   Prise en charge du médulloblastome de l'enfant; ; Misson, Jean-Paul  et alin Revue Médicale de Liège (2007), 62(4), 200-4 We present the experience of the Citadelle Hospital (Liege, B) in the diagnosis, treatment and follow-up of medulloblastoma in children. A retrospective study of 10 cases of medulloblastoma was performed ... [more ▼] We present the experience of the Citadelle Hospital (Liege, B) in the diagnosis, treatment and follow-up of medulloblastoma in children. A retrospective study of 10 cases of medulloblastoma was performed. Five years after diagnosis, the event-free survival was 77%. [less ▲] Detailed reference viewed: 76 (0 ULg) Evidence for a role of accessible galactosyl or mannosyl residues of Fc domain in the in vivo clearance of IgG antibody-coated autologous erythrocytes in the ratMalaise, Michel ; ; et alin Clinical Immunology and Immunopathology (1990), 54(3), 469-483 The potential role of accessible galactosyl or mannosyl residues of IgG in the clearance of IgG-coated autologous red blood cells (IgG-RBCs) by the spleen and the liver was investigated in the rat using ... [more ▼] The potential role of accessible galactosyl or mannosyl residues of IgG in the clearance of IgG-coated autologous red blood cells (IgG-RBCs) by the spleen and the liver was investigated in the rat using rabbit anti-rat RBC IgG antibody molecules differing from each other by their capacity to bind in vitro to peanut agglutinin (PNA) and concanavalin A (Con A), i.e., two lectins that specifically bind to beta-galactosyl and alpha-mannosyl residues of Fc domain, respectively. Those IgG molecules [IgG(PNA) or IgG(Con A)] were separated from the starting anti-RBC IgG antibody batch [IgG(total)] by affinity chromatography on lectin columns. Each IgG-RBC preparation was labeled with 99mTc, and was reinjected iv with autologous rat RBCs labeled with 111In to correct for 99mTc present in the blood contained in each organ. The mean specific spleen uptakes per gram of the three IgG-RBC preparations increased according to the level of RBC sensitization but were at least 10 times higher in each instance than the mean specific liver uptake per gram. Consistent with the clearance curves of IgG(PNA)-RBCs, the mean specific splenic uptake per gram of those RBCs was significantly increased as compared to the same parameters determined using either IgG(total)-RBCs or IgG(Con A)-RBCs. In contrast, the mean specific liver uptakes per gram of IgG(PNA)-RBCs, of IgG(Con A)RBCs, or of IgG(total)-RBCs were not significantly different under otherwise identical experimental conditions. The increase in the splenic removal of IgG(PNA)-RBCs was C3 independent. Furthermore, splenic macrophages isolated from rats were able to bind in vitro significantly more IgG(PNA)-RBCs than IgG(total)-RBCs or IgG(Con A)-RBCs. These data therefore support the concept that, in the rat, the kinetic of removal of IgG-RBCs from the bloodstream by the Fc receptors of splenic mononuclear phagocytes may vary according to the nature of accessible carbohydrates located in the Fc domain of IgG antibody molecules coating the erythrocytes. [less ▲] Effects of mannose and mannose derivatives on the clearance of IgG antibody-coated erythrocytes in the ratMalaise, Michel ; ; et alin Immunology (1989), 68(1), 126-132 The effects of D-mannose, mannose dimers, mannan, or lactotransferrin [a glycoprotein containing mannose alpha-(1,6) linkages] infusion on the clearance of IgG-coated, 99mTc-labelled, autologous red blood ... [more ▼] The effects of D-mannose, mannose dimers, mannan, or lactotransferrin [a glycoprotein containing mannose alpha-(1,6) linkages] infusion on the clearance of IgG-coated, 99mTc-labelled, autologous red blood cells (IgG-RBC) by the spleen and liver were investigated in the rat. Untreated autologous rat RBC labelled with 111In were simultaneously injected to correct for 99mTc present in the blood contained in each organ. In normal rats, the mean specific spleen uptake (per g) of IgG-RBC was about 10 times higher than the mean specific liver uptake (per g). Consistent with the clearance curves of IgG-RBC, the mean specific splenic uptake of those RBC significantly decreased after D-mannose, mannose dimers, mannan, or lactotransferrin injections, compared with that measured in normal rats or in control rats receiving i.v. physiological saline, 5% or 15% glucose. In contrast, the mean specific liver uptake of IgG-RBC remained unchanged under otherwise identical experimental conditions. The splenic blockade induced by mannan and mannose derivatives was dose-dependent, C3-independent and spontaneously reversible within 42 hr. Splenic macrophages isolated from mannose- or mannan-treated animals expressed a decreased receptor activity for the Fc domain of IgG, whereas no consistent effect on the C3 receptors was noted. These data show a transient and specific impairment of the Fc(IgG)-receptor function of rat splenic macrophages after the i.v. injection of D-mannose or of mannose derivatives. They support the concept that simple sugar compounds can exhibit immunoregulatory activities in vivo, as has been already shown in vitro. [less ▲] Detailed reference viewed: 3 (0 ULg)Influence de la grossesse sur certaines maladies auto-immunes; Malaise, Michel ; et alin Revue Médicale de Liège (1988), 43(22), 727-736 Detailed reference viewed: 12 (0 ULg)Greffe de moelle: résultats préliminaires au CHU.; ; et al in Revue Médicale de Liège (1987), 42(10), 510-5 Detailed reference viewed: 36 (16 ULg)Les cancers hématologiques en 1987. Chimiothérapie et immunothérapie.Fillet, Georges ; ; Beguin, Yves et alin Revue Médicale de Liège (1987), 42(10), 496-502 Detailed reference viewed: 28 (11 ULg)Étude de la fonction Fc-récepteur du système mononucléé phagocytaire dans les affections immunesMalaise, Michel ; ; et alin Bulletin et Mémoires de l'Académie Royale de Médecine de Belgique (1985), 140(10), 362-367 Detailed reference viewed: 4 (0 ULg) |
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