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See detailMOA-2010-BLG-311: A planetary candidate below the threshold of reliable detection
Yee, J. C.; Hung, L.-W.; Bond, I. A. et al

in Astrophysical Journal (2013), 769(1), 77

We analyze MOA-2010-BLG-311, a high magnification (A_max>600) microlensing event with complete data coverage over the peak, making it very sensitive to planetary signals. We fit this event with both a ... [more ▼]

We analyze MOA-2010-BLG-311, a high magnification (A_max>600) microlensing event with complete data coverage over the peak, making it very sensitive to planetary signals. We fit this event with both a point lens and a 2-body lens model and find that the 2-body lens model is a better fit but with only Delta chi^2~140. The preferred mass ratio between the lens star and its companion is $q=10^(-3.7+/-0.1), placing the candidate companion in the planetary regime. Despite the formal significance of the planet, we show that because of systematics in the data the evidence for a planetary companion to the lens is too tenuous to claim a secure detection. When combined with analyses of other high-magnification events, this event helps empirically define the threshold for reliable planet detection in high-magnification events, which remains an open question. [less ▲]

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See detailMOA-2010-BLG-523: "Failed Planet" = RS CVn Star
Gould, A.; Yee, J. C.; Bond, I. A. et al

in Astrophysical Journal (2013), 763

The Galactic bulge source MOA-2010-BLG-523S exhibited short-term deviations from a standard microlensing light curve near the peak of an A [SUB]max[/SUB] ~ 265 high-magnification microlensing event. The ... [more ▼]

The Galactic bulge source MOA-2010-BLG-523S exhibited short-term deviations from a standard microlensing light curve near the peak of an A [SUB]max[/SUB] ~ 265 high-magnification microlensing event. The deviations originally seemed consistent with expectations for a planetary companion to the principal lens. We combine long-term photometric monitoring with a previously published high-resolution spectrum taken near peak to demonstrate that this is an RS CVn variable, so that planetary microlensing is not required to explain the light-curve deviations. This is the first spectroscopically confirmed RS CVn star discovered in the Galactic bulge. Based on observations made with the European Southern Observatory telescopes, Program ID 85.B-0399(I). [less ▲]

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See detailMOA-2010-BLG-073L: An M-dwarf with a Substellar Companion at the Planet/Brown Dwarf Boundary
Street, R. A.; Choi, J.-Y.; Tsapras, Y. et al

in Astrophysical Journal (2013), 763

We present an analysis of the anomalous microlensing event, MOA-2010-BLG-073, announced by the Microlensing Observations in Astrophysics survey on 2010 March 18. This event was remarkable because the ... [more ▼]

We present an analysis of the anomalous microlensing event, MOA-2010-BLG-073, announced by the Microlensing Observations in Astrophysics survey on 2010 March 18. This event was remarkable because the source was previously known to be photometrically variable. Analyzing the pre-event source light curve, we demonstrate that it is an irregular variable over timescales >200 days. Its dereddened color, (V - I)[SUB] S, 0[/SUB], is 1.221 ± 0.051 mag, and from our lens model we derive a source radius of 14.7 ± 1.3 R [SUB]&sun;[/SUB], suggesting that it is a red giant star. We initially explored a number of purely microlensing models for the event but found a residual gradient in the data taken prior to and after the event. This is likely to be due to the variability of the source rather than part of the lensing event, so we incorporated a slope parameter in our model in order to derive the true parameters of the lensing system. We find that the lensing system has a mass ratio of q = 0.0654 ± 0.0006. The Einstein crossing time of the event, t [SUB]E[/SUB] = 44.3 ± 0.1 days, was sufficiently long that the light curve exhibited parallax effects. In addition, the source trajectory relative to the large caustic structure allowed the orbital motion of the lens system to be detected. Combining the parallax with the Einstein radius, we were able to derive the distance to the lens, D[SUB]L[/SUB] = 2.8 ± 0.4 kpc, and the masses of the lensing objects. The primary of the lens is an M-dwarf with M [SUB] L, 1[/SUB] = 0.16 ± 0.03 M [SUB]&sun;[/SUB], while the companion has M [SUB] L, 2[/SUB] = 11.0 ± 2.0 M [SUB]J[/SUB], putting it in the boundary zone between planets and brown dwarfs. [less ▲]

