 Release and Innate detection of host cell DNA mediates the adjuvant effects of aluminum salts on adaptive responsesMarichal, Thomas  ; ; et alin Proceedings of the 1St Winter School Immunology (2012, January) Detailed reference viewed: 26 (6 ULg) Nucleic acid sensing at the interface between innate and adaptive immunity in vaccinationDesmet, Christophe ; in Nature Reviews. Immunology (2012), 12(7), 479-491 The demand is currently high for new vaccination strategies, particularly to help combat problematic intracellular pathogens, such as HIV and malarial parasites. In the past decade, the identification of ... [more ▼] The demand is currently high for new vaccination strategies, particularly to help combat problematic intracellular pathogens, such as HIV and malarial parasites. In the past decade, the identification of host receptors that recognize pathogen-derived nucleic acids has revealed an essential role for nucleic acid sensing in the triggering of immunity to intracellular pathogens. This Review first addresses our current understanding of the nucleic acid-sensing immune machinery. We then explain how the study of nucleic acid-sensing mechanisms not only has revealed their central role in driving the responses mediated by many current vaccines, but is also revealing how they could be harnessed for the design of new vaccines. [less ▲] Detailed reference viewed: 14 (4 ULg)DNA released from dying host cells mediates aluminum adjuvant activityMarichal, Thomas ; ; et alin Nature Medicine (2011), 17 Aluminum-based adjuvants (alum) are widely used in human vaccination, although little is understood of their mechanisms of action. Here, we report that, in mice, alum causes the release of host cell DNA ... [more ▼] Aluminum-based adjuvants (alum) are widely used in human vaccination, although little is understood of their mechanisms of action. Here, we report that, in mice, alum causes the release of host cell DNA, which acts as a potent endogenous immunostimulatory signal mediating alum adjuvant activity. Furthermore, we propose that host DNA signaling differentially regulates IgE and IgG1 production upon alum immunization. Indeed, we support that host DNA induces primary B cell responses, including IgG1 production, through Interferon Response Factor (Irf) 3-independent mechanisms, and 'canonical' type 2 T cell responses associated with IgE isotype switching and peripheral effector responses through Irf3-dependent mechanisms. The finding that host cell DNA is a damage-associated molecular pattern relaying alum adjuvant activity may thus help in the comprehension of the mechanisms of action of current vaccines and in the design of novel adjuvants. [less ▲] Detailed reference viewed: 94 (24 ULg)Release and innate detection of host cell DNA mediates the adjuvant effects of aluminum saltsMarichal, Thomas ; ; et alin Proceedings of te 4th International Conference on Crossroads between Innate and Adaptive Immunity (2011) Detailed reference viewed: 15 (2 ULg)IRF-3 dependent activation of inflammatory dendritic cells by extracellular host DNA mediates the adjuvant activity of alum on Th2 responsesMarichal, Thomas ; ; et alin Proceedings of the 25th annual meeting of the European Macrophage and Dendritic Cell Society (2011) Detailed reference viewed: 9 (3 ULg)Self-DNA release mediates the adjuvant effect of aluminum saltsMarichal, Thomas ; ; et alin Proceedings of the 4th meeting on Harnessing immunity to prevent and treat diseases (2011) Detailed reference viewed: 15 (4 ULg) |
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