References of "Havelková, Helena"
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See detailAtopy controlling loci in Czech and Russian populations
Gusareva, Elena ULg; Badalová, Jana; Havelková, Helena et al

Poster (2010, April)

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See detailMouse to human comparative genetics reveals a novel immunoglobulin E-controlling locus on Hsa8q12
Gusareva, Elena ULg; Havelková, Helena; Blažková, Hana et al

in Immunogenetics (2009), 61(1), 15-25

Atopy is a predisposition to hyperproduction of immunoglobulin E (IgE) against common environmental allergens. It is often associated with development of allergic diseases such as asthma, rhinitis, and ... [more ▼]

Atopy is a predisposition to hyperproduction of immunoglobulin E (IgE) against common environmental allergens. It is often associated with development of allergic diseases such as asthma, rhinitis, and dermatitis. Production of IgE is influenced by genetic and environmental factors. In spite of progress in the study of heredity of atopy, the genetic mechanisms of IgE regulation have not yet been completely elucidated. The analysis of complex traits can benefit considerably from integration of human and mouse genetics. Previously, we mapped a mouse IgE-controlling locus Lmr9 on chromosome 4 to a segment of <9 Mb. In this study, we tested levels of total IgE and 25 specific IgEs against inhalant and food allergens in 67 Czech atopic families. In the position homologous to Lmr9 on chromosome 8q12 marked by D8S285, we demonstrated a novel human IgE-controlling locus exhibiting suggestive linkage to composite inhalant allergic sensitization (limit of detection, LOD=2.11, P=0.0009) and to nine specific IgEs, with maximum LOD (LOD=2.42, P=0.0004) to plantain. We also tested 16 markers at previously reported chromosomal regions of atopy. Linkage to plant allergens exceeding the LOD>2.0 was detected at 5q33 (D5S1507, LOD=2.11, P=0.0009) and 13q14 (D13S165, LOD=2.74, P=0.0002). The significant association with plant allergens (quantitative and discrete traits) was found at 7p14 (D7S2250, corrected P=0.026) and 12q13 (D12S1298, corrected P=0.043). Thus, the finding of linkage on chromosome 8q12 shows precision and predictive power of mouse models in the investigation of complex traits in humans. Our results also confirm the role of loci at 5q33, 7p14, 12q14, and 13q13 in control of IgE. [less ▲]

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See detailDifferent environmental influences on etiology of atopic diseases in European populations as a basis for study of geneenvironment interactions.
Gusareva, Elena ULg; Belozorov, Aleksey; Havelková, Helena et al

in Torres, S. L.; Marin, M. S. (Eds.) Genetic Predisposition to Disease (2008)

Atopy is a predisposition to hyperproduction of immunoglobulin E (IgE) against common environmental allergens. Sensitization to various airborne and food allergens contributes to different types of atopic ... [more ▼]

Atopy is a predisposition to hyperproduction of immunoglobulin E (IgE) against common environmental allergens. Sensitization to various airborne and food allergens contributes to different types of atopic diseases, including asthma, eczema, and allergic rhinitis. The development of these diseases is influenced by both genetic and environmental factors. Several loci and genes that control IgE level have been described in different chromosomal regions. Some of them have been detected in several populations, others only in one or a few populations. These differences might be caused by variations of genetic composition between populations, different lifestyles and/or by environmental variations in major allergens triggering development of atopic diseases. Thus, the environmental conditions may likely determine, which from the potential atopy-controlling genes will operate in a certain population. As the first step in study of such gene-environment interactions we analyzed the specificity and intensity of sensitization to 40 different allergens in atopic patients from the Czech Republic and Ukraine, representing two genetically not very distant populations, which live in different environmental conditions. The atopic patients from both countries displayed a higher reactivity to inhalant than to food allergens. We found highly significant differences in sensitization to airborne allergens between patients from the two countries. The most pronounced allergens for the atopic patients from Ukraine were allergens from dust mites Dermatophagoides pteronyssinus (38.5%), Dermatophagoides farinae (48.1%) and cat (44.2%). In the atopic patients from the Czech Republic the level of sensitization to these allergens was similar, but the level of sensitization to outdoor allergens, grasses and trees was dramatically higher. More than 68% of the patients from the Czech Republic in comparison with less than 25% of the patients from Ukraine have been sensitized to cocksfoot, sweet vernal grass, timothy grass and cultivated rye (Bonferroni-corrected P values ranged from 0.0007 to 0.000000003). More than 50% and 60% of the patients from the Czech Republic but only 2% and 19.2% of the patients from Ukraine reacted to alder (corrected P < 0.00009) and birch (corrected P < 0.002), respectively. The higher sensitization to plant allergens of the patients from the Czech Republic was present in those with asthma and rhinitis, but not with dermatitis. The higher sensitization levels to outdoor allergens in the Czech Republic suggest an influence of westernization on development of allergic reactivity. Genetic analysis of atopic patients from these two countries will establish which geneloci control development of atopy under different environmental conditions. [less ▲]

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See detailIgE controlling loci in Czech atopic patients.
Gusareva, Elena ULg; Havelková, Helena; Blažková, Hanna et al

Poster (2006, September 07)

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