References of "Hodzic, Didier"
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See detailA New Cis Element Is Involved in the Her2 Gene Overexpression in Human Breast Cancer Cells
Grooteclaes, Madeleine; Vernimmen, Douglas; Plaza, S. et al

in Cancer Research (1999), 59(11), 2527-31

The HER2 proto-oncogene product is overexpressed in 30% of breast cancers, and this correlates with poor prognosis. Increased levels of HER2 mRNA in breast cancer cell lines result from increased gene ... [more ▼]

The HER2 proto-oncogene product is overexpressed in 30% of breast cancers, and this correlates with poor prognosis. Increased levels of HER2 mRNA in breast cancer cell lines result from increased gene transcription. We report the identification of a new 17-bp-long cis sequence located between positions -506 and -489 from the transcription start site. This sequence is recognized by a trans-activating factor that we tentatively named HER2 transcription factor (HTF). This factor, involved in the increased transcription of the HER2 gene in the BT-474 mammary tumor cells, has a molecular weight of about Mr 50,000. HTF can also bind, but with a lower affinity, to a related cis sequence present in the epidermal growth factor receptor promoter. Interestingly, the HTF binding activity is high in nuclear extracts from several mammary tumor cells overexpressing the HER2 gene. [less ▲]

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See detailIdentification du site de fixation d'un facteur de transcription contribuant à la surexpression du gène c-erbB2 dans les cellules tumorales BT-474.
Grooteclaes, Madeleine; Pasleau, Françoise ULg; Hodzic, Didier et al

Conference (1996, February 14)

Detailed reference viewed: 18 (3 ULg)
See detailIdentification of the cis element recognized by a transcription factor specific to the tumor BT-474 mammary cells.
Grooteclaes, Madeleine; Pasleau, Françoise ULg; Hodzic, Didier et al

Conference (1996, February 03)

Detailed reference viewed: 7 (0 ULg)
Peer Reviewed
See detailSpecific transcription factors control the c-erbB2 gene expression in the mammary tumor BT-474 cells.
Grooteclaes, Madeleine; Pasleau, Françoise ULg; Garsoux, G. et al

Conference (1995, December)

Detailed reference viewed: 18 (1 ULg)