Familial secreting-pinealomas : biological and preliminary genetic studies
; Valdes Socin, Hernan Gonzalo ; et al
in 10th Meeting of the European Neuroendocrine Association - Abstract book (2002)
Introduction: Sporadic pinealomas are intracranial tumors which incidence account for less than 1/107. This is the second report of secretory familial pinealoma in a mother and sister. We report for the ... [more ▼]
Introduction: Sporadic pinealomas are intracranial tumors which incidence account for less than 1/107. This is the second report of secretory familial pinealoma in a mother and sister. We report for the first time neuroendocrine and preliminary genetic studies in these benign tumors. Methods and patients: Radioimmunoassay of urinary 6-sulphatoxymelatonin (a-MT6s) was performed in patients and in 90 control subjects aged 19-67 years. Samples were collected at 19-23 , 23-07 and 07-11 h. Endocrine studies including PRL, TSH, LH, FSH, ACTH, IGF1 and tumoral markers (bHCG, NSE, CEA) levels were measured. Lymphocytes caryotype was determined by CGH. Pituitary and pineal MRI were done in both patients. Results: The daughter was the index case. Diagnosis was done because of headaches. Pineal MRI showed a 17 x 14x 25 mm cystic lesion with gadolinium enhancement and no ventricular dilatation. Circadian rhythm of urinary a-MT6s was present but a-MT6s levels were clearly elevated compared to age-matched controls: 1455 ng/h at 19-23hs (308 261), 6012 ng/h at 23-07hs (1423753) and 3280 ng/h at 07-11hs (579340). The 55 years-old mother reported similar complaints during the daughter's follow-up. A pineal MRI identified a 18 x 20 x 14 mm cystic lesion. There were no signs of intracranial hypertension. None of the women reported sleep disturbances. Circadian rhythm of urinary a-MT6s was lost but a-MT6S levels were clearly elevated : 2380 ng/h at 19-23hs (173 153), 2812 ng/h at 23-07hs (768486) and 1897 ng/h at 07-11hs (480383). Endocrine studies and tumoral markers were in the normal range. No chromosomal abnormalities were found in both women (46,XX). Discussion: Due to the rare occurrence of sporadic pinealomas it is unlikely that such a tumor afflict two members in the same family. Although no histological proof was obtained in our patients, radiological findings and tumoral hypersecretion of melatonin derivated a-MT6s clearly suggest the pineal origin of these tumors. We suggest an autosomal dominant form of transmission with incomplete dominance as the most probable model of inheritance of familial pinealoma. [less ▲]Detailed reference viewed: 17 (3 ULg)
Effects of Alpha-Methyl-Para-Tyrosine on Monoamine Levels in the Japanese Quail: Sex Differences and Testosterone Effects
Balthazart, Jacques ; Foidart, Agnès ; et al
in Brain Research Bulletin (1992), 28(2), 275-88
Experiments were performed to obtain more information on the regulation by steroids of catecholaminergic systems in the brain of Japanese quail. Dose-response and time-response experiments were first ... [more ▼]
Experiments were performed to obtain more information on the regulation by steroids of catecholaminergic systems in the brain of Japanese quail. Dose-response and time-response experiments were first performed to determine optimal conditions for measuring turnover in the quail brain. The norepinephrine and dopamine turnover were then estimated in microdissected brain nuclei of birds that were either sexually mature or gonadectomized or gonadectomized and treated with testosterone. Two major facts that bear direct relationship with the control of masculine reproductive behavior were demonstrated. On one hand, the dopamine turnover in the medial preoptic nucleus, a sexually dimorphic brain structure which is critically implicated in the control of copulatory behavior was much higher in male than in female quail irrespective of the hormonal condition of the birds. On the other hand, norepinephrine concentrations appeared to be higher in several nuclei of the female brain by comparison with males. These sex differences might represent part of the causal factors that underlie the sex dimorphism in reproductive behavior in quail. [less ▲]Detailed reference viewed: 30 (1 ULg)
