Showing results 1 to 20 of 40
  First Application of an Innovative Design Space Optimization Strategy for the Development of a LC/MS MethodHubert, Cédric  ; Lebrun, Pierre ; Houari, Sabah et alPoster (2012, June 20) Detailed reference viewed: 46 (19 ULg) APPLICATION OF AN INNOVATIVE DESIGN SPACE OPTIMIZATION STRATEGY TO THE DEVELOPMENT OF LC METHODS TO COMBAT POTENTIALLY COUNTERFEIT NSAIDSMbinze Kindenge, Jérémie ; Lebrun, Pierre ; Debrus, Benjamin et alPoster (2012, June) Detailed reference viewed: 52 (27 ULg)INNOVATIVE GREEN SUPERCRITICAL FLUID CHROMATOGRAPHY DEVELOPMENT FOR THE SEPARATION OF NEUROTRANSMITTERS USING DESIGN SPACE STRATEGYDispas, Amandine ; Lebrun, Pierre ; Hubert, Cédric et alPoster (2012, June) Detailed reference viewed: 51 (10 ULg)Comparison of the quantitative performances and measurement uncertainty estimates obtained during method validation versus routine applications of a novel hydrophilic interaction chromatography method for the determination of cidofovir in human plasmaLecomte, Frédéric ; Hubert, Cédric ; et alin Journal of Pharmaceutical & Biomedical Analysis (2012), 57 Detailed reference viewed: 61 (19 ULg)Usefulness of capability indices in the framework of analytical methods validationBouabidi, Abderrahim ; Ziemons, Eric ; Marini Djang'Eing'A, Roland et alin Analytica Chimica Acta (2012), 714 Analytical methods capability evaluation can be a useful methodology to assess the fitness of purpose of these methods for their future routine application. However, care on how to compute the capability ... [more ▼] Analytical methods capability evaluation can be a useful methodology to assess the fitness of purpose of these methods for their future routine application. However, care on how to compute the capability indices has to be made. Indeed, the commonly used formulas to compute capability indices such as Cpk, will highly overestimate the true capability of the methods. Especially during methods validation or transfer, there are only few experiments performed and, using in these situations the commonly applied capability indices to declare a method as valid or as transferable to a receiving laboratory will conduct to inadequate decisions. In this work, an improved capability index, namely Cpk-tol and the corresponding estimator of proportion of non conforming results ( ) has been proposed. Through Monte-Carlo simulations, they have been shown to greatly increase the estimation of analytical methods capability in particular in low sample size situations as encountered during methods validation or transfer. Additionally, the usefulness of this capability index has been illustrated through several case studies covering applications commonly encountered in the pharmaceutical industry. Finally a methodology to determine the optimal sample size required to validate analytical methods is also given using the proposed capability metric. [less ▲] Detailed reference viewed: 30 (6 ULg) LCA-GE-005- Rapport de validation - VR001_V01Hubert, Cédric ; Ziemons, Eric ; Hubert, Philippe Report (2011) Detailed reference viewed: 23 (9 ULg)High Throughput determination of Levonorgestrel in human plasma using a Sensitive LC-MS/MS methodHubert, Cédric ; ; et alPoster (2011, June 19) Detailed reference viewed: 124 (17 ULg)Protocole d'essai LC/MS - P001 - V01Hubert, Cédric ; Ziemons, Eric ; Hubert, Philippe Report (2011) Detailed reference viewed: 9 (1 ULg)Qualitative analysis of potentials compounds contained in an aged matrix of a pharmaceutical speciality at the RT of an impurityHubert, Cédric ; Ziemons, Eric ; Hubert, Philippe Report (2011) Detailed reference viewed: 8 (1 ULg)Rapport de validation LC/MS - PVR-001 - V02Hubert, Cédric ; Ziemons, Eric ; Hubert, Philippe Report (2011) Detailed reference viewed: 5 (0 ULg)Comparison between new and old excipientsHubert, Cédric ; Ziemons, Eric ; Hubert, Philippe Report (2011) Detailed reference viewed: 9 (5 ULg)Report of the development of a LC-MS method for the assay of an impurity in a pharmaceutical specialityHubert, Cédric ; Ziemons, Eric ; Hubert, Philippe Report (2010) Detailed reference