References of "Kalenga, Masendu"
     in
Bookmark and Share    
Full Text
Peer Reviewed
See detailMathematical bias in assessment of placental residual blood volume
RIGO, Vincent ULg; LEFEBVRE, Caroline ULg; Kalenga, Masendu ULg

in Journal of Perinatology (in press)

This letter suggest a new computation of the relative placental residual blood volume.

Detailed reference viewed: 29 (1 ULg)
Full Text
Peer Reviewed
See detailPremière consultation ambulatoire du nouveau-né
RIGO, Vincent ULg; PIELTAIN, Catherine ULg; Schoffeniels, Colombe et al

in Revue Médicale de Liège (2017), 72(5), 253-259

The focus on outpatient follow-up of newborn infants increases as the duration of hospital stay after birth decreases. The first outpatient visit addresses the adequacy of the home transition. Appropriate ... [more ▼]

The focus on outpatient follow-up of newborn infants increases as the duration of hospital stay after birth decreases. The first outpatient visit addresses the adequacy of the home transition. Appropriate feedings are checked. Sudden infant death syndrome prevention and security advices are reminded. Realisation of both neonatal dried blood screen and hearing test is confirmed, as well as planning of specific follow-up appointments. The physical exam will focus on red flags for diseases or malformations with a delayed presentation. [less ▲]

Detailed reference viewed: 22 (3 ULg)
Full Text
Peer Reviewed
See detailSalmonella thyphimirium early onset neonatal sepsis
Thirion, Sophie ULg; RIGO, Vincent ULg; Snyers, Diane ULg et al

Poster (2017, May)

Background: Early onset neonatal sepsis due to salmonella spp is rare in developed countries. Vertical and horizontal transmissions were described, including faecal contamination of the birth canal. After ... [more ▼]

Background: Early onset neonatal sepsis due to salmonella spp is rare in developed countries. Vertical and horizontal transmissions were described, including faecal contamination of the birth canal. After a short incubation period, newborns may remain asymptomatic or present with sepsis or meningitis. Mortality rate as high as 58% were reported. Case Presentation Summary: We report a case of transplacental Salmonella Typhimurium infection in a premature infant. A mother with a one day history of fever and diarrhoea spontaneously delivered a premature boy at 35 weeks of gestation. On day 3, the infant presented with symptoms suggesting necrotizing enterocolitis: apnea, respiratory distress, feeding intolerance, bloody diarrhea and fever. Feeding were suspended and intravenous antibiotic therapy (ampicillin, amikacine and metronidazole) initiated. Laboratory data showed an inflammatory syndrome with elevated C-reactive proteine (71 mg/l), leukocytopenia (7270/mm3) and severe lymphopenia (580/mm3). Enterocolitis stage 1 (Bell classification) was diagnosed based on clinical and radiological evaluation. Salmonella spp were grown from the baby’s blood and stools and from the mother’s stools; the National Reference Center identified a Salmonella Typhimurium. Cerebrospinal fluid culture remained sterile. Clinical and biological evolutions were rapidly favourable with 14-days of cefotaxim IV. Maternal history revealed consumption of raw meat 3 days before delivery.Learning Points/Discussion: Salmonella spp should be considered in the differential diagnosis of early onset sepsis, particularly when mother presents gastrointestinal symptoms. Food safety education is crucial. The consumption of raw or uncooked meat during pregnancy should be avoided regardless toxoplasmosis immunization status. To avoid outbreaks in the neonatal ward (as reported in the literature), rapid detection and prompt institution of isolation and clustering measures are important. [less ▲]

Detailed reference viewed: 39 (0 ULg)
Full Text
See detailInterest of multisite bacterial screening for the diagnosis of congenital listerisosis with negative blood culture: a case report
Snyers, Diane ULg; Thirion, Sophie ULg; Kalenga, Masendu ULg et al

Scientific conference (2017, March 23)

Listeria monocytogenes (LM) is known to cause severe invasive disease in pregnant women and in newborns. Fortunately, despite the wide natural distribution of this pathogen, clinically overt neonatal ... [more ▼]

