References of "Jespers, P"
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See detailEffect of heart failure on dipeptidyl peptidase IV activity in plasma of dogs.
Gomez, N.; Matheeussen, V.; Damoiseaux, Cécile ULg et al

in Journal of Veterinary Internal Medicine (2012)

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See detailHigh serum transforming growth factor-beta 1 concentration in West Highland white terriers : a key to the breed predisposition in canine idiopathic pulmonary fibrosis
Krafft, Emilie ULg; Heikkilä, H.P.; Jespers, P et al

in Proceedings of the 21st ECVIM-CA Congress (2011, September)

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See detailDipeptidyl peptidase IV activity in plasma of dogs : physiological determinants and effect of heart failure
Gomez, Nelson; Matheeussen, V.; Tamborini, A. et al

in 21th ECVIM Meeting - Séville, Espagne - du 6 au 10 septembre 2011 (2011, September)

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See detailSerum and bronchoalveolar lavage fluid endothelin-1 concentrations as diagnostic biomarkers of canine idiopathic pulmonary fibrosis
Krafft, Emilie ULg; Heikkilä, H. P.; Jespers, P. et al

in Journal of Veterinary Internal Medicine (2011)

Background: Diagnosis of canine idiopathic pulmonary fibrosis (IPF) is challenging. Endothelin-1 (ET1) is a biomarker of IPF in humans, but whether ET1 can detect and differentiate IPF from other canine ... [more ▼]

Background: Diagnosis of canine idiopathic pulmonary fibrosis (IPF) is challenging. Endothelin-1 (ET1) is a biomarker of IPF in humans, but whether ET1 can detect and differentiate IPF from other canine respiratory diseases is unknown. Objective: To evaluate whether measurement of the concentration of ET1 in serum and bronchoalveolar lavage fluid (BALF) can be used to distinguish canine IPF from chronic bronchitis (CB) and eosinophilic bronchopneumopathy (EBP). Animals: Twelve dogs with IPF, 10 dogs with CB, 6 dogs with EBP, 13 privately owned healthy West Highland White Terriers (WHWT), and 9 healthy Beagle dogs. Methods: Prospective, case control study. ET1 concentration was determined by ELISA in serum and in BALF. Results: No significant difference in serum ET1 concentration was detected between healthy Beagle dogs and WHWT. Serum ET1 concentration was higher in dogs with IPF (median interquartile range; 2.32 pg/mL, 2.05-3.38) than healthy Beagle dogs (1.28, 1.07-1.53; P < .001), healthy WHWT (1.56, 1.25-1.85; P < .001), dogs with EBP (0.94 0.68-1.01; P = .001), and dogs with CB (1.54 0.74-1.82; P = .005). BALF ET1 concentration was below the detection limit in healthy WHWT and in dogs with CB, whereas it was measurable in all dogs with IPF. A cut-off serum concentration of 1.8 pg/mL had a sensitivity of 100% and a specificity of 81.2% for detection of IPF, with an area under the receiver operating characteristic curve of 0.818. Conclusions and Clinical Importance: Serum ET1 can differentiate dogs with IPF from dogs with EBP or CB. ET1 can be detected in BALF of dogs with IPF. [less ▲]

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See detailProcollagen type III amino terminal propeptide concentration in dogs with iodiopathic pulmonary fibrosis, chronic bronchitis and eosinophilic bronchopneumopathy
Heikkilä, H. P.; Krafft, Emilie ULg; Jespers, P. et al

in 20th ECVIM Meeting - Toulouse - France - 9-12 septembre 2010 (2010, September 09)

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See detailSerum endothelin-1 concentration in terrier dogs with idiopathic pulmonary fibrosis.
Krafft, Emilie ULg; Heikkilä, H.; Jespers, P. et al

in Proceedings of the 28th ACVIM Forum (2010, June)

