Daily Prediction of the patients outcome from cumulative laboratory data after an acute myocardial infarction

Poster (1989)

Short and long-term prognosis of small acute myocardial infarction: a natural history study

Poster (1987, September 05)

Validation of an early prognostic index by exercise test data in survivors from acute myocardial infarction

Conference (1987, June)

Laboratory and Clinical assessment of a new sensitive immunoradiometric assay for thyrotrophin in serum

Poster (1987)

Laboratory and clinical assessment of a new sensitive immuno-radiometric assay for thyrotrophin in serum

in Annals of Clinical Biochemistry (1987), (Suppl.2), 176

Differentiating muscle damage from myocardial injury by meaans of the serum creatinine kinase (CK) isoenzyme MB mass measurement/total CK activity ratio

in Clinical Chemistry (1986), 32(2), 291-5

We immunoenzymometrically measured creatine kinase (CK) isoenzyme MB in extracts of myocardium and in homogenates of five different skeletal muscles. CK-MB concentrations in the former averaged 80.9 ... [more ▼]

We immunoenzymometrically measured creatine kinase (CK) isoenzyme MB in extracts of myocardium and in homogenates of five different skeletal muscles. CK-MB concentrations in the former averaged 80.9 micrograms/g wet tissue; in the skeletal muscles it varied widely, being (e.g.) 25-fold greater in diaphragm than in psoas. CK-MB in skeletal muscles ranged from 0.9 to 44 ng/U of total CK; the mean for myocardium was 202 ng/U. In sera from 10 trauma and 36 burn patients without myocardial involvement, maximum ratios for CK-MB mass/total CK activity averaged 7 (SEM 1) ng/U and 18 (SEM 6) ng/U, respectively. Except for an infant (220 ng/U), the highest ratio we found for serum after muscular damage was 38 ng/U. In contrast, the mean maximum ratio determined in 23 cases of acute myocardial infarction exceeded 200 ng/U. Among seven determinations performed 8 to 32 h after onset of symptoms, each infarct patient demonstrated at least one ratio greater than or equal to 110 ng/U. Ratios observed after infarct were unrelated to treatment received during the acute phase. We propose a CK-MB/total CK ratio of 80 ng/U as the cutoff value for differentiating myocardial necrosis from muscular injury. [less ▲]

Assessing successful myocardium reperfusion after thrombolytic therapy in acute myocardial infarction patients by early measurement of the serum CK-MB isoenzyme and of the CK-MM isoforms

Poster (1986)

The value of serum CK-MB and myoglobin measurements for assessing perioperative myocardial infarction after cardiac surgery.

in Scandinavian Journal of Clinical & Laboratory Investigation (1986), 46(6), 519-26

In 41 patients who underwent coronary bypass surgery, creatine kinase (CK)-MB mass concentration was repeatedly measured in serum during and after the intervention using a new two-site immunoenzymetric ... [more ▼]

In 41 patients who underwent coronary bypass surgery, creatine kinase (CK)-MB mass concentration was repeatedly measured in serum during and after the intervention using a new two-site immunoenzymetric assay (IEMA). Serum CK-MB activity was determined with the use of four different techniques: immunoinhibition, immunoinhibition-immunoprecipitation, column chromatography and electrophoresis. Myoglobin (Mb) was also measured in each specimen by radioimmunoassay. In the 33 patients who followed a completely uneventful postoperative course, the cumulated CK-MB release was, on the average, 12.2-fold less than after acute myocardial infarction. The CK-MB peak concentrations using the IEMA were 33 +/- 3 micrograms/l (X +/- SEM) and occurred 6.4 +/- 0.5 h after the intervention was started; CK-MB levels had decreased to 2.9 +/- 0.4 micrograms/l at the end of the first postoperative day. The evolution of the CK-MB concentration was parallel to that of the enzyme activity. The serum Mb maximum concentrations (518 +/- 39 micrograms/l) were reached after 3.3 +/- 0.1 h. The other eight patients developed perioperative myocardial infarction (PMI); in this group, the cumulated CK-MB release was higher, and the serum CK-MB postoperative curves were of three different types. The patients with delayed CK-MB peaks (type I pattern) or sustained elevations (type III) of this isoenzyme also showed increased serum Mb levels at the end of the first postoperative day. The PMI patients with early (10 h) CK-MB elevations (type II) did not demonstrate abnormal serum Mb levels.(ABSTRACT TRUNCATED AT 250 WORDS) [less ▲]

Contrôle de l'efficacité du traitement fibrinolytique par mesures répétées de la CK-MB sérique chez le patient atteint d'infarctus myocardique aigu

Poster (1985, December)

Contribution de la Chimie clinique au diagnostic et au pronostic et au pronostic de l'infarctus du myocarde

Poster (1985, October 29)