The Induction by Testosterone of Aromatase Activity in the Preoptic Area and Activation of Copulatory Behavior
Balthazart, Jacques ; Foidart, Agnès ;
in Physiology & Behavior (1990), 47(1), 83-94
A series of 4 experiments was designed to study the relationships between the activity of the aromatase (AA) in the preoptic area (POA) and the activation by testosterone (T) of copulatory behavior in ... [more ▼]
A series of 4 experiments was designed to study the relationships between the activity of the aromatase (AA) in the preoptic area (POA) and the activation by testosterone (T) of copulatory behavior in gonadectomized male and female Japanese quail. The induction of AA by T in the POA is dose- and time-dependent. Levels of AA seen in sexually mature males are restored in castrated birds by a treatment with 20 to 40 mm silastic T capsules which produce physiological levels of steroid in the plasma. The minimal dose of T (10 mm implant) which reliably restores copulatory behavior approximately doubles the AA in the POA. The induction of AA is significantly larger in males than in females. A significant increase in AA is observed within 16 hours after the start of the treatment with T and the induction is maximal after 48 hours. Activation of copulatory behavior follows a similar time course but occurs with a delay of 24-48 hours. These results thus suggest that, in male quail, the activity of the aromatase in the POA is a limiting factor in the activation of copulatory behavior. This idea is confirmed by direct experimentation using an aromatase inhibitor, androstatrienedione (ATD). If T-treated birds receive at the same time silastic implants filled with ATD, the activation of behavior is suppressed for at least one week. This behavioral inhibition is, as expected, accompanied and very probably caused by the inhibition of the aromatase activity in the preoptic area and anterior hypothalamus. No increase of enzyme activity over the level seen in castrates was actually detected during the first 8 days of exposure to T. A moderate increase in AA was seen on day 16 and is probably responsible for the behavioral activation which was observed at the end of the experiment. [less ▲]Detailed reference viewed: 10 (1 ULg)
Essais de localisation des RNA polymérases dans des cellules tumorales d'Ehrlich par immunocytochimie ultrastructurale
Thiry, Marc ; ; et al
in Biology of the Cell (1986), 57Detailed reference viewed: 5 (0 ULg)
Etude immunocytochimique ultrastructurale de cellules tumorales d'Ehrlich à l'aide d'anticorps dirigés contre la RNA polymérase d'E. Coli
Thiry, Marc ; ; et al
in Bulletin de l'Association des Anatomistes (1986), 70Detailed reference viewed: 17 (0 ULg)
Effect of the presence of females on the pituitary-testicular activity in male Japanese quail (Coturnix coturnix japonica).
; ; et al
in General and Comparative Endocrinology (1984), 55(2), 295-305
Five experiments were carried out to study the role of the presence of a female on the reproductive endocrinology of male Japanese quail. In the first three experiments, exposure of an adult male raised ... [more ▼]
Five experiments were carried out to study the role of the presence of a female on the reproductive endocrinology of male Japanese quail. In the first three experiments, exposure of an adult male raised in long days to a female for l0 min or l week failed to increase plasma testosterone and LH levels; in fact a significant transitory decrease in plasma testosterone was observed, associated with a preceding increase in plasma corticosterone. These changes are interpreted as a result of the stress caused by repeated bleeding or by the continuous presence of a female in a limited space. In the last two experiments, an increase in the maturation rate of immature males could be observed in birds maintained in the continuous presence of females by comparison with birds kept in isolation. The paired males had larger cloacal glands and testes and higher plasma levels of testosterone and LH than the isolated one. This effect of the female was observed in long days (l6L:8D) as well as in marginally stimulating short days (l2L:l2D). [less ▲]Detailed reference viewed: 11 (0 ULg)
Testosterone metabolism and testosterone-dependent characteristics in Japanese quail.
