments were made before infiltration of PRP, and 6 weeks, 3 months and 1 year after the infiltration, using a 10-point Visual Analogic Scale, clinical examinations with a pressure algometer, algofunctional scores (IKDC and VISA-P), functional assessments (isokinetic and optojump evaluations) and imagery (ultrasounds and MRI). The PRP was obtained with an apheresis system (COM.TEC, Fresenius). Six millilitres of PRP were injected without local anaesthetic. One week after infiltration, patients started a standardised sub-maximal eccentric reeducation. We observed that with time, during the 1-year follow-up, VAS dropped significantly and both IKDC and VISA-P scores improved also significantly. During functional evaluation, it decreased as well, but without significant functional improvement. No improvements in the imagery measurements were observed. Younger patients seemed to be more susceptible to have a relief of pain by the PRP infiltration. Seventy percent of the patients reported a favourable evolution with decrease of pain, 15% reported no improvement and 15% were treated surgically. Seventy percent returned to sports activities, 64,3% without any pain and 50% recovered the same sports level. Even if 1 infiltration seems to be efficient in the indication of patellar tendinopathies, most studies evaluated the effects of 3 successive infiltrations. However, the multiplication of infiltrations risks increasing complications, and this treatment can be expensive. It seemed relevant to evaluate if 2 infiltrations of PRP would be more effective than only 1.Twenty patients suffering from jumper’s knee for more than 3 months were enrolled and randomized in 2 groups (1 or 2 infiltrations of PRP). The follow-up was made as follows: VAS, IKDC and VISA-P scores, algometer, isokinetic and ultrasounds evaluations. The concentration of the PRP used for each infiltration was similar in both groups, without any red or white blood cells. Results for all the evaluations did not show any difference between the groups. The comparison of 1 or 2 infiltrations of PRP did not show any difference between the 2 groups after a follow-up of 3 months. A second close infiltration of PRP to treat upper patellar tendinopathies is not necessary to improve the efficacy of this treatment in the short term. However, these results must be evaluated at a longer term. [less ▲]

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See detailIsocinétisme et muscles rotateurs d'épaule
Forthomme, Bénédicte ULg; Crielaard, Jean-Michel ULg; Kaux, Jean-François ULg et al

in Innovations technologiques et préhension (2014, October)

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See detailAdaptation interculturelle et validation du questionnaire VISA-P en français
Oppong-Kyei, Julian; Bruyère, Olivier ULg; Delvaux, François ULg et al

in 7ème Congrès National SFMES & SFTS 2014 (2014, September)

Introduction La tendinopathie patellaire est une affection musculo-squelettique très fréquentes chez le sportif et la plus fréquente au niveau du genou. Elle affecte le plus souvent des disciplines qui ... [more ▼]

Introduction La tendinopathie patellaire est une affection musculo-squelettique très fréquentes chez le sportif et la plus fréquente au niveau du genou. Elle affecte le plus souvent des disciplines qui nécessitent soit des impulsions et des sauts soit un travail important du quadriceps. Le Victorian Institute of Sports Assessment–Patellar (VISA-P) est un questionnaire permettant d’évaluer les symptômes et leurs retentissements sur les activités physiques quotidiennes et sportives de la tendinopathie patellaire (Jumper’s knee). Comme la plus part des questionnaires de ce type, le VISA-P fut originalement développé pour des patients anglophones et n'est donc pas adapté à une population francophone. En conséquence, l'objectif de cette étude sera de traduire, adapter et valider une version française fiable du VISA-P et d'en évaluer ses propriétés psychométriques. Matériel et méthode La traduction et l’adaptation interculturelle du VISA-P ont été réalisées selon les recommandations internationales (Guidelines for the Process of Cross-Cultural Adaptation of Self-Report Measures). Ce processus s'est déroulé en 6 étapes : traductions initiales, synthèse des traductions, traduction de retour vers la langue d’origine, comité expert, test de la version pré-finale et approbation du comité expert. La version française finale obtenue fut ensuite l’objet d’une évaluation de certaines propriétés psychométriques telles que la fidélité test-retest, la cohérence interne, la validité de construit et les effets plancher et plafond. Nonante-deux sujets furent recruté au total afin de tester ces propriétés psychométriques. Trois groupes de sujets furent utilisés pour répondre conjointement aux VISA-P et à un questionnaire supplémentaire, le Medical Outcomes Survey Short Form 36 questionnaire (SF-36) pour la validité de construit : un groupe de sujets pathologiques principalement recrutés parmi les patients du Centre Hospitalier Universitaire de Liège (28), un groupe de sujets asymptomatiques (22) et un groupe de sportifs à risque recrutés dans divers clubs sportif (42). L'ensemble des participants ont été recrutés au sein de la province de Liège. Résultats Aucun sujet ne présenta de grosses difficultés à comprendre le questionnaire suite au test de la version pré-finale. Les différents membres du comité expert se montrèrent satisfait de la version finale et donnèrent donc leur approbation. La moyenne des scores obtenu est de 53 (± 17) pour le groupe pathologique, 99 (± 2) pour le groupe sain et 86 (± 14) pour le groupe à risque. Les corrélations entre le VISA-P et certaines mesures divergentes du SF-36 semblent donner des résultats faibles. Les coefficients de corrélation mesurés entre les scores du VISA-P et les items convergents du SF-36 paraissent être élevés. Aucun effet plancher ou plafond n'a pu être observer lors de l'évaluation des propriétés psychométriques du VISA-P dans le groupe pathologique. Conclusion La version française du VISA-P est donc être un questionnaire compréhensible, fiable et adapté aux patients francophones souffrant d'une tendinopathie patellaire supérieur. [less ▲]