Listeria monocytogenes (LM) is known to cause severe invasive disease in pregnant women and in newborns. Fortunately, despite the wide natural distribution of this pathogen, clinically overt neonatal infections occurs rarely. As a consequence, listeriosis is not always considered for early onset neonatal infection, especially when blood culture is negative. Indeed, identification of listeria in the blood stream by conventional bacteriological methods remains the reference method for diagnosing listeriosis. We report a case of congenital listeriosis with negative blood culture despite typical chorioamnionitis, where the pathogen was cultured in gastric aspirate.Although the disease is rare, congenital listeriosis still remain a possible challenging condition in neonatal practice as revealed by this case report. This also shows the importance of multisite bacterial culture beside conventional blood and CSF culture, in combination with histological examination of the placenta for the diagnosis of congenital listeriosis. [less ▲]

Detailed reference viewed: 31 (3 ULg)
Full Text
Peer Reviewed
See detailInfection néonatale précoce à entérovirus: quand faut-il y penser?
Lagae, Donatienne; RIGO, Vincent ULg; Senterre, Jean-Marc et al

in Revue Médicale de Liège (2016), 71(2), 78-82

Enterovirus (EV) may cause a broad spectrum of clinical syndromes and even cause a sepsis-like picture. Although they are responsible for high morbidity and mortality rates, viral testing does not appear ... [more ▼]

Enterovirus (EV) may cause a broad spectrum of clinical syndromes and even cause a sepsis-like picture. Although they are responsible for high morbidity and mortality rates, viral testing does not appear in the algorithms for the evaluation of neonatal infections. During the month of June 2013, we identified 3 cases of EV meningitis in our unit of neonatology. All three infants had fever during the first week of life and their clinical examination revealed an irritability. The EV infection was detected by Real-Time Polymerase Chain Reaction (RT-PCR) EV on the cerebrospinal fluid (CSF). Two of the patients also had a positive RT-PCR EV in the blood. The 3 newborns were discharged from the hospital after a few days with no adverse outcome. Our clinical observations and the literature review suggest that EV infections in neonates ought to be identified as soon as possible by an early RT-PCR EV on the blood, and on the CSF if a lumbar puncture is indicated. This could help reduce the administration of antibiotics and the length of hospital stay. [less ▲]

Detailed reference viewed: 27 (6 ULg)
Full Text
Peer Reviewed
See detailDifférents manomètres pour améliorer la ventilation au masque et ballon
RIGO, Vincent ULg; Kreins, Nathalie; Eiras da Silva, Sandra et al

in Baud, Olivier; Saliba, Elie (Eds.) Congrès SFN-JFRN 2016, livre des communications (2015, December 17)

INTRODUCTION Les pressions employées lors de la ventilation au ballon sont difficiles à évaluer et souvent inadéquates. Les ballons disposent d’un connecteur où brancher un manomètre (manom) à ressort ou ... [more ▼]

INTRODUCTION Les pressions employées lors de la ventilation au ballon sont difficiles à évaluer et souvent inadéquates. Les ballons disposent d’un connecteur où brancher un manomètre (manom) à ressort ou une ligne vers un manom à cadran. Cependant, l’addition d’une variable à surveiller pourrait constituer une interférence et majorer le risque de fuite ou de rythme ventilatoire inadéquat. Cette étude évalue l’influence de manom simples sur la qualité de la ventilation. MÉTHODES Les participants aux Journées Belges de Pédiatrie pouvaient ventiler un mannequin aux voies respiratoires étanches avec un capteur de débit trachéal. Une pression de 25 mbar et une fréquence de 40 à 60/’ étaient visées. Une séquence de 45’’ avec un manom à ressort (R), une séquence avec un manom à cadran (C) et une sans (O) étaient réalisées dans un ordre aléatoire. La pression de pointe du ballon (P), le volume inspiratoire (VTi), et la fréquence de ventilation (FR) de chaque insufflation ont été analysées. La fuite autour du masque fut estimée en comparant VTi à un volume théorique dérivé d’une calibration avec masque scellé. RÉSULTATS Cinq néonatologues (Néo), 15 pédiatres et 11 internes ont réalisé 5279 insufflations. Les P obtenues avec un manom étaient plus élevées (O:176 mbar; R:184 mbar*; C:194 mbar*#) [*p<.05 vs O; #:p<.05 vs R] VTi augmentait légèrement (O:31 ml; R:3.11 ml*; C:3.21 ml*) FR était systématiquement trop élevé (77-82 bpm). L’usage d’un manom ne modifiait pas les paramètres pour les internes. Pour les Néo, ajouter un manom améliorait P, VTi et la fuite (P -O: 167 mbar; R and C: 204 mbar*) Sur les premières séquences de ventilation, le manom améliorait les paramètres (P-O: 124 mbar;R: 163 mbar*; C: 204 mbar*#), (VTi-O:21 ml; R:30.8 ml*; C:3.31 ml*#), (Fuite-O: 3816%; R: 2712%*; C: 3413%*#). CONCLUSIONS La ventilation au ballon reste difficile. Les pressions obtenues étaient éloignées de l’objectif, et le rythme souvent trop élevé. Si le manomètre permet d’améliorer les pressions et volumes obtenus, surtout en cas de ventilation sans feed-back préalable, cet effet bénéfique s’observe surtout pour les opérateurs expérimentés. Enfin, un congrès scientifique permet de recruter une population variée pour une étude de simulation simple. [less ▲]

