References of "Joossens, M"
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See detailMucosal gene signatures to predict response to infliximab in patients with inflammatory bowel disease
Arijs, I.; Van Lommel, L.; Van Steen, Kristel ULg et al

in Acta Gastro-Enterologica Belgica (2008)

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See detailStability Of Gut Microbiota Over Time In Crohn's Disease Patients Compared To Healthy Relatives
Joossens, M.; De Preter, V.; Van Steen, Kristel ULg et al

in Journal of Crohn’s and Colitis [=JCC] (2008), 2(1), 94

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See detailLong-term efficacy of infliximab and colectomy-free survival in outpatients with refractory ulcerative colitis.
Ferrante, M.; Vermeire, S.; Schnitzler, F. et al

in Journal of Crohn’s and Colitis [=JCC] (2008), 2(1), 3

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See detailStability of gut microbiota over time in Crohn's disease patients compared to healthy relatives
Joossens, M.; De Preter, V.; Van Steen, Kristel ULg et al

in Gastroenterology (2008), 134(4), 653-653

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See detailMucosal gene signatures to predict response to infliximab in patients with inflammatory bowel disease
Arijs, I.; Van Lommel, L.; Van Steen, Kristel ULg et al

in Journal of Crohn’s and Colitis [=JCC] (2008), 2(1), 64

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See detailGenetic markers and the risk of complicated disease behaviour in Crohn's disease patients
Henckaerts, L.; Cleynen, I.; Joossens, M. et al

in Gastroenterology (2008), 134(4), 349-349

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See detailMucosal gene signatures to predict response to infliximab in patients with inflammatory bowel disease.
Arijs, I.; Van Lommel, L.; Van Steen, Kristel ULg et al

in Gastroenterology (2008), 134

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See detailMicroarray study of mucosal antimicrobial peptides in patients with inflammatory bowel disease before and after infliximab treatment.
Arijs, I.; Van Lommel, L.; Van Steen, Kristel ULg et al

in Journal of Crohn’s and Colitis [=JCC] (2008), 2(1), 60

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See detailLong term stability of gut microbiota in Crohn’s disease patients compared to healthy relatives
Joossens, M.; De Preter, V.; Van Steen, Kristel ULg et al

in Acta Gastro-Enterologica Belgica (2008), 71

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See detailFaecal bacterial dgge profiles of Crohn's disease patients are different from those of their healthy first degree relatives and matched healthy controls
Joossens, M.; Vanhoutte, T.; De Preter, V. et al

in Gastroenterology (2007), 132(4), 704-704

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See detailMixed IBD families: A distinct entity within IBD
Pierik, M.; Van Steen, Kristel ULg; Joossens, M. et al

in Gastroenterology (2007), 132(4), 450-450

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See detailFaecal bacterial DGGE profiles of Crohn’s disease patients are different from those of their healthy first degree relatives and matched healthy controls
Joossens, M.; Vanhoutte, T.; De Preter, V. et al

in Acta Gastro-Enterologica Belgica (2007)

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See detailNew serological markers in inflammatory bowel disease are associated with complicated disease behavior
Ferrante, M.; Henckaerts, L.; Joossens, M. et al

in Gut (2007), 56(10), 1394-1403

OBJECTIVE: The human androgen receptor (AR) contains a polyglutamine and a polyglycine stretch which are highly polymorphic and are coded respectively by a CAG and GGN repeat in exon 1 of the AR gene ... [more ▼]

OBJECTIVE: The human androgen receptor (AR) contains a polyglutamine and a polyglycine stretch which are highly polymorphic and are coded respectively by a CAG and GGN repeat in exon 1 of the AR gene. Although the in vitro studies indicated a possible effect of the GGN repeat polymorphism on the AR gene transcription and clinical observations suggest that it might modulate the androgen action, its functional significance remains unclear. We wanted to assess whether the GGN repeat affects the serum testosterone levels in healthy men, which is the expected outcome through feedback regulation if it influences androgen action as has been shown to be the case for the CAG repeat. DESIGN AND PATIENTS: A population based cross-sectional cohort study including 1476 healthy young, middle-aged, and elderly men. MEASUREMENT: Testosterone and LH levels were determined by immunoassay; free testosterone (FT) levels were calculated. Genotyping of the GGN repeat was performed using the sequencing technique. RESULTS: The GGN repeat number was significantly associated with circulating testosterone and FT levels (P=0.017 and P=0.013 respectively). However, taking into account that age, body mass index, and CAG are already in the regression model, the GGN repeat could explain only a small part of the variation of both testosterone and FT. CONCLUSION: To our knowledge, this study is the first to demonstrate a significant positive association between the GGN repeat and androgen levels in a large cohort of healthy men. Although the present study thus adds credence to the view that the polyglycine tract in the AR can modulate AR action, this effect appears to be only small so that its clinical relevance remains questionable. [less ▲]

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See detailFaecal bacterial molecular profiles of Crohn’s disease patients differ from their healthy relatives and matched healthy controls.
Joossens, M.; De Preter, V.; Vanhoutte, T. et al

in Gut (2007), 56(Suppl III), 5

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