References of "Henrotin, Yves"
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See detailBone sialoprotein as a potential key factor implicated in the pathophysiology of osteoarthritis
Pesesse, Laurence ULg; Sanchez, Christelle ULg; Walsh, David et al

in Osteoarthritis and Cartilage (2014), 22(4), 547-56

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See detailImportance of synovitis in osteoarthritis: Evidence for the use of glycosaminoglycans against synovial inflammation.
Henrotin, Yves ULg; Lambert, Cécile ULg; Richette, Pascal

in Seminars in Arthritis & Rheumatism (2014), 43(5), 579-87

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See detailOARSI guidelines for the non-surgical management of knee osteoarthritis
McAlindon; Henrotin, Yves ULg

in Osteoarthritis and Cartilage (2014), 22(3), 363-388

This paper presents concise, up-to-date, patient-focused, evidence-based, expert consensus guidelines for the management of knee osteoarthritis, intended to inform patients, physicians and allied ... [more ▼]

This paper presents concise, up-to-date, patient-focused, evidence-based, expert consensus guidelines for the management of knee osteoarthritis, intended to inform patients, physicians and allied healthcare professionnal worlwide. [less ▲]

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See detailTargeting the synovial angiogenesis as a novel treatment approach to osteoarthritis.
Henrotin, Yves ULg; Pesesse, Laurence; Lambert, Cécile ULg

in Therapeutic Advances in Musculoskeletal Disease (2014), 6(1), 20-34

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See detailL'inhibition des voies de signalisation est-elle une possibilité thérapeutique pour l'arthrose?
Henrotin, Yves ULg

in Revue du Rhumatisme (2014)

Les voies de signalisation sont des cibles intéressantes pour les traitements de l’arthrose car leur inhibition ou leur activation permet de réguler l’expression d’un ensemble de gènes cibles directement ... [more ▼]

Les voies de signalisation sont des cibles intéressantes pour les traitements de l’arthrose car leur inhibition ou leur activation permet de réguler l’expression d’un ensemble de gènes cibles directement impliqués dans le dysfonctionnement métabolique des tissus articulaires. Cependant, les premiers essais cliniques réalisés dans la PR ont montré que la régulation spécifique de la voie JAK/STAT induit de nombreux effets secondaires. Ce point pourrait être un facteur limitant l’utilisation d’inhibiteurs ou d’activateurs spécifiques des voies de signalisation dans l’arthrose. Dans cette maladie, le rapport risque/bénéfice doit rester le facteur clé de la décision thérapeutique, car il s’agit de traiter une maladie d’évolution lente, de sévérité modérée et associée à de nombreuses comorbidités. [less ▲]

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See detailDoes signalling pathways inhibition hold therapeutic promise for osteoarthritis?
Henrotin, Yves ULg

in Joint Bone Spine (2014), 81

Signalling pathways inhibition hold promise as therapeutic targets in osteoarthritis but safety concern may limit their use to the more sevre form of the disease.

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See detailWhat is the current statut of chondroitin sulfate and glucosamine in the treatment of knee osteoarthritis?
Henrotin, Yves ULg; Marty, Marc; Mobasheri, Ali

in Maturitas (2014), 78

Chondroitin sulfate and glucosamine sulfate exert beneficial effects on the metabolism of in vitro models of cells derived from synovial joints: chondrocytes, synoviocytes and cells from subchondral bone ... [more ▼]

Chondroitin sulfate and glucosamine sulfate exert beneficial effects on the metabolism of in vitro models of cells derived from synovial joints: chondrocytes, synoviocytes and cells from subchondral bone, all of which are involved in osteoarthritis (OA). They increase type II collagen and proteoglycan synthesis in human articular chondrocytes and are able to reduce the production of some pro-inflammatory mediators and proteases, to reduce the cellular death process, and improve the anabolic/catabolic balance of the extracellular cartilage matrix (ECM). Clinical trials have reported a beneficial effect of chondroitin sulfate and glucosamine sulfate on pain and function. The structure-modifying effects of these compounds have been reported and analyzed in recent meta-analyses. The results for knee OA demonstrate a small but significant reduction in the rate of joint space narrowing. Chondroitin sulfate and glucosamine sulphate are recommended by several guidelines from international societies for the management of knee and hip OA, while others do not recommend these products or recommend only under condition. This comprehensive review clarifies the role of these compounds in the therapeutic arsenal for patients with knee OA [less ▲]

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See detailDecrease of a specific biomarker of collagen degradation in osteoarthritis, Coll2-1, by treatment with highly bioavailable curcumin during an exploratory clinical trial.
Henrotin, Yves; Henrotin, Yves ULg

in BMC Complimentary & Alternative Medicine (2014)

The management of osteoarthritis (OA) remains a challenge. There is a need not only for safe and efficient treatments but also for accurate and reliable biomarkers that would help diagnosis and monitoring ... [more ▼]