Detailed reference viewed: 17 (1 ULg)
Full Text
Peer Reviewed
See detailThe Good, the Bad, the Marginal: respiratory management of <29 weeks infants according to subjective assessment of perinatal adaptation.
RIGO, Vincent ULg; KALENGA, Masendu ULg

Poster (2015, October)

Background Even if a primary CPAP strategy gives benefits in extremely preterm infants, many still require intubation at birth. Half of those initially managed with primary CPAP will require further ... [more ▼]

Background Even if a primary CPAP strategy gives benefits in extremely preterm infants, many still require intubation at birth. Half of those initially managed with primary CPAP will require further support: surfactant administration or mechanical ventilation. Those infants have increased risks of death and neonatal morbidities, and will require longer duration of respiratory support. Identifying them early, during the birth stabilization process, might lead to improvements in respiratory care. A subjective classification of perinatal adaptation as Good, Bad or Marginal has been suggested but requires further evaluation. We aimed to evaluate respiratory management according to perinatal adaptation. Methods Premature infants of less than 29 weeks and admitted between 01/2013 and 07/2014 were retrospectively studied. Neonatal database and discharge summaries provided neonatal care and outcome data. Good perinatal adaptation (GPA) was considered for infants with good respiratory drive, tone and low oxygen requirement in the delivery room. Infants with marginal (M) PA had intermittent respiratory drive, normocardia with ventilation, and decreasing FiO2. Bad (B) PA is considered with hypotonia, bradycardia, apnea and high FiO2. Data are presented as mean +/- SD, median (interquartile range) or incidence and analyzed with ANOVA, Kuskal-Wallis test or Chi2. Results Sixteen infants had GPA, 19 MPA and 23 BPA. GA was 26 4/7 wk (24-28) and BW was 885  187g. Risk factors for bad adaptation are (NS) male gender, lower GA, and no complete antenatal steroid exposure. Apgar at 1 min. increases with better PA [B3 (2-5); M6 (3-7) and G8 (7-8)*] (*p<.05 vs B & M), and improves at 5 min.: [B7 (6-7); M7 (6-8); G 9 (8-9)*]. Risk of intubation at birth is associated with poorer adaptation (B 87%; M 47%; G 12%, p<.01) Primary CPAP success was not different according to group (B 3/3; M66%; G56%). Surfactant while on CPAP (LISA method) was given to 11/16 patients, including 7 delivery room administrations. If intubated by day 3, duration of first invasive ventilation was shorter (NS) for GPA (9h) [MPA (15h), BPA (29h)]. Early neonatal death tended to decrease with better PA: 26%, 16% and 0% (p=.08). There is no difference in BPD -36 wk (B 19%, M13%, G 12%). Conclusions Infants with better perinatal adaptation have increased chances of being initially managed with CPAP. Primary CPAP success may be improved with less invasive surfactant therapy. Outside of the delivery room, perinatal adaptation assessment tends to identify risk of early neonatal death, but is not predictive of respiratory outcomes. [less ▲]

Detailed reference viewed: 12 (0 ULg)
Full Text
Peer Reviewed
See detailSmall manometers improve bag and mask ventilation: a manikin study
RIGO, Vincent ULg; Kreins, Nathalie; Eiras da Silva, Sandra et al

Poster (2015, September)

