References of "Heusghem, C"
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See detailEarly prognostic index and late exercise test comapred in survivors from acute myocardial infarction
Chapelle, Jean-Paul ULg; Smeets, J. P.; El Allaf, M. et al

Poster (1987, September 05)

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See detailValidation of an early prognostic index by exercise test data in survivors from acute myocardial infarction
Chapelle, Jean-Paul ULg; Smeets, J. P.; El Allaf, M. et al

Conference (1987, June)

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See detailEarly pronostic index and late exercise test compared in survivors from acute myocardial infarction
Chapelle, Jean-Paul ULg; Smeets, J. P.; El Allaf, M. et al

in European Heart Journal Supplements : Journal of the European Society of Cardiology (1987), 8(suppl.2), 11

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See detailLaboratory and clinical assessment of a new sensitive immuno-radiometric assay for thyrotrophin in serum
El Allaf, M.; Chapelle, Jean-Paul ULg; Heusghem, C.

in Annals of Clinical Biochemistry (1987), (Suppl.2), 176

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See detailThrombolytic therapy reduces the acute phase response after acute myocardial infarction
El Allaf, M.; Chapelle, Jean-Paul ULg; Heusghem, C.

Poster (1986, May)

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See detailDifferentiating muscle damage from myocardial injury by meaans of the serum creatinine kinase (CK) isoenzyme MB mass measurement/total CK activity ratio
el Allaf, M.; Chapelle, Jean-Paul ULg; El Allaf, Dia ULg et al

in Clinical Chemistry (1986), 32(2), 291-5

We immunoenzymometrically measured creatine kinase (CK) isoenzyme MB in extracts of myocardium and in homogenates of five different skeletal muscles. CK-MB concentrations in the former averaged 80.9 ... [more ▼]

We immunoenzymometrically measured creatine kinase (CK) isoenzyme MB in extracts of myocardium and in homogenates of five different skeletal muscles. CK-MB concentrations in the former averaged 80.9 micrograms/g wet tissue; in the skeletal muscles it varied widely, being (e.g.) 25-fold greater in diaphragm than in psoas. CK-MB in skeletal muscles ranged from 0.9 to 44 ng/U of total CK; the mean for myocardium was 202 ng/U. In sera from 10 trauma and 36 burn patients without myocardial involvement, maximum ratios for CK-MB mass/total CK activity averaged 7 (SEM 1) ng/U and 18 (SEM 6) ng/U, respectively. Except for an infant (220 ng/U), the highest ratio we found for serum after muscular damage was 38 ng/U. In contrast, the mean maximum ratio determined in 23 cases of acute myocardial infarction exceeded 200 ng/U. Among seven determinations performed 8 to 32 h after onset of symptoms, each infarct patient demonstrated at least one ratio greater than or equal to 110 ng/U. Ratios observed after infarct were unrelated to treatment received during the acute phase. We propose a CK-MB/total CK ratio of 80 ng/U as the cutoff value for differentiating myocardial necrosis from muscular injury. [less ▲]

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See detailEvaluation of a new immunoassay analyzer: the photon "ERA"
El Allaf, M.; Chapelle, Jean-Paul ULg; Heusghem, C.

Poster (1986)

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See detailThe value of serum CK-MB and myoglobin measurements for assessing perioperative myocardial infarction after cardiac surgery.
Chapelle, Jean-Paul ULg; el Allaf, M.; Larbuisson, Robert ULg et al

in Scandinavian Journal of Clinical & Laboratory Investigation (1986), 46(6), 519-26

In 41 patients who underwent coronary bypass surgery, creatine kinase (CK)-MB mass concentration was repeatedly measured in serum during and after the intervention using a new two-site immunoenzymetric ... [more ▼]

In 41 patients who underwent coronary bypass surgery, creatine kinase (CK)-MB mass concentration was repeatedly measured in serum during and after the intervention using a new two-site immunoenzymetric assay (IEMA). Serum CK-MB activity was determined with the use of four different techniques: immunoinhibition, immunoinhibition-immunoprecipitation, column chromatography and electrophoresis. Myoglobin (Mb) was also measured in each specimen by radioimmunoassay. In the 33 patients who followed a completely uneventful postoperative course, the cumulated CK-MB release was, on the average, 12.2-fold less than after acute myocardial infarction. The CK-MB peak concentrations using the IEMA were 33 +/- 3 micrograms/l (X +/- SEM) and occurred 6.4 +/- 0.5 h after the intervention was started; CK-MB levels had decreased to 2.9 +/- 0.4 micrograms/l at the end of the first postoperative day. The evolution of the CK-MB concentration was parallel to that of the enzyme activity. The serum Mb maximum concentrations (518 +/- 39 micrograms/l) were reached after 3.3 +/- 0.1 h. The other eight patients developed perioperative myocardial infarction (PMI); in this group, the cumulated CK-MB release was higher, and the serum CK-MB postoperative curves were of three different types. The patients with delayed CK-MB peaks (type I pattern) or sustained elevations (type III) of this isoenzyme also showed increased serum Mb levels at the end of the first postoperative day. The PMI patients with early (10 h) CK-MB elevations (type II) did not demonstrate abnormal serum Mb levels.(ABSTRACT TRUNCATED AT 250 WORDS) [less ▲]

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See detailSerum creatine kinase isoenzyme MB concentration after endomyocardial biopsy.
Chapelle, Jean-Paul ULg; El Allaf, Dia ULg; el Allaf, M. et al

in Clinica Chimica Acta (1986), 157(1), 55-63

Serum total creatine kinase (CK), CK-MB and myoglobin (Mb) were serially determined in 17 patients who underwent endomyocardial biopsy. Mean total CK levels increased from 36 +/- 27 U/l 30 min before ... [more ▼]

Serum total creatine kinase (CK), CK-MB and myoglobin (Mb) were serially determined in 17 patients who underwent endomyocardial biopsy. Mean total CK levels increased from 36 +/- 27 U/l 30 min before biopsy to a maximum of 112 +/- 77 U/l 8 h following the procedure (p less than 0.05). Similarly, Mb concentrations rose from 57 +/- 55 micrograms/l to 119 +/- 57 micrograms/l 30 min after biopsy (p less than 0.05). Normalization of total CK and Mb levels occurred within 16 and 8 h, respectively. A new immunoenzymetric assay (IEMA) was used to measure the mass concentration of the CK-MB molecule. The initial CK-MB levels were 0.2 +/- 0.4 microgram/l; a small but significant elevation was recorded as early as 2 h after biopsy (1.6 +/- 1.5 micrograms/l, p less than 0.05). CK-MB returned to initial concentration 16 h after the beginning of the procedure. Comparison with the maximum CK-MB levels recorded in 16 myocardial infarction patients (258 +/- 172 micrograms/l, range 90-680 micrograms/l) indicated that the modest increase of CK-MB level detected after biopsy probably reflects a limited endomyocardium lesion at the sampling site, excluding any significant myocardial damage. Total CK and Mb, which showed more pronounced elevations than CK-MB, are likely to originate from other sources than the myocardium. [less ▲]

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