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See detailMOA-2010-BLG-328Lb: a sub-Neptune orbiting very late M dwarf ?
Furusawa, K.; Udalski, A.; Sumi, T. et al

in Astrophysical Journal (2013), 91

We analyze the planetary microlensing event MOA-2010-BLG-328. The best fit yields host and planetary masses of Mh = 0.11+/-0.01 M_{sun} and Mp = 9.2+/-2.2M_Earth, corresponding to a very late M dwarf and ... [more ▼]

We analyze the planetary microlensing event MOA-2010-BLG-328. The best fit yields host and planetary masses of Mh = 0.11+/-0.01 M_{sun} and Mp = 9.2+/-2.2M_Earth, corresponding to a very late M dwarf and sub-Neptune-mass planet, respectively. The system lies at DL = 0.81 +/- 0.10 kpc with projected separation r = 0.92 +/- 0.16 AU. Because of the host's a-priori-unlikely close distance, as well as the unusual nature of the system, we consider the possibility that the microlens parallax signal, which determines the host mass and distance, is actually due to xallarap (source orbital motion) that is being misinterpreted as parallax. We show a result that favors the parallax solution, even given its close host distance. We show that future high-resolution astrometric measurements could decisively resolve the remaining ambiguity of these solutions. [less ▲]

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See detailMOA 2010-BLG-477Lb: Constraining the Mass of a Microlensing Planet from Microlensing Parallax, Orbital Motion, and Detection of Blended Light
Bachelet, E.; Shin, I.-G.; Han, C. et al

in Astrophysical Journal (2012), 754

Microlensing detections of cool planets are important for the construction of an unbiased sample to estimate the frequency of planets beyond the snow line, which is where giant planets are thought to form ... [more ▼]

Microlensing detections of cool planets are important for the construction of an unbiased sample to estimate the frequency of planets beyond the snow line, which is where giant planets are thought to form according to the core accretion theory of planet formation. In this paper, we report the discovery of a giant planet detected from the analysis of the light curve of a high-magnification microlensing event MOA 2010-BLG-477. The measured planet-star mass ratio is q = (2.181 ± 0.004) × 10[SUP]-3[/SUP] and the projected separation is s = 1.1228 ± 0.0006 in units of the Einstein radius. The angular Einstein radius is unusually large θ[SUB]E[/SUB] = 1.38 ± 0.11 mas. Combining this measurement with constraints on the "microlens parallax" and the lens flux, we can only limit the host mass to the range 0.13 < M/M [SUB]&sun;[/SUB] < 1.0. In this particular case, the strong degeneracy between microlensing parallax and planet orbital motion prevents us from measuring more accurate host and planet masses. However, we find that adding Bayesian priors from two effects (Galactic model and Keplerian orbit) each independently favors the upper end of this mass range, yielding star and planet masses of M [SUB]*[/SUB] = 0.67[SUP]+0.33[/SUP] [SUB]- 0.13[/SUB] M [SUB]&sun;[/SUB] and m[SUB]p[/SUB] = 1.5[SUP]+0.8[/SUP] [SUB]- 0.3[/SUB] M [SUB]JUP[/SUB] at a distance of D = 2.3 ± 0.6 kpc, and with a semi-major axis of a = 2[SUP]+3[/SUP] [SUB]- 1[/SUB] AU. Finally, we show that the lens mass can be determined from future high-resolution near-IR adaptive optics observations independently from two effects, photometric and astrometric. [less ▲]

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See detailBiological actions of curcumin on articular chondrocytes.
Henrotin, Yves ULg; Clutterbuck, A. L.; Allaway, D. et al

in Osteoarthritis and Cartilage (2010), 18(2), 141-9

OBJECTIVES: Curcumin (diferuloylmethane) is the principal biochemical component of the spice turmeric and has been shown to possess potent anti-catabolic, anti-inflammatory and antioxidant, properties ... [more ▼]