INTRODUCTION: Self-inflating bags (SIB) remain widely used for neonatal resuscitation. Insufflation pressures from SIB are difficult to assess and can be inadequate. Ventilation monitoring improves ... [more ▼]

INTRODUCTION: Self-inflating bags (SIB) remain widely used for neonatal resuscitation. Insufflation pressures from SIB are difficult to assess and can be inadequate. Ventilation monitoring improves pressure control, but is not accessible to most resuscitators. Small spring manometer or a pressure line to a needle and dial manometer can be connected through a side port on the SIB. Those devices are cheap and easily available, but their efficacy needs to be assessed. Observation of the manometer could also be considered as a distraction, with increased risk of leak or inadequate insufflation rate. We therefore aimed to evaluate the effect of mechanical manometers on the quality of insufflations with a SIB. MATERIALS AND METHODS: Participants to the Belgian Pediatric Society meeting were invited to ventilate a manikin with a 300 ml SIB. The leak-free manikin was modified with a flow-meter at tracheal level connected to a neonatal test lung. Participants had to aim for a 25 mbar pressure and a rate of 40-60 during 3 sequences of 45 seconds. A spring (S), a dial (D) manometer or nothing (N) was added to the SIB in random sequence. Pressure data from the SIB and flow data from the manikin were obtained through a ventilation monitor. Peak pressure (PIP), tidal volume (VTi), and insufflations rate (RR) were calculated for each breath. Theoretical leak was evaluated by subtracting real from theoretical volumes derived from a leak free calibration (taped facemask). Data were analyzed with ANOVA and posthoc Bonferroni. RESULTS Five neonatologists (Neo), 15 pediatricians (Ped) and 11 residents ventilated the manikin for a total of 5279 insufflations. Manometer use was associated with an increase in PIP (N: 17+-6 mbar; S: 18+-4 mbar*; D: 19+-4 mbar*#) [*p<.05 vs N; #:p<.05 vs S]. Changes in VTi (N: 3+-1 ml; S: 3.1+-1 ml*; D: 3.2+-1 ml*) and RR (77-82 bpm) were small. Leak did not increase. The effect of manometer use on PIP, VTi and leak was more important with Neo (PIP-N: 16+-7 mbar; S and D: 20+-4 mbar*) and Ped. With residents, no change occurred in PIP (~17 mbar), Vti (2.9 ml) or leak (31-35%). However, for first sequences of ventilation, manometer use was associated with higher PIP (N: 12+-4 mbar; S: 16+-3 mbar*; D: 20+-4 mbar*#), VTi (N:2+-1 ml; S:3+-0.8 ml*; D:3.3+-1 ml*#) and lower leaks (N: 38+-16%; S: 27+-12%*; D: 34+-13%*#). This observation for first sequences was found in all 3 categories of providers. CONCLUSIONS Bag and mask ventilation remains difficult. In this model, the addition of a manometer is associated with improved pressures and VTi, and with decreased theoretical leak. This effect is predominant for initial (“naïve”) ventilation with a dial manometer, and is also related to operator experience. Small, inexpensive manometers have the potential to improve SIB ventilation of newborn infants. [less ▲]

Detailed reference viewed: 15 (1 ULg)
Full Text
Peer Reviewed
See detailSubjective assessment of perinatal adaptation and respiratory management in <29 weeks infants
RIGO, Vincent ULg; BROUX, Isabelle ULg; de HALLEUX, Virginie ULg et al

Poster (2015, March 12)

Background A primary CPAP strategy is beneficial even in extremely preterm infants. Many still require intubation for stabilization. Half of those managed with primary CPAP will also require further ... [more ▼]

