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See detailTranscriptional activation of cyclooxygenase-2 by tumor suppressor p53 requires nuclear factor-kappaB
Benoit, Valérie; de Moraes, E.; Dar, N. A. et al

in Oncogene (2006), 25(42), 5708-5718

Overexpression of cyclooxygenase-2 (Cox-2) is thought to exert antiapoptotic effects in cancer. Here we show that the tumor suppressor p53 upregulated Cox-2 in esophageal and colon cancer cell lines by ... [more ▼]

Overexpression of cyclooxygenase-2 (Cox-2) is thought to exert antiapoptotic effects in cancer. Here we show that the tumor suppressor p53 upregulated Cox-2 in esophageal and colon cancer cell lines by inducing the binding of nuclear factor-kappaB (NF-kappaB) to its response element in the COX-2 promoter. Inhibition of NF-kappaB prevented p53 induction of Cox-2 expression. Cooperation between p53 and NF-kappaB was required for activation of COX-2 promoter in response to daunomycin, a DNA-damaging agent. Pharmacological inhibition of Cox-2 enhanced apoptosis in response to daunomycin, in particular in cells containing active p53. In esophageal cancer, there was a correlation between Cox-2 expression and wild-type TP53 in Barrett's esophagus (BE) and in adenocarcinoma, but not in squamous cell carcinoma (P < 0.01). These results suggest that p53 and NF-kappaB cooperate in upregulating Cox-2 expression, promoting cell survival in inflammatory precursor lesions such as BE. [less ▲]

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See detailResistance to exogenous MMTV infection in a strain of "Swiss" mice is correlated with the presence of an endogenous proviral gene, mtv-3
Hainaut, Pierre; Vaira, Dolorès ULg; Calberg-Bacq, Claire Michèle et al

Poster (1987)

Detailed reference viewed: 8 (3 ULg)