References of "Herfs, Michael"
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See detailEpidermodysplasia Verruciformis–like HPV infection of the Vulva in Immunosuppressed Women
Pohthipornthawat, Natkrita; Feldman, Sarah; Granter, Scott et al

in International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists (in press)

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See detailAdénocarcinome du canal anal: identification de deux sous-types distincts
Herfs, Michael ULiege

Conference (2017, September 29)

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See detailMyoferlin controls mitochondrial structure in pancreatic ductal adenocarcinoma, and affects tumor aggressiveness
Rademaker, Gilles ULiege; Hennequière, Vincent ULiege; Brohée, Laura ULiege et al

Poster (2017, September 22)

Pancreatic ductal adenocarcinoma (PDAC) is the most common type of pancreatic cancer, and the third leading cause of cancer related death. Therapeutic options remain very limited and are still based on ... [more ▼]

Pancreatic ductal adenocarcinoma (PDAC) is the most common type of pancreatic cancer, and the third leading cause of cancer related death. Therapeutic options remain very limited and are still based on classical chemotherapies. Cell fraction can survive to the chemotherapy and is responsible for tumor relapse. It appears that these cells rely on OXPHOS for survival. Myoferlin, a membrane protein involved in cell fusion was recently shown by our laboratory to be overexpressed in pancreatic cancer. In the present study, we discovered that myoferlin was more expressed in cell lines undergoing oxidative phosphorylation (OXPHOS) than in glycolytic cell lines. In the former cell lines, we showed that myoferlin silencing reduced OXPHOS activity and forced cells to switch to glycolysis. The decrease in OXPHOS activity is associated with mitochondrial network disorganization. Dynamin-related protein (DRP)-1 phosphorylation led us to suggest mitochondrial fission, reducing cell proliferation, ATP production and inducing autophagy and ROS accumulation. To confirm the clinical importance of myoferlin in PDAC, we showed that low myoferlin expression was significantly correlated to high overall survival. Myoferlin staining of PDAC sections was negatively correlated with several 18FDG PET indices indicating that glycolytic lesions had less myoferlin. As the mitochondrial function is demonstrated to enhance the cell resistance to the treatment, the metabolic switch forced by myoferlin silencing could open up a new perspective in the development of therapeutic strategies. [less ▲]

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See detailA specific immune and lymphatic profile characterizes the pre-metastatic state of the sentinel lymph node in patients with early cervical cancer
Balsat, Cédric ULiege; Blacher, Silvia ULiege; Herfs, Michael ULiege et al

in Oncoimmunology (2017), 6(2), 1265718

The lymph node (LN) pre-metastatic niche is faintly characterized in lymphophilic human neoplasia, although LN metastasis is considered as the strongest prognostic marker of patient survival. Due to its ... [more ▼]

The lymph node (LN) pre-metastatic niche is faintly characterized in lymphophilic human neoplasia, although LN metastasis is considered as the strongest prognostic marker of patient survival. Due to its specific dissemination through a complex bilateral pelvic lymphatic system, early cervical cancer is a relevant candidate for investigating the early nodal metastatic process. In the present study, we analyzed in-depth both the lymphatic vasculature and the immune climate of pre-metastatic sentinel LN (SLN), in 48 cases of FIGO stage IB1 cervical neoplasms. An original digital image analysis methodology was used to objectively determine whole slide densities and spatial distributions of immunostained structures. We observed a marked increase in lymphatic vessel density (LVD) and a specific capsular and subcapsular distribution in pre-metastatic SLN when compared with non-sentinel counterparts. Such features persisted in the presence of nodal metastatic colonization. The inflammatory profile attested by CD8+, Foxp3, CD20 and PD-1expression was also significantly increased in pre-metastatic SLN. Remarkably, the densities of CD20+ B cells and PD-1 expressing germinal centers were positively correlated with LVD. All together, these data strongly support the existence of a pre-metastatic dialog between the primary tumor and the first nodal relay. Both lymphatic and immune responses contribute to the elaboration of a specific pre-metastatic microenvironment in human SLN. Moreover, this work provides evidence that, in the context of early cervical cancer, a pre-metastatic lymphangiogenesis occurs within the SLN (pre-metastatic niche) and is associated with a specific humoral immune response. [less ▲]

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See detailPapillomaviruses and cervical neoplasia
Herfs, Michael ULiege; Chang, Martin; Crum, Christopher

in Holland-Frei Cancer Medicine, ninth edition (2017)

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See detailProteomic signatures reveal a dualistic and clinically relevant classification of anal canal carcinoma
Herfs, Michael ULiege; Longuespée, Rémi ULiege; Quick, Charles et al

in Journal of Pathology (The) (2017), 241

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See detailCancer du canal anal: identification de deux sous-types distincts
Herfs, Michael ULiege

Conference (2016, September)

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See detailComprehensive Human Papilloma Virus (HPV) Genotyping in Cervical Squamous Cell Carcinomas and its Relevance to Cervical Cancer Prevention in Malawian Women
Howitt, Brooke; Herfs, Michael ULiege; Tomoka, Tamiwe et al

in Journal of Global Oncology (2016), 3

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See detailCellular origin of HPV-related (pre)cancer
Herfs, Michael ULiege

Conference (2016, May)

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See detailp16ink4 and cytokeratin 7 immunostaining in predicting HSIL outcome for low-grade squamous intraepithelial lesions: A case series, literature review and commentary
Huang, Eric; Tomic, Mary; Hanamornroongruang, Suchanan et al

in Modern Pathology : An Official Journal of the United States & Canadian Academy of Pathology, Inc (2016)

Detailed reference viewed: 31 (1 ULiège)
See detailHPV infection, squamo-columnar junction and potential cancer prevention
Herfs, Michael ULiege

Conference (2015, October 26)

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See detailTranscriptionally active HPV infection in the cervical squamo-columnar junction
Herfs, Michael ULiege

Conference (2015, October 01)

Detailed reference viewed: 27 (3 ULiège)
See detailPathways of recurrent high-grade squamous intraepithelial lesions of the cervix
Herfs, Michael ULiege

Conference (2015, September 20)

Detailed reference viewed: 14 (2 ULiège)
See detailHPV infection, squamo-columnar junction and cancer prevention
Herfs, Michael ULiege

Conference (2015, May)

Detailed reference viewed: 16 (1 ULiège)