References of "Karlsson, Anders"
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See detailThe Search for Worlds Like Our Own
Fridlund, Malcolm; Eiroa, Carlos; Henning, Thomas et al

in Astrobiology (2010), 10(1), 5-17

The direct detection of Earth-like exoplanets orbiting nearby stars and the characterization of such planets -- particularly, their evolution, their atmospheres, and their ability to host life ... [more ▼]

The direct detection of Earth-like exoplanets orbiting nearby stars and the characterization of such planets -- particularly, their evolution, their atmospheres, and their ability to host life -- constitute a significant problem. The quest for other worlds as abodes of life has been one of mankind's great questions for several millennia. For instance, as stated by Epicurus 300 BC: Other worlds, with plants and other living things, some of them similar and some of them different from ours, must exist. Demokritos from Abdera (460-370 BC), the man who invented the concept of indivisible small parts - atoms - also held the belief that other worlds exist around the stars and that some of these worlds may be inhabited by life-forms. The idea of the plurality of worlds and of life on them has since been held by scientists like Johannes Kepler and William Herschel, among many others. Here, one must also mention Giordano Bruno. Born in 1548, Bruno studied in France and came into contact with the teachings of Nicolas Copernicus. He wrote the book De l'Infinito, Universo e Mondi in 1584, in which he claimed that the Universe was infinite, that it contained an infinite amount of worlds like Earth, and that these worlds were inhabited by intelligent beings. At the time, this was extremely controversial, and eventually Bruno was arrested by the church and burned at the stake in Rome in 1600, as a heretic, for promoting this and other equally confrontational issues (though it is unclear exactly which idea was the one that ultimately brought him to his end). In all the aforementioned cases, the opinions and results were arrived at through reasoning--not by experiment. We have only recently acquired the technological capability to observe planets orbiting stars other than 6our Sun; acquisition of this capability has been a remarkable feat of our time. We show in this introduction to the Habitability Primer that mankind is at the dawning of an age when, by way of the scientific method and 21st-century technology, we will be able to answer this fascinating controversial issue that has persisted for at least 2500 years. [less ▲]

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See detailMaraviroc for previously treated patients with R5 HIV-1 infection.
Gulick, Roy M; Lalezari, Jacob; Goodrich, James et al

in New England Journal of Medicine [=NEJM] (2008), 359(14), 1429-41

BACKGROUND: CC chemokine receptor 5 antagonists are a new class of antiretroviral agents. METHODS: We conducted two double-blind, placebo-controlled, phase 3 studies--Maraviroc versus Optimized Therapy in ... [more ▼]

BACKGROUND: CC chemokine receptor 5 antagonists are a new class of antiretroviral agents. METHODS: We conducted two double-blind, placebo-controlled, phase 3 studies--Maraviroc versus Optimized Therapy in Viremic Antiretroviral Treatment-Experienced Patients (MOTIVATE) 1 and MOTIVATE 2--with patients who had R5 human immunodeficiency virus type 1 (HIV-1) only. They had been treated with or had resistance to three antiretroviral-drug classes and had HIV-1 RNA levels of more than 5000 copies per milliliter. The patients were randomly assigned to one of three antiretroviral regimens consisting of maraviroc once daily, maraviroc twice daily, or placebo, each of which included optimized background therapy (OBT) based on treatment history and drug-resistance testing. Safety and efficacy were assessed after 48 weeks. RESULTS: A total of 1049 patients received the randomly assigned study drug; the mean baseline HIV-1 RNA level was 72,400 copies per milliliter, and the median CD4 cell count was 169 per cubic millimeter. At 48 weeks, in both studies, the mean change in HIV-1 RNA from baseline was greater with maraviroc than with placebo: -1.66 and -1.82 log(10) copies per milliliter with the once-daily and twice-daily regimens, respectively, versus -0.80 with placebo in MOTIVATE 1, and -1.72 and -1.87 log(10) copies per milliliter, respectively, versus -0.76 with placebo in MOTIVATE 2. More patients receiving maraviroc once or twice daily had HIV-1 RNA levels of less than 50 copies per milliliter (42% and 47%, respectively, vs. 16% in the placebo group in MOTIVATE 1; 45% in both maraviroc groups vs. 18% in MOTIVATE 2; P<0.001 for both comparisons in each study). The change from baseline in CD4 counts was also greater with maraviroc once or twice daily than with placebo (increases of 113 and 122 per cubic millimeter, respectively, vs. 54 in MOTIVATE 1; increases of 122 and 128 per cubic millimeter, respectively, vs. 69 in MOTIVATE 2; P<0.001 for both comparisons in each study). Frequencies of adverse events were similar among the groups. CONCLUSIONS: Maraviroc, as compared with placebo, resulted in significantly greater suppression of HIV-1 and greater increases in CD4 cell counts at 48 weeks in previously treated patients with R5 HIV-1 who were receiving OBT. (ClinicalTrials.gov numbers, NCT00098306 and NCT00098722.) [less ▲]

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See detailInherent modulation: a fast chopping method for nulling interferometry
Absil, Olivier ULg; Karlsson, Anders; Kaltenegger, Lisa

in Shao, Michael (Ed.) Interferometry in Space (2003, February 01)

The reduction of the thermal background emission from the local and exozodiacal dust clouds is a critical element for the success of ESA's space mission, DARWIN. Internal modulation, a technique using ... [more ▼]

The reduction of the thermal background emission from the local and exozodiacal dust clouds is a critical element for the success of ESA's space mission, DARWIN. Internal modulation, a technique using fast signal chopping, isolating the planetary signal from these noise sources, was proposed by Mennesson and Léger. In this paper, a short review of internal modulation is given, and new configurations with internal modulation are proposed to reduce the complexity of the beam-combining optics. A modification to the implementation of internal modulation is then investigated. It provides similar performance with a single detector and a greatly simplified optical layout: the number of beam-combiners is reduced by a factor of about two. The principle of inherent modulation is different from internal modulation in that no sub-interferometers are used: different phase shifts are applied to the input beams before recombination such that an asymmetric transmission map is obtained directly, without plus or minuspi/2 modulation as used in internal modulation. By combining the phase shifts and the input beams differently a transposed transmission map is obtained, allowing the signal to be chopped. During operations, multiplexing between the two interferometers is performed, such that at any time only one interferometer is being used. [less ▲]

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See detailDarwin ground-based European nulling interferometer experiment (GENIE)
Gondoin, Philippe; Absil, Olivier ULg; Fridlund, C V Malcolm et al

in Traub, Wesley (Ed.) Interferometry for Optical Astronomy II (2003, February 01)

Darwin is one of the most challenging space projects ever considered by the European Space Agency (ESA). Its principal objectives are to detect Earth-like planets around nearby stars and to characterize ... [more ▼]

Darwin is one of the most challenging space projects ever considered by the European Space Agency (ESA). Its principal objectives are to detect Earth-like planets around nearby stars and to characterize their atmospheres. Darwin is conceived as a space "nulling interferometer" which makes use of on-axis destructive interferences to extinguish the stellar light while keeping the off-axis signal of the orbiting planet. Within the frame of the Darwin program, the European Space Agency (ESA) and the European Southern Observatory (ESO) intend to build a ground-based technology demonstrator called GENIE (Ground based European Nulling Interferometry Experiment). Such a ground-based demonstrator built around the Very Large Telescope Interferometer (VLTI) in Paranal will test some of the key technologies required for the Darwin Infrared Space Interferometer. It will demonstrate that nulling interferometry can be achieved in a broad mid-IR band as a precursor to the next phase of the Darwin program. The present paper will describe the objectives and the status of the project. [less ▲]

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