References of "Jodogne, C"
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See detailBehavioral sensitization and tolerance to the D-sub-2 agonist RU 24213 : dissociation between several patterns in mice
Tirelli, Ezio ULg; Jodogne, C.

in Pharmacology, Biochemistry & Behavior (1993), 44(3), 627-632

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See detailOxytocin blocks the environmentally conditioned compensatory response present after tolerance to ethanol-induced hypothermia in mice
Tirelli, Ezio ULg; Jodogne, C.; Legros, Jean-Jacques ULg

in Pharmacology, Biochemistry & Behavior (1992), 43(4), 1263-1267

The present study tested the hypothesis that the attenuation by oxytocin of tolerance to ethanol-induced hypothermia relies upon an impairment of the putative conditioning processes underlying environment ... [more ▼]

The present study tested the hypothesis that the attenuation by oxytocin of tolerance to ethanol-induced hypothermia relies upon an impairment of the putative conditioning processes underlying environment-specific tolerance. According to the conditioning model of tolerance, such tolerance occurs because an opposite compensatory response conditioned to ethanol-paired cues attenuates ethanol's effects. Tolerance to ethanol-induced hypothermia was established to a particular environment over 4 days by injecting mice (daily) with oxytocin 2 h before ethanol, outside the colony room. As controls, other mice were injected similarly but following testing in the animal room. We found that oxytocin suppressed the conditioned compensatory response, revealed by injecting saline to every group in the tolerance-associated environment. These results suggest that oxytocin acted, at least partly, via an inhibition of the associative learning processes that facilitate tolerance development. [less ▲]

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See detailOxytocin attenuates tolerance not only to the hypothermic but also to the myorelaxant and akinesic effects of ethanol in mice
Jodogne, C.; Tirelli, Ezio ULg; Klingbiel, P. et al

in Pharmacology, Biochemistry & Behavior (1991), 40(2), 261-265

Inhibition of ethanol tolerance by oxytocin has been demonstrated previously using the hypothermic effect only. The purpose of the present experiment was to investigate the effect of oxytocin on the ... [more ▼]

Inhibition of ethanol tolerance by oxytocin has been demonstrated previously using the hypothermic effect only. The purpose of the present experiment was to investigate the effect of oxytocin on the development of tolerance to ethanol-induced hypothermia, myorelaxation and akinesia in mice. Four groups of mice received daily intraperitoneal injections of saline or oxytocin (0.005 mg) plus saline or ethanol (2 g/kg). The peptide was administered 2 hours before ethanol. For five consecutive days, temperature measurements were performed 20 minutes before and after ethanol injection. Myorelaxation and akinesia were evaluated following the second temperature measure. Oxytocin pretreatment, which had no intrinsic effects, resulted in a robust selective attenuation of tolerance to ethanol-induced hypothermia, myorelaxation and akinesia. These results suggest that the mechanisms for peptide modulation are common to these three typical effects of ethanol. [less ▲]

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See detailAdult-like biphasic neurobehavioral changes induced by a GABA-A agonist in infant and weanling mice
Tirelli, Ezio ULg; Jodogne, C.; Perikel, J. J.

in Brain Research. Developmental Brain Research (1991), 61(2), 207-215

The neurobehavioral responsivity to peripherally injected muscimol, a gamma-aminobutyric acid-A (GABA-A) agonist, was assessed in infant (14-day-old), weanling (20-day-old) and young adult (53-day-old ... [more ▼]

