References of "Grignet, Christine"
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See detailLa protection de l’environnement et les installations classées en Belgique
Grignet, Christine ULg

Conference given outside the academic context (2013)

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See detailLa gestion du risque biologique en Belgique
Grignet, Christine ULg

Conference given outside the academic context (2013)

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See detailGestion du risque biologique en laboratoires : démarche et enjeux
Grignet, Christine ULg

Scientific conference (2013, February 27)

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See detailThe practical challenges of the Biosafety officer : interacting with the user
Grignet, Christine ULg

in The Biosafety Professional: roles and interactions in a complex network (2008)

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See detailAttempt to enhance the suicide gene therapy agaisnt breast cancer cells by using connexin 43 gene
Grignet, Christine ULg; Hajitou, Amin; Noël, Agnès ULg et al

in Acta Clinica Belgica (2002), 57(2), 99

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See detailThe antitumoral effect of endostatin and angiostatin is associated with a down-regulation of vascular endothelial growth factor expression in tumor cells
Hajitou, Amin; Grignet, Christine ULg; Devy, L. et al

in FASEB Journal (2002), 16

Endostatin and angiostatin are known as tumor-derived angiogenesis inhibitors, but their mechanisms of action are not yet completely defined. We report here that endostatin and angiostatin, delivered by ... [more ▼]

Endostatin and angiostatin are known as tumor-derived angiogenesis inhibitors, but their mechanisms of action are not yet completely defined. We report here that endostatin and angiostatin, delivered by adenoviral vectors, reduced in vitro the neovessel formation in the mouse aortic ring assay by 85 and 40%, respectively. We also demonstrated in vivo that both endostatin and angiostatin inhibited local invasion and tumor vascularization of transplanted murine malignant keratinocytes, and reduced by 50 and 90% the development of highly vascularized murine mammary tumors. This inhibition of tumor growth was associated with a reduction of tumor vascularization. Expression analysis of vascular endothelial growth factor (VEGF) carried out in the mouse aortic ring model revealed a 3- to 10-fold down-regulation of VEGF mRNA expression in endostatin-treated rings. A similar down-regulation of VEGF expression at both mRNA and protein levels was also observed in the two in vivo cancer models after treatment with each angiogenesis inhibitor. This suggests that endostatin and angiostatin effects may be mediated, at least in part, by their ability to down-regulate VEGF expression within the tumor. This work provides evidence that endostatin and angiostatin act on tumor cells themselves. [less ▲]

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See detailFactors involved in the bystander effect induced by Varicella zoster and Herpes simplex viral thymidine kinase suicide gene therapy
Grignet, Christine ULg; Cool, V.; Baudson, N. et al

in Journal of Gene Medicine (The) (1999), 1

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See detailPotential of Varicella zoster virus thymidine kinase as a suicide gene in breast cancer cells
Grignet, Christine ULg; Calberg-Bacq, Claire-Michelle

in Gene Therapy (1997), 4

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