Background A primary CPAP strategy is beneficial even in extremely preterm infants. Many still require intubation for stabilization. Half of those managed with primary CPAP will also require further support: surfactant administration or mechanical ventilation, and have increased risks of death or neonatal morbidities, and will require longer respiratory support. Identifying them early, during the birth stabilization process, might lead to improvements in respiratory care. A subjective classification of perinatal adaptation as Good, Bad or Marginal has been suggested but not evaluated. Methods Single center retrospective study of <29 weeks premature infants admitted between 01/2013 and 07/2014. Neonatal database and discharge summaries provide neonatal care and outcome data. Good perinatal adaptation (GPA) is considered for infants with good respiratory drive, tone and low oxygen requirement in the delivery room. Infants with marginal (M) PA had intermittent respiratory drive, normocardia with ventilation, and decreasing FiO2. Bad (B) PA is considered with hypotonia, bradycardia, apnea and high FiO2. Results Among 58 infants (50 inborn), 16 had GPA, 19 MPA and 23 BPA. Risk factors for bad adaptation are (not significantly different-NS) male gender, lower GA , and absent/incomplete antenatal steroid exposure. Apgar score at 1 minute increases according to perinatal adaptation quality (B3,5; M5,5 and G7,4; p<0,01), with improvements at 5 minutes: 6,6; 7,0 (NS) and 8,3 (p(B)<0,01). Risk of intubation in the delivery room is associated with poorer adaptation: B83%, M58% and G12% (p<0,01). Primary CPAP success was not different according to groups (B 3/3; M66%; G56%). However, more infants with MPA received surfactant while on CPAP (LISA method): B 2/3; M:5/6 and G:4/7. This surfactant was given in the delivery room in 1, 4 and 2 infants respectively. For children intubated within day 3, the duration of the first invasive ventilation duration was 29 hours (B), 15h (M) and 9h (G), NS. Risk of early neonatal death decreases with improving perinatal adaptation: 26%, 16% (NS) and 0% (pB <0,05). Risk of BPD at 36 weeks is not different among groups (B 19%, M13%, G 12%), but combined risk of death or BPD at 36 weeks tends to decreases (B 43%, M 31%, G 12%, p=0,12). Conclusions Better perinatal adaptation improves chances of being initially managed with CPAP. CPAP success may be improved with less invasive surfactant therapy, especially in preterm infants with marginal adaptation. Perinatal adaptation assessment identifies mortality risk. [less ▲]

Detailed reference viewed: 14 (0 ULg)
Full Text
Peer Reviewed
See detailL'histiocytose de Langerhans, une cause rare de Blueberry Muffin Syndrome
Kreins, Nathalie; Kalenga, Masendu ULg; RIGO, Vincent ULg

in Tijdschrift van de Belgische Kinderarts = Journal du Pédiatre Belge (2015, March 12), 17(1), 72

La présentation du Blueberry Muffin Syndrome est typique, et permet de rapidement orienter le bilan étiologique. La biopsie cutanée est importante pour établir le diagnostic, qui lui-même conditionne le ... [more ▼]

La présentation du Blueberry Muffin Syndrome est typique, et permet de rapidement orienter le bilan étiologique. La biopsie cutanée est importante pour établir le diagnostic, qui lui-même conditionne le pronostic. [less ▲]

Detailed reference viewed: 13 (1 ULg)
Full Text
Peer Reviewed
See detailImplementation of placental transfusion protocol
Lefebvre, Caroline; MASSON, Véronique ULg; Kalenga, Masendu ULg et al

in Tijdschrift van de Belgische Kinderarts = Journal du Pédiatre Belge (2015, March 12), 17(1), 72

A clear protocol for placental transfusion gives the opportunity to improve care of preterm infants. Initial information session and simulation practice for medical and midwifes staffs helps with its ... [more ▼]

A clear protocol for placental transfusion gives the opportunity to improve care of preterm infants. Initial information session and simulation practice for medical and midwifes staffs helps with its implementation. Delayed clamping and cord milking are not difficult after a learning phase like for most new procedures. [less ▲]

Detailed reference viewed: 11 (1 ULg)
Full Text
Peer Reviewed
See detailBenefits of placental transfusion in very preterm infants
Lefebvre, Caroline; MASSON, Véronique ULg; Kalenga, Masendu ULg et al

in Tijdschrift van de Belgische Kinderarts = Journal du Pédiatre Belge (2015, March), 17(1), 84

Introduction Cord clamping is not a trivial process. Its timing influences the significant physiological changes involved with this nearly universal practice. While the fetal and placental blood volumes ... [more ▼]