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See detailAdaptation interculturelle et validation du questionnaire VISA-A en français
Oppong-Kyei, Julian; Bruyère, Olivier ULg; Delvaux, François ULg et al

in 7ème Congrès National SFMES & SFTS 2014 (2014, September)

Introduction La tendinopathie d’Achille, dont la discipline athlétique implique une grosse activité de course à pied, représente une source de douleurs et de handicap. Cette pathologie fait actuellement l ... [more ▼]

Introduction La tendinopathie d’Achille, dont la discipline athlétique implique une grosse activité de course à pied, représente une source de douleurs et de handicap. Cette pathologie fait actuellement l'objet de nouvelles découvertes sur le plan de la physiopathologie permettant l'exploration de nouvelles pistes thérapeutiques. Dans le cadre de telles études, des échelles d’évaluation sont utilisées afin d'évaluer des phénomènes subjectifs ou complexes tels la douleur, la qualité de vie, le handicap, etc. Elles sont généralement composées de plusieurs items dont la cotation est combinée en un score global ou des sous scores dimensionnels. La majorité des échelles algo-fonctionnelles sont développés dans des pays anglophones et sont par conséquence uniquement pertinents pour des sujets parlant l’anglais. Ceci est la cas pour le Victorian Institute of Sports Assessment–Achilles (VISA-A), un questionnaire développé dans le but d'évaluer la sévérité des symptômes de la tendinopathie achilléenne. L’intérêt de ce mémoire est donc de valider une version française fiable de ce questionnaire. Matériel et méthode La traduction et l’adaptation interculturelle du VISA-A ont été réalisées selon les recommandations internationales (Guidelines for the Process of Cross-Cultural Adaptation of Self-Report Measures). Ce processus s'est déroulé en 6 étapes : traductions initiales, synthèse des traductions, traduction de retour vers la langue d’origine, comité expert, test de la version pré-finale et approbation du comité expert. La version française finale obtenue fut ensuite l’objet d’une évaluation de certaines propriétés psychométriques telles que la fidélité test-retest, la cohérence interne, la validité de construit et les effets plancher et plafond. Pour ces évaluations, 116 sujets furent recruté et répartis en 3 groupes : un groupe de sujets pathologiques principalement recrutés parmi les patients du Centre Hospitalier Universitaire de Liège (31), un groupe de sujets asymptomatiques (22) et un groupe de sportifs à risque (63). Tous ces sujets durent également répondre à un questionnaire supplémentaire, le Medical Outcomes Survey Short Form 36 questionnaire (SF-36) pour la validité de construit. L'ensemble des participants ont été recrutés au sein de la province de Liège. Résultats Aucun sujets ne présenta de difficultés à comprendre le questionnaire suite au test de la version pré-finale. Les différents membres du comité expert se montrèrent satisfait de la version finale et donnèrent donc leur approbation. La moyenne des scores obtenus dans le groupe pathologique est de 59 (± 18), celle du groupe sain est de 99 (± 1) et celle du groupe à risque est de 94 (± 7). Aucun effet plancher ou plafond n'a pu être observer lors de l'évaluation des propriétés psychométriques du VISA-A (dans le groupe pathologique). Les corrélations entre le VISA-A et certaines mesures divergentes du SF-36 semblent être faibles. Les coefficients de corrélation mesurés entre les scores du VISA-A et les items convergents du SF-36 paraissent être élevé. Conclusion La version française du VISA-A est donc être un questionnaire compréhensible, fiable et adapté aux patients francophones souffrant d'une tendinopathie d'Achille. [less ▲]

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