viewed: 16 (6 ULg)Validation of a HILIC method for the determination of cidofovir in plasmaLecomte, Frédéric ; Jasselette, Christophe ; Hubert, Cédric et alPoster (2010, September) Detailed reference viewed: 132 (35 ULg)TOLERANCE INTERVALS AS CONTROL CHART: COMPARISON TO CLASSIC SHEWHART X̅-R CONTROL CHARTMarini Djang'Eing'A, Roland ; ; Denooz, Raphael et alPoster (2010, September) Detailed reference viewed: 119 (41 ULg)Estimation of uncertainty from the total error strategy: Application to internal and normative methodsMarini Djang'Eing'A, Roland ; Rozet, Eric ; Hubert, Cédric et alin Acta Clinica Belgica (2010), 65 Based on the importance of uncertainty, another approach to estimate this parameter of performance considering the total error (systematic and random) was applied. The data were obtained from the two main ... [more ▼] Based on the importance of uncertainty, another approach to estimate this parameter of performance considering the total error (systematic and random) was applied. The data were obtained from the two main steps of an analytical method lifecycle: validation and routine for levonorgestrel (LNG) assay and routine for oxygen assay. Results obtained allowed drawing suitable conclusion in terms of prediction of routine and establishment of norms. [less ▲] Detailed reference viewed: 185 (49 ULg) Développement et validation d'une méthode de dosage de la glucosamine par SPE/LC/MS dans le plamsa caninHubert, Cédric ; Houari, Sabah ; Lecomte, Frédéric et alScientific conference (2010, January 26) Detailed reference viewed: 98 (25 ULg)Intérêt de la chromatographie en mode HILIC pour le dosage du cidofovir dans des fluides biologiquesLecomte, Frédéric ; Hubert, Cédric ; Rozet, Eric et alScientific conference (2010, January 26) Detailed reference viewed: 95 (20 ULg)Development and validation of a quantitative method for the selective determination of tin species in tin octoate by differential pulse polarographyHubert, Cédric ; Ziemons, Eric ; Rozet, Eric et alin Talanta (2010), 80(3), 1413-1420 Tin octoate is used as a catalyst in the synthesis of polydimethylsiloxane (PDMS), a room temperature vulcanizing (RTV) silicone rubber. This rubber is largely used in the medical field due to its great ... [more ▼] Tin octoate is used as a catalyst in the synthesis of polydimethylsiloxane (PDMS), a room temperature vulcanizing (RTV) silicone rubber. This rubber is largely used in the medical field due to its great biocompatibility. In this framework, a high-speed and costless analytical method for the determination of stannic ions, Sn(IV), in the presence of stannous ions, Sn(II), has been developed. The separation of these two ions was carried out using differential pulse polarography (DPP). For this purpose, the tin species contents in the catalyst is quantitatively extracted under inert condition to avoid any changes in the ratio Sn(IV)/Sn(II). Polarography showed well-shaped oxidation and reduction peaks respectively at −650 and −860 mV for stannous ions. The peak of the stannic ion was well separated and appeared at −1210 mV. Many parameters such as extraction process, extraction time, pH, chelating agents and polarographic conditions were optimized. We have also demonstrated that no oxidation of the stannous ions occurred during the sample preparation. The dosing range considered in this study extends between 10 and 40 μg/mL, corresponding to 6.8% and 27.2% of the degradation product (Sn(IV)) in the catalyst, regarding to the sampling. Finally this method was successfully validated using the total error concept. [less ▲] Detailed reference viewed: 159 (53 ULg)Pré-requis aux travaux pratiques de chimie analytique - Deuxième baccalauréat en Sciences pharmaceutiquesLejeune, Robert ; Hubert, Cédric ; Ziemons, Eric Learning material (2010) Detailed reference viewed: 79 (18 ULg)Notes des travaux pratiques de chimie analytique - Deuxième baccalauréat en Sciences pharmaceutiquesLejeune, Robert ; Hubert, Cédric ; Ziemons, Eric Learning material (2010) Detailed reference viewed: 77 (17 ULg) |
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