Introduction Cord clamping is not a trivial process. Its timing influences the significant physiological changes involved with this nearly universal practice. While the fetal and placental blood volumes add up to 100-120 ml/kg, their distributions differ between preterm and term neonates. The placenta accounts for 50% of the total blood volume in preterm infants and for only 33% in term neonates. Placental transfusion for 60 seconds increases neonatal blood volume by ± 16 ml/kg. In randomized trials, delayed cord clamping in preterm birth is associated with a more stable transitional circulation, a decrease need for inotropic support, and reduce blood transfusions, necrotizing enterocolitis, and intraventricular hemorrhages. Given those benefits, placental transfusion is integrated systematically in our management of preterm births since October 2013. This study aims to confirm expected benefits in a clinical setting. Patients and Methods We conducted a retro-prospective trial in a single tertiary care center. Very preterm infants (VPTi; <32 weeks GA) and VLBWi (BW<1500g) born between April 1st and September 30th 2013 were managed conventionally, with early cord clamping and constitute the control group. These data were collected retrospectively. October 2013 is the month for the new protocols implementation, and infants born this month are not included. Data from VPTi and VLBWi with delayed cord clamping or cord milking were collected prospectively from November 1st 2013 to April 30st 2014. Exclusion criteria were maternal and fetal vital emergencies, Rhesus sensitization, known major congenital abnormalities, tight nuchal cord, meconium teinted liquor, or mother infection by HIV or hepatitis. Results Fifty-two patients are included in the control group. In the second period, 26/XX preterm infants received a placental transfusion, including 6 with a 60 seconds delay in cord clamping and 20 with cord milking. Maternal and neonates’ characteristics were not significantly different. Mean birth weights (BW) were 1208g in the control and 1157g in the placental transfusion groups, with mean gestational age of 28 weeks 4/7 and 28 weeks 6/7, respectively. Mean arterial pressure is significantly increased with placental transfusion (H0 p=0.0006), (H12 p=0.032), (H24 p=0.01). Hemoglobin (H24 p=0,01) and hematocrit (H0 p=0,03), (H12 p=0,05), (H24 p=0,007) are also significantly higher. The number of transfusions per patient transfused (early group 3±2.5 vs. placental transfusion 1±0.4) is significantly lower (p=0.038). No infant with a BW>950g managed with delayed clamping or cord milking did required a transfusion. Conclusion Placental transfusion is associated with a higher blood pressure during the first 24 hours. Placental transfusion also reduces transfusion requirements, with reduction in the number of multi-transfused patients. We found this procedure safe and did not identify short or medium term adverse effects. For preterm infants, the third stage of labor management should evolve toward a more physiological practice, with systematic placental transfusion. [less ▲]

Detailed reference viewed: 12 (1 ULg)
Full Text
Peer Reviewed
See detailIs early aggressive feeding dangerous for extremely low birth weight infants?
Blecic, Anne-Sophie; Delbos, Marion; RIGO, Vincent ULg et al

in Tijdschrift van de Belgische Kinderarts = Journal du Pédiatre Belge (2015), 17(1), 83

Detailed reference viewed: 58 (10 ULg)
Full Text
Peer Reviewed
See detailCerebellar hemorrhage : a rare condition in the term infant
MERINDOL, Ninon; BROUX, Isabelle ULg; DECORTIS, Thierry et al

Poster (2015)

Cerebellar hemorrhage is a rare condition in full-term newborns. Early diagnosis based on the identification of risk factors, particular clinical signs and correct medical imaging is primordial to ... [more ▼]

Cerebellar hemorrhage is a rare condition in full-term newborns. Early diagnosis based on the identification of risk factors, particular clinical signs and correct medical imaging is primordial to optimize the immediate treatment and to assess the long term prognosis. [less ▲]

Detailed reference viewed: 89 (14 ULg)
Full Text
Peer Reviewed
See detailUne occlusion digestive inhabituelle chez un prématuré, à propos d’un cas.
Fontaine, Célia; GILSON, Nathalie ULg; PIELTAIN, Catherine ULg et al

Poster (2014, March 20)

Appendicitis in the newborn is a rare but difficult diagnosis. Delayed diagnosis and a risk of complications as digestive perforation, peritonitis and sepsis are associated with a high mortality and ... [more ▼]

Appendicitis in the newborn is a rare but difficult diagnosis. Delayed diagnosis and a risk of complications as digestive perforation, peritonitis and sepsis are associated with a high mortality and morbidity risk. [less ▲]

Detailed reference viewed: 16 (0 ULg)
Full Text
Peer Reviewed
See detailPrise en charge des enfants à risque de sevrage.
Counson, Florence; Decortis, Thierry; Kalenga, Masendu ULg et al

in Tijdschrift van de Belgische Kinderarts = Journal du Pédiatre Belge (2014, March)

Description of care and outcomes of infants at risk of withdrawal syndrom from in utero exposure to addictive of psychotropic drugs.