OBJECTIVES: Curcumin (diferuloylmethane) is the principal biochemical component of the spice turmeric and has been shown to possess potent anti-catabolic, anti-inflammatory and antioxidant, properties. This article aims to provide a summary of the actions of curcumin on articular chondrocytes from the available literature with the use of a text-mining tool. We highlight both the potential benefits and drawbacks of using this chemopreventive agent for treating osteoarthritis (OA). We also explore the recent literature on the molecular mechanisms of curcumin mediated alterations in gene expression mediated via activator protein 1 (AP-1)/nuclear factor-kappa B (NF-kappaB) signalling in chondrocytes, osteoblasts and synovial fibroblasts. METHODS: A computer-aided search of the PubMed/Medline database aided by a text-mining tool to interrogate the ResNet Mammalian database 6.0. RESULTS: Recent work has shown that curcumin protects human chondrocytes from the catabolic actions of interleukin-1 beta (IL-1beta) including matrix metalloproteinase (MMP)-3 up-regulation, inhibition of collagen type II and down-regulation of beta1-integrin expression. Curcumin blocks IL-1beta-induced proteoglycan degradation, AP-1/NF-kappaB signalling, chondrocyte apoptosis and activation of caspase-3. CONCLUSIONS: The available data from published in vitro and in vivo studies suggest that curcumin may be a beneficial complementary treatment for OA in humans and companion animals. Nevertheless, before initiating extensive clinical trials, more basic research is required to improve its solubility, absorption and bioavailability and gain additional information about its safety and efficacy in different species. Once these obstacles have been overcome, curcumin and structurally related biochemicals may become safer and more suitable nutraceutical alternatives to the non-steroidal anti-inflammatory drugs that are currently used for the treatment of OA. [less ▲]

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See detailNutritional biochemistry of curcumin (diferuloymethane) and a review of its biological actions on articular chondrocytes
Mobasheri, A; Henrotin, Yves ULg; Clutterbuck, A et al

in Haugen, Sondre; Meijer, Simen (Eds.) Handbook of Nutritional Biochemistry (2009)

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See detailEffect of nutritional antioxidant supplementation on systemic and pulmonary antioxidant status, airway inflammation and lung function in heaves-affected horses
Kirschvink, Nathalie; Fievez, Laurence ULg; Bougnet, V. et al

in Equine Veterinary Journal (2002), 34

An oxidant/antioxidant imbalance in favour of oxidants has been identified as playing a decisive role in the pathogenesis of chronic inflammatory airway diseases. Nutritional antioxidant supplementation ... [more ▼]

An oxidant/antioxidant imbalance in favour of oxidants has been identified as playing a decisive role in the pathogenesis of chronic inflammatory airway diseases. Nutritional antioxidant supplementation might reduce oxidative damage by enhancement of the antioxidant defence, thereby modulating inflammatory processes. In a placebo-controlled, blind study, it was tested whether a dietary antioxidant supplement administered for 4 weeks would improve lung function and reduce airway inflammation in heaves-affected horses. Eight horses in clinical remission of heaves were investigated at rest and after a standardised exercise test before and after treatment with an antioxidant supplement (consisting of a mixture of natural antioxidants including vitamins E and C and selenium from a variety of sources) or placebo (oatfeed pellets without additive). Pulmonary function and exercise tolerance were monitored; systemic and pulmonary lining fluid uric acid, glutathione and 8-epi-PGF(2alpha) were analysed, and bronchoalveolar lavage (BAL) cytology and inflammatory scoring of the airways were performed. The antioxidant treatment significantly improved exercise tolerance and significantly reduced endoscopic inflammatory score. Plasma uric acid concentrations were significantly reduced, suggesting downregulation of the xanthine-dehydrogenase and xanthine-oxydase pathway. Haemolysate glutathione showed a nonsignificant trend to increase, while plasma 8-epi-PGF(2alpha) remained unchanged. Pulmonary markers and BAL cytology were not significantly affected by antioxidant supplementation. The present study suggests that the antioxidant supplement tested modulated oxidant/antioxidant balance and airway inflammation of heaves-affected horses [less ▲]

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