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See detailDevelopment, validation and comparison of NIR and Raman methods for the identification and assay of poor-quality oral quinine drops.
Mbinze Kidenge, Jérémie; Sacre, Pierre-Yves ULg; Yemoa, Achille et al

in Journal of Pharmaceutical & Biomedical Analysis (2015), 111

Poor quality antimalarial drugs are one of the public’s major health problems in Africa. The depth of this problem may be explained in part by the lack of effective enforcement and the lack of efficient ... [more ▼]

Poor quality antimalarial drugs are one of the public’s major health problems in Africa. The depth of this problem may be explained in part by the lack of effective enforcement and the lack of efficient local drug analysis laboratories. To tackle part of this issue, two spectroscopic methods with the ability to detect and to quantify quinine dihydrochloride in children’s oral drops formulations were developed and validated. Raman and Near Infrared (NIR) spectroscopy were selected for the drug analysis due to their low cost, non-destructive and rapid characteristics. Both of the methods developed were successfully validated using the total error approach in the range of 50-150% of the target concentration (20% W/V) within the 10% acceptance limits. Samples collected on the Congolese pharmaceutical market were analyzed by both techniques to detect potentially substandard drugs. After a comparison of the analytical performance of both methods, it has been decided to implement the method based on NIR spectroscopy to perform the routine analysis of quinine oral drop samples in the Quality Control Laboratory of Drugs at the University of Kinshasa (DRC). [less ▲]

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See detailRADIOPHARMACY GMP QC HPLC VALIDATION
Aerts, Joël ULg; Giacomelli, Fabrice ULg; Hubert, Philippe ULg et al

Conference (2015, May 09)

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See detailMédicaments: Faux et usage de faux
Sacre, Pierre-Yves ULg; Marini Djang'Eing'A, Roland ULg; Ziemons, Eric ULg et al

Article for general public (2015)

La contrefaçon de médicaments ets en constante progression, voire en pleine explosion. Chaque année, elle tue des centaines de milliers de personnes, principalement en Afrique. Véritable fléau, elle est ... [more ▼]

La contrefaçon de médicaments ets en constante progression, voire en pleine explosion. Chaque année, elle tue des centaines de milliers de personnes, principalement en Afrique. Véritable fléau, elle est de plus en plus souvent aux mains de réseaux transnationaux d'une profonde opacité. [less ▲]

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See detailMédicaments: Faux et usage de faux
Sacre, Pierre-Yves ULg; Marini Djang'Eing'A, Roland ULg; Ziemons, Eric ULg et al

Article for general public (2015)

La contrefaçon des médicaments est en constante progression, voire en pleine explosion. Chaque année, elle tue des centaines de milliers de personnes, principalement en Afrique. Véritable fléau, elle est ... [more ▼]

La contrefaçon des médicaments est en constante progression, voire en pleine explosion. Chaque année, elle tue des centaines de milliers de personnes, principalement en Afrique. Véritable fléau, elle est de plus en plus souvent aux mains de réseaux transnationaux d'une profonde opacité. [less ▲]

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See detailFalsification des médicaments: Est-il possible d'améliorer la puissance des outils de détection ?
Ziemons, Eric ULg; Sacre, Pierre-Yves ULg; Marini Djang'Eing'A, Roland ULg et al

Conference given outside the academic context (2015)

La mise sur le marché de médicaments falsifiés est une réalité dont on imagine rarement l’importance et la nuisance : on estime pourtant que ce marché rapporte plus que le trafic de drogue et il arrive ... [more ▼]

La mise sur le marché de médicaments falsifiés est une réalité dont on imagine rarement l’importance et la nuisance : on estime pourtant que ce marché rapporte plus que le trafic de drogue et il arrive que localement, des produits falsifiés soient plus nombreux que les produits originaux (cas des anti-malariques au Congo). La lutte contre la falsification s’est d’abord focalisée sur les emballages et les identificateurs tels que les codes-barres, qui aujourd’hui ne garantissent plus le contenu du médicament vu les progrès réalisés par les organisations criminelles en matière de reproduction d’emballage. La solution sûre consiste donc à analyser, sur place, la composition du produit à travers l’emballage et à comparer le résultat à la «carte d’identité» du médicament établie par le producteur. Les besoins portent donc sur des instruments d’analyse portables et capables de dialoguer à distance avec des banques de données de «cartes d’identité». Ceux-ci requièrent une approche pluridisciplinaire impliquant notamment des micro-électroniciens et des informaticiens. [less ▲]

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See detailEstimation of the Time Interval between the Administration of Heroin and the Sampling of Blood in Chronic Inhalers
DUBOIS, Nathalie ULg; HALLET, Claude ULg; SEIDEL, Laurence ULg et al

in Journal of Analytical Toxicology (2015)

To develop a model for estimating the time delay between last heroin consumption and blood sampling in chronic drug users. Eleven patients, all heroin inhalers undergoing detoxification, were included in ... [more ▼]

To develop a model for estimating the time delay between last heroin consumption and blood sampling in chronic drug users. Eleven patients, all heroin inhalers undergoing detoxification, were included in the study. Several plasma samples were collected during the detoxification procedure and analyzed for the heroin metabolites 6-acetylmorphine (6AM), morphine (MOR), morphine-6-glucuronide (M6G) and morphine-3-glucuronide (M3G), according to a UHPLC/MSMS method. The general linear mixed model was applied to time-related concentrations and a pragmatic four-step delay estimation approach was proposed based on the simultaneous presence of metabolites in plasma. Validation of the model was carried out using the jackknife technique on the 11 patients, and on a group of 7 test patients. Quadratic equations were derived for all metabolites except 6AM. The interval delay estimation was 2–4 days when only M3G present in plasma, 1–2 days when M6G and M3G were both present, 0–1 day when MOR, M6G and M3G were present and <2 h for all metabolites present. The ‘jackknife’ correlation between declared and actual estimated delays was 0.90. The overall precision of the delay estimates was 8–9 h. The delay between last heroin consumption and blood sampling in chronic drug users can be satisfactorily predicted from plasma heroin metabolites. [less ▲]

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See detailIntroduction à l’incertitude de mesure - Partim 2
Marini Djang'Eing'A, Roland ULg; Vermaercke, Peter; Hubert, Philippe ULg

Learning material (2015)

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See detailIntroduction à l’incertitude de mesure - Partim 1
Marini Djang'Eing'A, Roland ULg; Vermaercke, Peter; Hubert, Philippe ULg

Learning material (2015)

Detailed reference viewed: 10 (1 ULg)