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See detailEndothelin-1 as a serum biomarker in idiopathic pulmonary fibrosis in dogs
Krafft, Emilie ULg; Heikkilä, H.P.; Jespers, P. et al

in Proceedings of the 20th ECVIM-CA Congress (2010)

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See detailIs transforming growth factor- beta 1 involved in the pathogenesis of IPF in dogs ?
Krafft, Emilie ULg; Heikkilä, H. P.; De Lorenzi, D. et al

in Proceedings of the 20th Annual Congress of the ECVIM-CA (2010)

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See detailProcollagen Type-III aminoterminal peptide in serum, bronchoalveolar lavage fluid and bronchial brush specimens in a model of chronic bronchitis in dogs
Lonneux, M.; Bolognin, M.; Jespers, P. et al

in 19h ECVIM Meeting - Porto, Portugal - 8-10 septembre 2009 (2009, September 08)

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See detailAnalytical, physiologic, and clinical validation of a radioimmunoassay for measurement of procollagen type III amino terminal propeptide in serum and bronchoalveolar lavage fluid obtained from dogs
Schuler, S.; Valentin, S.; Remy, Bernadette et al

in American Journal of Veterinary Research (2006), 67(5), 749-755

OBJECTIVE: To validate a radioimmunoassay for measurement of procollagen type III amino terminal propeptide (PIIINP) concentrations in canine serum and bronchoalveolar lavage fluid (BALF) and investigate ... [more ▼]

OBJECTIVE: To validate a radioimmunoassay for measurement of procollagen type III amino terminal propeptide (PIIINP) concentrations in canine serum and bronchoalveolar lavage fluid (BALF) and investigate the effects of physiologic and pathologic conditions on PIIINP concentrations. SAMPLE POPULATION: Sera from healthy adult (n = 70) and growing dogs (20) and dogs with chronic renal failure (CRF; 10), cardiomyopathy (CMP; 12), or degenerative valve disease (DVD; 26); and sera and BALF from dogs with chronic bronchopneumopathy (CBP; 15) and healthy control dogs (10 growing and 9 adult dogs). PROCEDURE: A radioimmunoassay was validated, and a reference range for serum PIIINP (S-PIIINP) concentration was established. Effects of growth, age, sex, weight, CRF, and heart failure on S-PIIINP concentration were analyzed. In CBP-affected dogs, S-PIIINP and BALF-PIIINP concentrations were evaluated. RESULTS: The radioimmunoassay had good sensitivity, linearity, precision, and reproducibility and reasonable accuracy for measurement of S-PIIINP and BALF-PIIINP concentrations. The S-PIIINP concentration reference range in adult dogs was 8.86 to 11.48 mug/L. Serum PIIINP concentration correlated with weight and age. Growing dogs had significantly higher S-PIIINP concentrations than adults, but concentrations in CRF-, CMP-, DVD-, or CBP-affected dogs were not significantly different from control values. Mean BALF-PIIINP concentration was significantly higher in CBP-affected dogs than in healthy adults. CONCLUSIONS AND CLINICAL RELEVANCE: In dogs, renal or cardiac disease or CBP did not significantly affect S-PIIINP concentration; dogs with CBP had high BALF-PIIINP concentrations. Data suggest that the use of PIIINP as a marker of pathologic fibrosis might be limited in growing dogs. [less ▲]

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See detailProcollagen type-III aminoterminal peptide in serum and bronchoalveolar lavage fluid in dogs with chronic bronchopneumopathies – preliminary results
Schuller, S.; Talavera, J.; Jespers, P. et al

in 15th ESVIM Meeting - Glasgow - Ecosse - Septembre 2005 (2005, September)

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See detailAnalytical, physiological and clinical validation of a radioimmunoassay for serum Procollagen Type-III aminoterminal peptide in the dog
Schuller, S.; Valentin, S.; Remy, B. et al

in 14th ESVIM Meeting - Barcelona - Espagne (2004, June)

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