The neurobehavioral responsivity to peripherally injected muscimol, a gamma-aminobutyric acid-A (GABA-A) agonist, was assessed in infant (14-day-old), weanling (20-day-old) and young adult (53-day-old) outbred male mice. In the first experiment, relatively high doses of muscimol (ranging from 0.05 to 0.40 mg/kg in developing and from 0.50 to 3 mg/kg in adult animals) were found to dose-dependently induced solid catalepsy and ataxia, evaluated 5 times at 20-min intervals. In the second experiment, the GABA agonist was injected in dose ranges which include relatively small concentrations in order to assess its excitatory properties, observable in adults, on rearing and locomotion in developing mice. It appeared that levels of rearing and especially locomotion were enhanced at the low doses (0.025 and 0.050 mg/kg in developing, and 1.3 and 1.9 mg/kg in adult mice) and inhibited at the higher ones (0.150 mg/kg in developing and 1.9 and 2.5 mg/kg in adult mice). This adult-like biphasic action of muscimol in developing mice--excitation at low and depression/sedation at high doses--strongly suggests a full maturation of the GABA-A-related behavioral functions at a period of ontogeny where adult-like locomotion emerges. Given that previous studies have shown that muscimol can biphasically affect behavioral activity in newborn murines as well, it is suggested that GABA-related behavioral functions mature near-monotonically during ontogeny, unlike those related to other major neurotransmitter systems. [less ▲]

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See detailAdult-like neurobehavioral changes induced by a GABA-A agonist in infant and weanling mice
Tirelli, Ezio ULg; Jodogne, C.; Perikel, J.

in Developmental Brain Research (1991), 61(2), 207-215

Neurobehavioral responsivity to peripherally injected muscimol, a gamma-aminobutyric acid-A (GABA-A) agonist, was assessed in infant (14-day-old), weanling (20-day-old), and young adult (53-day-old ... [more ▼]

Neurobehavioral responsivity to peripherally injected muscimol, a gamma-aminobutyric acid-A (GABA-A) agonist, was assessed in infant (14-day-old), weanling (20-day-old), and young adult (53-day-old) outbred male mice. In Exp 1, relatively high doses of muscimol (0.05-0.40 mg/kg in developing and 0.50-3 mg/kg in adult Ss) were found to dose-dependently induce solid catalepsy and ataxia. In Exp 2, the GABA agonist was injected in dose ranges that included relatively small concentrations to assess its excitatory properties, observable in adults, on rearing and locomotion in developing mice. Levels of rearing and especially locomotion were enhanced at low doses (0.025-0.050 mg/kg in developing and 1.3-2.9 mg/kg in adult mice) and inhibited at higher ones (0.150 mg/kg in developing and 1.9 and 2.5 mg/kg in adult mice). ((c) 1997 APA/PsycINFO, all rights reserved) [less ▲]

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See detailModulation of tolerance to the GABA-sub(A) agonist THIP by environmental cues
Jodogne, C.; Tirelli, Ezio ULg

in Behavioural Brain Research (1990), 36(1-2), 33-40

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See detailDopamine-GABAergic mechanisms of rearing and locomotion in infant and weanling mice
Tirelli, Ezio ULg; Jodogne, C.

in Psychobiology (1990), 18(4), 443-450

Examined tue modulatory effects of the gamma-aminobutyric acid(GABA)-A agonist muscimol on supported rearing and locomotion induced by the indirect dopamine agonist D-amphetamine (DAM). A total of 288 ... [more ▼]

Examined tue modulatory effects of the gamma-aminobutyric acid(GABA)-A agonist muscimol on supported rearing and locomotion induced by the indirect dopamine agonist D-amphetamine (DAM). A total of 288 infant, weanling, and adult outbred mice were tested in 2 experiments. In adult mice, muscimol at 1,3 mg/kg DAM-induced locomotion but not rearing, whereas 1,9 mg/kg muscimol blocked both behaviors. While 0,025 mg/kg muscimol reduced 2mg/kg DAM-induced rearing without altering locomotion in infants, it affected neither rearing nor locomotion in weanlings. In infant mice, 0,075 mg/kg muscimol engendered gnawing and self-biting, a typical effect of dopamine^GABAergic pharmacological activation. Maturation of dopamine^GABAergic behavioral functions may follow a near-monotonic continuity starting a few days after birth. ((c) 1997 APA/PsycINFO, all rights reserved) [less ▲]

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