References of "Herné, Patrick"
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See detailFeasibility assessment of heroin-assisted treatment in Liège, Belgium
Demaret, Isabelle ULg; Herné, Patrick ULg; Lemaître, André ULg et al

in Acta Psychiatrica Belgica (2011), 111(1), 3-8

A new heroin-assisted treatment, TADAM, has begun in Liège, Belgium. With the number of methadone patients (n=2046) in 2007, we estimated the geographical distribution of methadone treatments in the ... [more ▼]

A new heroin-assisted treatment, TADAM, has begun in Liège, Belgium. With the number of methadone patients (n=2046) in 2007, we estimated the geographical distribution of methadone treatments in the province of Liège, of heroin addicts and of potential participants for TADAM. The methadone treatments were unequally distributed. Some urban areas showed a signifi cant number of heroin addicts: more than 14/1000 of the population aged 15-64. As a conclusion, the trial is appropriately targeted to those high-density addiction areas. [less ▲]

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See detailDetermination of Meprobamate in Pharmaceutical Dosage Forms Also Containing Carbromal by Liquid Chromatography and Indirect Photometric Detection
Bechet, I.; Ceccato, Attilio ULg; Hubert, Philippe ULg et al

in Journal of Pharmaceutical & Biomedical Analysis (1992), 10(10-12, Oct-Dec), 995-9

In a pharmaceutical form also containing carbromal, meprobamate could not be quantified selectively by classical methods described in pharmacopoeias due to a significant interference from carbromal ... [more ▼]

In a pharmaceutical form also containing carbromal, meprobamate could not be quantified selectively by classical methods described in pharmacopoeias due to a significant interference from carbromal. Consequently, reversed-phase HPLC methods have been developed to separate the two active ingredients using indirect photometric detection to visualize and determine meprobamate which has very poor chromophoric properties. Different parameters influencing the sensitivity of the indirect response, such as the nature of the highly absorbing compound added to the mobile phase (the marker) as well as the methanol content and the pH of this phase, have been studied. Two chromatographic systems containing benzoic acid or cinnamic acid as the marker, have been optimized and validated. Good linearity and reproducibility have been obtained with both systems but the cinnamic acid method has the advantage that meprobamate and carbromal can be determined simultaneously at 273 nm. [less ▲]

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See detailIndirect Uv Detection of Hydrophilic Ionized Compounds in Reversed-Phase Liquid Chromatography by Use of a Uv-Absorbing Ion of the Same Charge
Crommen, Jacques ULg; Herné, Patrick ULg

in Journal of Pharmaceutical & Biomedical Analysis (1984), 2(2), 241-53

Ion-pair reversed-phase liquid chromatographic systems have been developed that allow the detection and quantitation of low amounts of hydrophilic ionized substances, which otherwise display little or no ... [more ▼]

Ion-pair reversed-phase liquid chromatographic systems have been developed that allow the detection and quantitation of low amounts of hydrophilic ionized substances, which otherwise display little or no capability for optical detection. The mobile phase contains a UV-absorbing ion of the same charge and hydrophobic character as the samples, most often together with a hydrophobic counter-ion to give the samples suitable retention; the stationary phase consists of octadecylsilica. Chromatograms featuring two system peaks are usually obtained, and these give rise to some deviations from the usual response pattern. In the present work the influence on retention and detection sensitivity of the non-absorbing counter-ion, the UV-absorbing ion and the uncharged organic modifier have been studied systematically. Principles for optimizing the detector response by changing the mobile phase composition have been deduced. Examples of applications of the indirect detection technique to the analysis of hydrophilic compounds of pharmaceutical and biological interest, such as amino acids, water-soluble vitamins and piperazine, are presented. [less ▲]

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