; ; et al
in Physiology & Behavior (1984), 33(5), 817-23
In 2 independent experiments, we measured and correlated in maturing male Japanese quail the individual variations in sexual and aggressive behavior, cloacal gland size, testes weight, plasma testosterone ... [more ▼]
In 2 independent experiments, we measured and correlated in maturing male Japanese quail the individual variations in sexual and aggressive behavior, cloacal gland size, testes weight, plasma testosterone concentrations and intracellular testosterone metabolism by hypothalamus and cloacal gland. Cloacal gland area was only weakly related to plasma testosterone levels but was positively correlated with the production of active androgenic metabolites and negatively related to the production of 5 beta-reduced androgens (inactive) in the glandular tissue. Several measures of behavior were correlated with aspects of the testosterone metabolism in the anterior hypothalamus. In both experiments, the behavior of the birds was also strongly correlated with their testes weight and their cloacal gland area but weakly or not at all with their plasma testosterone levels. These studies suggest that testosterone metabolism is involved in the control of hormone action in maturing animals. [less ▲]Detailed reference viewed: 29 (0 ULg)
Effects of in vivo corticosterone treatment on the in vitro metabolism of testosterone in the comb and brain of the young male chicken.
; Balthazart, Jacques ; et al
in General and Comparative Endocrinology (1982), 48(3), 398-402Detailed reference viewed: 13 (0 ULg)
Endocrine effects of castration followed by androgen replacement and ACTH injections in the male domestic duck (Anas platyrhynchos L.).
; Balthazart, Jacques ; et al
in General and Comparative Endocrinology (1980), 41(1), 53-61Detailed reference viewed: 16 (0 ULg)
Effects of exogenous gonadotropic and steroid hormones on the social behaviour and gonadal maturation of male domestic ducklings Anas platyrhynchos L.
Balthazart, Jacques ;
in Archives Internationales de Physiologie et de Biochimie (1979), 87(4), 741-61
Male domestic ducklings were injected during their first month of life with mammalian gonadotrophins (ovine LH or FSH, HMG) or gonadal steroids (testosterone or oestradiol). LH and testosterone stimulated ... [more ▼]
Male domestic ducklings were injected during their first month of life with mammalian gonadotrophins (ovine LH or FSH, HMG) or gonadal steroids (testosterone or oestradiol). LH and testosterone stimulated sexual behaviour while oestradiol inhibited the increase of aggression observed in control birds during the experiment. The mammalian gonadotrophins did not increase plasma testosterone but nevertheless they all stimulated the testis growth. Several hypotheses which could explain this finding (stimulation of spermatogenesis without any apparent effect on testosterone) are discussed and the possibility of a direct action of LH on the sexual behaviour is analysed. Social displays were only moderately stimulated by testosterone and not at all by gonadotrophins. The hormonal controls of these behaviour patterns remains thus largely unknown. [less ▲]Detailed reference viewed: 25 (1 ULg)
Steroidal control of plasma luteiyizing hormone, comb growth and sexual behaviour in male chicks.
Balthazart, Jacques ;
in Journal of Endocrinology (1978), 77(1), 149-50Detailed reference viewed: 15 (0 ULg)
Controle hormonal du comportement et de la croissance testiculaire chez la caille coturnix corturnix japonica
Balthazart, Jacques ;
in Comptes Rendus Biologies (1977), 171(3), 656-63Detailed reference viewed: 25 (2 ULg)
Diurnal variations of plasma gonadotrophins in male domestic ducks during the sexual cycle.
Balthazart, Jacques ; ;
in General and Comparative Endocrinology (1977), 32(4), 376-89Detailed reference viewed: 8 (0 ULg)
Dosage radioimmunologique de l'hormone folliculo-stimulante (FSH) hypophysaire de canard a l'aide d'un systeme de mammiferes
; ; Balthazart, Jacques et al
in Comptes Rendus des Séances de la Société de Biologie et de ses Filiales (1974), 168(1), 136-40Detailed reference viewed: 45 (1 ULg)