Detailed reference viewed: 17 (0 ULg)
Full Text
Peer Reviewed
See detailThrombose veineuse rénale : un cas didactique
Tribolet, Sophie ULg; DRESSE, Marie-Françoise ULg; Lombet, Jacques et al

in Journal du pédiatre Belge (2014)

On retiendra que, devant toute hématurie macroscopique accompagnée d’une thrombocytopénie, d’une masse abdominale et/ou d’une anurie, voire d’une hypertension artérielle chez un nouveau-né, le diagnostic ... [more ▼]

On retiendra que, devant toute hématurie macroscopique accompagnée d’une thrombocytopénie, d’une masse abdominale et/ou d’une anurie, voire d’une hypertension artérielle chez un nouveau-né, le diagnostic de thrombose veineuse rénale doit être évoqué. L’échographie Doppler rénale est l’examen de choix pour le confirmer. En l’absence de consensus thérapeutique, outre la surveillance et la correction éventuelle des troubles hydroélectrolytiques, une héparinothérapie pourrait être initiée afin d’éviter l’extension thrombotique. La fibrinolyse est à réserver aux cas exceptionnels d’atteinte bilatérale. Cette pathologie reste malheureusement grevée d’une morbidité importante, avec parfois une atrophie, une insuffisance rénale et une hypertension artérielle. [less ▲]

Detailed reference viewed: 32 (4 ULg)
Full Text
Peer Reviewed
See detailCOMMENT J’EXPLORE ET TRAITE UNE THROMBOSE VEINEUSE RÉNALE NÉONATALE : à propos d’un cas
Tribolet, S.; DRESSE, Marie-Françoise ULg; Lombet, J. et al

in Revue Médicale de Liège (2014), 69(4), 169-174

Neonatal renal vein thrombosis is a rare condition. The present case is rather unfrequent and particularly educative since it shows the complete diagnostic triad including hematuria, flank mass and ... [more ▼]

Neonatal renal vein thrombosis is a rare condition. The present case is rather unfrequent and particularly educative since it shows the complete diagnostic triad including hematuria, flank mass and thrombocytopenia. The diagnosis relies on the demonstration, by Doppler ultrasound, of an obstructed renal venous bed. The investigation is completed by a platelet count and the determination of the prothrombin time, of the activated partial thromboplastin time as well as of the concentration of fibrinogen. The screening also includes the search for a possible etiology, such as a deficiency in coagulation proteins, the presence of antiphospholipid antibodies or of a genetic mutation of one of the coagulation factors. Since there exist no evidence based guidelines for the management of the disease, we will discuss the diagnosis and treatment in relation with the published literature. [less ▲]

Detailed reference viewed: 43 (8 ULg)
Peer Reviewed
See detailAn unusual presentation for congenital cytomegalovirus infection
Hennuy, Nadège; PIERART; Demarche, Martine et al

Poster (2014)

Detailed reference viewed: 28 (8 ULg)
Full Text
Peer Reviewed
See detailSurprising causes of C5-carnitine false positive results in newborn screening.
BOEMER, François ULg; SCHOOS, Roland ULg; de HALLEUX, Virginie ULg et al

in Molecular genetics and metabolism (2014), 111(1), 52-4

During an 18-month period, we noticed an alarming increase of newborn screening false positivity rate in identifying isovaleric acidemia. In 50 of 50 newborns presenting elevated C5-carnitine, we ... [more ▼]

During an 18-month period, we noticed an alarming increase of newborn screening false positivity rate in identifying isovaleric acidemia. In 50 of 50 newborns presenting elevated C5-carnitine, we confirmed the presence of pivaloylcarnitine. Exogenous pivalate administration had been previously identified as the causal agent of this concern. No pivalic-ester prodrug is commercially available in Belgium, but pivalic derivates are also used in the cosmetic industry as emollient under the term "neopentanoate". We have identified neopentanoate-esters in a nipple-fissure unguent that was provided to young mothers. Ceasing distribution of this product hugely reduced the C5-carnitine false positivity rate. [less ▲]

Detailed reference viewed: 77 (22 ULg)