The management of osteoarthritis (OA) remains a challenge. There is a need not only for safe and efficient treatments but also for accurate and reliable biomarkers that would help diagnosis and monitoring both disease activity and treatment efficacy. Curcumin is basically a spice that is known for its anti-inflammatory properties. In vitro studies suggest that curcumin could be beneficial for cartilage in OA. The aim of this exploratory, non-controlled clinical trial was to evaluate the effects of bio-optimized curcumin in knee OA patients on the serum levels of specific biomarkers of OA and on the evaluation of pain. This study highlighted the potential effect of curcumin in knee OA patient. This effect was reflected by the variation of a cartilage specific biomarker, Coll2-1 that was rapidly affected by the treatment. These results are encouraging for the qualification of Coll2-1 as a biomarker for the evaluation of curcumin in OA treatment. (Trial registration: NCT01909037 at clinicaltrials.gov) [less ▲]

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See detailGene expression pattern of synovial cells from inflammatory and normal areas of osteoarthritis synovial membrane.
Lambert, Cécile ULg; Dubuc, Jean-Emile; Montell, Eulalia et al

in Arthritis and Rheumatism (2014), sous presse

Objective: The aim of this study was to compare the gene expression pattern of synovial cells from inflammatory (I) or normal/reactive (N/R) areas of a synovial membrane harvested from the same ... [more ▼]

Objective: The aim of this study was to compare the gene expression pattern of synovial cells from inflammatory (I) or normal/reactive (N/R) areas of a synovial membrane harvested from the same osteoarthritis (OA) patient. Methods: Synovial tissues were obtained from 12 knee OA patients at the time of total knee replacement. The inflammatory status of the synovial membrane was characterized according to macroscopic criteria and sorted as N/R and I. Biopsies were cultured separately for 7 days. Microarray gene expression profiling between N/R and I areas was performed. Western blot and immunohistochemistry confirmed the identified genes that were differentially expressed. Results: 896 differentially expressed genes between N/R and I zones were identified. The key pathways were related to inflammation, cartilage metabolism, Wnt signaling and angiogenesis. In the inflammatory network, TREM1 and S100A9 were strongly up-regulated. MMP-3 and -9, cathepsin H and S were significantly up-regulated in the cartilage catabolism pathway, whereas the most up-regulated anabolism enzyme was HAS1. Wnt-5A and LRP5 were up-regulated whereas FZD2 and DKK3 were down-regulated in the Wnt signaling. Finally, STC1, a protein involved in angiogenesis was identified as the most up-regulated gene in I zones compared to N/R zones. Conclusion: This study is the first to identify different expression pattern between two areas of the synovial membrane in the same patient. These differences concern several key pathways involved in OA pathogenesis. This analysis also provides information regarding new genes and proteins as potential targets for the future therapeutic. (c) 2013 American College of Rheumatology. [less ▲]

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See detailOleuropein or rutin consumption decreases the spontaneous development of OA in Hartley guinea pig
Sanchez, Christelle ULg; Horcajada, Marie-Noëlle; Membrez, Fanny et al

Conference (2013, November 23)

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See detailEFFECTS OF CHONDROITIN SULFATE ON THE GENE EXPRESSION PROFILE IN THE INFLAMED SYNOVIAL MEMBRANE
Lambert, Cécile ULg; Dubuc, Jean-Emile; Montell, E et al

Conference (2013, November 23)

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See detailEFFECTS OF CHONDROITIN SULFATE ON THE GENE EXPRESSION PROFILE IN INTERLEUKIN-1Β STIMULATED SYNOVIAL FIBROBLAST CELLS CULTURES
Lambert, Cécile ULg; Dubuc, Jean-Emile; Montell, E et al

Conference (2013, November 23)

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See detailProtective effect of a new CHITOSAN BIOMATERIAL against the development of experimental osteoarthritis lesions in rabbit
Oprenyeszk, Frédéric ULg; Chausson, M; Maquet, V et al

Conference (2013, November 23)

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See detailASSOCIATION BETWEEN CHONDROCYTE HYPERTROPHY AND ANGIOGENESIS OF CARTILAGE IN OSTEOARTHRITIS
Pesesse, Laurence ULg; Sanchez, Christelle ULg; Delcour, Jean-Pierre et al

Conference (2013, November)

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See detailBONE SIALOPROTEIN AS A KEY FACTOR IN THE PATHOPHYSIOLOGY OF OSTEOARTHRITIS
Pesesse, Laurence ULg; Sanchez, Christelle ULg; Walsh, David et al

Conference (2013, November)

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See detailOARSI recommended performance-based tests to assess clinical function in osteoathritis of hip and knee: author's reply
Dobson, Flora; Henrotin, Yves ULg

in Osteoarthritis and Cartilage (2013), 21(10), 1625-1626

The OARSI recommended set of performance-based tests of physical function represents the tests of typical activities relevant to individuals diagnosed with hip or knee OA and following joint replacements ... [more ▼]

The OARSI recommended set of performance-based tests of physical function represents the tests of typical activities relevant to individuals diagnosed with hip or knee OA and following joint replacements. These tests are complementary to patient-reported measures and are recommended as prospective outcome measures in future OA research and to assist decision-making in clinical practice. Further research should be directed to expanding the measurement-property evidence of the recommended tests. [less ▲]

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